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Allostatic load increases the incidence and risk of adverse prognosis in inflammatory bowel disease

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Advancements in Immunomodulatory Therapies for IBD and Their Interplay With the Gut–Brain Axis: An Updated Review of Current Literature and Beyond

Jha, M., Waheed, A., Hooti, J. A., Nair, S., Najam, A., Mal, M. M., Tummala, N., Shariq, A. S., Hurairah, A., & Daniel, M. G. (2025) · Health Science Reports · doi:10.1002/hsr2.71157 · Cited by 11 · see citing works

Impact of Helicobacter pylori Eradication on Inflammatory Bowel Disease Onset and Disease Activity: To Eradicate or Not to Eradicate?

Gravina, A. G., Pellegrino, R., Iascone, V., Palladino, G., Federico, A., & Zagari, R. M. (2024) · Diseases · doi:10.3390/diseases12080179 · Cited by 10 · see citing works

Zhumeria majdae essential oil attenuates TNBS-induced colitis in rats by regulating inflammatory and apoptotic pathways

Aghamiri, H., Mohammadgholi-Beiki, A., Rashidian, R., Motevalian, M., Rahimi‐Moghaddam, P., Sheibani, M., & Jafari‐Sabet, M. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01574-0 · Cited by 9 · see citing works

The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection

Tyus, D., Leslie, J. L., Naz, F., Uddin, M. J., Thompson, B. A., & Petri, W. A. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101771 · Cited by 10 · see citing works

A central amygdala input to the dorsal vagal complex controls gastric motility in mice under restraint stress

Wang, H., Liu, W.-J., Wang, X., Chen, X., Cai, R.-L., Zhang, M.-T., Wang, H., He, G., Zhang, Z., & Shen, G.-M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1074979 · Cited by 8 · see citing works

The variation characteristics of fecal microbiota in remission UC patients with anxiety and depression

Xu, L., Li, Y., & He, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1237256 · Cited by 8 · see citing works

iACT4IBD: a randomised controlled trial of a brief online intervention based on acceptance and commitment therapy to improve wellbeing for adults with inflammatory bowel disease

Lin, K., Cavadino, A., Ow, M., Douglas, M., & Serlachius, A. S. (2025) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1587765 · Cited by 7 · see citing works

Heterogeneity in Psychological Adaptation Patterns and Its Predictive Factors Among Patients with Inflammatory Bowel Disease: A Latent Profile Analysis

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Defense mechanisms and inflammatory bowel diseases: a narrative review

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DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering

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The emerging role of intestinal stem cells in ulcerative colitis

Chen, S., Zhang, Q., Zhou, S., Xu, Y., & Zhu, Y. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1569328 · Cited by 6 · see citing works

The gut–brain axis in irritable bowel syndrome: neuroendocrine and epigenetic pathways

Koumbi, L., Giannelou, M.-A., & Castelli, L. (2025) · Academia Biology · doi:10.20935/acadbiol7748 · Cited by 6 · see citing works

Chronic psychological stress-orchestrated glial-ILC3 circuit exacerbates intestinal inflammation and depression

Zhang, Z., Ren, S., Fan, X., Chen, H., Chen, J., Wang, X., Zong, H., Zhang, S., Zhao, T., Sun, Y., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106118 · Cited by 6 · see citing works

Current Perspectives on the Inflammatory Bowel Disease Pathogenesis of Microbiota and the Gut-Brain Axis, and Emerging Therapeutics

Lin, Y., Lu, P., Ding, Q., & Liu, M. (2026) · Biomedicines · doi:10.3390/biomedicines14040859 · Cited by 7 · see citing works

“Inside the Gut–Brain Axis”: Psychological Profiles of Adolescents with Inflammatory Bowel Diseases and with Restrictive Eating Disorders

Riva, A., Arienti, G., Zuin, G., Spini, L., Sansotta, N., Cavanna, A. E., & Nacinovich, R. (2025) · Nutrients · doi:10.3390/nu17101706 · Cited by 5 · see citing works

Microbial regulation of stress-associated signaling molecules and its role in health and disease

Sie, C., & Tropini, C. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-026-00932-w · Cited by 6 · see citing works

Psychological disorders and coping strategies in patients with Inflammatory Bowel Disease. Their impact in health-related quality of life.

