The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults
Open accessAbstract
To elucidate the effects of endurance training on circulating irisin levels in young and middle-aged/older adults, and to determine the association between endurance training-induced alteration of irisin and reduction in body fat. Twenty-five healthy young (age 21 ± 1 years; 16 men, 9 women) and 28 healthy middle-aged/older adults (age 67 ± 8 years; 12 men, 16 women) participated in the study. Each age cohort was divided into two groups: the endurance-training group (14 young, 14 middle-aged/older) and the control group. Subjects in the training groups completed an 8-week endurance-training program (cycling at 60-70% peak oxygen uptake [V̇O2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated serum irisin level, V̇O2peak, and body composition. The increase in V̇O2peak in the young and middle-aged/older training groups after the intervention period was significantly greater than those in the young and middle-aged/older control groups (P < 0.05). Serum irisin level was significantly increased in the middle-aged/older training group after the intervention period (P < 0.01), but not in the young training group. Furthermore, in the middle-aged/older training group, the endurance training-induced reduction in visceral adipose tissue area was negatively correlated with the change in serum irisin level (r = -0.54, P < 0.05). These results suggest a possible role for secreted irisin in the exercise-induced alteration of abdominal visceral fat in middle-aged and older adults.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“After an 8-week endurance training in healthy adults, increased circulating irisin levels were positively correlated with the amount of visceral fat loss measured by DEXA scan [121].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [121]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The main results indicated an increase in serum irisin levels in the elderly group compared to the young group (age 21 ± 1 years)”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Miyamoto-Mikami et al., 2015
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“accompanied by a reduction in visceral adiposity which was negatively correlated with irisin levels (r = −0.54, P < 0.05; Miyamoto-Mikami et al., 2015).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Miyamoto-Mikami et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Age-predicted maximal heart rate revisited
Tanaka, H., Monahan, K. D., & Seals, D. R. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01054-8 · Cited by 3,775 · cited 1×
“7 × age) [11], and (IV) RPE 18.”
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470
Subcutaneous and visceral adipose tissue: Structural and functional differences
Ibrahim, M. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00623.x · Cited by 2,238
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040
Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788
The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk
Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631
FNDC5/irisin is not only a myokine but also an adipokine
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · cited 1×
“FNDC5mRNA is expressed at higher levels in skeletal muscle than in other organs [9], and FNDC5 expression in skeletal muscle contributes significantly to circulating irisin levels [5, 9, 22].”
BackgroundEffect of Exercise Training Intensity on Abdominal Visceral Fat and Body Composition
Irving, B. A., Davis, C. K., Brock, D. W., Weltman, J. Y., Swift, D. L., Barrett, E. J., Gaesser, G. A., & WELTMAN, A. L. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181801d40 · Cited by 407
Is irisin a human exercise gene?
Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 393
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–142 of 142
The Hormone-like Myokines Irisin as Novel Biomarker for Cardiovascular Risk Stratification”,
Berezin, A. A., Myrnyi, D. P., Myrnyi, S. P., & Berezin, A. Е. (2021) · Pharmacophore · doi:10.51847/cx5vhf76yw · Cited by 4
