Disturbance in the mucosa-associated commensal bacteria is associated with the exacerbation of chronic colitis by repeated psychological stress; is that the new target of probiotics
Open accessAbstract
Psychological stress can exacerbate inflammatory bowel disease. However, the mechanisms underlying how psychological stress affects gut inflammation remain unclear. Here, we focused on the relationship between changes in the microbial community of mucosa-associated commensal bacteria (MACB) and mucosal immune responses induced by chronic psychological stress in a murine model of ulcerative colitis. Furthermore, we examined the effect of probiotic treatment on exacerbated colitis and MACB composition changes induced by chronic psychological stress. Repeated water avoidance stress (rWAS) in B6-Tcra-/- mice severely exacerbated colitis, which was evaluated by both colorectal tissue weight and histological score of colitis. rWAS treatment increased mRNA expression of UCN2 and IFN-γ in large intestinal lamina propria mononuclear cells (LI-LPMC). Interestingly, exacerbated colitis was associated with changes in the microbial community of MACB, specifically loss of bacterial species diversity and an increase in the component ratio of Clostridium, revealed by 16S rRNA gene amplicon analysis. Finally, the oral administration of a probiotic Lactobacillus strain was protective against the exacerbation of colitis and was associated with a change in the bacterial community of MACB in rWAS-exposed Tcra-/- mice. Taken together, these results suggested that loss of species diversity in MACB might play a key role in exacerbated colitis induced by chronic psychological stress. In addition, probiotic treatment may be used as a tool to preserve the diversity of bacterial species in MACB and alleviate gut inflammation induced by psychological stress.
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A probiotic Lactobacillus strain can assist in protecting against enteritis aggravated by stress.
“Arase et al. studied microbiota-targeted therapies and found that a probiotic Lactobacillus strain can assist in protecting against enteritis aggravated by stress (137).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [137]
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Stress triggers flare of inflammatory bowel disease in children and adults
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- Authors
- Arase, S., Watanabe, Y., Setoyama, H., Nagaoka, N., Kawai, M., & Matsumoto, S.
- Affiliations
- Yakult Central Institute (JP)
- Corresponding author
- Arase, Sohei
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-08-08
- Volume
- 11
- Issue
- 8
- Pages
- e0160736
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4976886
- OpenAlex
- W2516700628
- Cited by
- 18
- References
- 66
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 4
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- chronic psychological stress, ulcerative colitis, inflammatory bowel disease, probiotics, Lactobacillus, water avoidance stress, gut microbiota diversity, Clostridium, interferon-gamma, lamina propria mononuclear cells, T cell-deficient mice, intestinal inflammation
- MeSH terms
- Animals, Chronic Disease, Colitis, Disease Models, Animal, Female, Intestinal Mucosa, Lactobacillus, Mice, Inbred BALB C, Mice, Inbred C57BL, RNA, Ribosomal, 16S, Stress, Psychological, Mice, Knockout, Genes, T-Cell Receptor alpha, Probiotics, Mice
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