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Identification of Anion Channels Responsible for Fluoride Resistance in Oral Streptococci
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![Fig 1 Locations of eriC and crcB genes in 18 oral streptococci. These species were selected based on the following criteria: identification in ≥ 10% of 166 orally healthy subjects and ≥ 0.01% of the mean relative abundance [10].](/paper-figures/22ea9e2abec44b70b93f53228ad53f26/identification-of-anion-channels-responsible-for-fluoride-resistance-in-oral-figure-1.jpg)
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In the citing paper
“different studies have come to different conclusions about whether 1289 only (19), or both 1289 and 1290 (30), contribute to fluoride efflux.”
From Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models (2024) · cites this paper as [19]
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In the citing paper
“Genetic knockout of fluoride exporters causes fluoride hypersensitivity in multiple species, including oral microbiota, reducing the inhibitory concentration of fluoride to the tens-to-hundreds of micromolar range (17–19).”
From Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models (2024) · cites this paper as [19]
Experimental — accuracy not yet measuredIn the citing paper
“The literature features contrasting results, with one study concluding that both ORFs 1289 and 1290 contribute to fluoride resistance (30), and another study concluding that 1289 only was responsible for the fluoride resistance phenotype(19)”
From Fluoride export is required for the competitive fitness of pathogenic microorganisms in dental biofilm models (2024) · cites this paper as [19]
In the citing paper
“deletion of the CLCF genes severely impairs growth of the oral bacteria S. mutans and Streptococcus anginosus in fluoride-containing media(49).”
From Membrane exporters of fluoride ion (2021) · cites this paper as [49]
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Citations
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Research works printed but not linked: 26
- RE Marquis, 2003, Fluoride and organic weak acids as modulators of microbial physiology, FEMS Microbiol Rev, 26, 493, 10.1111/j.1574-6976.2003.tb00627.x · DOI · Paper page
- RR Mayhew, 1981, Comparative effect of SnF2, NaF, and SnCl2 on the growth of Streptococcus mutans, J Dent Res, 60, 1809, 10.1177/00220345810600101301 · DOI
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- JL Streckfuss, 1980, Fluoride resistance and adherence of selected strains of Streptococcus mutans to smooth surfaces after exposure to fluoride, J Dent Res, 59, 151, 10.1177/00220345800590021501 · DOI
- FR Bunick, 1981, Enolases from fluoride-sensitive and fluoride-resistant streptococci, Infect Immun, 34, 856, 10.1128/IAI.34.3.856-863.1981 · DOI
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- C Van Loveren, 1991, Acidogenesis in relation to fluoride resistance of Streptococcus mutans, Oral Microbiol Immunol, 6, 288, 10.1111/j.1399-302X.1991.tb00494.x · DOI
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- JL Baker, 2012, Widespread genetic switches and toxicity resistance proteins for fluoride, Science, 35, 233, 10.1126/science.1215063 · DOI · Paper page
- Y Liao, 2015, Identification and functional analysis of genome mutations in a fluoride-resistant Streptococcus mutans strain, PloS One, 10, e0122630, 10.1371/journal.pone.0122630 · DOI · Paper page
- D Hanahan, 1983, Studies on transformation of Escherichia coli with plasmids, J Mol Biol, 166, 557, 10.1016/S0022-2836(83)80284-8 · DOI
- D Perry, 1983, Genetic transformation of putative cariogenic properties in Streptococcus mutans, Infect Immun, 41, 722, 10.1128/IAI.41.2.722-727.1983 · DOI
- D Li, 2012, A novel gene involved in the survival of Streptococcus mutans under stress conditions, Appl Environ Microbiol, 80, 97, 10.1128/AEM.02549-13 · DOI
- M Kawada-Matsuo, 2009, Role of two component signaling response regulators in acid tolerance of Streptococcus mutans, Oral Microbiol Immunol, 24, 173, 10.1111/j.1399-302X.2008.00485.x · DOI
- RB Stockbridge, 2012, Fluoride resistance and transport by riboswitch-controlled CLC antiporters, Proc Natl Acad Sci USA, 109, 15289, 10.1073/pnas.1210896109 · DOI · Paper page
- TJ Jentsch, 2002, Molecular structure and physiological function of chloride channels, Physiol rev, 82, 503, 10.1152/physrev.00029.2001 · DOI
- M Maduke, 1999, High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel, J Gen Physiol, 114, 713, 10.1085/jgp.114.5.713 · DOI
- S Li, 2013, Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins, Proc Natl Acad Sci USA, 110, 19018, 10.1073/pnas.1310439110 · DOI · Paper page
- Y Kawamura, 1995, Determination of 16S rRNA sequences of Streptococcus mitis and Streptococcus gordonii and phylogenetic relationships among members of the genus Streptococcus, Int J Sys Bacteriol, 45, 406, 10.1099/00207713-45-2-406 · DOI
- R Dutzler, 2002, MacKinnon, R. X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity, Nature, 415, 287, 10.1038/415287a · DOI · Paper page
- T Murata, 2016, Contribution of chloride channel permease to fluorideresistance in Streptococcus mutans, FEMS Microbiol, 363, fnw101, 10.1093/femsle/fnw101 · DOI · Paper page
Cited by
Sorted by citations
Stockbridge, R. B., & Wackett, L. P. (2024) · Nature Communications · doi:10.1038/s41467-024-49018-1 · Cited by 80
Membrane exporters of fluoride ion
McIlwain, B. C., Ruprecht, M. T., & Stockbridge, R. B. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-071520-112507 · Cited by 69
Banerjee, A., Kang, C.-Y., An, M., Koff, B. B., Sunder, S., Kumar, A., Tenuta, L. M. A., & Stockbridge, R. B. (2024) · mBio · doi:10.1128/mbio.00184-24 · Cited by 17
Metadata
- Authors
- Men, X., Shibata, Y., Takeshita, T., & Yamashita, Y.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-11-08
- Volume
- 11
- Issue
- 11
- Pages
- e0165900
- ISSN
- 1932-6203
- PMC
- PMC5100911
- Cited by
- 37
- References
- 0
- Language
- en
- Funders
- Grant-in Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (25463251, 25293428)
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