Cited by 532Functional Brain Connectivity StudiesPain Mechanisms and TreatmentsPain Management and Treatment

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Functional Reorganization of the Default Mode Network across Chronic Pain Conditions

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Baliki, Marwan N., Mansour, Ali R., Baria, Alex T., Apkarian, A. Vania·2014·PLoS ONE

DOI 10.1371/journal.pone.0106133PMC PMC4152156

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Abstract

Chronic pain is associated with neuronal plasticity. Here we use resting-state functional magnetic resonance imaging to investigate functional changes in patients suffering from chronic back pain (CBP), complex regional pain syndrome (CRPS) and knee osteoarthritis (OA). We isolated five meaningful resting-state networks across the groups, of which only the default mode network (DMN) exhibited deviations from healthy controls. All patient groups showed decreased connectivity of medial prefrontal cortex (MPFC) to the posterior constituents of the DMN, and increased connectivity to the insular cortex in proportion to the intensity of pain. Multiple DMN regions, especially the MPFC, exhibited increased high frequency oscillations, conjoined with decreased phase locking with parietal regions involved in processing attention. Both phase and frequency changes correlated to pain duration in OA and CBP patients. Thus chronic pain seems to reorganize the dynamics of the DMN and as such reflect the maladaptive physiology of different types of chronic pain.

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Authors: Baliki, M. N., Mansour, A. R., Baria, A. T., & Apkarian, A. V.
Affiliations: Northwestern University (US)
Corresponding author: Apkarian, A. Vania
ORCID: Baliki, Marwan N.
Mansour, Ali R.
Apkarian, A. Vania
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2014-09-02
Volume: 9
Issue: 9
Pages: e106133
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0106133
PMC: PMC4152156
OpenAlex: W2045895137
Cited by: 532
References: 54
Citations by year: 2026: 36 · 2025: 42 · 2024: 48 · 2023: 45 · 2022: 57 · 2021: 39 · 2020: 56 · 2019: 43 · 2018: 47 · 2017: 50 · 2016: 42 · 2015: 24 · 2014: 2
FWCI: 21.93
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS35115, R01NS035115)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: chronic pain, default mode network, chronic back pain, complex regional pain syndrome, knee osteoarthritis, resting-state functional connectivity, medial prefrontal cortex, insula, high-frequency oscillations, phase locking, attention, pain duration, neuroplasticity
MeSH terms: Adult, Aged, Female, Humans, Male, Middle Aged, Nerve Net, Neural Pathways, Rest, Case-Control Studies, Prefrontal Cortex, Young Adult, Chronic Pain

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Functional Reorganization of the Default Mode Network across Chronic Pain Conditions

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