Fernández, L. J., Ferrer, J. Á., Calle, J. L. P., Álvarez, L. M., & Serrano, P. L. (2023) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2023.9935/2023 · Cited by 5 · see citing works

Appraising the causal association between Crohn’s disease and breast cancer: a Mendelian randomization study

Yu, C.-D., Xu, J.-W., Xu, S., Huang, Y., Tang, L., Zeng, X.-Q., Yu, T.-H., Chen, W., & Sun, Z. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1275913 · Cited by 3 · see citing works

Linking Psychological Stress to Epigenetic Regulation via the Gut–Liver–Brain Axis in Irritable Bowel Syndrome and Metabolic Dysfunction-Associated Fatty Liver Disease

Crocetta, A., Giannelou, M.-A., Benfante, A., Castelli, L., & Koumbi, L. (2025) · Livers · doi:10.3390/livers5030043 · Cited by 4 · see citing works

Psychological distress predicts disease activity in inflammatory bowel disease: Results from the mind-body IBD longitudinal study

Seaton, N., Hudson, J. L., Mondelli, V., Raymond, L., Schmill, P., Hart, A. L., & Moss-Morris, R. E. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101147 · Cited by 4 · see citing works

The epidemiology of inflammatory bowel disease: exploring the impacts of environmental factors

Park, J., & Cheon, J. H. (2025) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2025.083 · Cited by 4 · see citing works

Using metabolomics to investigate the relationship between the metabolomic profile of the intestinal microbiota derivatives and mental disorders in inflammatory bowel diseases: a narrative review

Zarei, P., Adibi, P., Vaez, A., & Keshteli, A. H. (2025) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_273_23 · Cited by 4 · see citing works

Intolerance of uncertainty and mental health in patients with IBD: the mediating role of maladaptive coping

Zhang, X., Ta, N., Yi, S., & Xiong, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-86600-z · Cited by 4 · see citing works

Impact of a 10-week multimodal stress management and lifestyle modification program on stress response and immune function in Crohn’s disease: a mixed-methods approach using the Trier Social Stress Test

Öznur, Ö., Utz, S., Schlee, C., & Langhorst, J. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101006 · Cited by 4 · see citing works

Exploring the dual role of Mangifera indica L. in regulating immune response and pain persistence in inflammatory bowel disease

Lucarini, E., Schettino, A., Marigliano, N., Ciampi, C., Smimmo, M., Romano, F., Paolillo, A., Izzo, L., Begum, J., Mansour, A. A., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107773 · Cited by 3 · see citing works

Fatigue in inflammatory bowel disease: Prevalence, risk factors, assessment, outcomes, and management

Giri, S., Harindranath, S., Kulkarni, A., Sahoo, J. K., Joshi, H., Nath, P., & Sahu, M. K. (2025) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v16.i3.107573 · Cited by 3 · see citing works

Relationship between stress, diet, and gut microbiota: a cross-sectional study

Ahmed, F., Alhodieb, F. S., Alsanie, S. A., Rasheed, M., & Ndagire, C. T. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01014-y · Cited by 3 · see citing works

Efficacy of Gut Microbiome-Targeted Interventions on Mental Health Symptoms in Women Across Key Hormonal Life Stages: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Dubois, N., Vincent, C., & Giroux, I. (2025) · Healthcare · doi:10.3390/healthcare13222851 · Cited by 4 · see citing works

Inflammatory bowel diseases (IBDs): a cross-sectional analysis of the psychological and biological mechanisms underlying intestinal and extra-intestinal symptoms—GastroPsy study protocol

Caruso, A., Latella, G., Giacomo, D. D., Cavicchioli, M., & Galli, F. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-103374 · Cited by 3 · see citing works

Understanding the Tripartite Relationship Between Dietary Practices, Psychological Well-Being, and Disease Experience in Greek Patients with IBD: A Mixed-Methods Exploration

Strongylou, D. E., Svolos, V., Vlachou, A., Zoupa, E., Vakouftsi, V. R., Ntanou, A., Argyriou, K., Kapsoritakis, A., Bonoti, F., & Androutsos, O. (2026) · Nutrients · doi:10.3390/nu18091439 · Cited by 3 · see citing works

Gut microbiota alterations associated with anxiety and depression in inflammatory bowel disease: a systematic review of prospective cohorts and randomized trials

Zhang, T., Wang, L., Ren, Z., Man, R., Cheng, X., Wang, L., Wang, J., Bu, X., & Yu, Y. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1853009 · Cited by 3 · see citing works

Effect of chronic stress on gel-forming mucins in the small intestine of BALB/c mice

Godínez‐Victoria, M., Sección de Estudios de Posgrado e Investigación, E. S. D. M., Guzmán‐Mejía, F., Departamento de Sistemas Biológicos, U. A. M. U. X., Gutiérrez-Galicia, J. K., Sección de Estudios de Posgrado e Investigación, E. S. D. M., Drago-Serrano, M. E., Departamento de Sistemas Biológicos, U. A. M. U. X., Oros‐Pantoja, R., & Facultad de Medicina, U. A. D. E. D. M. (2024) · Journal of Medicine and Life · doi:10.25122/jml-2023-0473 · Cited by 3 · see citing works

