Multidrug-resistant endemic clonal strain of Candida auris in India

Chowdhary, A.; Anil Kumar, V.; Sharma, C.; Prakash, A.; Agarwal, K.; Babu, R.; Dinesh, K. R.; Karim, S.; Singh, S. K.; Hagen, F.; Meis, J. F.

doi:10.1007/s10096-013-2027-1

Cited by 373Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

Multidrug-resistant endemic clonal strain of Candida auris in India

Open access

Chowdhary, A., Anil Kumar, V., Sharma, C., Prakash, A., Agarwal, K., Babu, R., Dinesh, K. R., Karim, S. +3 more·2014·European Journal of Clinical Microbiology & Infectious Diseases

DOI 10.1007/s10096-013-2027-1

Open this paper in CoChat — free account Open PDF

Abstract

Candida auris is a recently described rare agent of fungemia. It is notable for its antifungal resistance. A total of 15 C. auris isolates, originating from seven cases of fungemia, three cases of diabetic gangrenous foot, and one case of bronchopneumonia from a tertiary care hospital in south India, were investigated. All of the 15 isolates were identified by sequencing and 14 of these along with 12 C. auris isolates previously reported from two hospitals in Delhi, north India, two each from Japan and Korea were genotyped by amplified fragment length polymorphism (AFLP). In vitro antifungal susceptibility testing (AFST) was done by the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method. Candida auris isolates were misidentified as Candida haemulonii by VITEK. All were resistant to fluconazole [geometric mean minimum inhibitory concentration (MIC) 64 μg/ml] and 11 isolates were resistant to voriconazole (MIC ≥1 μg/ml). Forty-seven percent of the C. auris isolates were resistant to flucytosine (MIC ≥64 μg/ml) and 40% had high MIC (≥1 μg/ml) of caspofungin. Breakthrough fungemia developed in 28.6% of patients and therapeutic failure in 4 (66.7%) patients. Interestingly, the 26 Indian C. auris isolates from north and south India were clonal and phenotypically and genotypically distinct from Korean and Japanese isolates. The present study demonstrates that C. auris is a potential emerging pathogen that can cause a wide spectrum of human mycotic infections. The prevalence of a C. auris endemic clonal strain resistant to azoles and other antifungals in Indian hospitals with high rates of therapeutic failure in cases of fungemia is worrisome.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s10096-013-2027-1

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nearly clonal isolates have emerged from hospitals in north and south India.
“Indeed, nearly clonal isolates have emerged from hospitals in north and south India (77) and can spread through local transmission (78).”
From Transcriptomics and Phenotyping Define Genetic Signatures Associated with Echinocandin Resistance in Candida auris (2022) · cites this paper as [77]
Most C. auris isolates are resistant to fluconazole.
“C. auris is well known for its multi-drug resistant characteristics, with most isolates resistant to fluconazole, an important first-line antifungal agent (3, 6, 10, 11).”
From Clinical Efficacy and Safety of a Novel Antifungal, Fosmanogepix, in Patients with Candidemia Caused by Candida auris : Results from a Phase 2 Trial (2023) · cites this paper as [10]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics
White, T. J., Bruns, T., Lee, S., & Taylor, J. (1990) · PCR Protocols · doi:10.1016/b978-0-12-372180-8.50042-1 · Cited by 36,648 · see citing works
PCR protocols — A guide to methods and applications
(1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90186-a · Cited by 11,826 · see citing works
PCR protocols — A guide to methods and applications
U.G. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90252-7 · Cited by 11,750 · see citing works
Clinical and Laboratory Standards Institute
Gressner, A. M., & Arndt, T. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-48986-4_300416 · Cited by 5,092 · see citing works
Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital
Satoh, K., Makimura, K., Hasumi, Y., Nishiyama, Y., Uchida, K., & Yamaguchi, H. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2008.00083.x · Cited by 1,381 · see citing works
ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients
Cornely, O. A., Bassetti, M., Calandra, T., Garbino, J., Kullberg, B. J., Lortholary, O., Meersseman, W., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12039 · Cited by 1,217 · see citing works
Identification of clinically important ascomycetous yeasts based on nucleotide divergence in the 5' end of the large-subunit (26S) ribosomal DNA gene
Kurtzman, C. P., & Robnett, C. J. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.5.1216-1223.1997 · Cited by 963 · see citing works
First Three Reported Cases of Nosocomial Fungemia Caused by Candida auris
