Incidence of Acute Myeloid Leukemia and Hepatocellular Carcinoma in Mice Irradiated with 1 GeV/nucleon56Fe Ions

SOURCES AND EFFECTS OF IONIZING RADIATION : United Nations Scientific Committee on the Effects of Atomic Radiation UNSCEAR 2000 Report to the General Assembly, with Scientific Annexes

岩崎, 民. (2002) · Isotope news · Cited by 7,482 · see citing works

Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series

Smith, S. M., Beau, M. M. L., Huo, D., Karrison, T. G., Sobecks, R. M., Anastasi, J., Vardiman, J. W., Rowley, J. D., & Larson, R. A. (2003) · Blood · doi:10.1182/blood-2002-11-3343 · Cited by 681 · see citing works

G ENETICS OF M YELOID L EUKEMIAS

Kelly, L. M., & Gilliland, D. G. (2002) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.3.032802.115046 · Cited by 522 · see citing works

Chronic Active Hepatitis and Associated Liver Tumors in Mice Caused by a Presistent Bacterial Infection With a Novel Helicobacter Species

Ward, J. M., Fox, J. G., Anver, M. R., Haines, D. C., George, C. V., Collins, M. J., Gorelick, P. L., Nagashima, K., Gonda, M. A., Gilden, R. V., et al. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.16.1222 · Cited by 386 · see citing works

Heavy-Ion Radiobiology: Cellular Studies

Blakely, E. A., Ngo, F. Q. H., Curtis, S. B., & Tobias, C. A. (1984) · Advances in radiation biology · doi:10.1016/b978-0-12-035411-5.50013-7 · Cited by 233 · see citing works

Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice

Burich, A., Hershberg, R. M., Waggie, K. S., Zeng, W., Brabb, T., Westrich, G., Viney, J. L., & Maggio‐Price, L. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g764 · Cited by 179 · see citing works

Dose—Response Relationships

Hartung, R. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5290-7_3 · Cited by 176 · see citing works

PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain

Cook, W. D., McCaw, B. J., Herring, C., John, D. L., Foote, S. J., Nutt, S. L., & Adams, J. M. (2004) · Blood · doi:10.1182/blood-2004-06-2234 · Cited by 140 · see citing works

Helicobacter bilis Infection Accelerates and H. hepaticus Infection Delays the Development of Colitis in Multiple Drug Resistance-Deficient (mdr1a−/−) Mice

Maggio‐Price, L., Shows, D. M., Waggie, K. S., Burich, A., Zeng, W., Escobar, S. M., Morrissey, P., & Viney, J. L. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64894-8 · Cited by 135 · see citing works

Late Effects of Fast Neutrons and Gamma-Rays in Mice as Influenced by the Dose Rate of Irradiation: Induction of Neoplasia

Upton, A. C., Randolph, M. L., Conklin, J. W., Kastenbaum, M. A., Slater, M., Melville, G. S., Conte, F. P., & Sproul, J. A. (1970) · Radiation Research · doi:10.2307/3572837 · Cited by 133 · see citing works

Chromosome mapping of the genes that control differentiation and malignancy in myeloid leukemic cells.

Azumi, J., & Sachs, L. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.1.253 · Cited by 123 · see citing works

The dose-response for x-ray induction of myeloid leukaemia in male CBA/H mice

Mole, R. H., & Papworth, D. G. (1983) · British Journal of Cancer · doi:10.1038/bjc.1983.37 · Cited by 103 · see citing works

Chromosomal aberrations observed in 52 mouse myeloid leukemias.

Hayata, I., Seki, M., Yoshida, K., Hirashima, K., Sado, T., Yamagiwa, J., & Ishihara, T. (1983) · PubMed · Cited by 97 · see citing works

Thorotrast-Induced Liver Neoplasia: A Collective Review

Lipshutz, G. S., Brennan, T. V., & Warren, R. S. (2002) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(02)01287-5 · Cited by 95 · see citing works

Liver Cancers in Mayak Workers

Gilbert, E. S., Koshurnikova, N. A., Эдуардович, С. М., Khokhryakov, V. F., Miller, S. C., Preston, D. L., Romanov, S. A., Shilnikova, N. S., Suslova, K. G., & Vostrotin, V. V. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)154[0246:lcimw]2.0.co;2 · Cited by 89 · see citing works

Quantitative comparisons of cancer induction in humans by internally deposited radionuclides and external radiation

Harrison, J. D., & Muirhead, C. R. (2003) · International Journal of Radiation Biology · doi:10.1080/0955300021000038671 · Cited by 78 · see citing works

Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumor suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11-12

Silver, A., Moody, J., Dunford, R., Clark, D., Ganz, S., Bulman, R. A., Bouffler, S. D., Finnon, P., Meijne, E. I. M., Huiskamp, R., et al. (1999) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199902)24:2 · Cited by 72 · see citing works

Hepatitis C virus: from oxygen free radicals to hepatocellular carcinoma

Farinati, F., Cardin, R., Bortolami, M., Burra, P., Russo, F. P., Rugge, M., Guido, M., Sergio, A., & Naccarato, R. (2007) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2007.00878.x · Cited by 71 · see citing works