Epidemiological profile of patients hospitalized with Crohn’s disease due to severe acute respiratory infection during the COVID-19 pandemic: a 2-year report from Brazil

Nascimento, L. S., Marson, F. A. L., & dos Santos, R. D. C. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1440101 · Cited by 3 · see citing works

The Current Role of Imaging in the Diagnosis of Inflammatory Bowel Disease and Detection of Its Complications: A Systematic Review

Younis, M. Y., Khan, M. U., Khan, U., Khan, T. L., Mukarram, H., Jain, K., Ilyas, I., & Jain, W. (2024) · Cureus · doi:10.7759/cureus.73134 · Cited by 3 · see citing works

Exploring Immune Cell Infiltration and Small Molecule Compounds for Ulcerative Colitis Treatment

Lu, Y., Lu, D., Li, C., & Chen, L. (2024) · Genes · doi:10.3390/genes15121548 · Cited by 3 · see citing works

Impact of Psychosocial and Neurodevelopmental Disorders on Pediatric Ulcerative Colitis: A Single-Center, Retrospective, Observational Study

Nakamura, A., Jimbo, K., Suzuki, M., Hibio, M., Nagata, M., Arai, N., Miyata, E., Kudo, T., Hoshino, E., & Shoji, H. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf034 · Cited by 3 · see citing works

Type D personality, insomnia severity, perceived stress, and health-related quality of life in inflammatory bowel disease: A case–control study

Sonbol, H. M., El‐Sayed, M. M., Khedr, M. A., Ibrahim, M. A., Osama, M., Abdel-Sattar, A. A., Elsaied, H. F., Ali, E. A., Mohsen, S., & Abdelmawgoud, A. S. (2025) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2025.112199 · Cited by 3 · see citing works

Fatigue Is Strongly Associated with Depressive Symptoms in Patients with Inflammatory Bowel Disease

Mona, R., Göldi, A., Schneider, T., Panne, I., Egger, A., Niess, J. H., & Hruz, P. L. (2025) · Inflammatory Intestinal Diseases · doi:10.1159/000545572 · Cited by 2 · see citing works

Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis

Li, Y., Wang, Y., Chen, S., & Liu, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-08633-8 · Cited by 2 · see citing works

Fermented casein with Lactobacillus gasseri KML39 alleviates systemic inflammation interacting with the gut-brain-microbiome axis in dextran sulfate sodium–induced colitis mice

Choi, H. S., Joung, J. Y., Bae, H. J., & Oh, N. S. (2025) · Journal of Dairy Science · doi:10.3168/jds.2025-26659 · Cited by 2 · see citing works

The Global, Regional, and National Burden of Inflammatory Bowel Disease among Children and Adolescents from 1990 to 2021 and Trend Projections up to 2036

Chen, Y., Yu, J., Zhang, J., Chen, X., & Huang, W.-F. (2025) · Gut and Liver · doi:10.5009/gnl250261 · Cited by 2 · see citing works

Human Milk Oligosaccharides and Gut Microbes in Host Brain Development and Health

Biagioli, V., & Striano, P. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.0018 · Cited by 2 · see citing works

Are conventional antidepressants enough? The gut microbiome and nanocarrier-based delivery systems as future prospects for depression treatment

Gastaldo-Jordán, I., Villalba-Pita, C., Martı́nez-Raga, J., Sanz, Y., & Medina-Rodriguez, E. M. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106421 · Cited by 2 · see citing works

From Genome-Wide SNPs to Neuroimmune Crosstalk: Mapping the Genetic Landscape of IBD and Its Brain Overlap

Tripathi, U., Stern, Y., Dagan, I., Nayak, R., Romanovsky, E., Zittan, E., & Stern, S. (2025) · Biology · doi:10.3390/biology14101433 · Cited by 2 · see citing works

From discourse to effectiveness: A communication studies perspective on college counselors' individual psychological counseling

Zheng, H., Feng, Q., & Wang, G. (2025) · Acta Psychologica · doi:10.1016/j.actpsy.2025.105828 · Cited by 2 · see citing works

Meta-analysis of yoga-based mind-body interventions in the management of inflammatory bowel disease

Pan, L., Chen, X., Wu, Y., Zhou, Z., & Xu, D. (2025) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2025.103287 · Cited by 2 · see citing works

Albumin and psychological resilience: key modifiable factors for hospital length of stay in ulcerative colitis

Yang, M., Lei, L., An, H., Shi, L., He, Y., Yang, M., Peng, L., Li, L., Ding, X., & Luo, X. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1704658 · Cited by 2 · see citing works

Mental Health Disorders in Pediatric Inflammatory Bowel Disease: Epidemiology, Mechanisms, and Interventions

