The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions
Open accessAbstract
The Global Burden of Disease (GBD) Study 2010 estimated the GBD attributable to 15 categories of skin disease from 1990 to 2010 for 187 countries. For each of the following diseases, we performed systematic literature reviews and analyzed resulting data: eczema, psoriasis, acne vulgaris, pruritus, alopecia areata, decubitus ulcer, urticaria, scabies, fungal skin diseases, impetigo, abscess, and other bacterial skin diseases, cellulitis, viral warts, molluscum contagiosum, and non-melanoma skin cancer. We used disability estimates to determine nonfatal burden. Three skin conditions, fungal skin diseases, other skin and subcutaneous diseases, and acne were in the top 10 most prevalent diseases worldwide in 2010, and eight fell into the top 50; these additional five skin problems were pruritus, eczema, impetigo, scabies, and molluscum contagiosum. Collectively, skin conditions ranged from the 2nd to 11th leading cause of years lived with disability at the country level. At the global level, skin conditions were the fourth leading cause of nonfatal disease burden. Using more data than has been used previously, the burden due to these diseases is enormous in both high- and low-income countries. These results argue strongly to include skin disease prevention and treatment in future global health strategies as a matter of urgency.
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- Findingreasoning
Eczema consistently contributes a large share of disability burden worldwide.
“However, the high burden of disability related to eczema remains consistent globally.”
Quote in the paperNot a substantial claim - Findingown data
At the country level, skin conditions ranged from the 2nd to 11th leading cause of years lived with disability in 2010.
“Collectively, skin conditions ranged from being the 2nd to 11th leading cause of years lived with disability at the country level for 2010; they range from 3rd to 28th, taking into account premature deaths.”
Quote in the paperNot a substantial claim - Findingcitation
In Oceania, sub-Saharan Africa, southeast Asia, and tropical Americas, skin infections accounted for a higher proportion of the skin disease burden.
“In Oceania, sub-Saharan Africa, southeast Asia, and the tropical Americas, skin infections assume a higher proportion of the disease burden (Leekassa et al., 2005;Steer et al., 2009).”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Leekassa et al., 2005
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- cites Steer et al., 2009 source
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- Findingown data
Albania, Lithuania, Romania, and Indonesia had the lowest nonfatal skin disease burden per capita in both 1990 and 2010.
“Singapore, Brunei, Hungary, and Sudan experienced the most nonfatal skin disease burden per capita in both 1990 and 2010, and Albania, Lithuania, Romania, and Indonesia the least.”
Quote in the paperNot a substantial claim - Findingown data
Singapore, Brunei, Hungary, and Sudan had the highest nonfatal skin disease burden per capita in both 1990 and 2010.
“Singapore, Brunei, Hungary, and Sudan experienced the most nonfatal skin disease burden per capita in both 1990 and 2010, and Albania, Lithuania, Romania, and Indonesia the least.”
Quote in the paperNot a substantial claim
- Findingnone given
Across specific causes, ages, and regions, skin disease burden was higher among females.
“Across specific causes, ages, and regions, burden is higher among females.”
Quote in the paperNot a substantial claim - Findingown data
When premature death is included as DALYs, skin conditions were the 18th leading cause of health burden worldwide in 2010.
“Collectively, skin conditions were the 4th leading cause of nonfatal burden expressed as years lost due to disability in 2010; taking into account health loss due to premature death expressed as disability-adjusted life years (DALYs), skin remains the 18th leading cause of health burden worldwide (Tables 1 and 2).”
Quote in the paperNot a substantial claim - Findingreasoning
Eczema was the leading cause of skin condition DALYs across countries, ages, sex, and time.
“The leading cause of skin condition DALYs is eczema, when looking across countries, ages, sex, and time because of the combined high prevalence across geographies and population and relatively high average disability weight.”
Quote in the paperSubstantial claim - Findingcitation
Other skin and subcutaneous diseases were the 5th most prevalent disease globally in 2010.
“Three skin conditions were in the top 10 most prevalent diseases globally in 2010-fungal skin diseases (4th global prevalence ¼ 984,290,432), other skin and subcutaneous diseases (5th), and acne vulgaris (8th global prevalence ¼ 645,499,136; Vos et al., 2012).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Vos et al., 2012 source
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- Findingown data
Eight skin conditions were among the top 50 most prevalent diseases worldwide in 2010.
“Three skin conditions, fungal skin diseases, other skin and subcutaneous diseases, and acne were in the top 10 most prevalent diseases worldwide in 2010, and eight fell into the top 50; these additional five skin problems were pruritus, eczema, impetigo, scabies, and molluscum contagiosum.”
Quote in the paperNot a substantial claim - Findingown data
At the country level, skin conditions ranged from the 3rd to 28th leading cause when premature deaths are included.
