Revisiting inflammation in bipolar disorder

Fries, Gabriel R.; Walss-Bass, Consuelo; Bauer, Moises E.; Teixeira, Antonio L.

doi:10.1016/j.pbb.2018.12.006

Cited by 147Bipolar Disorder and TreatmentTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Revisiting inflammation in bipolar disorder

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Fries, Gabriel R., Walss-Bass, Consuelo, Bauer, Moises E., Teixeira, Antonio L.·2019·Pharmacology Biochemistry and Behavior

DOI 10.1016/j.pbb.2018.12.006

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Abstract

Bipolar disorder (BD) has been associated with immune changes, and yet their underlying mechanisms are still not fully understood. Here, we review the current state of the field, concerning the inflammatory alterations observed in the periphery and in the central nervous system, followed by a discussion of potential underlying mechanisms. We focus mainly on recently proposed mechanisms including the role of the gut-brain axis, the release of damage-associated molecular patterns (DAMPs), and the genetic and epigenetic mechanisms. BD immunology is an evolving field and current studies indicate this disease is more than a brain disorder, and it can be conceptualized as a multi-system condition.

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Inflammation is one of several etiopathological mechanisms contributing to bipolar disorder.
“Inflammation is one of many etiopathological mechanisms of bipolar disorder that have recently been highlighted [7].”
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Pfaffenseller, B., Wollenhaupt-Aguiar, B., Fries, G. R., Colpo, G. D., Burque, R. K., Bristot, G., Ferrari, P., Ceresér, K. M. M., Rosa, A. R., Klamt, F., et al. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000443 · Cited by 83 · see citing works
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Fries, G. R., Li, Q., McAlpin, B. R., Rein, T., Walss‐Bass, C., Soares, J. C., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.010 · Cited by 82 · see citing works
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The miRNome of bipolar disorder
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Bipolar Disorder and Metabolic Syndrome: A Systematic Review
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Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder
Papiol, S., Rosa, A., Gutiérrez, B., Martín, B., Salgado, P., Catalán, R., Arias, B., & Fañanás, L. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.012914 · Cited by 80 · see citing works
Seroreactive marker for inflammatory bowel disease and associations with antibodies to dietary proteins in bipolar disorder
Severance, E. G., Gressitt, K. L., Yang, S., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Alaedini, A., Dickerson, F., & Yolken, R. H. (2013) · Bipolar Disorders · doi:10.1111/bdi.12159 · Cited by 79 · see citing works
Association of polygenic score for schizophrenia and HLA antigen and inflammation genes with response to lithium in bipolar affective disorder: a genome-wide association study
Amare, A., Schubert, K., Hou, L., Clark, S., Papiol, S., Heilbronner, U., Degenhardt, F., Ayele, F. T., Hsu, Y., Shekhtman, T., et al. (2017) · MPG.PuRe (Max Planck Society) · Cited by 72 · see citing works
Multiple levels of impaired neural plasticity and cellular resilience in bipolar disorder: Developing treatments using an integrated translational approach
Machado‐Vieira, R., Soeiro‐de‐Souza, M. G., Richards, E. M., Teixeira, A. L., & Zarate, C. A. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.830775 · Cited by 70 · see citing works
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Bipolar disorder and diabetes mellitus: evidence for disease-modifying effects and treatment implications
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Insight into the mechanisms regulating immune homeostasis in health and disease.