Radiation Leukemogenesis in Mice: Loss ofPU.1on Chromosome 2 in CBA and C57BL/6 Mice after Irradiation with 1 GeV/nucleon56Fe Ions, X Rays or γ Rays. Part I. Experimental Observations

Peng, Y., Brown, N., Finnon, R., Warner, C. L., Liu, X., Genik, P. C., Callan, M. A., Ray, F. A., Borak, T. B., Badie, C., et al. (2009) · Radiation Research · doi:10.1667/rr1547.1 · Cited by 62 · see citing works

Early and late mammalian responses to heavy charged particles

Ainsworth, E. J. (1986) · Advances in Space Research · doi:10.1016/0273-1177(86)90288-7 · Cited by 53 · see citing works

High-LET radiation carcinogenesis

Fry, R. J., Ullrich, R. L., Powers-Risius, P., Alpen, E. L., & Ainsworth, E. J. (1983) · Advances in Space Research · doi:10.1016/0273-1177(83)90194-1 · Cited by 52 · see citing works

Myeloid leukemia in male RFM mice following irradiation with fission spectrum neutrons or gamma rays.

Ullrich, R. L., & Preston, R. J. (1987) · PubMed · Cited by 45 · see citing works

Effects of Radiation on Incidence of Primary Liver Cancer among Atomic Bomb Survivors

COLOGNE, J. B., Tokuoka, S., Beebe, G. W., Fukuhara, T., & Mabuchi, K. (1999) · Radiation Research · doi:10.2307/3580221 · Cited by 43 · see citing works

Myeloid Leukemia in Male RFM Mice Following Irradiation with Fission Spectrum Neutrons or γ Rays

Ullrich, R. L., & Rj, P. (1987) · Radiation Research · doi:10.2307/3576877 · Cited by 41 · see citing works

Influence of microbial environment on development of myeloid leukemia in X‐irradiated rfm mice

Walburg, H. E., Cosgrove, G. E., & Upton, A. C. (1968) · International Journal of Cancer · doi:10.1002/ijc.2910030118 · Cited by 36 · see citing works

Gene Expression Profiles in Mouse Liver Cells after Exposure to Different Types of Radiation

Roudkenar, M. H., Li, L., Baba, T., Kuwahara, Y., Nakagawa, H., Wang, L., Kasaoka, S., Ohkubo, Y., Ono, K., & Fukumoto, M. (2008) · Journal of Radiation Research · doi:10.1269/jrr.07078 · Cited by 27 · see citing works

The Rate of Progression of Radiation-Transformed Mammary Epithelial Cells Is Enhanced after Low-Dose-Rate Neutron Irradiation

Ullrich, R. L. (1986) · Radiation Research · doi:10.2307/3576726 · Cited by 24 · see citing works

The role of promotion in carcinogenesis from protracted high-LET exposure.

Curtis, S. B., Luebeck, E. G., Hazelton, W. D., & Moolgavkar, S. H. (2001) · PubMed · Cited by 20 · see citing works

Radiation Leukemogenesis in Mice: Loss ofPU.1on Chromosome 2 in CBA and C57BL/6 Mice after Irradiation with 1 GeV/nucleon56Fe Ions, X Rays or γ Rays. Part II. Theoretical Considerations Based on Microdosimetry and the Initial Induction of Chromosome Aberrations

Peng, Y., Borak, T. B., Bouffler, S. D., Ullrich, R. L., Weil, M. M., & Bedford, J. S. (2009) · Radiation Research · doi:10.1667/rr1548.1 · Cited by 15 · see citing works

The Charlotte Friend Memorial Lecture. The role of hematopoietic growth factors in the development and suppression of myeloid leukemias

Metcalf, D. (1997) · Leukemia · doi:10.1038/sj.leu.2400831 · Cited by 13 · see citing works

Marked Liver Tumorigenesis by Helicobacter hepaticus Requires Perinatal Exposure

Diwan, B. A., Sipowicz, M. A., Logsdon, D. L., Gorelick, P. L., Anver, M. R., Kasprzak, K. S., & Anderson, L. M. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11493 · Cited by 11 · see citing works

Bone cancer risk in mice exposed to 224Ra: protraction effects from promotion

Heidenreich, W., Müller, W., Paretzke, H. G., & Rosemann, M. (2005) · Radiation and Environmental Biophysics · doi:10.1007/s00411-005-0278-7 · Cited by 10 · see citing works

Neutron Quality Parameters versus Energy below 4 MeV from Microdosimetric Calculations

Stinchcomb, T. G., & Borak, T. B. (1983) · Radiation Research · doi:10.2307/3575939 · Cited by 9 · see citing works

Radiation Induced Deletion of Chromosome 2 in Myeloid Leukemogenesis

Haran‐Ghera, N. (1989) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-74623-9_3 · Cited by 7 · see citing works

Neutron Carcinogenesis in Mice: A Study of the Dose-Response Curves

Covelli, V., Majo, V. D., Coppola, M., & Rebessi, S. (1991) · Radiation Research · doi:10.2307/3578012 · Cited by 4 · see citing works