“Collectively, skin conditions ranged from being the 2nd to 11th leading cause of years lived with disability at the country level for 2010; they range from 3rd to 28th, taking into account premature deaths.”
Quote in the paperNot a substantial claim - Findingown data
Skin conditions collectively were the 4th leading cause of nonfatal burden expressed as years lived with disability (YLD) globally in 2010.
“Collectively, skin conditions were the 4th leading cause of nonfatal burden expressed as years lost due to disability in 2010; taking into account health loss due to premature death expressed as disability-adjusted life years (DALYs), skin remains the 18th leading cause of health burden worldwide (Tables 1 and 2).”
Quote in the paperSubstantial claim - Findingown data
The burden of skin conditions, notably acne vulgaris and decubitus ulcer, shows marked age patterns.
“The burden of skin conditions, notably acne vulgaris and decubitus ulcer, show marked age patterns (Figure 2a and b).”
Quote in the paperNot a substantial claim - Interpretationcitation
The findings support that skin disease accounts for a large share of primary care diagnoses in all health settings.
“These results confirm why, in all health settings, skin disease constitutes a major proportion of all diagnoses in primary care (NHANES, 1978;Scholfield et al., 2009).”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites NHANES, 1978
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- cites Scholfield et al., 2009
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- Study design and conductreasoning
Because GBD 2010 treated disease states as mutually exclusive and collectively exhaustive, the skin disease burden estimates may be underestimates.
“Unfortunately, in GBD 2010, each disease state was mutually exclusive and collectively exhaustive.This means, e.g., that lupus erythematosus burden forms part of ''other musculoskeletal disease,'' with the related dermatological manifestations taken into account in the disability weight.The estimates shown here, therefore, may underestimate the total burden of skin diseases.”
Quote in the paperSubstantial claim - Premisecitation
Earlier estimates of skin disease prevalence and health impact used flawed epidemiological studies, analytical methods, and disability weighting.
“Previous attempts have been made to estimate the prevalence and health impact of skin diseases (Murray and Lopez, 1996;Global Burden of Disease, 2008) but these have relied on epidemiological studies, analytical methods, and disability weighting, which had flaws (Salomon, 2010).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Salomon, 2010 source
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- Premisecitation
The harmful consequences of skin disease span from physical disability to death.
“Its detrimental effects on health range from physical incapacity to death (Basra and Shahrukh, 2009).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Basra and Shahrukh, 2009
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- May combine two claims. 24
- Classified as probably not a substantial claim. 21
May combine two claims.
FindingcitationFungal skin diseases were the 4th most prevalent disease globally in 2010, with an estimated prevalence of 984,290,432.
“Three skin conditions were in the top 10 most prevalent diseases globally in 2010-fungal skin diseases (4th global prevalence ¼ 984,290,432), other skin and subcutaneous diseases (5th), and acne vulgaris (8th global prevalence ¼ 645,499,136; Vos et al., 2012).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Vos et al., 2012 source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataPruritus had a global prevalence of 279,889,120 in 2010.
“There are further five skin diseases in the top 50 most common causes of diseasepruritus (global prevalence ¼ 279,889,120), eczema (global prevalence ¼ 229,761,000), impetigo (global prevalence ¼ 140,495,000), molluscum contagiosum/warts (global prevalence ¼ 122,601,000), and scabies (global prevalence ¼ 100,625,000).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingnone givenPeople over 70 carry a high skin disease burden, with eczema, ulcers, other skin conditions, NMSC, infections, and pruritus as major problems.
“There is also a high burden of skin disease in the elderly above the age of 70 years, where eczema, ulceration, other skin conditions, NMSC, infections, and pruritus are key problems.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataRegional prevalence rates differ substantially by cause: western Europe had the highest pruritus prevalence and lowest scabies prevalence; eastern sub-Saharan Africa had the highest cellulitis, fungal skin disease, and viral warts prevalence and lowest urticaria prevalence.
“Rates differ substantially by cause across regions: western Europe has the highest prevalence rate for pruritus but the lowest for scabies and eastern sub-Saharan Africa has the highest rates of cellulitis, fungal skin disease, and viral warts but the lowest rates of urticaria.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingnone givenSkin problems become an important cause of disability by age 1, and disability levels are high in adolescence.
“By age 1 year, skin problems already assume importance as a reason for disability with high levels seen in teenage years.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataImpetigo had a global prevalence of 140,495,000 in 2010.
“There are further five skin diseases in the top 50 most common causes of diseasepruritus (global prevalence ¼ 279,889,120), eczema (global prevalence ¼ 229,761,000), impetigo (global prevalence ¼ 140,495,000), molluscum contagiosum/warts (global prevalence ¼ 122,601,000), and scabies (global prevalence ¼ 100,625,000).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataScabies had a global prevalence of 100,625,000 in 2010.