Sirisinha, S. (2011) · PubMed · Cited by 68 · see citing works
Polymorphism of Toll-like receptor 4 gene in bipolar disorder
Oliveira, J., Busson, M., Étain, B., Jamain, S., Hamdani, N., Boukouaci, W., Amokrane, K., Bennabi, M., Guen, E. L., Dargél, A., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.09.043 · Cited by 66 · see citing works
Bipolar Disorder and the Vascular System: Mechanisms and New Prevention Opportunities
Goldstein, B. I. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.10.006 · Cited by 64 · see citing works
Differential neuroendocrine and immune responses to acute psychosocial stress in women with type 1 bipolar disorder
Wieck, A., Grassi-Oliveira, R., do Prado, C. H., Rizzo, L. B., de Oliveira, A. S., Kommers-Molina, J., Viola, T. W., Teixeira, A. L., & Bauer, M. E. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.07.005 · Cited by 63 · see citing works
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The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder
Becking, K., Haarman, B. C. M., Grosse, L., Nolen, W. A., Claes, S. J., Arolt, V., Schoevers, R. A., & Drexhage, H. A. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.03.004 · Cited by 62 · see citing works
A Randomized, Double-Blind Placebo-Controlled Trial on Effectiveness and Safety of Celecoxib Adjunctive Therapy in Adolescents with Acute Bipolar Mania
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C-reactive protein and white blood cell levels in schizophrenia, bipolar disorders and depression - associations with mortality and psychiatric outcomes: a population-based study
Horsdal, H. T., Köhler‐Forsberg, O., Benros, M. E., & Gasse, C. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.04.012 · Cited by 60 · see citing works
Gray matter deficits in bipolar disorder are associated with genetic variability at interleukin‐1 beta gene (2q13)
Papiol, S., Molina, V., Desco, M., Rosa, A., Reig, S., Sanz, J., Palomo, T., & Fañanás, L. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00421.x · Cited by 59 · see citing works
A preliminary investigation on the efficacy of <i>N</i> -acetyl cysteine for mania or hypomania
Vieira da Silva Magalhães, P., Dean, O. M., Bush, A. I., Copolov, D. L., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., & Berk, M. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413481631 · Cited by 58 · see citing works
Systemic autoimmune diseases are associated with an increased risk of bipolar disorder: A nationwide population-based cohort study
Wang, L.-Y., Chiang, J., Chen, S., & Shen, Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.027 · Cited by 56 · see citing works
Genetic and Environmental Influences on Pro-Inflammatory Monocytes in Bipolar Disorder
Padmos, R. C., van Baal, G. C. M., Vonk, R., Wijkhuijs, A. J. M., Kahn, R. S., Nolen, W. A., & Drexhage, H. A. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.116 · Cited by 55 · see citing works
A pilot study of minocycline for the treatment of bipolar depression: Effects on cortical glutathione and oxidative stress in vivo
Murrough, J. W., Huryk, K. M., Mao, X., Iacoviello, B. M., Collins, K. A., Nierenberg, A. A., Kang, G., Shungu, D. C., & Iosifescu, D. V. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.12.067 · Cited by 54 · see citing works
Damage‐associated molecular patterns and immune activation in bipolar disorder
Stertz, L., Fries, G. R., Rosa, A. R., Kauer‐Sant'anna, M., Ferrari, P., Paz, A. V. C., Green, C., Cunha, Â. B. M., Dal‐Pizzol, F., Gottfried, C., et al. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12417 · Cited by 53 · see citing works
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Taking the fuel out of the fire: Evidence for the use of anti-inflammatory agents in the treatment of bipolar disorders
Ayorech, Z., Tracy, D. K., Baumeister, D., & Giaroli, G. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.015 · Cited by 53 · see citing works
Infectious and immunogenetic factors in bipolar disorder
Oliveira, J., Oliveira-Maia, A. J., Tamouza, R., Brown, A. S., & Leboyer, M. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12791 · Cited by 52 · see citing works
Prevalences of autoimmune diseases in schizophrenia, bipolar I and II disorder, and controls
