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Cited by 215

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Epidemiology and Microbiologic Characterization of Nosocomial Candidemia from a Brazilian National Surveillance Program

Open access
Doi, André Mario, Pignatari, Antonio Carlos Campos, Edmond, Michael B., Marra, Alexandre Rodrigues, Camargo, Luis Fernando Aranha, Siqueira, Ricardo Andreotti, da Mota, Vivian Pereira, Colombo, Arnaldo Lopes·2016·PLOS ONE
DOI 10.1371/journal.pone.0146909
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Abstract

Candidemia is a growing problem in hospitals all over the world. Despite advances in the medical support of critically ill patients, candidiasis leads to prolonged hospitalization, and has a crude mortality rate around 50%. We conducted a multicenter surveillance study in 16 hospitals distributed across five regions of Brazil to assess the incidence, species distribution, antifungal susceptibility, and risk factors for bloodstream infections due to Candida species. From June 2007 to March 2010, we studied a total of 2,563 nosocomial bloodstream infection (nBSI) episodes. Candida spp. was the 7th most prevalent agent. Most of the patients were male, with a median age of 56 years. A total of 64 patients (46.7%) were in the ICU when candidemia occurred. Malignancies were the most common underlying condition (32%). The crude mortality rate of candidemia during the hospital admission was 72.2%. Non-albicans species of Candida accounted for 65.7% of the 137 yeast isolates. C. albicans (34.3%), Candida parapsilosis (24.1%), Candida tropicalis (15.3%) and Candida glabrata (10.2%) were the most prevalent species. Only 47 out of 137 Candida isolates were sent to the reference laboratory for antifungal susceptibility testing. All C. albicans, C. tropicalis and C. parapsilosis isolates were susceptible to the 5 antifungal drugs tested. Among 11 C. glabrata isolates, 36% were resistant to fluconazole, and 64% SDD. All of them were susceptible to anidulafungin and amphotericin B. We observed that C. glabrata is emerging as a major player among non-albicans Candida spp. and fluconazole resistance was primarily confined to C. glabrata and C. krusei strains. Candida resistance to echinocandins and amphotericin B remains rare in Brazil. Mortality rates remain increasingly higher than that observed in the Northern Hemisphere countries, emphasizing the need for improving local practices of clinical management of candidemia, including early diagnosis, source control and precise antifungal therapy.

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Metadata

Authors
Doi, A. M., Pignatari, A. C. C., Edmond, M. B., Marra, A. R., Camargo, L. F. A., Siqueira, R. A., da Mota, V. P., & Colombo, A. L.
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2016-01-25
Volume
11
Issue
1
Pages
e0146909
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0146909
OpenAlex
W2265485478
Cited by
215
References
12
FWCI
23.24
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Epidemiology and Microbiologic Characterization of Nosocomial Candidemia from a Brazilian National Surveillance Program. https://app.cochat.ai/papers/10.1371/journal.pone.0146909
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Doi, A. M., Pignatari, A. C. C., Edmond, M. B., Marra, A. R., Camargo, L. F. A., Siqueira, R. A., da Mota, V. P., & Colombo, A. L. (2016). Epidemiology and Microbiologic Characterization of Nosocomial Candidemia from a Brazilian National Surveillance Program. PLOS ONE. https://doi.org/10.1371/journal.pone.0146909

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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