Quality Factor Calculations For Neutron Spectra Below 4 MeV

Borak, T. B., & Stinchcomb, T. G. (1979) · Health Physics · doi:10.1097/00004032-197906000-00004 · Cited by 2 · see citing works

Assessing the risk of second malignancies after modern radiotherapy

Newhauser, W. D., & Durante, M. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3069 · Cited by 380 · see citing works

How Safe Is Safe Enough? Radiation Risk for a Human Mission to Mars

Cucinotta, F. A., Kim, M.-H. Y., Chappell, L. J., & Huff, J. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074988 · Cited by 250 · see citing works

ICRP Publication 123: Assessment of Radiation Exposure of Astronauts in Space

Dietze, G., Bartlett, D. T., Cool, D. A., Cucinotta, F. A., Jia, X., McAulay, I. R., Pelliccioni, M., Petrov, V., Reitz, G., & Sato, T. (2013) · Annals of the ICRP · doi:10.1016/j.icrp.2013.05.004 · Cited by 239 · see citing works

Space Radiation Cancer Risk Projections and Uncertainties – 2012

Cucinotta, F. A., Y.Kim, M.-H., & Chappell, L. J. (2013) · NASA · doi:10.13140/rg.2.1.1413.3528 · Cited by 218 · see citing works

Space radiation risks for astronauts on multiple International Space station missions

Cucinotta, F. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096099 · Cited by 203 · see citing works

Biological effects of space radiation and development of effective countermeasures

Kennedy, A. R. (2014) · Life Sciences in Space Research · doi:10.1016/j.lssr.2014.02.004 · Cited by 188 · see citing works

Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications

Miousse, I. R., Kutanzi, K. R., & Koturbash, I. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1287454 · Cited by 166 · see citing works

Response of transposable elements to environmental stressors

Miousse, I. R., Chalbot, M. G., Lumen, A., Ferguson, A., Kavouras, I. G., & Koturbash, I. (2015) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2015.05.003 · Cited by 144 · see citing works

Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and Inflammation

Sridharan, D. M., Asaithamby, A., Bailey, S. M., Costes, S. V., Doetsch, P. W., Dynan, W. S., Kronenberg, A., Rithidech, K. N., Saha, J., Snijders, A. M., et al. (2015) · Radiation Research · doi:10.1667/rr13804.1 · Cited by 124 · see citing works

New challenges in high-energy particle radiobiology

Durante, M. (2013) · British Journal of Radiology · doi:10.1259/bjr.20130626 · Cited by 124 · see citing works

Review of NASA Approach to Space Radiation Risk Assessments for Mars Exploration

Cucinotta, F. A. (2014) · Health Physics · doi:10.1097/hp.0000000000000255 · Cited by 124 · see citing works

Predictions of space radiation fatality risk for exploration missions

Cucinotta, F. A., To, K., & Cacao, E. (2017) · Life Sciences in Space Research · doi:10.1016/j.lssr.2017.01.005 · Cited by 107 · see citing works

Risk of subsequent primary cancers after carbon ion radiotherapy, photon radiotherapy, or surgery for localised prostate cancer: a propensity score-weighted, retrospective, cohort study

Mohamad, O., Tabuchi, T., Nitta, Y., Nomoto, A. K., Sato, A., Kasuya, G., Makishima, H., Choy, H., Yamada, S., Morishima, T., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30931-8 · Cited by 104 · see citing works

Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy

Allen, C., Borak, T. B., Tsujii, H., & Nickoloff, J. A. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.02.012 · Cited by 91 · see citing works

Non-Targeted Effects Models Predict Significantly Higher Mars Mission Cancer Risk than Targeted Effects Models

Cucinotta, F. A., & Cacao, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-02087-3 · Cited by 85 · see citing works

Effects of 28Si ions, 56Fe ions, and protons on the induction of murine acute myeloid leukemia and hepatocellular carcinoma

Weil, M. M., Ray, F. A., Genik, P. C., Yu, Y., McCarthy, M., Fallgren, C. M., & Ullrich, R. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104819 · Cited by 83 · see citing works

Heavy-ion induced chromosomal aberrations: A review

Ritter, S., & Durante, M. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.04.007 · Cited by 82 · see citing works

A New Approach to Reduce Uncertainties in Space Radiation Cancer Risk Predictions

Cucinotta, F. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0120717 · Cited by 79 · see citing works

Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater β-Catenin Activation than γ Radiation in APCMin/+ Mice

Datta, K., Suman, S., Kallakury, B. V. S., & Fornace, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059295 · Cited by 75 · see citing works

Long-term space missions’ effects on the human organism: what we do know and what requires further research

Tomsia, M., Cieśla, J., Śmieszek, J., Florek, S., Macionga, A. A., Michalczyk, K., & Stygar, D. M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1284644 · Cited by 112 · see citing works

Applied nuclear physics at the new high-energy particle accelerator facilities

Durante, M., Golubev, A., Park, W.-Y., & Trautmann, C. (2019) · Physics Reports · doi:10.1016/j.physrep.2019.01.004 · Cited by 72 · see citing works