Cremaschi, L., Kardell, M., Johansson, V., Isgren, A., Sellgren, C. M., Altamura, A. C., Hultman, C. M., & Landén, M. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.09.071 · Cited by 52 · see citing works
Proliferation and apoptosis of T lymphocytes in patients with bipolar disorder
Pietruczuk, K., Lisowska, K. A., Grabowski, K., Landowski, J., & Witkowski, J. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21769-0 · Cited by 48 · see citing works
Adapting to environmental stresses: the role of the microbiota in controlling innate immunity and behavioral responses
Fagundes, C. T., Amaral, F. A., Teixeira, A. L., Souza, D. G., & Teixeira, M. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01077.x · Cited by 47 · see citing works
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Altered intracellular signaling cascades in peripheral blood mononuclear cells from BD patients
Barbosa, I. G., Nogueira, C. R. C., Rocha, N. P., Queiroz, A. L. L., Vago, J. P., Tavares, L. P., Assis, F., Fagundes, C. T., Huguet, R. B., Bauer, M. E., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.08.019 · Cited by 46 · see citing works
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Update on bipolar disorder biomarker candidates
Teixeira, A. L., Salem, H., Frey, B. N., Barbosa, I. G., & Machado‐Vieira, R. (2016) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2016.1248413 · Cited by 46 · see citing works
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White matter microstructure alterations correlate with terminally differentiated CD8+ effector T cell depletion in the peripheral blood in mania: Combined DTI and immunological investigation in the different phases of bipolar disorder
Magioncalda, P., Martino, M., Tardito, S., Sterlini, B., Conio, B., Marozzi, V., Adavastro, G., Capobianco, L., Russo, D., Parodi, A., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.04.017 · Cited by 46 · see citing works
Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders
Rios, A. C., Maurya, P. K., Pedrini, M., Zeni‐Graiff, M., Asevedo, E. D. M., Mansur, R. B., Wieck, A., Grassi‐Oliveira, R., McIntyre, R. S., Hayashi, M. A. F., et al. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0001 · Cited by 45 · see citing works
Bipolar and panic disorders may be associated with hereditary defects in the innate immune system
Foldager, L., Köhler‐Forsberg, O., Steffensen, R., Thiel, S., Kristensen, A. S., Jensenius, J. C., & Mors, O. N. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.017 · Cited by 41 · see citing works
The Impact of Obesity on Cognitive Functioning in Euthymic Bipolar Patients
Mora, E., Portella, M. J., Martínez‐Alonso, M., Teres, M., Forcada, I., Vieta, E., & Mur, M. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m10968 · Cited by 41 · see citing works
Association between toll-like receptor 2 gene diversity and early-onset bipolar disorder
Oliveira, J., Hamdani, N., Busson, M., Étain, B., Bennabi, M., Amokrane, K., Boukouaci, W., Fortier, C., Marzais, F., Bengoufa, D., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.059 · Cited by 40 · see citing works
The role of macrophage polarization on bipolar disorder: Identifying new therapeutic targets
Ascoli, B. M., Géa, L. P., Colombo, R., Barbé‐Tuana, F. M., Kapczinski, F. P., & Rosa, A. R. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416642846 · Cited by 40 · see citing works
Long-term risk of myocardial infarction and stroke in bipolar I disorder: A population-based Cohort Study
Prieto, M. L., Schenck, L. A., Kruse, J. L., Klaas, J. P., Chamberlain, A. M., Bobo, W. V., Bellivier, F., Leboyer, M., Roger, V. L., Brown, R. D., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.01.015 · Cited by 39 · see citing works
Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression
Ryan, J., Pilkington, L., Neuhaus, K., Ritchie, K., Ancelin, M., & Saffery, R. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1515-8 · Cited by 39 · see citing works
The MCP-1 Gene (SCYA2) and Mood Disorders: Preliminary Results of a Case-Control Association Study
Altamura, A. C., Mundo, E., Cattaneo, E., Pozzoli, S. M., Dell’Osso, B. M., Gennarelli, M., Vergani, C., Trabattoni, D., Arosio, B., & Clerici, M. (2009) · NeuroImmunoModulation · doi:10.1159/000258696 · Cited by 38 · see citing works
Increased risk of gout among patients with bipolar disorder: A nationwide population-based study