“There are further five skin diseases in the top 50 most common causes of diseasepruritus (global prevalence ¼ 279,889,120), eczema (global prevalence ¼ 229,761,000), impetigo (global prevalence ¼ 140,495,000), molluscum contagiosum/warts (global prevalence ¼ 122,601,000), and scabies (global prevalence ¼ 100,625,000).”
Quote in the paperNot a substantial claimMay combine two claims.
FindingcitationAcne vulgaris was the 8th most prevalent disease globally in 2010, with an estimated prevalence of 645,499,136.
“Three skin conditions were in the top 10 most prevalent diseases globally in 2010-fungal skin diseases (4th global prevalence ¼ 984,290,432), other skin and subcutaneous diseases (5th), and acne vulgaris (8th global prevalence ¼ 645,499,136; Vos et al., 2012).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Vos et al., 2012 source
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Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataMolluscum contagiosum/warts had a global prevalence of 122,601,000 in 2010.
“There are further five skin diseases in the top 50 most common causes of diseasepruritus (global prevalence ¼ 279,889,120), eczema (global prevalence ¼ 229,761,000), impetigo (global prevalence ¼ 140,495,000), molluscum contagiosum/warts (global prevalence ¼ 122,601,000), and scabies (global prevalence ¼ 100,625,000).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataEczema had a global prevalence of 229,761,000 in 2010.
“There are further five skin diseases in the top 50 most common causes of diseasepruritus (global prevalence ¼ 279,889,120), eczema (global prevalence ¼ 229,761,000), impetigo (global prevalence ¼ 140,495,000), molluscum contagiosum/warts (global prevalence ¼ 122,601,000), and scabies (global prevalence ¼ 100,625,000).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductreasoningTraining from the Institute of Health Metrics and a shared procedure manual were used to standardize the investigation.
“To ensure uniformity of investigational approach, training was provided by the Institute of Health Metrics, and participants used a common procedure manual.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductnone givenStudies were included if published from 1980 to 2010 and reported relevant disease incidence or prevalence.
“The inclusion criteria were studies that were published between 1980 and 2010 that provided data on relevant disease incidence or prevalence.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationBetween 30% and 70% of people are affected by skin disease, and at-risk subgroups have higher rates.
“It pervades all cultures, occurs at all ages, and affects between 30% and 70% of individuals, with even higher rates in at-risk subpopulations (NHANES, 1978;Bickers et al., 2006;Scholfield et al., 2009;Hay and Fuller, 2012).”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites NHANES, 1978
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- cites Bickers et al., 2006 source
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- cites Scholfield et al., 2009
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May combine two claims.
Study design and conductown dataA Bayesian meta-regression tool, DisMod-MR, was used to harmonize discordant estimates and fill geographic, temporal, and age-sex gaps.
“Data were analyzed using a Baysian meta-regression tool, described below, to harmonize discordant data where multiple estimates were available as well as fill in gaps in geography, time, or age-sex groups, where data were lacking.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductcitationDisability weights came from a survey using international volunteer panels, telephone interviews, and a web tool, with consistency shown across six sources.
“Disability was derived from an analysis of the comparative impact of the direct disabling consequences of skin disease such as itch and disfigurement against other conditions through a disability weights survey, which involved the use of international panels of volunteers, a telephone-based survey, and a web-based tool.Consistency was demonstrated among all six sources (Salomon et al., 2012).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Salomon et al., 2012 source
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May combine two claims.
Study design and conductown dataData sources varied in age ranges, survey design, and case definitions.
“In terms of age ranges, design of surveys, and even case definitions, data sources did not follow a uniform approach.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenYLD and DALY estimates were applied to entire populations without adjustment for social class or environment.
“Both measures are applied to whole populations without differentiating for potential variables such as social class or environment.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationPoverty, affluence, inequality, education, and health-care access are important social determinants in skin disease epidemiology.
“Social factors such as poverty, affluence, inequality, education, and access to health care all have an important role in the epidemiology of skin disease (NHANES, 1978;Williams et al., 1994;Gibbs, 1996;Figueroa et al., 1998;Scholfield et al., 2009).”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites NHANES, 1978
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- cites Williams et al., 1994
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- cites Gibbs, 1996 source
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Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductreasoningAlthough similar skin disease severity can affect individuals very differently, disability weights were defined uniformly for consistency and due to data limits.
“Skin diseases of similar severities and extents will affect different subject's lives in strikingly different ways, but for consistency and because of data limitations, the disability weights were defined as such.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataThe team identified substantial regional gaps and variable data quality.
