Association of DNA Methylation with Acute Mania and Inflammatory Markers
Open accessAbstract
In order to determine whether epigenetic changes specific to the manic mood state can be detected in peripheral blood samples we assayed DNA methylation levels genome-wide in serum samples obtained from 20 patients hospitalized for mania and 20 unaffected controls using the Illumina 450K methylation arrays. We identified a methylation locus in the CYP11A1 gene, which is regulated by corticotropin, that is hypo-methylated in individuals hospitalized for mania compared with unaffected controls. DNA methylation levels at this locus appear to be state related as levels in follow-up samples collected from mania patients six months after hospitalization were similar to those observed in controls. In addition, we found that methylation levels at the CYP11A1 locus were significantly correlated with three inflammatory markers in serum in acute mania cases but not in unaffected controls. We conclude that mania is associated with alterations in levels of DNA methylation and inflammatory markers. Since epigenetic markers are potentially malleable, a better understanding of the role of epigenetics may lead to new methods for the prevention and treatment of mood disorders.
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It is known that schizophrenia patients have upregulated genes for inflammatory cytokines, and downregulated Bdnf gene transcription.
“It is known that schizophrenia patients have upregulated genes for inflammatory cytokines [122, 123], and downregulated Bdnf gene transcription [124, 125].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [122]
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- Authors
- Sabunciyan, S., Maher, B., Bahn, S., Dickerson, F., & Yolken, R. H.
- Affiliations
- Johns Hopkins University (US)
- University of Cambridge (GB)
- Sheppard Pratt Health System (US)
- Corresponding author
- Sabunciyan, Sarven
- Yolken, Robert H.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-07-06
- Volume
- 10
- Issue
- 7
- Pages
- e0132001
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4492496
- OpenAlex
- W2302031863
- Cited by
- 35
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 2
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Stanley Medical Research Institute
- Johns Hopkins University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- DNA methylation, acute mania, bipolar disorder, CYP11A1, ACTH, inflammatory markers, serum biomarkers, epigenetics, mood disorders
- MeSH terms
- Acute Disease, Adult, Aged, Bipolar Disorder, Cholesterol Side-Chain Cleavage Enzyme, Female, Humans, Male, Middle Aged, Biomarkers, Inflammation Mediators, DNA Methylation, Genetic Loci
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