Safe days in space with acceptable uncertainty from space radiation exposure

Cucinotta, F. A., Alp, M., Rowedder, B., & Kim, M.-H. Y. (2015) · Life Sciences in Space Research · doi:10.1016/j.lssr.2015.04.002 · Cited by 71 · see citing works

Non-targeted effects and the dose response for heavy ion tumor induction

Cucinotta, F. A., & Chappell, L. J. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.01.012 · Cited by 69 · see citing works

Exposure to Low-Dose 56Fe-Ion Radiation Induces Long-Term Epigenetic Alterations in Mouse Bone Marrow Hematopoietic Progenitor and Stem Cells

Miousse, I. R., Shao, L., Chang, J., Feng, W., Wang, Y., Allen, A. R., Turner, J., Stewart, B., Raber, J., Zhou, D., et al. (2014) · Radiation Research · doi:10.1667/rr13580.1 · Cited by 67 · see citing works

Research plans in Europe for radiation health hazard assessment in exploratory space missions

Walsh, L., Schneider, U., Fogtman, A., Kausch, C., McKenna-Lawlor, S., Narici, L., Ngo-Anh, J., Reitz, G., Sabatier, L., Santin, G., et al. (2019) · Life Sciences in Space Research · doi:10.1016/j.lssr.2019.04.002 · Cited by 59 · see citing works

Health Risks of Space Exploration: Targeted and Nontargeted Oxidative Injury by High-Charge and High-Energy Particles

Li, M., Gonon, G., Buonanno, M., Autsavapromporn, N., de Toledo, S. M., Pain, D., & Azzam, E. I. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5649 · Cited by 56 · see citing works

Harderian gland tumorigenesis: low-dose- and LET-response

Chang, P. Y., Cucinotta, F. A., Bjornstad, K. A., Bakke, J., Rosen, C. J., Du, N., Fairchild, D. G., Cacao, E., & Blakely, E. A. (2016) · Radiation Research · doi:10.1667/rr14335.1 · Cited by 58 · see citing works

Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC1638N/+ Mice

Suman, S., Kumar, S., Moon, B., Strawn, S. J., Thakor, H., Fan, Z., Shay, J. W., Fornace, A. J., & Datta, K. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.10.057 · Cited by 53 · see citing works

Carcinogenesis induced by space radiation: A systematic review

Guo, Z., Zhou, G., & Hu, W. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100828 · Cited by 52 · see citing works

Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals

Hudson, D., Kovalchuk, I., Koturbash, I., Kolb, B. E., Martin, O. A., & Kovalchuk, O. (2011) · Aging · doi:10.18632/aging.100340 · Cited by 52 · see citing works

Animal Studies of Charged Particle-induced Carcinogenesis

Bielefeldt‐Ohmann, H., Genik, P. C., Fallgren, C. M., Ullrich, R. L., & Weil, M. M. (2012) · Health Physics · doi:10.1097/hp.0b013e318265a257 · Cited by 51 · see citing works

Characterization of sulfation patterns of beef and pig mucosal heparins by nuclear magnetic resonance spectroscopy.

Casu, B., Guerrini, M., Naggi, A., Torri, G., De-Ambrosi, L., Boveri, G., Gonella, S., Cedro, A., Ferro, L. J., Lanzarotti, E., et al. (1996) · PubMed · Cited by 50 · see citing works

Space radiation-associated lung injury in a murine model

Christofidou‐Solomidou, M., Pietrofesa, R. A., Arguiri, E., Schweitzer, K. S., Berdyshev, E. V., McCarthy, M. P., Corbitt, A., Alwood, J. S., Yu, Y., Globus, R. K., et al. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00260.2014 · Cited by 41 · see citing works

Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer

Kennedy, E. M., Powell, D. R., Li, Z., Bell, J. S. K., Barwick, B. G., Feng, H., McCrary, M. R., Dwivedi, B., Kowalski, J., Dynan, W. S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24755-8 · Cited by 42 · see citing works

Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation

Hada, M., Ikeda, H., Rhone, J., Beitman, A., Plante, I., Souda, H., Yoshida, Y., Held, K. D., Fujiwara, K., Saganti, P. B., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010043 · Cited by 40 · see citing works

Relative effectiveness at 1 Gy after acute and fractionated exposures of heavy ions with different linear energy transfer for lung tumorigenesis

Wang, X., Farris III, A. B., Wang, P., Zhang, X., Wang, H., & Wang, Y. (2015) · Radiation Research · doi:10.1667/rr13884.1 · Cited by 39 · see citing works

A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection

Cucinotta, F. A., Schimmerling, W., Blakely, E. A., & Hei, T. K. (2021) · Life Sciences in Space Research · doi:10.1016/j.lssr.2021.07.005 · Cited by 35 · see citing works

Defining the Biological Effectiveness of Components of High-LET Track Structure

Sridharan, D., Chappell, L. J., Whalen, M. B., Cucinotta, F. A., & Pluth, J. M. (2015) · Radiation Research · doi:10.1667/rr13684.1 · Cited by 33 · see citing works

Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion– and γ-ray–induced tumors