Shamas, S. (2019) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2019.283 · Cited by 4
Poggi, A. I., Andreasen, M. W., Sahl, R. E., Hansen, M. T., Rømer, T., Frandsen, J., Linden, F. H., Høgh‐Schmidt, E., Boesen, M., Ostrowski, S. R., et al. (2024) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14612 · Cited by 2
Li, H., & Thirupathi, A. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1639427 · Cited by 2
Inoue, K., Fujie, S. J., Uchida, M., Ito, R., Nakao, K., Kanemoto, M., & Iemitsu, M. (2026) · Scientific Reports · doi:10.1038/s41598-026-39903-8 · Cited by 2
Zhai, X., & Wang, D. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106653 · Cited by 2
Sarfraz, M., Shadmehr, A., Naz, E., Ali, M. N., & Rahim, A. (2022) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs22168729 · Cited by 2
The impact of sports on the normal functioning of the prostate gland: A review
Валерьевич, Е. А. (2023) · Consilium Medicum · doi:10.26442/20751753.2022.12.202036 · Cited by 2
Doença hepática gordurosa não alcoólica, hormônios e exercício físico: uma abordagem fisiológica
Lima, W. P., & Vieira, A. L. R. (2018) · Revista Brasileira de Fisiologia do Exercício · doi:10.33233/rbfe.v16i5.2091 · Cited by 2
Research on the impact of exercise on body composition of elderly
Aksović, N., Anđelković, I., & Ličina, M. (2016) · Godisnjak Fakulteta sporta i fizickog vaspitanja · doi:10.5937/gfsfv1622006a · Cited by 2
EL-GHANNAM, M. D. K. I. A. M. A., & Habib, M. A. (2019) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2019.52360 · Cited by 2
Weber‐Rajek, M., Radzimińska, A., Pilarska, B., Kozakiewicz, M., & Goch, A. (2019) · Wiadomości Lekarskie · doi:10.36740/wlek201903110 · Cited by 2
Barhoma, R. A., & Elshamy, A. M. (2020) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2020.29385.1056 · Cited by 2
Obesity, Myokines, and Metabolic Health
Malandrino, N., & Ahima, R. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_56 · Cited by 2
Brain and Brawn: Role of Exercise-Induced Myokines
Bae, J. H., & Song, W. J. (2019) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2019.28.3.145 · Cited by 2
Endurance Training for Volleyball Athletes: The Efficacy of Tabata and Circuit Training Models
Kastrena, E., & Revianny, R. M. (2023) · JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA · doi:10.17509/jpjo.v8i2.62809 · Cited by 1
Hu, S., Chen, T., Liu, X., Wu, Z., & Wang, X. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07744-8 · Cited by 1
Sex specific effects of irisin on the skeleton
Shimonty, A., & Bonewald, L. F. (2026) · Bone Research · doi:10.1038/s41413-026-00542-4 · Cited by 1
Placenta Previa with history of Previous Caesarean Delivery – an obstetrician's nightmare
Mazumder, U., Rouf, S., & Sarkar, S. (2015) · Journal of Woman s Reproductive Health · doi:10.14302/issn.2381-862x.jwrh-17-1750 · Cited by 1
Sarraf, V. S., Nikoukheslat, S., & Niknam, Z. (2019) · Medical Journal of Tabriz University of Medical Sciences and Health Services · doi:10.34172/mj.2020.006 · Cited by 1
Zagrodna, A., Książek, A., Słowińska-Lisowska, M. R., Chmura, J., Ponikowski, P. P., & Lombardi, G. (2023) · Journal of Sports Sciences · doi:10.1080/02640414.2023.2240618 · Cited by 1
de Manizales, U. A., Ruíz, J. C., Montealegre-Mesa, L. M., de Manizales, U. A., Villada, M. F., de Manizales, U. A., Mejía, G., de Manizales, U. A., Quechotl-Benítez, R., & México, B. U. A. D. P. (2023) · Revista digital Actividad Física y Deporte · doi:10.31910/rdafd.v10.n1.2024.2326 · Cited by 1
Berković, M. C., Cigrovski, V., & Ružić, L. (2025) · World Journal of Methodology · doi:10.5662/wjm.v15.i4.105462 · Cited by 4
Khosravi, A., Keshvari, M., & Tahramuzi, M. A. (2019) · Medical Journal of Tabriz University of Medical Sciences and Health Services · doi:10.34172/mj.2019.018 · Cited by 2
Effect of Eight Weeks Sports Programs on Blood Irisin Level in Healthy Male Sport Practitioners
Al-Naemi, R. S., Khalid, A., & Al-Doski, D. (2021) · Govara zanistîn mirovayetî ya-zankoya Zaxo · doi:10.26436/hjuoz.2021.9.2.687 · Cited by 1