“The study group also found, as anticipated, that there were substantial areas of missing and variable quality data at the regional level.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataThe GBD 2010 Skin Conditions Expert Group led data collection and disease consultation.
“The GBD 2010 Skin Conditions Expert Group provided the lead in data collection and disease consultation for all analyses.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductown dataExclusion criteria covered self-reported data lacking physician validation, occupational groups, first hospital or clinic presentation unless deemed accurate, non-random samples, specific ethnic or social groups, dates outside 1980-2010, samples under 100, clinical trial experimental arms, and papers giving estimates rather than data.
“Studies were excluded for the following reasons: Data in study were self-reported unless it had been validated by the diagnosis of a trained physician”
- Also stated in: § Search strategy for identification of studies · plain
“Sample size smaller than 100 Experimental arm of a clinical trial Papers that provided estimates rather than data”
Quote in the paperSubstantial claim- Also stated in: § Search strategy for identification of studies · plain
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe burden of skin disease often falls most heavily on children and their families.
“Children and their families often bear the brunt of this disease burden (Mahe, 2005).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Mahe, 2005
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Study design and conductown dataThe review process had three stages: title/abstract screening, full-article review, and quality-criteria evaluation.
“The reviews were carried out in three stages: Round (1): Title/abstract review of hits from searches of medical literature databases.”
- Also stated in: § Search strategy for identification of studies · plain
“Round (2): Whole article review of hits remaining after Round 1. Round (3): Evaluation of articles remaining after Round 2 using agreed quality criteria.”
Quote in the paperNot a substantial claim- Also stated in: § Search strategy for identification of studies · plain
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe literature review for data collection had two stages.
“Data were collected in a two stage literature review.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataThe analysis used 895 country-years of data from 82 countries, with individual cause models using 16 to 155 country-years.
“Ultimately, 895 country-years of data were used, covering 82 countries.Individual cause models used from 16 to 155 country-years worth of data.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationPreviously reported GBD estimated annual deaths for skin disease included 66.5×10^3 from bacterial skin infections such as cellulitis and 30.6×10^3 from NMSC.
“Previously reported GBD estimated annual deaths for skin disease included 66.5 Â 10 3 from bacterial skin infections such as cellulitis and 30.6 Â 10 3 from NMSC (Lozano et al., 2012).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Lozano et al., 2012 source
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Classified as probably not a substantial claim. May combine two claims.
Study design and conductcitationDisease definitions were standardized: atopic dermatitis used the UK Working Party definition, NMSC required histopathological confirmation, and other conditions used diagnosis by a trained health worker.
“Standardized disease definitions were established in several ways.For instance, with atopic dermatitis, within the broader heading of eczema, definitions such as the UK working party definition of AD were used (Williams et al., 1994).Likewise in NMSC histopathological confirmation was required.Elsewhere, the diagnosis of a trained health worker was the standard case definition.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Williams et al., 1994
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May combine two claims.
Study design and conductreasoningUsing ICD-10 for skin disease classification placed most dermatology-clinic diseases under skin, but some skin problems fell under other specialties.
“The classification of skin disease was derived from International Classification of Disease 10, which led to the inclusion of most diseases seen in dermatology clinics under skin, but other skin problems under other medical specialities.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataSkin conditions are common, rank among the most prevalent and disabling diseases, and cause substantial loss of healthy life.
“However, this can now be contextualized with all other disease to show that skin conditions are both widespread and among the most prevalent and disabling diseases, and a source of considerable loss of healthy life.”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationreasoningThe smaller skin-infection burden in high-income Asia suggests that poverty, as well as climate, shapes risk.
“The lower burden due to skin infection in the high-income Asian region highlights the impact of poverty in addition to climate in defining risk.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown dataSystematic literature reviews were conducted and data analyzed for each of 15 skin disease categories.
“For each of the following diseases, we performed systematic literature reviews and analyzed resulting data: eczema, psoriasis, acne vulgaris, pruritus, alopecia areata, decubitus ulcer, urticaria, scabies, fungal skin diseases, impetigo, abscess, and other bacterial skin diseases, cellulitis, viral warts, molluscum contagiosum, and non-melanoma skin cancer.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable). May combine two claims.
InterpretationreasoningSkin disease impact should be assessed against local health needs, since regional disability differences may stem from both prevalence and health-care access.
“Therefore, the impact of skin diseases must be viewed in terms of local health needs, as regional variations in disability may reflect differences in both prevalence and availability of health care.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductown dataThe team searched global literature and databases for incidence, prevalence, and remission data, applying accepted case definitions and strict validity criteria.
“The team reviewed world literature and databases for incidence, prevalence, and remission rates, using acceptable case definitions and stringent criteria for validity of data collection.”
Quote in the paperSubstantial claim
The paper relies on this without support.