Edmondson, E. F., Gatti, D. M., Ray, F. A., Garcia, E., Fallgren, C. M., Kamstock, D. A., & Weil, M. M. (2020) · Science Advances · doi:10.1126/sciadv.aax5940 · Cited by 31 · see citing works

Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice

Jangiam, W., Tungjai, M., & Rithidech, K. N. (2015) · International Journal of Radiation Biology · doi:10.3109/09553002.2015.1001882 · Cited by 31 · see citing works

Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer

Delgado, O., Batten, K. G., Richardson, J. A., Xie, X.-J., Gazdar, A. F., Kaisani, A. A., Girard, L., Behrens, C., Suraokar, M. B., Fasciani, G., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2589 · Cited by 30 · see citing works

Biological Effectiveness of Accelerated Particles for the Induction of Chromosome Damage: Track Structure Effects

George, K. A., Hada, M., Chappell, L. J., & Cucinotta, F. A. (2013) · Radiation Research · doi:10.1667/rr3291.1 · Cited by 30 · see citing works

Space Radiation Protection Issues

Kronenberg, A., & Cucinotta, F. A. (2012) · Health Physics · doi:10.1097/hp.0b013e3182690caf · Cited by 30 · see citing works

Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review

Drago‐Ferrante, R., Fiore, R. D., Karouia, F., Subbannayya, Y., Das, S., Mathyk, B. A., Arif, S., Guevara-Cerdán, A. P., Seylani, A., Galsinh, A. S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137465 · Cited by 30 · see citing works

Proceedings of the National Cancer Institute Workshop on Charged Particle Radiobiology

Mohan, R., Held, K. D., Story, M. D., Grosshans, D. R., & Capala, J. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.12.260 · Cited by 25 · see citing works

Age-Dependent Changes in DNA Repair in Radiation-Exposed Mice

Kovalchuk, I., Golubov, A., Koturbash, I. V., Kutanzi, K. R., Martin, O. A., & Kovalchuk, O. (2014) · Radiation Research · doi:10.1667/rr13697.1 · Cited by 21 · see citing works

Influence of radiation quality on mouse chromosome 2 deletions in radiation-induced acute myeloid leukaemia

Brown, N., Finnon, R., Manning, G., Bouffler, S. D., & Badie, C. (2015) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2015.07.012 · Cited by 19 · see citing works

A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data

Dekkers, F., Bijwaard, H., Bouffler, S. D., Ellender, M., Huiskamp, R., Kowalczuk, C. I., Meijne, E. I. M., & Sutmuller, M. (2010) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0328-7 · Cited by 19 · see citing works

Tracking preleukemic cells in vivo to reveal the sequence of molecular events in radiation leukemogenesis

Verbiest, T., Finnon, R., Brown, N., Cruz-Garcia, L., Finnon, P., O’Brien, G., Ross, E., Bouffler, S. D., Scudamore, C. L., & Badie, C. (2018) · Leukemia · doi:10.1038/s41375-018-0085-1 · Cited by 18 · see citing works

Eighth Warren K. Sinclair Keynote Address

Durante, M. (2012) · Health Physics · doi:10.1097/hp.0b013e318264b4b6 · Cited by 17 · see citing works

Biophysics of NASA radiation quality factors

Cucinotta, F. A. (2015) · Radiation Protection Dosimetry · doi:10.1093/rpd/ncv144 · Cited by 17 · see citing works

Incorporation of boron into metakaolin-based geopolymers for radionuclide immobilisation and neutron capture potential

Niu, X., Elakneswaran, Y., Li, A., Seralathan, S., Kikuchi, R., Hiraki, Y., Sato, J., Osugi, T., & Walkley, B. (2025) · Cement and Concrete Research · doi:10.1016/j.cemconres.2025.107814 · Cited by 16 · see citing works

Age and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk

Beheshti, A., Sachs, R. K., Peluso, M. J., Rietman, E. A., Hahnfeldt, P., & Hlatky, L. (2013) · Radiation Research · doi:10.1667/rr3100.1 · Cited by 16 · see citing works

Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome

Laiakis, E. C., Shuryak, I., Deziel, A., Wang, Y.-W., Barnette, B. L., Yu, Y., Ullrich, R. L., Fornace, A. J., & Emmett, M. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063070 · Cited by 16 · see citing works

MASM, a Matrine Derivative, Offers Radioprotection by Modulating Lethal Total-Body Irradiation-Induced Multiple Signaling Pathways in Wistar Rats

Li, J., Xu, J., Lu, Y., Qiu, L., Xu, W., Lu, B., Hu, Z., Chu, Z.-Y., Chai, Y., & Zhang, J. (2016) · Molecules · doi:10.3390/molecules21050649 · Cited by 16 · see citing works

An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer

Moding, E. J., Min, H. D., Castle, K. D., Ali, M., Woodlief, L. Z., Williams, N. T., Ma, Y., Kim, Y., Lee, C., & Kirsch, D. G. (2016) · JCI Insight · doi:10.1172/jci.insight.86698 · Cited by 15 · see citing works

Mouse models in the era of large human tumour sequencing studies

de Ruiter, J. R., Wessels, L. F. A., & Jonkers, J. (2018) · Open Biology · doi:10.1098/rsob.180080 · Cited by 15 · see citing works