Bogdani, A., & Pano, G. (2021) · Winter Conferences of Sports Science · doi:10.14198/jhse.2021.16.proc3.56 · Cited by 1
Does Irisin Link Physical Exercise with Alzheimer’s Disease?Preprint
Sumsuzzman, D. M., Jin, Y., & Hong, Y. (2017) · Preprints.org · doi:10.20944/preprints201712.0023.v1
Adaptation to the levels of MDA and SOD Enzyme Activity of MICT and HIIT Exercise On Wistar
Mu’arif, S., & Widiyanto, M. (2019) · International Conference on Sports Sciences and Health (ICSSH) · doi:10.2991/icssh-18.2019.37
Acute and chronic effects of exercise on irisin in healthy adults
Jafari, M., & Ravasi, A. A. (2021) · فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران · doi:10.52547/iau.31.2.135
Prevención de la demencia: beneficios de la actividad física
Terrón, C., & Palomo, M. S. M. (2021) · Kranion · doi:10.24875/kranion.m21000008
Peningkatan Kadar Irisin Setelah 8 Minggu Latihan Resisten Intensitas Sedang Pada Wanita Obesitas
Saputra, F. E., Merawati, D., & Sugiharto, S. (2023) · Jurnal Patriot · doi:10.24036/patriot.v5i2.966
Obesity, Myokines, and Metabolic Health
Malandrino, N., & Ahima, R. S. (2023) · Springer eBooks · doi:10.1007/978-3-319-12125-3_56-1
Amine, B. M. E., Adel, B., Oumri, D., & Ahmed, A. (2023) · GYMNASIUM · doi:10.29081/gsjesh.2023.24.1.09
Rahmi, U., Goenawan, H., Sylviana, N., Setiawan, S., & Ray, H. R. D. (2023) · Journal of Law and Sustainable Development · doi:10.55908/sdgs.v11i10.1074
Role of Myokines and prospects for their role in Diabetes Mellitus Therapy
Nuriya, K., Farida, M., Sharma, R., Liliya, S., Mkhitaryan, X. E., Chergizova, B., Salikhova, Y., Niyazova, Y., Ryspayeva, G., Evnevich, A., et al. (2024) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2024.00786
Adilakshmi, P., Suganthi, V., Sayana, S. B., Kumar, S., & Rao, K. S. (2024) · Cureus · doi:10.7759/cureus.75870
Gharaat, M., & Karami, S. (2025) · مجله دانشگاه علوم پزشکی اراک · doi:10.61186/jams.28.1.24
Myokines — the cardiometabolic risk potential biomarkers
Timofeev, Y. S., Metelskaya, V. A., Sheptulina, A. F., Neshkova, E. A., Dubovskaya, N. I., Yafarova, A. A., Мамутовна, М. Э., Валерьевна, Д. Н., Khatri, D. N., & Drapkina, O. M. (2025) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202528071119
Arazi, H., Bagherpour, F., & Tinsley, G. M. (2026) · Biological Research For Nursing · doi:10.1177/10998004261460028
Gao, R., Zhang, Y., & Quan, L. (2026) · Comprehensive physiology · doi:10.1002/cph4.70248
Skeletal Muscle Aging Is a Significant Contributor to Systemic Aging
Li, M.-M., Liu, X., Li, Y., Li, H., Wang, Y., Qiu, K., & Kong, W. (2026) · Biomolecules · doi:10.3390/biom16101527
Akashi, N., Kondo, K., Kadota, A., Torii, S., Kadowaki, S., Miyazawa, I., Sekine, C., Iemitsu, M., HISAMATSU, T., 原田, 晃., et al. (2026) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2026.10.003
Metadata
- Authors
- Miyamoto-Mikami, E., Sato, K., Kurihara, T., Hasegawa, N., Fujie, S., Fujita, S., Sanada, K., Hamaoka, T., Tabata, I., & Iemitsu, M.
- Affiliations
- Ritsumeikan University (JP)
- Corresponding author
- Iemitsu, Motoyuki
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-03-20
- Volume
- 10
- Issue
- 3
- Pages
- e0120354
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4368602
- OpenAlex
- W1969017622
- Cited by
- 143
- References
- 25
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 13 · 2023: 14 · 2022: 23 · 2021: 16 · 2020: 10 · 2019: 18 · 2018: 10 · 2017: 13 · 2016: 3 · 2015: 3
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
- Kobe University Repository Kernel (Kobe University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (25560378)
- Japan Society for the Promotion of Science (26282199, 25560378, 26350825, 24300235, 24300239)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- irisin, endurance training, visceral fat, middle-aged and older adults, peak oxygen uptake, body composition, aging, cycling training
- MeSH terms
- Aged, Body Composition, Body Weight, Female, Fibronectins, Humans, Male, Middle Aged, Physical Endurance, Case-Control Studies, Intra-Abdominal Fat, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