Skin disease receives comparatively little attention in national and global health policy discussions.
“Yet despite this profound impact, skin disease continues to receive relatively little attention in the national or global health debate.”
The paper relies on this without support.
A few skin conditions account for most of the skin disease burden.
“a pattern dominated by a few conditions accounting for most of the skin disease burden.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
More than 2000 recognized skin diseases exist, spanning inflammatory dermatoses, infections, deposit disease, and neoplastic lesions.
“Among the challenges in this field are the vast range of skin pathologies, with more than 2000 recognized skin diseases spanning from inflammatory dermatoses, infections, deposit disease, and neoplastic lesions [1].”
From Artificial Intelligence in Dermatopathology: An Update and Review of the Current Literature (2026) · cites this paper as [1]
The Introduction and Materials and Methods describe more than 1,000 skin or skin-related disease entities, supporting the claim that skin diseases are numerous, but not its figure of more than 2,000. The conditions listed include inflammatory diseases, infections, and non-melanoma skin cancer; the copy does not identify deposit disease as part of the claimed range. (LLM, conf=0.88)
Experimental — accuracy not yet measuredAI models have been proven to provide high sensitivity in identifying malignant tumors and differentiating various skin diseases, making them useful for dermatologists.
“These models have been proven to provide high sensitivity in the identification of malignant tumors and differentiation of various skin diseases thus being useful for dermatologists (6, 39, 40).”
From Revolutionizing dermatopathology using AI in skin diagnostics: scoping review (2026) · cites this paper as [39]
The Analysis of data section describes epidemiological modeling of skin-disease prevalence, not AI-based diagnosis. The Introduction and Discussion mention melanoma and dermatology clinics but do not report AI models’ diagnostic sensitivity or usefulness to dermatologists. Searches for AI-model sensitivity and skin-lesion classification found no passage addressing the claim; page numbers were not available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredSkin and subcutaneous disorders ranked fourth among causes of nonfatal disease burden globally in 2010 and 2013.
“skin and subcutaneous disorders were the 4th leading cause of nonfatal disease burden worldwide in 2010 and 2013”
From Global Burden of Skin Disease: Inequities and Innovations (2017) · cites this paper as [4]
GBD skin disease burden estimates are likely underestimated because ICD classification places some skin conditions under other entities, such as melanoma under cancer.
“the GBD is based on the ICD classification system, which leads to categorization of certain skin conditions under other entities, for example, melanoma is classified under “cancer.””
From Global Burden of Skin Disease: Inequities and Innovations (2017) · cites this paper as [4]
Effects of skin conditions on quality of life in resource-replete settings are profound and well-documented.
“The effects of skin conditions on QoL in resource-replete settings is profound and well-documented”
From Global Burden of Skin Disease: Inequities and Innovations (2017) · cites this paper as [4]
GBD skin disease burden estimates are likely underestimated because dermatological manifestations of systemic illnesses are not individually categorized, e.g., lupus burden is included under musculoskeletal disease.
“the dermatological manifestations of systemic illnesses are not necessarily individually categorized; the burden of lupus erythematosus is therefore entirely included under that of musculoskeletal disease”
From Global Burden of Skin Disease: Inequities and Innovations (2017) · cites this paper as [4]
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“The prevalence ranges from 5 to 20%.(289,290) The incidence tends to be higher in children than adults.”
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“The Global Burden of Diseases Study recently demonstrated that skin diseases were the fourth leading cause of nonfatal disease burden (Hay et al., 2014).”
BackgroundA deep learning system for differential diagnosis of skin diseases
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A global perspective on the epidemiology of acne
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“J Eur Acad Dermatol Venereol 2007;21(5):643-9.”
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“S kin disease is one of the leading causes of global disease burden, affecting millions of people worldwide.(1) Aging, environmental and genetic factors, and trauma can result in the development of a diverse set of skin diseases, with over 3000 entities identified in the literature.”
BackgroundSelf-citationPrevalence and Incidence of Atopic Dermatitis: A Systematic Review
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“Superscript numbers (1-22) show the order in the statistical testing hierarchy; all P-values in the hierarchy were controlled for multiplicity.”
BackgroundBurden and socioeconomics of asthma, allergic rhinitis, atopic dermatitis and food allergy
Dierick, B. J. H., van der Molen, T., Blok, B. M. J. F.-D., Muraro, A. M., Postma, M. J., Kocks, J. W. H., & van Boven, J. F. M. (2020) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1080/14737167.2020.1819793 · Cited by 385 · see citing works
“This is because of the high prevalence worldwide and the relatively high average disability weight [118].”