Live cell detection of chromosome 2 deletion and Sfpi1/PU1 loss in radiation-induced mouse acute myeloid leukaemia

Olme, C.-H., Finnon, R., Brown, N., Kabacik, S., Bouffler, S. D., & Badie, C. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.05.019 · Cited by 15 · see citing works

Genetic Susceptibility

Peng, Y., Nagasawa, H., Warner, C. L., & Bedford, J. S. (2012) · Health Physics · doi:10.1097/hp.0b013e31826945b9 · Cited by 15 · see citing works

Molecular characterisation of murine acute myeloid leukaemia induced by 56Fe ion and 137Cs gamma ray irradiation

Steffen, L. S., Bacher, J., Peng, Y., Le, P. N., Ding, L.-H., Genik, P. C., Ray, F. A., Bedford, J. S., Fallgren, C. M., Bailey, S. M., et al. (2012) · Mutagenesis · doi:10.1093/mutage/ges055 · Cited by 15 · see citing works

Late-occurring chromosome aberrations and global DNA methylation in hematopoietic stem/progenitor cells of CBA/CaJ mice exposed to silicon (28Si) ions

Rithidech, K. N., Honikel, L., Reungpatthanaphong, P., Tungjai, M., Jangiam, W., & Whorton, E. B. (2015) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2015.09.001 · Cited by 14 · see citing works

Hepatocellular Carcinoma in Non-cirrhotic Liver Without Evidence of Iron Overload in a Patient with Primary Hemochromatosis. Review

Singh, P., Kaur, H., Lerner, R. G., Patel, R., Rafiyath, S. M., & Lamba, G. S. (2010) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-010-9205-5 · Cited by 14 · see citing works

High Energy Particle Radiation-associated Oncogenic Transformation in Normal Mice: Insight into the Connection between Activation of Oncotargets and Oncogene Addiction

Aravindan, N., Aravindan, S., Krishnan, M., & Natarajan, M. (2016) · Scientific Reports · doi:10.1038/srep37623 · Cited by 14 · see citing works

Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure

Patel, R., Zhang, L., Desai, A. B., Hoenerhoff, M. J., Kennedy, L. H., Radivoyevitch, T., Ban, Y. J., Chen, X., Gerson, S. L., & Welford, S. M. (2018) · Leukemia · doi:10.1038/s41375-018-0269-8 · Cited by 13 · see citing works

Radiation and Radiation Disorders

Jones, J. A., Karouia, F., Pinsky, L. S., & Cristea, O. (2019) · Springer eBooks · doi:10.1007/978-1-4939-9889-0_2 · Cited by 14 · see citing works

Induction of Chronic Inflammation and Altered Levels of DNA Hydroxymethylation in Somatic and Germinal Tissues of CBA/CaJ Mice Exposed to 48Ti Ions

Rithidech, K. N., Jangiam, W., Tungjai, M., Gordon, C. R., Honikel, L., & Whorton, E. B. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00155 · Cited by 13 · see citing works

Harmonizing heterogeneous transcriptomics datasets for machine learning-based analysis to identify spaceflown murine liver-specific changes

Ilangovan, H., Kothiyal, P., Hoadley, K. A., Elgart, S. R., Eley, G. D., & Eslami, P. (2024) · npj Microgravity · doi:10.1038/s41526-024-00379-3 · Cited by 12 · see citing works

Genetic background and lymphocyte populations after total-body exposure to iron ion radiation

Gridley, D. S., & Pecaut, M. J. (2010) · International Journal of Radiation Biology · doi:10.3109/09553002.2010.518203 · Cited by 12 · see citing works

DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives

Miousse, I. R., Ewing, L., Kutanzi, K. R., Griffin, R. J., & Koturbash, I. (2018) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2018025687 · Cited by 12 · see citing works

Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation

Liu, F., Wang, Z., Li, W., & Wei, Y. (2019) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2019.01.014 · Cited by 11 · see citing works

Modeling Radiation-Induced Neoplastic Cell Transformation In Vitro and Tumor Induction In Vivo with the Local Effect Model

Hufnagl, A., Scholz, M., & Friedrich, T. (2021) · Radiation Research · doi:10.1667/rade-20-00160.1 · Cited by 11 · see citing works

Flying without a Net: Space Radiation Cancer Risk Predictions without a Gamma-ray Basis

Cucinotta, F. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084324 · Cited by 11 · see citing works

Space Radiation Effects on Crew During and After Deep Space Missions

Straume, T. (2018) · Current Pathobiology Reports · doi:10.1007/s40139-018-0175-9 · Cited by 11 · see citing works

Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention

Luitel, K., Kim, S. B., Barron, S., Richardson, J. A., & Shay, J. W. (2019) · Life Sciences in Space Research · doi:10.1016/j.lssr.2019.07.011 · Cited by 11 · see citing works

Mitochondrial Effects in the Liver of C57BL/6 Mice by Low Dose, High Energy, High Charge Irradiation

Barnette, B. L., Yu, Y., Ullrich, R. L., & Emmett, M. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111806 · Cited by 10 · see citing works

