Effects of 28Si ions, 56Fe ions, and protons on the induction of murine acute myeloid leukemia and hepatocellular carcinoma
Open accessAbstract
Estimates of cancer risks posed to space-flight crews by exposure to high atomic number, high-energy (HZE) ions are subject to considerable uncertainty because epidemiological data do not exist for human populations exposed to similar radiation qualities. We assessed the carcinogenic effects of 300 MeV/n 28Si or 600 MeV/n 56Fe ions in a mouse model for radiation-induced acute myeloid leukemia and hepatocellular carcinoma. C3H/HeNCrl mice were irradiated with 0.1, 0.2, 0.4, or 1 Gy of 300 MeV/n 28Si ions, 600 MeV/n 56Fe ions or 1 or 2 Gy of protons simulating the 1972 solar particle event (1972SPE) at the NASA Space Radiation Laboratory. Additional mice were irradiated with 137Cs gamma rays at doses of 1, 2, or 3 Gy. All groups were followed until they were moribund or reached 800 days of age. We found that 28Si or 56Fe ions do not appear to be substantially more effective than gamma rays for the induction of acute myeloid leukemia. However, 28Si or 56Fe ion irradiated mice had a much higher incidence of hepatocellular carcinoma than gamma ray irradiated or proton irradiated mice. These data demonstrate a clear difference in the effects of these HZE ions on the induction of leukemia compared to solid tumors, suggesting potentially different mechanisms of tumorigenesis. Also seen in this study was an increase in metastatic hepatocellular carcinoma in the 28Si and 56Fe ion irradiated mice compared with those exposed to gamma rays or 1972SPE protons, a finding with important implications for setting radiation exposure limits for space-flight crew members.
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In hepatocellular carcinoma in male C3H/HeNCrl mice, incidence of metastatic tumors significantly increased with Si and Fe particles compared to γ-rays or simulated solar protons.
“Incidence of metastatic tumors significantly increased with Si and Fe particles compared to γ-rays or simulated solar protons.”
From A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection (2021) · cites this paper as Weil et al., 2014
In hepatocellular carcinoma in male C3H/HeNCrl mice, the dose response for Si and Fe particles was qualitatively different from γ-rays.
“Hepatocellular carcinoma in male C3H/HeNCrl mice (Weil et al., 2009;Weil et al., 2014) Dose response for Si and Fe particles was qualitatively different from γ-rays.”
From A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection (2021) · cites this paper as Weil et al., 2014
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A New Approach to Reduce Uncertainties in Space Radiation Cancer Risk Predictions
Cucinotta, F. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0120717 · Cited by 79 · see citing works
A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection
Cucinotta, F. A., Schimmerling, W., Blakely, E. A., & Hei, T. K. (2021) · Life Sciences in Space Research · doi:10.1016/j.lssr.2021.07.005 · Cited by 35 · see citing works
- Authors
- Weil, M. M., Ray, F. A., Genik, P. C., Yu, Y., McCarthy, M., Fallgren, C. M., & Ullrich, R. L.
- Affiliations
- Colorado State University (US)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Weil, Michael M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-08-15
- Volume
- 9
- Issue
- 8
- Pages
- e104819
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4134239
- OpenAlex
- W1993314127
- Cited by
- 83
- References
- 6
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 12 · 2014: 1
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Digital Collections of Colorado (Colorado State University) (submittedVersion, other-oa)
- Digital Collections of Colorado (Colorado State University) (submittedVersion, cc-by)
- Funders
- National Aeronautics and Space Administration (NNX09AM08G)
- Brookhaven National Laboratory
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Keywords
- 56Fe ions, protons, acute myeloid leukemia, hepatocellular carcinoma, metastatic hepatocellular carcinoma, space radiation, solar energetic particle events, 137Cs gamma rays, radiation-induced cancer, mouse model
- MeSH terms
- Animals, Cosmic Radiation, Carcinoma, Hepatocellular, Humans, Iron, Leukemia, Radiation-Induced, Liver Neoplasms, Experimental, Male, Mice, Inbred C3H, Radiation Injuries, Experimental, Silicon, Space Flight, Leukemia, Myeloid, Acute
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