GNB3 and CREB1 gene polymorphisms combined with negative life events increase susceptibility to major depression in a Chinese Han population
Open accessAbstract
BACKGROUND: Major depression (MD) is caused by a combination of genetic and environmental factors. In this study we investigated the interaction of variations in the G-protein beta 3 subunit (GNB3) and cAMP response element binding protein 1 (CREB1) genes with negative life events in the pathogenesis of MD. One GNB3 polymorphism (rs5443) and four CREB1 polymorphisms (rs2253206, rs2551941, rs6740584, rs11904814) were investigated based on known associations with MD. METHODS: 512 patients with MD and 513 control subjects were genotyped. The frequency and severity of negative life events were measured by the Life Events Scale (LES). Gene-environment interactions (G×E) were assessed using the generalized multifactor dimensionality reduction (GMDR) method. RESULTS: Differences in GNB3 rs5443 allele frequencies and genotype distributions were observed between MD patients and controls. Significant G×E interactions were detected between negative life events and genotypic variation of all five single nucleotide polymorphisms (SNPs). Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events. However, individuals with the T+ allele of rs5443 (CT, TT) were susceptible to MD when exposed to low negative life events. CONCLUSIONS: Interactions between GNB3, CREB1 and negative life events were revealed. Further evidence is provided about the role of the environment in genetic vulnerability to MD.
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The environment and genetics interact to increase the risk of depression.
“The environment and genetics interact to increase the risk of depression”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [82]
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Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
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- Authors
- Ma, J., Wang, L., Yang, Y., Qiao, Z., Fang, D., Qiu, X., Yang, X., Zhu, X., He, J., Pan, H., Ban, B., Zhao, Y., & Sui, H.
- Affiliations
- Harbin Medical University (CN)
- Northwestern University (US)
- Second Xiangya Hospital of Central South University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Peking Union Medical College Hospital (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Corresponding author
- Yang, Yanjie
- Qiao, Zhengxue
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-02-22
- Volume
- 12
- Issue
- 2
- Pages
- e0170994
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5321408
- OpenAlex
- W2589500908
- Cited by
- 26
- References
- 44
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81473054, 81302484)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, GNB3, CREB1, gene-environment interaction, negative life events, single nucleotide polymorphisms, genetic susceptibility, Han Chinese, CREB
- MeSH terms
- Adult, Alleles, China, Major Depressive Disorder, Female, Gene Frequency, Genotype, Humans, Life Change Events, Male, Middle Aged, Cyclic AMP Response Element-Binding Protein, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Heterotrimeric GTP-Binding Proteins, Asian People, Gene-Environment Interaction
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