Lee, W. G., Shin, J. H., Uh, Y., Kang, M. G., Kim, S. H., Park, K. H., & Jang, H. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.00319-11 · Cited by 524 · see citing works
Progress in Antifungal Susceptibility Testing of Candida spp. by Use of Clinical and Laboratory Standards Institute Broth Microdilution Methods, 2010 to 2012
Pfaller, M. A., & Diekema, D. J. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.00937-12 · Cited by 484 · see citing works
New Clonal Strain ofCandida auris, Delhi, India
Chowdhary, A., Sharma, C., Duggal, S., Agarwal, K., Prakash, A., Singh, P. K., Jain, S., Kathuria, S., Randhawa, H. S., Hagen, F., et al. (2013) · Emerging infectious diseases · doi:10.3201/eid1910.130393 · Cited by 418 · see citing works
Self-citation
Candida haemuloniiand Closely Related Species at 5 University Hospitals in Korea: Identification, Antifungal Susceptibility, and Clinical Features
Kim, M., Shin, J. H., Sung, H., Lee, K., Kim, E.-C., Ryoo, N. H., Lee, J., Jung, S., Park, K. H., Kee, S., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/597108 · Cited by 310 · see citing works
Reclassification of the Candida haemulonii Complex as Candida haemulonii (C. haemulonii Group I), C. duobushaemulonii sp. nov. (C. haemulonii Group II), and C. haemulonii var. vulnera var. nov.: Three Multiresistant Human Pathogenic Yeasts
Cendejas‐Bueno, E., Kolecka, A., Alastruey‐Izquierdo, A., Theelen, B., Groenewald, M., Kostrzewa, M., Cuenca‐Estrella, M., Gómez‐López, A., & Boekhout, T. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.02248-12 · Cited by 234 · see citing works
Biofilm formation and genotyping ofCandida haemulonii, Candida pseudohaemulonii, and a proposed new species (Candida auris) isolates from Korea
Oh, B. J., Shin, J. H., Kim, M., Sung, H., Lee, K., Joo, M. Y., Shin, M., Suh, S., & Ryang, D. W. (2010) · Medical Mycology · doi:10.3109/13693786.2010.493563 · Cited by 143 · see citing works
Validation of 24-Hour Fluconazole MIC Readings versus the CLSI 48-Hour Broth Microdilution Reference Method: Results from a Global Candida Antifungal Surveillance Program
Pfaller, M. A., Boyken, L. B., Hollis, R. J., Kroeger, J. S., Messer, S. A., Tendolkar, S., & Diekema, D. J. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01391-08 · Cited by 47 · see citing works
Clinical Significance of Filamentous Basidiomycetes Illustrated by Isolates of the Novel Opportunist Ceriporia lacerata from the Human Respiratory Tract
Chowdhary, A., Agarwal, K., Kathuria, S., Singh, P. K., Roy, P., Gaur, S. N., de Hoog, S., & Meis, J. F. G. M. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.02943-12 · Cited by 43 · see citing works
Self-citation
Validation of 24-Hour Posaconazole and Voriconazole MIC Readings versus the CLSI 48-Hour Broth Microdilution Reference Method: Application of Epidemiological Cutoff Values to Results from a Global Candida Antifungal Surveillance Program
Pfaller, M. A., Boyken, L. B., Hollis, R. J., Kroeger, J. S., Messer, S. A., Tendolkar, S., & Diekema, D. J. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.02437-10 · Cited by 34 · see citing works
Environmental isolation and characterisation of Cryptococcus species from living trees in Havana city, Cuba
Zaragozí, M. T. I., Martínez-Machín, G., Andreu, C. F., Lancha, M. R. P., Theelen, B., Boekhout, T., Meis, J. F. G. M., & Klaassen, C. H. W. (2012) · Mycoses · doi:10.1111/j.1439-0507.2012.02168.x · Cited by 28 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
Lockhart, S. R., Etienne, K. A., Vallabhaneni, S., Farooqi, J., Chowdhary, A., Govender, N. P., Colombo, A. L., Calvo, B., Cuomo, C. A., Desjardins, C. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw691 · Cited by 1,662 · see citing works
Self-citation
The global problem of antifungal resistance: prevalence, mechanisms, and management
Perlin, D. S., Rautemaa-Richardson, R., & Alastruey-Izquierdo, A. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30316-x · Cited by 1,055 · see citing works
First hospital outbreak of the globally emerging Candida auris in a European hospital
Schelenz, S., Hagen, F., Rhodes, J. L., Abdolrasouli, A., Chowdhary, A., Hall, A., Ryan, L., Shackleton, J., Trimlett, R., Meis, J. F., et al. (2016) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-016-0132-5 · Cited by 768 · see citing works
Self-citation
Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally
Chowdhary, A., Sharma, C., & Meis, J. F. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006290 · Cited by 750 · see citing works
Self-citation
Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment
Arendrup, M. C., & Patterson, T. F. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix131 · Cited by 707 · see citing works
Candida auris: Epidemiology, biology, antifungal resistance, and virulence
Du, H., Bing, J., Hu, T., Ennis, C. L., Nobile, C. J., & Huang, G. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008921 · Cited by 609 · see citing works