BackgroundGlobal Burden of Skin Disease: Inequities and Innovations
Seth, D., Cheldize, K., Brown, D., & Freeman, E. E. (2017) · Current Dermatology Reports · doi:10.1007/s13671-017-0192-7 · Cited by 366 · see citing works
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“Recent estimates of the global burden of impetigo are 111 million children from developing countries [1] to 140 million [2, 3] people affected at any one time.”
BackgroundInfluentialSelf-citationWu, H., Li, F., Wang, S., Lu, J., Li, J., Du, Y., Sun, X., Chen, X. S., Gao, J., & Ling, D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.018 · Cited by 340 · see citing works
Association of Atopic Dermatitis With Sleep Quality in Children
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“A topic dermatitis ranks among the largest components of the nonfatal disease burden worldwide.(1) Sleep disturbances have been identified as central to qualityof-life decrements in atopic dermatitis,(2,3) but little is known about their association with sleep in the general population.”
The role of IL ‐23 and the IL ‐23/ T H 17 immune axis in the pathogenesis and treatment of psoriasis
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“considered in published reports of disability.(10,11) In totality, these implications are alarming and underscore the public health concerns of AD reported in global epidemiologic studies.”
BackgroundInfluentialElectronic textiles: New age of wearable technology for healthcare and fitness solutions
Meena, J. S., Choi, S. B., Jung, S., & Kim, J. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100565 · Cited by 253 · see citing works
Epidemiology of adult atopic dermatitis
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Treatment of atopic dermatitis with ruxolitinib cream (JAK1/JAK2 inhibitor) or triamcinolone cream
Kim, B. S., Howell, M. D., Sun, K., Papp, K., Nasir, A., & Kuligowski, M. E. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.08.042 · Cited by 226 · see citing works
“The Global Burden of Disease project identified AD as one of the most common diseases worldwide, increasing in prevalence, and having the second highest disability rank of all nonmalignant skin diseases.(6) Despite the significant impact of medical, quality of life, and cost of AD on society,(1) treatments remain limi…”
BackgroundZaenglein, A. L. (2018) · New England Journal of Medicine · doi:10.1056/nejmcp1702493 · Cited by 225 · see citing works
Age-associated skin conditions and diseases: Current perspectives and future options
Blume-Peytavi, U., Kottner, J., Sterry, W., Hodin, M. W., Griffiths, T. W., Watson, R. E. B., Hay, R. J., & Griffiths, C. E. M. (2016) · The Gerontologist · doi:10.1093/geront/gnw003 · Cited by 221 · see citing works
“This finding is supported by the latest Global Burden of Disease Study (2010), where the years lost due to disability caused by skin conditions were highest in the aged (Hay et al., 2014).”
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“The chronic inflammatory and recurrent skin condition acne vulgaris, commonly referred to as acne, is a disease of the pilosebaceous unit (hair, hair follicle, erector pili muscle and sebaceous gland) and, strikingly, the eighth most prevalent disease globally, affecting approximately 10% of the world’s population [35…”
BackgroundCounting the Burden: Atopic Dermatitis and Health-related Quality of Life
Ali, F. M., Vyas, J., & Finlay, A. Y. (2020) · Acta Dermato Venereologica · doi:10.2340/00015555-3511 · Cited by 221 · see citing works
“Using DALYs, the global burden of skin disease survey revealed that eczema causes the highest burden of all skin diseases worldwide (85).”
BackgroundPrevalence of most common skin diseases in Europe: a population‐based study
Richard, M. ‐., Paul, C. F., Nijsten, T. E. C., et al. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18050 · Cited by 205 · see citing works
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“The predominant types of skin diseases include fungal diseases, subcutaneous diseases, acne vulgaris, pruritus, eczema, impetigo, molluscum contagiosum/warts, and scabies (Hay et al., 2014).”
BackgroundIntegrated Control and Management of Neglected Tropical Skin Diseases
Mitjà, O., Marks, M., Bertran, L., Kollie, K., Argaw, D., Fahal, A. H., Fitzpatrick, C., Fuller, L. C., Garcia Izquierdo, B., Hay, R., et al. (2017) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0005136 · Cited by 183 · see citing works
“[10] For example, contractures and resulting disability in BU, advanced lymphoedema and hydrocele in LF, the consequences of permanent nerve damage in leprosy, amputations in mycetoma, and bone involvement in yaws can lead to debilitating deformities and difficulty in securing employment.[11] In addition, skin NTDs re…”
BackgroundSelf-citationAjjoun, M., Kharchoufa, L., Merrouni, I. A., & Elachouri, M. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115532 · Cited by 195 · see citing works
A Benchmark for Automatic Visual Classification of Clinical Skin Disease Images
Sun, X., Yang, J., Sun, M., & Wang, K. (2016) · Lecture Notes in Computer Science · doi:10.1007/978-3-319-46466-4_13 · Cited by 197 · see citing works
“It pervades all cultures, occurs at all ages, and affects between 30% and 70% of individuals [1].”