Space Radiobiology

Hellweg, C. E., Arena, C., Baatout, S., Baselet, B., Beblo‐Vranesevic, K., Caplin, N., Coos, R., Pieve, F. D., Micco, V. D., Foray, N., et al. (2023) · Springer eBooks · doi:10.1007/978-3-031-18810-7_10 · Cited by 10 · see citing works

Efficient identification of multiple pathways: RNA-Seq analysis of livers from 56Fe ion irradiated mice

Nia, A. M., Chen, T., Barnette, B. L., Khanipov, K., Ullrich, R. L., Bhavnani, S. K., & Emmett, M. R. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-3446-5 · Cited by 10 · see citing works

Protons and High-Linear Energy Transfer Radiation Induce Genetically Similar Lymphomas With High Penetrance in a Mouse Model of the Aging Human Hematopoietic System

Patel, R., Zhang, L., Desai, A. B., Hoenerhoff, M. J., Kennedy, L. H., Radivoyevitch, T., Tessa, C. L., Gerson, S. L., & Welford, S. M. (2020) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2020.06.070 · Cited by 10 · see citing works

Modeling radiation effects at the tissue level

Müller, M., Durante, M., Horst Stöcker, B., Merz, F., & Bechmann, I. (2010) · The European Physical Journal D · doi:10.1140/epjd/e2010-00030-y · Cited by 10 · see citing works

Tumor induction in mice after local irradiation with single doses of either carbon-ion beams or gamma rays

Andō, K., Koike, S., Ohmachi, Y., Ando, Y., & Kobashi, G. (2014) · International Journal of Radiation Biology · doi:10.3109/09553002.2014.932030 · Cited by 10 · see citing works

Decreased RXRα is Associated with Increased β-Catenin/TCF4 in 56Fe-Induced Intestinal Tumors

Suman, S., Kumar, S., Fornace, A. J., & Datta, K. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00218 · Cited by 9 · see citing works

Probability of Causation for Space Radiation Carcinogenesis Following International Space Station, Near Earth Asteroid, and Mars Missions

Cucinotta, F. A., & Johnson, L. B. (2012) · NASA Technical Reports Server (NASA) · Cited by 8 · see citing works

Tumor Induction in Mice After Localized Single- or Fractionated-Dose Irradiation: Differences in Tumor Histotype and Genetic Susceptibility Based on Dose Scheduling

Edmondson, E. F., Hunter, N. R., Weil, M. M., & Mason, K. A. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.03.002 · Cited by 8 · see citing works

Defining Molecular and Cellular Responses after Low and High Linear Energy Transfer Radiations to Develop Biomarkers of Carcinogenic Risk or Therapeutic Outcome

Story, M. D., Ding, L., Brock, W. A., Ang, K. K., Alsbeih, G., Minna, J. D., Park, S., & Das, A. K. (2012) · Health Physics · doi:10.1097/hp.0b013e3182692085 · Cited by 8 · see citing works

High-energy particle beam and gamma radiation exposure, familial relatedness and cancer in mice

Chernyavskiy, P., Edmondson, E. F., Weil, M. M., & Little, M. P. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.141 · Cited by 8 · see citing works

Possible impacts of cosmic radiation on leukemia development during human deep space exploration

Ghani, F., & Zubair, A. C. (2025) · Leukemia · doi:10.1038/s41375-025-02624-4 · Cited by 7 · see citing works

Leukemogenesis in HeterozygousPU.1Knockout Mice

Genik, P. C., Vyazunova, I., Steffen, L. S., Bacher, J. W., Bielefeldt‐Ohmann, H., McKercher, S. R., Ullrich, R. L., Fallgren, C. M., Weil, M. M., & Ray, F. A. (2014) · Radiation Research · doi:10.1667/rr13738.1 · Cited by 7 · see citing works

Lessons learned using different mouse models during space radiation-induced lung tumorigenesis experiments

Wang, J., Zhang, X., Wang, X., Wang, Y., Farris, A. B., & Wang, Y. (2016) · Life Sciences in Space Research · doi:10.1016/j.lssr.2016.04.002 · Cited by 7 · see citing works

Alpha-Particle Exposure Induces Mainly Unstable Complex Chromosome Aberrations which do not Contribute to Radiation-Associated Cytogenetic Risk

Hartel, C., Nasonova, E., Ritter, S., & Friedrich, T. (2021) · Radiation Research · doi:10.1667/rade-21-00116.1 · Cited by 7 · see citing works

Proteomic Profiling of Hematopoietic Stem/Progenitor Cells after a Whole Body Exposure of CBA/CaJ Mice to Titanium (48Ti) Ions

Rithidech, K. N., Tungjai, M., Jangiam, W., Honikel, L., Gordon, C. R., Lai, X., & Witzmann, F. A. (2015) · Proteomes · doi:10.3390/proteomes3030132 · Cited by 7 · see citing works

Synergistic Effect of High Charge and Energy Particle Radiation and Chronological Age on Biomarkers of Oxidative Stress and Tissue Degeneration: A Ground-Based Study Using the Vertebrate Laboratory Model Organism Oryzias latipes

