Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

Fonseca, Maria I.; Chu, Shuhui; Pierce, Aimee L.; Brubaker, William D.; Hauhart, Richard E.; Mastroeni, Diego; Clarke, Elizabeth V.; Rogers, Joseph; Atkinson, John P.; Tenner, Andrea J.

doi:10.1371/journal.pone.0149792

Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

Chronic activation of the complement system and induced inflammation are associated with neuropathology in Alzheimer’s disease (AD). Recent large genome wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in the C3b/C4b receptor (CR1 or CD35) that are associated…