Diagnostic delay and antibiotic overuse in acute pulmonary blastomycosis.
Open accessAbstract
The diagnosis of blastomycosis is often delayed. We identified 28 cases of pulmonary blastomycosis in a retrospective chart review. Most patients received multiple antibiotic courses before being diagnosed, and the sputum KOH smear was rarely used. Diagnostic delay can be decreased with higher suspicion for pulmonary blastomycosis and early use of the sputum KOH smear.
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This time interval is consistent with a previous report describing a median of 23 days between examination at a healthcare facility and a median of 2.5 courses of antibacterial medications for presumed bacterial infection before pulmonary blastomycosis was correctly diagnosed.
“This time interval is consistent with a previous report describing a median of 23 days between examination at a healthcare facility and a median of 2.5 courses of antibacterial medications for presumed bacterial infection before pulmonary blastomycosis was correctly diagnosed (3).”
From Blastomycosis Surveillance in 5 States, United States, 1987–2018 (2021) · cites this paper as [3]
The clinical similarities between blastomycosis and other pulmonary infections often result in diagnostic delays and unnecessary empiric antimicrobial drug treatment for suspected bacterial pneumonia.
“The clinical similarities between blastomycosis and other pulmonary infections often result in diagnostic delays and unnecessary empiric antimicrobial drug treatment for suspected bacterial pneumonia (3).”
From Blastomycosis Surveillance in 5 States, United States, 1987–2018 (2021) · cites this paper as [3]
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Cites
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Blastomycosis in Minnesota, USA, 1999-2018.
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Blastomycosis Surveillance in 5 States, United States, 1987–2018
Benedict, K., Gibbons-Burgener, S., Kocharian, A., Ireland, M., Rothfeldt, L., Christophe, N., Signs, K., & Jackson, B. R. (2021) · Emerging Infectious Diseases · doi:10.3201/eid2704.204078 · Cited by 29 · see citing works
- Authors
- Alpern, J. D., Bahr, N. C., Vazquez-Benitez, G., Boulware, D. R., Sellman, J. S., & Sarosi, G. A.
- Affiliations
- Regions Hospital (US)
- University of Minnesota (US)
- HealthPartners Institute for Education and Research, Minneapolis
- Corresponding author
- Alpern, Jonathan D.
- Venue
- Open Forum Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2016
- Volume
- 3
- Issue
- 2
- Pages
- ofw078-ofw078
- ISSN
- 2328-8957 (ISSN-L)
- PMC
- PMC4943562
- OpenAlex
- W2340649443
- Cited by
- 42
- References
- 16
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Open Forum Infectious Diseases (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- HealthPartners GME Resident Research
- National Institute of Allergy and Infectious Disease (T32AI055433)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Microbiology › Actinomycetales infections and treatment
- Keywords
- pulmonary blastomycosis, delayed diagnosis, antibiotic overuse, early diagnosis, fungal lung infection, antifungal therapy
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