Candida auris: a Review of the Literature
Jeffery-Smith, A., Taori, S. K., Schelenz, S., Jeffery, K. J., Johnson, E. M., Borman, A. M., Candida auris Incident Management Team, Manuel, R. J., & Brown, C. S. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-17 · Cited by 610 · see citing works
A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance
Chowdhary, A., Prakash, A., Sharma, C., Kordalewska, M., Kumar, A., Sarma, S., Tarai, B., Singh, A., Upadhyaya, G., Upadhyay, S., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx480 · Cited by 577 · see citing works
Self-citation
Changes in the epidemiological landscape of invasive candidiasis
Lamoth, F., Lockhart, S. R., Berkow, E. L., & Calandra, T. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx444 · Cited by 547 · see citing works
Multidrug-Resistant Candida auris Misidentified as Candida haemulonii: Characterization by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and DNA Sequencing and Its Antifungal Susceptibility Profile Variability by Vitek 2, CLSI Broth Microdilution, and Etest Method
Kathuria, S., Singh, P. K., Sharma, C., Prakash, A., Masih, A., Kumar, A., Meis, J. F. G. M., & Chowdhary, A. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.00367-15 · Cited by 536 · see citing works
Self-citation
Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses
Chow, N. A., Muñoz, J. F., Gade, L., Berkow, E., Li, X., Welsh, R. M., Forsberg, K., Lockhart, S. R., Adam, R., Alanio, A., et al. (2020) · doi:10.1101/2020.01.06.896548 · Cited by 463 · see citing works
Molecular Evolution of Antifungal Drug Resistance
Robbins, N., Caplan, T., & Cowen, L. E. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-030117-020345 · Cited by 441 · see citing works
Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species
Muñoz, J. F., Gade, L., Chow, N. A., Loparev, V. N., Juieng, P., Berkow, E. L., Farrer, R. A., Litvintseva, A. P., & Cuomo, C. A. (2018) · Nature Communications · doi:10.1038/s41467-018-07779-6 · Cited by 458 · see citing works
First report of Candida auris in America: Clinical and microbiological aspects of 18 episodes of candidemia
Calvo, B., Melo, A. S. D. A., Mena, A. J. P., Hernandez, M., Francisco, E. C., Hagen, F., Meis, J. F. G. M., & Colombo, A. L. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.07.008 · Cited by 448 · see citing works
Self-citation
Candida auris : The recent emergence of a multidrug-resistant fungal pathogen
Forsberg, K., Woodworth, K., Walters, M., Berkow, E. L., Jackson, B., Chiller, T., & Vallabhaneni, S. (2019) · Medical Mycology · doi:10.1093/mmy/myy054 · Cited by 421 · see citing works
The emerging pathogen Candida auris: growth phenotype, virulence factors, activity of antifungals, and effect of SCY-078, a novel glucan synthesis inhibitor, on growth morphology and biofilm formation
Larkin, E., Hager, C., Chandra, J., Mukherjee, P. K., Retuerto, M., Salem, I., Long, L., Isham, N., Kovanda, L., Borroto-Esoda, K., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02396-16 · Cited by 395 · see citing works
Candida auris: an Emerging Fungal Pathogen
Spivak, E. S., & Hanson, K. E. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.01588-17 · Cited by 393 · see citing works
Candida auris candidaemia in Indian ICUs: analysis of risk factors
Rudramurthy, S. M., Chakrabarti, A., Paul, R. A., Sood, P., Kaur, H., Capoor, M. R., Kindo, A. J., Marak, R. S. K., Arora, A., Sardana, R., et al. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx034 · Cited by 357 · see citing works
An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital
Ruiz‐Gaitán, A., Moret, A. M., Tasias‐Pitarch, M., Aleixandre‐López, A. I., Martínez‐Morel, H., Calabuig, E., Salavert‐Lletí, M., Ramírez, P., López‐Hontangas, J. L., Hagen, F., et al. (2018) · Mycoses · doi:10.1111/myc.12781 · Cited by 343 · see citing works
Self-citation
Comparative Pathogenicity of United Kingdom Isolates of the Emerging Pathogen Candida auris and Other Key Pathogenic Candida Species
Borman, A. M., Szekely, A., & Johnson, E. M. (2016) · mSphere · doi:10.1128/msphere.00189-16 · Cited by 333 · see citing works
Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris
Cortegiani, A., Misseri, G., Fasciana, T., Giammanco, A., Giarratano, A., & Chowdhary, A. (2018) · Journal of Intensive Care · doi:10.1186/s40560-018-0342-4 · Cited by 332 · see citing works
Self-citation
Global epidemiology of emerging Candida auris
Rhodes, J., & Fisher, M. C. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.05.008 · Cited by 315 · see citing works
Candida auris : A systematic review and meta‐analysis of current updates on an emerging multidrug‐resistant pathogen
Sekyere, J. O. (2018) · MicrobiologyOpen · doi:10.1002/mbo3.578 · Cited by 307 · see citing works
