Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer’s Disease
Open accessAbstract
Alzheimer's disease (AD) is the most common form of dementia among the elderly. Neuritic plaques whose primary component is amyloid beta peptide (Aβ) and neurofibrillary tangles which are composed of hyperphosphorylated tau, are known to be the neuropathological hallmarks of AD. In addition, impaired synaptic plasticity in neuronal networks is thought to be important mechanism underlying for the cognitive deficits observed in AD. Although various causative factors, including excitotoxicity, mitochondrial dysregulation and oxidative damage caused by Aβ, are involved in early onset of AD, fundamental therapeutics that can modify the progression of this disease are not currently available. In the present study, we investigated whether phloroglucinol (1, 3, 5-trihydroxybenzene), a component of phlorotannins, which are plentiful in Ecklonia cava, a marine brown alga species, displays therapeutic activities in AD. We found that phloroglucinol attenuates the increase in reactive oxygen species (ROS) accumulation induced by oligomeric Aβ1-42 (Aβ1-42) treatment in HT-22, hippocampal cell line. In addition, phloroglucinol was shown to ameliorate the reduction in dendritic spine density induced by Aβ1-42 treatment in rat primary hippocampal neuron cultures. We also found that the administration of phloroglucinol to the hippocampal region attenuated the impairments in cognitive dysfunction observed in 22-week-old 5XFAD (Tg6799) mice, which are used as an AD animal model. These results indicate that phloroglucinol displays therapeutic potential for AD by reducing the cellular ROS levels.
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A consistent decrease in synaptophysin or PSD95 has not been observed prior to nine months of age.
“a consistent decrease in synaptophysin or PSD95 has not been observed prior to nine months of age [35,63,74,75,76].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [75]
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- Authors
- Yang, E.-J., Ahn, S., Ryu, J., Choi, M.-S., Choi, S., Chong, Y. H., Hyun, J.-W., Chang, M.-J., & Kim, H.-S.
- Affiliations
- Seoul National University (KR)
- Ewha Womans University (KR)
- Jeju National University (KR)
- Kookmin University (KR)
- Corresponding author
- Chang, Moon-Jeong
- Kim, Hye-Sun
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-08-18
- Volume
- 10
- Issue
- 8
- Pages
- e0135686
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4540482
- OpenAlex
- W1837384645
- Cited by
- 87
- References
- 53
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 7 · 2021: 12 · 2020: 9 · 2019: 10 · 2018: 6 · 2017: 5 · 2016: 6
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Education, Science and Technology
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- phloroglucinol, Alzheimer's disease, 5xFAD mice, amyloid-beta 42, reactive oxygen species, oxidative stress, dendritic spine density, synaptic plasticity, cognitive impairment, phlorotannins, Ecklonia cava, hippocampus, neuroprotection
- MeSH terms
- Disks Large Homolog 4 Protein, Alzheimer Disease, Animals, Cell Line, Cognition, Disease Models, Animal, Female, Hippocampus, Humans, Membrane Proteins, Peptide Fragments, Phloroglucinol, Pregnancy, Synapses, Amyloid beta-Peptides, Synaptophysin, Reactive Oxygen Species, Protein Structure, Secondary, Maze Learning, Intracellular Space, Dendritic Spines, Mice, Rats, Guanylate Kinases, Protein Multimerization
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