Incidence and trends of blastomycosis-associated hospitalizations in the United States.
Open accessAbstract
We used the State Inpatient Databases from the United States Agency for Healthcare Research and Quality to provide state-specific age-adjusted blastomycosis-associated hospitalization incidence throughout the entire United States. Among the 46 states studied, states within the Mississippi and Ohio River valleys had the highest age-adjusted hospitalization incidence. Specifically, Wisconsin had the highest age-adjusted hospitalization incidence (2.9 hospitalizations per 100,000 person-years). Trends were studied in the five highest hospitalization incidence states. From 2000 to 2011, blastomycosis-associated hospitalizations increased significantly in Illinois and Kentucky with an average annual increase of 4.4% and 8.4%, respectively. Trends varied significantly by state. Overall, 64% of blastomycosis-associated hospitalizations were among men and the median age at hospitalization was 53 years. This analysis provides a complete epidemiologic description of blastomycosis-associated hospitalizations throughout the endemic area in the United States.
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Blastomycosis is endemic throughout much of the midwestern US, particularly along the Great Lakes and the Mississippi, Ohio, and Saint Lawrence River valleys.
“It is endemic throughout much of the midwestern US [171,172], particularly along the Great Lakes and the Mississippi, Ohio, and Saint Lawrence River valleys [173,174].”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [174]
Approximately 1,000 blastomycosis-associated hospitalizations occur nationwide.
“In contrast, ≈1,000 blastomycosis-associated hospitalizations occur nationwide (10,11)”
From Blastomycosis Surveillance in 5 States, United States, 1987–2018 (2021) · cites this paper as [10]
For most states in the analysis, relatively stable incidence and hospitalization rates over time were consistent with a previous analysis of blastomycosis-related hospitalizations during 2000-2011.
“For most states in this analysis, the relatively stable incidence and hospitalization rates over time were consistent with a previous analysis of blastomycosis-related hospitalizations during 2000–2011 (10).”
From Blastomycosis Surveillance in 5 States, United States, 1987–2018 (2021) · cites this paper as [10]
More blastomycosis hospitalizations typically occur among men.
“More blastomycosis hospitalizations typically occur among men (10,13), although a recent study found female sex was independently associated with death in blastomycosis patients with acute respiratory distress syndrome (14).”
From Blastomycosis Surveillance in 5 States, United States, 1987–2018 (2021) · cites this paper as [10]
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- Authors
- Seitz, A. E., Younes, N., Steiner, C. A., & Prevots, D. R.
- Affiliations
- National Institutes of Health (US)
- George Washington University (US)
- Agency for Healthcare Research and Quality (US)
- Corresponding author
- Seitz, Amy E.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-08-15
- Volume
- 9
- Issue
- 8
- Pages
- e105466
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4134307
- OpenAlex
- W2055046247
- Cited by
- 51
- References
- 40
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 6
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- Agency for Healthcare Research and Quality
- National Institute of Allergy and Infectious Diseases
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Microbiology › Actinomycetales infections and treatment
- Keywords
- blastomycosis, hospitalization incidence, temporal trends, regional variation, endemic areas, Wisconsin, Illinois, Kentucky, sex differences, State Inpatient Database
- MeSH terms
- Blastomycosis, Female, Hospitalization, Humans, Male, Middle Aged, United States, Incidence
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