Multidrug-Resistant Candida haemulonii and C. auris , Tel Aviv, Israel
Ben-Ami, R., Berman, J., Novikov, A., Bash, E., Shachor-Meyouhas, Y., Zakin, S., Maor, Y., Tarabia, J., Schechner, V., Adler, A., et al. (2017) · Emerging Infectious Diseases · doi:10.3201/eid2302.161486 · Cited by 297 · see citing works
The global burden of fungal diseases
Vallabhaneni, S., Mody, R. K., Walker, T., & Chiller, T. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.004 · Cited by 292 · see citing works
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Arastehfar, A. A., Gabaldón, T., Garcia‐Rubio, R., Jenks, J. D., Hoenigl, M., Salzer, H. J. F., İlkit, M., Lass‐Flörl, C., & Perlin, D. S. (2020) · Antibiotics · doi:10.3390/antibiotics9120877 · Cited by 294 · see citing works
Candida auris in Healthcare Facilities, New York, USA, 2013–2017
Adams, E., Quinn, M., Tsay, S., Poirot, E., Chaturvedi, S., Southwick, K., Greenko, J., Fernandez, R., Kallen, A., Vallabhaneni, S., et al. (2018) · Emerging Infectious Diseases · doi:10.3201/eid2410.180649 · Cited by 284 · see citing works
Comparison of EUCAST and CLSI Reference Microdilution MICs of Eight Antifungal Compounds for Candida auris and Associated Tentative Epidemiological Cutoff Values
Arendrup, M. C., Prakash, A., Meletiadis, J., Sharma, C., & Chowdhary, A. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00485-17 · Cited by 270 · see citing works
Self-citation
Candida auris: epidemiology, diagnosis, pathogenesis, antifungal susceptibility, and infection control measures to combat the spread of infections in healthcare facilities
Ahmad, S., & Alfouzan, W. (2021) · Microorganisms · doi:10.3390/microorganisms9040807 · Cited by 269 · see citing works
Candida auris–Associated Candidemia, South Africa
Magobo, R. E., Corcoran, C., Seetharam, S., & Govender, N. P. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2007.131765 · Cited by 259 · see citing works
Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris
Kordalewska, M., Lee, A., Park, S., Berrio, I., Chowdhary, A., Zhao, Y., & Perlin, D. S. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00238-18 · Cited by 247 · see citing works
Self-citation
Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris
Chatterjee, S., Alampalli, S. V., Nageshan, R. K., Chettiar, S. T., Joshi, S., & Tatu, U. S. (2015) · BMC Genomics · doi:10.1186/s12864-015-1863-z · Cited by 247 · see citing works
Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris
Rhodes, J., Abdolrasouli, A., Farrer, R. A., Cuomo, C. A., Aanensen, D. M., Armstrong-James, D., Fisher, M. C., & Schelenz, S. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0045-x · Cited by 246 · see citing works
Controlling a possible outbreak of Candida auris infection: lessons learnt from multiple interventions
Biswal, M., Rudramurthy, S. M., Jain, N., Shankarnarayan, S. A., Sharma, D., Jain, K., Yaddanapudi, L. N., & Chakrabarti, A. (2017) · Journal of Hospital Infection · doi:10.1016/j.jhin.2017.09.009 · Cited by 224 · see citing works
Epidemiology and Microbiologic Characterization of Nosocomial Candidemia from a Brazilian National Surveillance Program
Doi, A. M., Pignatari, A. C. C., Edmond, M. B., Marra, A. R., Camargo, L. F. A., Siqueira, R. A., da Mota, V. P., & Colombo, A. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146909 · Cited by 219 · see citing works
Multidrug-resistant Candida auris: ‘New kid on the block’ in hospital-associated infections?
Chowdhary, A., Voss, A., & Meis, J. F. (2016) · Journal of Hospital Infection · doi:10.1016/j.jhin.2016.08.004 · Cited by 214 · see citing works
Self-citation
Candida auris—the growing menace to global health
Lone, S. A., & Ahmad, A. (2019) · Mycoses · doi:10.1111/myc.12904 · Cited by 210 · see citing works
Candida auris and multidrug resistance: Defining the new normal
Lockhart, S. R. (2019) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2019.103243 · Cited by 205 · see citing works
Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
Sharma, C., Kumar, N., Pandey, R., Meis, J. F., & Chowdhary, A. (2016) · New Microbes and New Infections · doi:10.1016/j.nmni.2016.07.003 · Cited by 202 · see citing works
Self-citation
Rapid and Accurate Molecular Identification of the Emerging Multidrug-Resistant Pathogen Candida auris
Kordalewska, M., Zhao, Y., Lockhart, S. R., Chowdhary, A., Berrío, I., & Perlin, D. S. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.00630-17 · Cited by 195 · see citing works
Self-citation
The first isolate of Candida auris in China: clinical and biological aspects
Wang, X., Bing, J., Zheng, Q., Zhang, F., Liu, J., Yue, H., Tao, L., Du, H., Wang, Y., Wang, H., et al. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0095-0 · Cited by 191 · see citing works
Candida aurisCandidemia in Kuwait, 2014