Zheng, X., Zhang, X., Ding, L., Lee, J. R., Weinberger, P., & Dynan, W. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111362 · Cited by 6 · see citing works

Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of 56Fe, 16O, and 28Si irradiation on the induction of murine hepatocellular carcinoma

Nia, A. M., Khanipov, K., Barnette, B. L., Ullrich, R. L., Golovko, G., & Emmett, M. R. (2020) · BMC Genomics · doi:10.1186/s12864-020-06869-4 · Cited by 6 · see citing works

Effects of 1 GeV/nucleon56Fe Particles on Longevity, Carcinogenesis and Neuromotor Ability inAtm-Deficient Mice

Yamamoto, M. L., Hafer, K., Reliene, R., Fleming, S. M., Kelly, O. J., Hacke, K., & Schiestl, R. H. (2010) · Radiation Research · doi:10.1667/rr2312.1 · Cited by 6 · see citing works

Tumor aggressiveness is independent of radiation quality in murine hepatocellular carcinoma and mammary tumor models

Udho, E. B., Huebner, S. M., Albrecht, D. M., Matkowskyj, K. A., Clipson, L. J., Hedican, C. A., Koth, R., Snow, S., Eberhardt, E. L., Miller, D. D., et al. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1900946 · Cited by 5 · see citing works

Low-Dose Radiation-Induced Enhancement of Thymic Lymphomagenesis in Lck-Bax Mice is Dependent on LET and Gender

Jacobus, J. A., Duda, C. G., Coleman, M. C., Martin, S. M., Mapuskar, K. A., Mao, G., Smith, B. J., Aykin‐Burns, N., Guida, P. M., Gius, D. R., et al. (2013) · Radiation Research · doi:10.1667/rr3293.1 · Cited by 5 · see citing works

MMR Deficiency Does Not Sensitize or Compromise the Function of Hematopoietic Stem Cells to Low and High LET Radiation

Patel, R., Qing, Y., Kennedy, L. H., Yan, Y., Pink, J. J., Aguila, B., Desai, A. B., Gerson, S. L., & Welford, S. M. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0295 · Cited by 4 · see citing works

Medical Concerns with Space Radiation and Radiobiological Effects

Straume, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-03952-7_4 · Cited by 4 · see citing works

56Fe-ion Exposure Increases the Incidence of Lung and Brain Tumors at a Similar Rate in Male and Female Mice

Finkelstein, S. R., Patel, R., Deland, K., Mercer, J., Starr, B. F., Zhu, D., Min, H. D., Reinsvold, M. H., Campos, L. D. S., Williams, N. T., et al. (2024) · Radiation Research · doi:10.1667/rade-24-00004.1 · Cited by 3 · see citing works

Advances in Radiation Biology of Particle Irradiation

Helm, A., Tinganelli, W., & Durante, M. (2018) · Progress in tumor research · doi:10.1159/000486998 · Cited by 3 · see citing works

Fluorescence in situ hybridization analysis of chromosomal aberrations in mouse splenocytes at one- and two-months after total body exposure to iron-56 (Fe) ion particles or X-rays

Katsube, T., Wang, B., Tanaka, K., Ninomiya, Y., Hirakawa, H., Liu, C., Maruyama, K., Varès, G., Liu, Q., Murakami, M., et al. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2022.503548 · Cited by 2 · see citing works

Effects of 28Si ions, 56Fe ions, and protons on the induction of murine acute myeloid leukemia and hepatocellular carcinoma

Weil, M. M., Ray, F. A., Genik, P. C., Yu, Y., McCarthy, M., Fallgren, C. M., & Ullrich, R. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104819 · Cited by 83 · see citing works

Relative Effectiveness of HZE Iron-56 Particles for the Induction of Cytogenetic DamageIn Vivo

Brooks, A. L., Bao, S., Rithidech, K. N., Couch, L. A., & Braby, L. A. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0353:reohip]2.0.co;2 · Cited by 65 · see citing works

Accelerated hematopoietic toxicity by high energy56Fe radiation

Datta, K., Suman, S., Trani, D., Doiron, K., Rotolo, J. A., Kallakury, B., Kolesnick, R. N., Cole, M. F., & Fornace, A. J. (2011) · International Journal of Radiation Biology · doi:10.3109/09553002.2012.639434 · Cited by 39 · see citing works

Fluorescence in situ hybridization analysis of chromosomal aberrations in mouse splenocytes at one- and two-months after total body exposure to iron-56 (Fe) ion particles or X-rays

Katsube, T., Wang, B., Tanaka, K., Ninomiya, Y., Hirakawa, H., Liu, C., Maruyama, K., Varès, G., Liu, Q., Murakami, M., et al. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2022.503548 · Cited by 2 · see citing works

Relative Effectiveness of Heavy Ion Irradiations from Accelerated Iron-56 Particles for Induction of Genotoxicity in the Hematopoietic System in Mice

Wang, B., Tanaka, K., KATSUBE, T., Ninomiya, Y., Hirakawa, H., Liu, C., Maruyama, K., Vares, G., Nakajima, T., Nagamatsu, A., et al. (2016) · Institutional Repositories DataBase (IRDB)