Chung, K., Huang, C., & Lin, H. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.07.012 · Cited by 38 · see citing works
Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States
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Increased Proapoptotic Serum Activity in Patients with Chronic Mood Disorders
Politi, P., Brondino, N., & Emanuele, E. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.07.011 · Cited by 36 · see citing works
Phosphorylation status of glucocorticoid receptor, heat shock protein 70, cytochrome c and Bax in lymphocytes of euthymic, depressed and manic bipolar patients
Bei, E., Salpeas, V., Pappa, D., Anagnostara, C., Alevizos, V., & Moutsatsou, P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.002 · Cited by 35 · see citing works
Association of DNA Methylation with Acute Mania and Inflammatory Markers
Sabunciyan, S., Maher, B., Bahn, S., Dickerson, F., & Yolken, R. H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0132001 · Cited by 35 · see citing works
Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder
Fries, G. R., Vasconcelos-Moreno, M. P., Gubert, C., Tietbohl-Santos, B., da Rosa, A. L. S. T., Eisele, B. S., Sartori, J., Pfaffenseller, B., Kapczinski, F. P., & Kauer‐Sant’Anna, M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.07.027 · Cited by 34 · see citing works
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State-dependent alterations of lipid profiles in patients with bipolar disorder
Huang, Y., Tsai, S., Chung, K., Chen, P., Huang, S., & Kuo, C. (2017) · The International Journal of Psychiatry in Medicine · doi:10.1177/0091217417749786 · Cited by 33 · see citing works
Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis
Fries, G. R., Quevedo, J., Zeni, C., Kazimi, I. F., Zunta‐Soares, G. B., Spiker, D. E., Bowden, C. L., Walss‐Bass, C., & Soares, J. C. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.32 · Cited by 31 · see citing works
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Omega‐3 supplementation associated with improved parent‐rated executive function in youth with mood disorders: secondary analyses of the omega 3 and therapy (OATS) trials
Vesco, A. T., Young, A. S., Arnold, L. E., & Fristad, M. A. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12830 · Cited by 31 · see citing works
Resolution of a manic episode treated with activated charcoal: Evidence for a brain–gut axis in bipolar disorder
Hamdani, N., Boukouaci, W., Hallouche, M. R., Charron, D. J., Krishnamoorthy, R., Leboyer, M., & Tamouza, R. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415595873 · Cited by 27 · see citing works
Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein
van der Doef, T. F., Doorduin, J., van Berckel, B. N. M., & Červenka, S. (2015) · Clinical and Translational Imaging · doi:10.1007/s40336-015-0140-0 · Cited by 25 · see citing works
Leukocytes in peripheral blood in patients with bipolar disorder – Trait and state alterations and association with levels of cytokines and C-reactive protein
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Genetic association between a ‘standing’ variant of NOD2 and bipolar disorder
Oliveira, J., Hamdani, N., Étain, B., Bennabi, M., Boukouaci, W., Amokrane, K., Fortier, C., Marzais, F., Bengoufa, D., Bellivier, F., et al. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.06.003 · Cited by 20 · see citing works
Pharmacologic implications of inflammatory comorbidity in bipolar disorder
Rosenblat, J. D., Gregory, J. M., & McIntyre, R. S. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.06.007 · Cited by 19 · see citing works
Increased risk of chronic obstructive pulmonary disease in patients with bipolar disorder: A population-based study
Hsu, J., Chien, I., & Lin, C. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.05.049 · Cited by 17 · see citing works
Non-genetic transgenerational transmission of bipolar disorder: targeting DNA methyltransferases
Fries, G. R., Walss‐Bass, C., Soares, J. C., & Quevedo, J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.172 · Cited by 16 · see citing works
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The Psychoneuroimmunological Role of Omega-3 Polyunsaturated Fatty Acids in Major Depressive Disorder and Bipolar Disorder.