Emara, M., Ahmad, S., Khan, Z., Joseph, L., Al-Obaid, I., Purohit, P., & Bafna, R. (2015) · Emerging infectious diseases · doi:10.3201/eid2106.150270 · Cited by 185 · see citing works
Untitled work
Ademe, M. (2020) · doi:10.2147/idr.s249864 · Cited by 182 · see citing works
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
Gonçalves, S. S., Souza, A. C. R., Chowdhary, A., Meis, J. F. G. M., & Colombo, A. L. (2016) · Mycoses · doi:10.1111/myc.12469 · Cited by 182 · see citing works
Self-citation
Candida auris: Disinfectants and Implications for Infection Control
Ku, T. S. N., Walraven, C. J., & Lee, S. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00726 · Cited by 177 · see citing works
Development and Validation of a Real-Time PCR Assay for Rapid Detection of Candida auris from Surveillance Samples
Leach, L., Zhu, Y., & Chaturvedi, S. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.01223-17 · Cited by 170 · see citing works
Emerging and reemerging fungal infections
Lockhart, S. R., & Guarner, J. (2019) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2019.04.010 · Cited by 169 · see citing works
Evidence of genotypic diversity among Candida auris isolates by multilocus sequence typing, matrix-assisted laser desorption ionization time-of-flight mass spectrometry and amplified fragment length polymorphism
Prakash, A., Sharma, C., Singh, A. K., Singh, P. K., Kumar, A., Hagen, F., Govender, N. P., Colombo, A. L., Meis, J. F. G. M., & Chowdhary, A. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.022 · Cited by 167 · see citing works
Self-citation
Confirmation of fifth Candida auris clade by whole genome sequencing
Spruijtenburg, B., Badali, H., Abastabar, M., Mirhendi, H., Khodavaisy, S., Sharifisooraki, J., Taghizadeh Armaki, M., de Groot, T., & Meis, J. F. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2125349 · Cited by 164 · see citing works
Self-citation
Laboratory Analysis of an Outbreak of Candida auris in New York from 2016 to 2018: Impact and Lessons Learned
Zhu, Y., O’Brien, B., Leach, L., Clark, A., Bates, M., Adams, E. H., Ostrowsky, B. E., Quinn, M., Dufort, E. M., Southwick, K. L., et al. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.01503-19 · Cited by 166 · see citing works
Is the superbug fungus really so scary? A systematic review and meta-analysis of global epidemiology and mortality of Candida auris
Chen, J., Tian, S., Han, X., Chu, Y., Wang, Q., Zhou, B., & Shang, H. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05543-0 · Cited by 159 · see citing works
Nosocomial fungemia by Candida auris: First four reported cases in continental Europe
Gaitán, A. C. R., Moret, A. M., Hontangas, J. L. L., Molina, J. M. R., López, A., Hernández-Cabezas, A., Maseres, J. B. M., Chouman-Arcas, R., Ruiz, M. D. G., Chiveli, M.-A., et al. (2017) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2016.11.002 · Cited by 158 · see citing works
Emerging fungal pathogen Candida auris evades neutrophil attack
Johnson, C. J., Davis, J. M., Huttenlocher, A., Kernien, J. F., & Nett, J. E. (2018) · mBio · doi:10.1128/mbio.01403-18 · Cited by 157 · see citing works
Approach to the Investigation and Management of Patients With Candida auris, an Emerging Multidrug-Resistant Yeast
Tsay, S. V., Kallen, A. J., Jackson, B. R., Chiller, T. M., & Vallabhaneni, S. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix744 · Cited by 155 · see citing works
Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of Candida auris
Kean, R., & Ramage, G. (2019) · mSphere · doi:10.1128/msphere.00458-19 · Cited by 155 · see citing works
The world’s ten most feared fungi
Hyde, K. D., Al‐Hatmi, A. M. S., Andersen, B., Boekhout, T., Buzina, W., Dawson, T. L., Eastwood, D. C., Jones, E. B. G., de Hoog, S., Kang, Y., et al. (2018) · Fungal Diversity · doi:10.1007/s13225-018-0413-9 · Cited by 152 · see citing works
Self-citation
Current perspective on emergence, diagnosis and drug resistance in Candida auris
Sarma, S., & Upadhyay, S. (2017) · Infection and Drug Resistance · doi:10.2147/idr.s116229 · Cited by 147 · see citing works
Candida auris : An emerging multidrug-resistant pathogen
Sears, D., & Schwartz, B. S. (2017) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2017.08.017 · Cited by 146 · see citing works
Synthetic macromolecules as therapeutics that overcome resistance in cancer and microbial infection
Tan, J., Tay, J., Hedrick, J. L., & Yang, Y. Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120078 · Cited by 143 · see citing works
First Candida auris Outbreak during a COVID-19 Pandemic in a Tertiary-Care Center in Lebanon
Allaw, F., Zahreddine, N. K., Ibrahim, A., Tannous, J., Taleb, H., Bizri, A. R., Dbaibo, G. S., & Kanj, S. S. (2021) · Pathogens · doi:10.3390/pathogens10020157 · Cited by 142 · see citing works
Candida Auris, An Agent of Hospital-Associated Outbreaks: Which Challenging Issues Do We Need to Have in Mind?