Liu, Y., Hu, Y., Zheng, J., & Wu, Z. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s594782 · Cited by 2 · see citing works

Caffeic acid attenuates stress-induced colon inflammation and barrier disruption in Sprague-Dawley rats

Mazumder, S., Dubey, I., Gupta, A., Bhardwaj, S., Gautam, R. K., Nalla, S. V., & Kushwaha, S. (2026) · Cytokine · doi:10.1016/j.cyto.2026.157187 · Cited by 2 · see citing works

Lifestyle Intervention Modulates the CD4+ T Cell Profile in the Blood of Crohn’s Disease Patients

Mekes-Adamczyk, A., Gausmann, N., Öznur, Ö., Pfuhlmann, K., Dziobaka, J., Buer, J., Langhorst, J., & Westendorf, A. M. (2024) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae154 · Cited by 2 · see citing works

Neuroprotective effects of whey and buttermilk-based formulas on a DSS-induced colitis murine model

Buey, B., Latorre, E., Castro, M., Valero, M. S., Plaza, M. Á., Arruebo, M. P., Abad, I., Rodríguez‐Largo, A., Sánchez, L., & Mesonero, J. E. (2024) · Biochemistry and Cell Biology · doi:10.1139/bcb-2024-0153 · Cited by 2 · see citing works

The influence of stress, coping mechanisms and psychological symptoms on inflammatory bowel disease activity: A retrospective case-control analysis

Shirvani, J. S., Petrodi, S. T. H., Shirafkan, H., Shahrokhi, S., & Faramarzi, M. (2025) · Indian Journal of Gastroenterology · doi:10.1007/s12664-024-01714-y · Cited by 2 · see citing works

CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome

Shibao, T., Hase, H., Mizokami, K., Usui, A., Kitae, K., Ueda, Y., Jingushi, K., & Tsujikawa, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-91933-w · Cited by 2 · see citing works

Clinical Diagnosis and Treatment System for Neurological Psychological Gastrointestinal Diseases Based on Multimodal Artificial Intelligence and Immunology

Li, L., Jiang, J., Guo, L., Santos, J., González-Castro, A. M., Li, S., & Qin, Y. (2025) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010359130250413024112 · Cited by 2 · see citing works

Black and Latino/a Participants With Inflammatory Bowel Disease Are More Likely to Be at Risk for Post-Traumatic Stress Than Their White Counterparts: A Matched Control Comparison Study

Marchese, S. H., Raza, H. S., Naffouj, S., Mutlu, E., & Taft, T. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf290 · Cited by 2 · see citing works

Psychoemotional disorders of patients with inflammatory bowel diseases: prevalence, pathogenesis and treatment options

Бакулин, И. Г., Stamboltsyan, V. S., & Oganezova, I. A. (2023) · Russian Family Doctor · doi:10.17816/rfd321284 · Cited by 2 · see citing works

Role reversals: non-canonical roles for immune and non-immune cells in the gut

Tearle, J. L. E., Tang, A., Vasanthakumar, A., & James, K. R. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.11.004 · Cited by 2 · see citing works

The microbiota's funnel effect: How multiple factors independently converge in changing the microbiota

Agnoletti, M., & Fasano, A. (2025) · PNEI REVIEW · doi:10.3280/pnei2025oa19441 · Cited by 3 · see citing works

Low-intensity pulsed ultrasound irradiation ameliorates gut inflammation and neuroinflammation in mice with DSS-induced colitis

Tian, S., Hu, Y., Zhou, Y., Li, J., Liu, J., & Zhou, Q. S. (2025) · APL Bioengineering · doi:10.1063/5.0263732 · Cited by 1 · see citing works

The Effect of Stress on the Pathology of Idiopathic Inflammatory Bowel Disease.

Zacharová, B. (2024) · Digital Repository (National Repository of Grey Literature)

Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease

Abautret-Daly, Á., Dempsey, E., Parra‐Blanco, A., Medina, C., & Harkin, A. (2017) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.3 · Cited by 185 · see citing works

Effects of psychological stress on inflammatory bowel disease via affecting the microbiota–gut–brain axis

Chen, Y., Chen, X., Lin, S., Huang, S., Li, L., Hong, M., Li­, ­., Ma, L., & Ma, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003389 · Cited by 29 · see citing works

A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration

Tavakoli, P., Vollmer-Conna, U. S., Hadzi-Pavlovic, D., & Grimm, M. (2021) · Public health reviews · doi:10.3389/phrs.2021.1603990 · Cited by 173 · see citing works

The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases

Peppas, S., Pansieri, C., Piovani, D., Danese, S., Peyrin‐Biroulet, L., Tsantes, A. G., Brunetta, E., Tsantes, A. Ε., & Bonovas, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030377 · Cited by 114 · see citing works