Ih, R., As, K., Sahito, S., & Kumar, V. (2017) · PubMed · Cited by 15 · see citing works
Chemokine and Chemokine Receptor Polymorphisms in Bipolar Disorder
Tokac, D., Tüzün, E., Güleç, H., Yılmaz, V., Bireller, E. S., Çakmakoğlu, B., & Küçükali, C. İ. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.5.541 · Cited by 10 · see citing works
Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population
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HLA haplotype A26–B38 in affective disorders: Lack of association
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Unravelling immune alterations in schizophrenia: can DNA methylation provide clues?
Frydecka, D., Karpiński, P., & Misiak, B. (2014) · Epigenomics · doi:10.2217/epi.14.26 · Cited by 9 · see citing works
Not All Inflammatory Biomarkers Are Elevated in Bipolar Disorder: Evidence for Procalcitonin
Barbosa, I. G., Rocha, N. P., Filho, L. H. P., Oliveira, C., Junior, V. A. N., & Teixeira, A. L. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.010 · Cited by 8 · see citing works
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COX-2 gene variants in bipolar disorder-I.
ÖZDEMİRCAN, A., Daşdemir, S., Küçükali, C. İ., Bireller, E. S., Ozturk, H. Z. Y., & Çakmakoğlu, B. (2015) · PubMed · Cited by 7 · see citing works

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The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management
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Chemokine alterations in bipolar disorder: A systematic review and meta-analysis
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Gut-brain axis: A matter of concern in neuropsychiatric disorders…!
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ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system
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Factors associated with depression, anxiety and severe mental illness among adults with atopic eczema or psoriasis: a systematic review and meta-analysis
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p38α Mitogen-Activated Protein Kinase—An Emerging Drug Target for the Treatment of Alzheimer’s Disease
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A comparison of inflammatory markers in manic and euthymic states of bipolar disorder
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DNA damage and repair in neuropsychiatric disorders. What do we know and what are the future perspectives?
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Association of Bipolar Disorder With Major Adverse Cardiovascular Events: A Population-Based Historical Cohort Study
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Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder
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Gender Differences in Complete Blood Count and Inflammatory Ratios among Patients with Bipolar Disorder
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Comparison of the stability of glycoprotein acetyls and high sensitivity C ‐reactive protein as markers of chronic inflammation
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Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorder
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Diabetes and mood disorders: shared mechanisms and therapeutic opportunities
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Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities
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Gut Microbiota and Mental Health: A Comprehensive Review of Gut-Brain Interactions in Mood Disorders
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How to prevent the malignant progression of bipolar disorder
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Is there a relationship between morphological and functional platelet changes and depressive disorder?
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Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort
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Lipid Biomarker Research in Bipolar Disorder: A Scoping Review of Trends, Challenges, and Future Directions
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The Relationship Between Epigenetics and Microbiota in Neuropsychiatric Diseases
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Human iPSC-Derived Glia as a Tool for Neuropsychiatric Research and Drug Development
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Advances in the pathophysiology of bipolar disorder
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Heightened inflammation in bipolar disorder occurs independent of symptom severity and is explained by body mass index
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Impaired blood‐brain barrier in the microbiota‐gut‐brain axis: Potential role of bipolar susceptibility gene TRANK1
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A serum proteomic study of two case-control cohorts identifies novel biomarkers for bipolar disorder
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The Effect of Adjunctive Probiotics on Markers of Inflammation and Oxidative Stress in Bipolar Disorder: A Double-blind, Randomized, Controlled Trial
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COVID-19 vaccine acceptance and perceived stigma in patients with depression: a network perspective
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Severe mental disorders and vaccinations – a systematic review
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Higher Levels of C-reactive Protein Are Associated With Higher Cortical Surface Area and Lower Cortical Thickness in Youth With Bipolar Disorder
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The relationship between polyunsaturated fatty acids and inflammation: evidence from cohort and Mendelian randomization analyses
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Association between neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and C-reactive protein levels and metabolic status in patients with a bipolar disorder
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Eotaxin-1/CCL11 Correlates with Left Superior Temporal Gyrus in Bipolar Disorder: A Preliminary Report Suggesting Accelerated Brain Aging
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Acetylsalicylic Acid and Mood Disorders: A Systematic Review
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Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders
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Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein
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Bipolar disorder and the risk of cardiometabolic diseases, heart failure, and all-cause mortality: a population-based matched cohort study in South Korea
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COVID-19 Vaccination Prioritization Strategies in Malaysia: A Retrospective Analysis of Early Evidence
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Beyond Latency: Chronic Toxoplasma Infection and Its Unveiled Behavioral and Clinical Manifestations—A 30-Year Research Perspective
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Examining the Association between Inflammation and Motivational Anhedonia in Neuropsychiatric Disorders: A Systematic Review
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Does Decreased Vitamin D Level Trigger Bipolar Manic Attacks?