Sabino, R., Veríssimo, C., Pereira, Á. A., & Antunes, F. (2020) · Microorganisms · doi:10.3390/microorganisms8020181 · Cited by 133 · see citing works
Epidemiology of fungal infections in China
Chen, M., Xu, Y., Hong, N., Yang, Y., Lei, W., Du, L., Zhao, J., Lei, X., Xiong, L., Cai, L., et al. (2018) · Frontiers of Medicine · doi:10.1007/s11684-017-0601-0 · Cited by 137 · see citing works
Candida auris Clinical Isolates from South Korea: Identification, Antifungal Susceptibility, and Genotyping
Kwon, Y. J., Shin, J. H., Byun, S. A., Choi, M. J., Won, E. J., Lee, D., Lee, S. Y., Chun, S., Lee, J. H., Choi, H., et al. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.01624-18 · Cited by 136 · see citing works
Isolates of the emerging pathogen Candida auris present in the UK have several geographic origins
Borman, A. M., Székely, A., & Johnson, E. M. (2016) · Medical Mycology · doi:10.1093/mmy/myw147 · Cited by 133 · see citing works
Emergence ofCandida auris: An International Call to Arms
Clancy, C. J., & Nguyen, M. H. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw696 · Cited by 133 · see citing works
Ibrexafungerp: A First-in-Class Oral Triterpenoid Glucan Synthase Inhibitor
Jallow, S., & Govender, N. P. (2021) · Journal of Fungi · doi:10.3390/jof7030163 · Cited by 129 · see citing works
Candida auris Isolates of the Southern Asian and South African Lineages Exhibit Different Phenotypic and Antifungal Susceptibility Profiles In Vitro
Szekely, A., Borman, A. M., & Johnson, E. M. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.02055-18 · Cited by 125 · see citing works
Identification of Drug Resistant Candida auris
Kordalewska, M., & Perlin, D. S. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01918 · Cited by 134 · see citing works
Candida auris: What Have We Learned About Its Mechanisms of Pathogenicity?
Rossato, L., & Colombo, A. L. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03081 · Cited by 121 · see citing works
Comparative virulence of Candida auris with Candida haemulonii, Candida glabrata and Candida albicans in a murine model
Fakhim, H., Vaezi, A., Dannaoui, É., Chowdhary, A., Nasiry, D., Faeli, L., Meis, J. F. G. M., & Badali, H. (2018) · Mycoses · doi:10.1111/myc.12754 · Cited by 123 · see citing works
Self-citation
Candida parapsilosis Resistance to Fluconazole: Molecular Mechanisms and In Vivo Impact in Infected Galleria mellonella Larvae
Souza, A. C. R., Fuchs, B. B., Pinhati, H. M. S., Siqueira, R. A., Hagen, F., Meis, J. F., Mylonakis, E., & Colombo, A. L. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01177-15 · Cited by 121 · see citing works
Self-citation
Fungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyond
Bastos, R. W., Rossato, L. L., Goldman, G. H., & Santos, D. A. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010073 · Cited by 112 · see citing works
Colonisation and Transmission Dynamics of Candida auris among Chronic Respiratory Diseases Patients Hospitalised in a Chest Hospital, Delhi, India: A Comparative Analysis of Whole Genome Sequencing and Microsatellite Typing
Yadav, A., Singh, A. K., Wang, Y., van Haren, M. H. I., Singh, A. K., de Groot, T., Meis, J. F. G. M., Xu, J., & Chowdhary, A. (2021) · Journal of Fungi · doi:10.3390/jof7020081 · Cited by 111 · see citing works
Self-citation
Increasing prevalence, molecular characterization and antifungal drug susceptibility of serial Candida auris isolates in Kuwait
Khan, Z., Ahmad, S., Al-Sweih, N., Joseph, L., Alfouzan, W., & Asadzadeh, M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195743 · Cited by 109 · see citing works
Candida auris candidaemia in an intensive care unit - Prospective observational study to evaluate epidemiology, risk factors, and outcome
Shastri, P. S., Shankarnarayan, S. A., Oberoi, J., Rudramurthy, S. M., Wattal, C., & Chakrabarti, A. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.01.004 · Cited by 103 · see citing works
Control of Candida auris in healthcare institutions: Outcome of an International Society for Antimicrobial Chemotherapy expert meeting
Kenters, N., Kiernan, M., Chowdhary, A., Denning, D. W., Pemán, J., Saris, K., Schelenz, S., Tartari, E., Widmer, A., Meis, J. F., et al. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.08.013 · Cited by 102 · see citing works
Self-citation
In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris
Fakhim, H., Chowdhary, A., Prakash, A., Vaezi, A., Dannaoui, É., Meis, J. F. G. M., & Badali, H. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01056-17 · Cited by 104 · see citing works
Self-citation
Identification and typing of the emerging pathogen Candida auris by matrix‐assisted laser desorption ionisation time of flight mass spectrometry
Girard, V., Mailler, S., Chetry, M., Vidal, C., Durand, G., van Belkum, A., Colombo, A. L., Hagen, F., Meis, J. F. G. M., & Chowdhary, A. (2016) · Mycoses · doi:10.1111/myc.12519 · Cited by 100 · see citing works