BackgroundVekemans, J., Gouvea-Reis, F., Kim, J. H., Excler, J., Smeesters, P. R., O’Brien, K. L., Beneden, C. V., Steer, A. C., Carapetis, J. R., & Kaslow, D. C. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciy1143 · Cited by 176 · see citing works
“Implications on the vaccine evaluations should be further considered [38].”
BackgroundThe epidemiology of skin conditions in the aged: A systematic review
Hahnel, E., Lichterfeld, A., Blume‐Peytavi, U., & Kottner, J. (2016) · Journal of Tissue Viability · doi:10.1016/j.jtv.2016.04.001 · Cited by 174 · see citing works
“For example non-melanoma skin cancer, pressure ulcers or fungal skin diseases have in comparison to younger age groups growing disability-adjusted life years lost by 100,000 [14] overall.”
BackgroundMethodPre-trained multimodal large language model enhances dermatological diagnosis using SkinGPT-4
Zhou, J., He, X., Sun, L., Xu, J., Chen, X., Chu, Y., Zhou, L., Liao, X., Zhang, B., Afvari, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50043-3 · Cited by 189 · see citing works
“Skin and subcutaneous diseases rank as the fourth major cause of nonfatal disease burden worldwide, affecting a considerable proportion of individuals,with a prevalenceranging from 30 to 70% across all ages and regions 1 .”
The global state of psoriasis disease epidemiology: a workshop report
Griffiths, C. E. M., van der Walt, J. M., Ashcroft, D. M., Flohr, C., Naldi, L., Nijsten, T. E. C., & Augustin, M. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15610 · Cited by 172 · see citing works
Self-citationReviewing the global burden of acne: how could we improve care to reduce the burden?*
Layton, A., Thiboutot, D. M., & Tan, J. K. L. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19477 · Cited by 173 · see citing works
Mueller, S. M., Hongler, V. N. S., Jungo, P., Cajacob, L., Schwegler, S., Steveling, E. H., Thomas, Z. M., Fuchs, O., Navarini, A. A., Scherer, K., et al. (2020) · Journal of Medical Internet Research · doi:10.2196/15599 · Cited by 171 · see citing works
“Patients with AD have a high motivation to conduct online searches, and this usually correlates with disease burden [39,40].”
BackgroundStudies on Different CNN Algorithms for Face Skin Disease Classification Based on Clinical Images
Wu, Z., Zhao, S., Peng, Y., He, X., Zhao, X., Huang, K., Wu, X., Fan, W., Li, F., Chen, M., et al. (2019) · IEEE Access · doi:10.1109/access.2019.2918221 · Cited by 167 · see citing works
Hossen, M. N., Panneerselvam, V., Koundal, D., Ahmed, K., Bui, F. M., & Ibrahim, S. M. (2022) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2022.3149288 · Cited by 169 · see citing works
“According to the Global Burden of Disease (GBD) Study 2010 [1], in the cause of nonfatal diseases in the world as a burden, skin disease was fourth on the list of most common diseases.”
MethodPlant-Derived Products as Antibacterial and Antifungal Agents in Human Health Care
Kokoška, L., Klouček, P., Leuner, O., & Nový, P. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180831144344 · Cited by 165 · see citing works
Putting the burden of skin diseases on the global map
Flohr, C., & Hay, R. J. (2021) · British Journal of Dermatology · doi:10.1111/bjd.19704 · Cited by 164 · see citing works
Self-citationMSCA-Net: Multi-scale contextual attention network for skin lesion segmentation
Sun, Y., Dai, D.-W., Zhang, Q.-N., Wang, Y.-Q., Xu, S.-Y., & Lian, C. (2023) · Pattern Recognition · doi:10.1016/j.patcog.2023.109524 · Cited by 142 · see citing works
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Bhat, S. A., Mounsey, K. E., Liu, X., & Walton, S. F. (2017) · Parasites & Vectors · doi:10.1186/s13071-017-2320-4 · Cited by 146 · see citing works
“It was reported in 2010 that about 100 million of the global population is infected with scabies [2] and prevalence in different regions ranged from 0.”
BackgroundTREM2 macrophages induced by human lipids drive inflammation in acne lesions
Do, T. H., Ma, F., Andrade, P. R., Teles, R., de Andrade Silva, B. J., Hu, C., Espinoza, A., Hsu, J.-E., Cho, C.-S., Kim, M., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abo2787 · Cited by 139 · see citing works
Williams, H. C., Bath-Hextall, F. J., Ozolins, M., Armstrong, S., Colver, G., Perkins, W. A., & Miller, P. S. J. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.10.019 · Cited by 138 · see citing works
“, 2015), yet poor registration of BCC makes it difficult to compare estimates across the world (Hay et al., 2014).”