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From the immune system to mood disorders especially induced by Toxoplasma gondii: CD4+ T cell as a bridge
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Linking hearts and minds: understanding the cardiovascular impact of bipolar disorder
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The anti-inflammation pharmacodynamics of lithium: Therapy of bipolar disorder
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Association of pro-inflammatory cytokines with clinical features in euthymic patients with Bipolar-I-Disorder
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Exploring real-world evidence to uncover unknown drug benefits and support the discovery of new treatment targets for depressive and bipolar disorders
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Evaluation of postmortem microarray data in bipolar disorder using traditional data comparison and artificial intelligence reveals novel gene targets
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Role of gut microbiota in the GBR12909 model of mania-like behavior in mice
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Psychoneuroimmunology of Mood Disorders
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Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study
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Treatment-induced mood switching in affective disorders
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Neutrophil-Lymphocyte Ratio, Monocyte-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Manic Episode Patients with Bipolar Disorder
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Utilizing the Systemic Immune-Inflammation Index and Blood-Based Biomarkers in Association with Treatment Responsiveness amongst Patients with Treatment-Resistant Bipolar Depression
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Promising immunomodulators for management of substance and alcohol use disorders
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Effects of comorbid alcohol use disorder on bipolar disorder: Focusing on neurocognitive function and inflammatory markers.
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Bipolar disorder and the gut microbiota: a bibliometric analysis
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Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders
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Circulating T‐cell subsets discrepancy between bipolar disorder and major depressive disorder during mood episodes: A naturalistic, retrospective study of 1015 cases
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Therapeutic approaches employing natural compounds and derivatives for treating bipolar disorder: emphasis on experimental models of the manic phase
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Cardiovascular Disease and Bipolar Disorder: A Review of Pathophysiology and Treatment Implications
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Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances
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Association between infection with Toxoplasma gondii and psychiatric disorders
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Effects of olanzapine combined with sodium valproate on symptoms, inflammatory markers, and cognitive function in patients with bipolar disorder
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Microglia contribute to bipolar depression through Serinc2-dependent phospholipid synthesis
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Mood Disorders in Youth
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Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia
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High-Sensitive c-Reactive Protein Levels in Euthymic Bipolar Patients: Case-Control Study
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Authors: Fries, G. R., Walss-Bass, C., Bauer, M. E., & Teixeira, A. L.
Affiliations: The University of Texas Health Science Center at Houston (US)
ORCID: Fries, Gabriel R.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2019-02
Volume: 177
Pages: 12-19
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/j.pbb.2018.12.006
OpenAlex: W2906287592
Cited by: 147
References: 137
Citations by year: 2026: 9 · 2025: 15 · 2024: 15 · 2023: 27 · 2022: 27 · 2021: 27 · 2020: 23 · 2019: 4
FWCI: 2.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
PUCRS Repository (Pontifical Catholic University of Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: bipolar disorder, inflammation, neuroinflammation, immunological changes, gut-brain axis, damage-associated molecular patterns, epigenetics, genetic mechanisms, peripheral inflammation
MeSH terms: Alarmins, Gastrointestinal Microbiome, Anti-Inflammatory Agents, Bipolar Disorder, Brain, Humans, Hypothalamo-Hypophyseal System, Inflammation, Cytokines, Microglia, Epigenesis, Genetic

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