Self-citation
Axillary Digital Thermometers uplifted a multidrug‐susceptible Candidaauris outbreak among COVID‐19 patients in Brazil
Nobrega de Almeida, J., Brandão, I. B., Francisco, E. C., de Almeida, S. L. R., de Oliveira Dias, P., Pereira, F. M., Santos Ferreira, F., de Andrade, T. S., de Miranda Costa, M. M., de Souza Jordão, R. T., et al. (2021) · Mycoses · doi:10.1111/myc.13320 · Cited by 100 · see citing works
Self-citation
Multi-omics Signature of Candida auris , an Emerging and Multidrug-Resistant Pathogen
Zamith-Miranda, D., Heyman, H. M., Cleare, L. G., Couvillion, S. P., Clair, G. C., Bredeweg, E. L., Gacser, A., Nimrichter, L., Nakayasu, E. S., & Nosanchuk, J. D. (2019) · mSystems · doi:10.1128/msystems.00257-19 · Cited by 99 · see citing works
Candida auris : multi-omics signature of an emerging and multidrug-resistant pathogen
Zamith-Miranda, D., Heyman, H. M., Cleare, L. G., Couvillion, S., Clair, G., Bredeweg, E., Gacser, A., Nimrichter, L., Nakayasu, E. S., & Nosanchuk, J. D. (2019) · doi:10.1101/528232 · Cited by 99 · see citing works
Resistance to Antifungal Drugs
Ben‐Ami, R., & Kontoyiannis, D. P. (2021) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2021.03.003 · Cited by 101 · see citing works
Evaluation of the efficacy of rezafungin, a novel echinocandin, in the treatment of disseminated Candida auris infection using an immunocompromised mouse model
Hager, C. L., Larkin, E. L., Long, L. A., & Ghannoum, M. A. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky153 · Cited by 95 · see citing works
Attack, Defend and Persist: How the Fungal Pathogen Candida auris was Able to Emerge Globally in Healthcare Environments
de Jong, A. W., & Hagen, F. (2019) · Mycopathologia · doi:10.1007/s11046-019-00351-w · Cited by 98 · see citing works
Self-citation
The Candida auris Alert: Facts and Perspectives
Lamoth, F., & Kontoyiannis, D. P. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix597 · Cited by 95 · see citing works
Candida auris: An emerging drug resistant yeast – A mini-review
Bidaud, A.-L., Chowdhary, A., & Dannaoui, É. (2018) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2018.06.007 · Cited by 94 · see citing works
Self-citation
Detection and treatment of Candida auris in an outbreak situation: risk factors for developing colonization and candidemia by this new species in critically ill patients
Gaitán, A. C. R., Martínez, H., Moret, A. M., Calabuig, E., Tasias, M., Alastruey‐Izquierdo, A., Zaragoza, Ó., Mollar, J., Frasquet, J., Salavert, M., et al. (2019) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2019.1592675 · Cited by 93 · see citing works
Antifungal Resistance in Candida auris: Molecular Determinants
Frías-De-León, M. G., Hernández-Castro, R., Vite-Garín, T., Arenas, R., Bonifaz, A., Castañón-Olivares, L., Acosta-Altamirano, G., & Martínez-Herrera, E. (2020) · Antibiotics · doi:10.3390/antibiotics9090568 · Cited by 93 · see citing works
Hospital-Associated Multicenter Outbreak of Emerging Fungus Candida auris, Colombia, 2016
Armstrong, P. A., Rivera, S. M., Escandón, P., Caceres, D. H., Chow, N. A., Stuckey, M. J., Díaz, J., Gomez, A., Vélez, N., Espinosa-Bode, A., et al. (2019) · Emerging infectious diseases · doi:10.3201/eid2507.180491 · Cited by 93 · see citing works
Clinical Efficacy and Safety of a Novel Antifungal, Fosmanogepix, in Patients with Candidemia Caused by Candida auris : Results from a Phase 2 Trial
Vazquez, J. A., Pappas, P. G., Boffard, K., Paruk, F., Bien, P. A., Tawadrous, M., Ople, E., Wedel, P., Oborska, I., & Hodges, M. R. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01419-22 · Cited by 92 · see citing works
Candida auris for the Clinical Microbiology Laboratory: Not Your Grandfather's Candida Species
Lockhart, S. R., Berkow, E. L., Chow, N. A., & Welsh, R. M. (2017) · Clinical Microbiology Newsletter · doi:10.1016/j.clinmicnews.2017.06.003 · Cited by 92 · see citing works
Identification of Candida auris by Use of the Updated Vitek 2 Yeast Identification System, Version 8.01: a Multilaboratory Evaluation Study
Ambaraghassi, G., Dufresne, P. J., Dufresne, S. F., Vallières, É., Muñoz, J. F., Cuomo, C. A., Berkow, E. L., Lockhart, S. R., & Luong, M. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.00884-19 · Cited by 94 · see citing works
Pharmacodynamic Optimization for Treatment of Invasive Candida auris Infection
Lepak, A. J., Zhao, M., Berkow, E. L., Lockhart, S. R., & Andes, D. R. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00791-17 · Cited by 92 · see citing works
CHROMagarTM Candida Plus: A novel chromogenic agar that permits the rapid identification of Candida auris
Borman, A. M., Fraser, M., & Johnson, E. M. (2020) · Medical Mycology · doi:10.1093/mmy/myaa049 · Cited by 89 · see citing works
Candida auris outbreak: Mortality, interventions and cost of sustaining control