BackgroundSelf-citationSevere Dermatophytosis and Acquired or Innate Immunodeficiency: A Review
Rouzaud, C., Hay, R. J., Chosidow, O., et al. (2015) · Journal of Fungi · doi:10.3390/jof2010004 · Cited by 133 · see citing works
“They affect 20% to 25% of the world’s population and represent the fourth most prevalent of human diseases [1–3].”
BackgroundSelf-citationOpportunities for Integrated Control of Neglected Tropical Diseases That Affect the Skin
Engelman, D., Fuller, L. C., Solomon, A. W., McCarthy, J. S., Hay, R. J., Lammie, P. J., & Steer, A. C. (2016) · Trends in Parasitology · doi:10.1016/j.pt.2016.08.005 · Cited by 128 · see citing works
“The disease burden is conservatively estimated at 100 million cases at any time [11], but prevalence data from most regions remain patchy.”
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“As a prevalent disease in adolescents and adults and one of the 10 most prevalent disorders in the world, acne affects 47–90% of adolescents and the young (Cooper, 1998; Hay et al., 2014; Patel, Bowe, Heughebaert, & Shalita, 2010; Perkins, Maglione, Hillebrand, Miyamoto, & Kimball, 2012).”
BackgroundUpadacitinib plus topical corticosteroids in atopic dermatitis: Week 52 AD Up study results
Silverberg, J. I., de Bruin-Weller, M. S., Bieber, T. R. M., Soong, W., Kabashima, K., Costanzo, A., Rosmarin, D. M., Lynde, C. W., Liu, J., Gamelli, A., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.07.036 · Cited by 130 · see citing works
Oral spironolactone for acne vulgaris in adult females: a hybrid systematic review
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“1 Introduction Acne is the eighth most prevalent disease globally [1].”
BackgroundFerreira, S., Guttman‐Yassky, E., & Torres, T. R. (2020) · American Journal of Clinical Dermatology · doi:10.1007/s40257-020-00548-6 · Cited by 126 · see citing works
Zagórska-Dziok, M., & Sobczak, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050396 · Cited by 126 · see citing works
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Roh, Y. S., Choi, J., Sutaria, N. H., & Kwatra, S. G. (2021) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2021.07.076 · Cited by 122 · see citing works
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“It pervades all cultures, occurs at all ages, and affects the health of 30% to 70% of individuals, with even higher rates for the at-risk subpopulations [21, 22].”
BackgroundImplications of climate variability and change on urban and human health: A review
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BackgroundAssessment of severity and burden of pruritus
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“According to WHO Global Burden of Diseases initiative at least 230 million people worldwide have AD (1) making it the leading cause of non-fatal disease burden of skin conditions (2).”
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- Authors
- Hay, R. J., Johns, N. E., Williams, H. C., Bolliger, I. W., Dellavalle, R. P., Margolis, D. J., Marks, R., Naldi, L., Weinstock, M. A., Wulf, S. K., Michaud, C., J.L. Murray, C., & Naghavi, M.
- Affiliations
- University of Washington (US)
- University of Nottingham (GB)
- Denver VA Medical Center (US)
- University of Pennsylvania (US)
- Skin and Cancer Foundation (AU)
- Ospedale Papa Giovanni XXIII (IT)
- Brown University (US)
- China Medical Board (US)
- Corresponding author
- Hay, Roderick J.
- ORCID
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 134
- Issue
- 6
- Pages
- 1527-1534
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2051521434
- Semantic Scholar
- 5f720423986eece0d00d0b522e9e594f0a7ca829
- Cited by
- 1,706
- References
- 31
- Citations by year
- 2026: 144 · 2025: 178 · 2024: 185 · 2023: 202 · 2022: 201 · 2021: 144 · 2020: 166 · 2019: 116 · 2018: 113 · 2017: 90 · 2016: 86 · 2015: 57 · 2014: 21
- FWCI
- 64.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Bill and Melinda Gates Foundation
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Health Professions › Health Information Management › Global Health and Epidemiology
- Keywords
- skin diseases, global burden of disease, prevalence, years lived with disability, atopic dermatitis, psoriasis, acne, pruritus, alopecia areata, pressure ulcers, urticaria, scabies, fungal skin infection, impetigo, bacterial skin infections, cellulitis, viral warts, molluscum contagiosum, non-melanoma skin cancer
- MeSH terms
- Dermatology, Female, Disabled Persons, Persons with Disabilities, Humans, Male, Mortality, Skin, Skin Diseases, Skin Neoplasms, Global Health, Prevalence, Cost of Illness, Quality-Adjusted Life Years
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-07.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-07.
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