Taori, S. K., Khonyongwa, K., Hayden, I., Athukorala, G. D. A., Letters, A., Fife, A., Desai, N., & Borman, A. M. (2019) · Journal of Infection · doi:10.1016/j.jinf.2019.09.007 · Cited by 83 · see citing works
The first cases of Candida auris candidaemia in Oman
Mohsin, J., Hagen, F., Al‐Balushi, Z. A. M., de Hoog, S., Chowdhary, A., Meis, J. F. G. M., & Al‐Hatmi, A. M. S. (2017) · Mycoses · doi:10.1111/myc.12647 · Cited by 84 · see citing works
Self-citation
Drug Resistance and Novel Therapeutic Approaches in Invasive Candidiasis
Murphy, S. E., & Bicanic, T. A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.759408 · Cited by 85 · see citing works
Emergence of clonal fluconazole-resistant Candida parapsilosis clinical isolates in a multicentre laboratory-based surveillance study in India
Singh, A. K., Singh, P. K., de Groot, T., Kumar, A., Mathur, P., Tarai, B., Sachdeva, N., Upadhyaya, G., Sarma, S., Meis, J. F. G. M., et al. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz029 · Cited by 82 · see citing works
Self-citation
Epidemiology of Candidemia and Antifungal Susceptibility in Invasive Candida Species in the Asia-Pacific Region
Wang, H., Xu, Y., & Hsueh, P. (2016) · Future Microbiology · doi:10.2217/fmb-2016-0099 · Cited by 83 · see citing works
Candida auris in various hospitals across Kuwait and their susceptibility and molecular basis of resistance to antifungal drugs
Ahmad, S., Khan, Z., Al‐Sweih, N., Alfouzan, W. A., & Joseph, L. (2019) · Mycoses · doi:10.1111/myc.13022 · Cited by 78 · see citing works

Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation
Sharma, C., Kumar, N., Pandey, R., Meis, J. F., & Chowdhary, A. (2016) · New Microbes and New Infections · doi:10.1016/j.nmni.2016.07.003 · Cited by 202 · see citing works
Self-citation
DISPATCHES New Clonal Strain of Candida auris,
Chowdhary, A., Sharma, C., Duggal, S., Agarwal, K., Jain, S., Kathuria, S., R, H. S., Hagen, F., & Meis, J. F. (2014)
Self-citation
New Clonal Strain ofCandida auris, Delhi, India
Chowdhary, A., Sharma, C., Duggal, S., Agarwal, K., Prakash, A., Singh, P. K., Jain, S., Kathuria, S., Randhawa, H. S., Hagen, F., et al. (2013) · Emerging infectious diseases · doi:10.3201/eid1910.130303 · Cited by 2 · see citing works
Self-citation
266. Clinical Profile and Treatment Outcomes of Candida auris Isolates from a Tertiary Care Hospital in South India
Warrier, A. R., Wilson, A., Babu, R., Prakash, S., & Bhargava, M. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz360.341
Self-citation
Candida auris Infection Among Patients With Cancer in an Oncology Center in Eastern India
Bhattacharya, S., Das, P., Goel, G., Mukherjee, S., Ghosh, P. S., Singh, R. K., Sinha, S., Chandy, M., Walia, K., & Chakrabarti, A. (2020) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2020.664

Authors: Chowdhary, A., Anil Kumar, V., Sharma, C., Prakash, A., Agarwal, K., Babu, R., Dinesh, K. R., Karim, S., Singh, S. K., Hagen, F., & Meis, J. F.
Affiliations: University of Delhi (IN)
Amrita Institute of Medical Sciences and Research Centre (IN)
Canisius-Wilhelmina Ziekenhuis (NL)
Radboud University Medical Center (NL)
Corresponding author: Chowdhary, A.
ORCID: Chowdhary, A.
Sharma, C.
Prakash, A.
Agarwal, K.
Dinesh, K. R.
Singh, S. K.
Hagen, F.
Meis, J. F.
Venue: European Journal of Clinical Microbiology & Infectious Diseases
Publisher: Springer Science and Business Media LLC
Published: 2013-12-20
Volume: 33
Issue: 6
Pages: 919-926
ISSN: 0934-9723 (ISSN-L)
1435-4373
DOI: 10.1007/s10096-013-2027-1
OpenAlex: W1979435687
Cited by: 373
References: 17
Citations by year: 2026: 13 · 2025: 15 · 2024: 23 · 2023: 32 · 2022: 34 · 2021: 40 · 2020: 46 · 2019: 50 · 2018: 40 · 2017: 52 · 2016: 17 · 2015: 7 · 2014: 4
FWCI: 6.79
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: University Grants Commission (F.2-15/2003SA-I)
Fonds National de la Recherche Luxembourg
Qatar National Research Fund (5-298-3-086, NPRP 5‐298‐3‐086)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: Candida auris, multidrug resistance, fungemia, clonal strains, endemic fungal infection, antifungal resistance, azole resistance, fluconazole resistance, voriconazole resistance, flucytosine resistance, caspofungin resistance, emerging fungal pathogens
MeSH terms: Adult, Aged, Aged, 80 and over, Antifungal Agents, Candida, Candidiasis, Child, Preschool, DNA, Fungal, Female, Genotype, Humans, India, Male, Microbial Sensitivity Tests, Middle Aged, Cluster Analysis, Mycological Typing Techniques, Treatment Failure, Endemic Diseases, Drug Resistance, Multiple, Fungal, Amplified Fragment Length Polymorphism Analysis, Young Adult, Molecular Typing, Tertiary Care Centers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Multidrug-resistant endemic clonal strain of Candida auris in India

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks