The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.
Benzodiazepines, Z-drugs and the risk of hip fracture: A systematic review and meta-analysis
Open accessAbstract
BACKGROUND: Hip fractures in the older person lead to an increased risk of mortality, poorer quality of life and increased morbidity. Benzodiazepine (BNZ) use is associated with increased hip fracture rate, consequently Z-drugs are fast becoming the physician's hypnotic prescription of choice yet data on their use is limited. We compared the risk of hip fracture associated with Z-drugs and BNZ medications, respectively, and examined if this risk varied with longer-term use. METHODS AND FINDINGS: We carried out a systematic review of the literature and meta-analysis. MEDLINE and SCOPUS were searched to identify studies involving BNZ or Z-drugs and the risk of hip fracture up to May 2015. Each included study was quality-assessed. A pooled relative risk of hip fracture was calculated using the generic inverse variance method, with a random effects model, with the length of hypnotic usage as a subgroup. Both BNZ, and Z-drug use respectively, were significantly associated with an increased risk of hip fracture (RR = 1.52, 95% CI 1.37-1.68; and RR = 1.90, 95% CI 1.68-2.13). Short-term use of BNZ and Z-drugs respectively, was also associated with the greatest risk of hip fracture (RR = 2.40, 95% CI 1.88-3.05 and RR = 2.39, 95% CI 1.74-3.29). CONCLUSIONS: There is strong evidence that both BNZ and Z-drugs are associated with an increased risk of hip fracture in the older person, and there is little difference between their respective risks. Patients newly prescribed these medicines are at the greatest risk of hip fracture. Clinicians and policy makers need to consider the increased risk of fallings and hip fracture particularly amongst new users of these medications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Longer-term use is associated with a number of physical and cognitive risks, including physical dependence, tolerance, loss of efficacy, falls, and fractures ( Donnelly et al., 2017) and memory disturbance (Lister, 1985).”
From Pharmacological principles for safe benzodiazepine and Z-drug dose reduction (2026) · cites this paper as Donnelly et al., 2017
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Wang, G., Ma, R., Qiao, G., Wada, K., Aizawa, Y., & Satoh, T. (2015) · Integrative Medicine International · doi:10.1159/000368408 · Cited by 18,762
Cochrane Handbook for Systematic Reviews of Interventions
Higgins, J. P. T., Green, S., & Ben Van Den, A. (2020) · International Coaching Psychology Review · doi:10.53841/bpsicpr.2020.15.2.123 · Cited by 5,670
Cochrane Handbook for Systematic Reviews of Interventions
Tarsilla, M. (2010) · Journal of MultiDisciplinary Evaluation · doi:10.56645/jmde.v6i14.284 · Cited by 5,232
Risk Factors for Hip Fracture in White Women
Cummings, S. R., Nevitt, M. C., Browner, W. S., Stone, K., Fox, K. M., Ensrud, K. E., Cauley, J., Black, D., & Vogt, T. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503233321202 · Cited by 3,595
Chapter 9: Analysing Data and Undertaking Meta-Analyses
Deeks, J. J., Higgins, J. P. T., & Altman, D. G. (2008) · Cited by 2,782
Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
Glass, J., Lanctôt, K. L., Herrmann, N., Sproule, B. A., & Busto, U. E. (2005) · BMJ · doi:10.1136/bmj.38623.768588.47 · Cited by 1,161
Flagged first, then by citations
2 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- J Boddaert, 2015, Hip fractures: Epidemiology and risk factors, Annales françaises de médecine d’urgence, 5, 119
- F Hoffmann, 2006, New use of benzodiazepines and the risk of hip fracture: A case-crossover study, Zeitschrift fur Gerontologie und Geriatrie, 39, 143
Cited by
Sorted by citations
Insomnia in Elderly Patients: Recommendations for Pharmacological Management
Abad, V. C., & Guilleminault, C. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0569-8 · Cited by 185
The importance of the circadian system & sleep for bone health
Swanson, C. M., Kohrt, W. M., Buxton, O. M., Everson, C. A., Wright, K. P., ORWOLL, E. S., & Shea, S. A. (2017) · Metabolism · doi:10.1016/j.metabol.2017.12.002 · Cited by 161
Morin, C. M., & Buysse, D. J. (2024) · New England Journal of Medicine · doi:10.1056/nejmcp2305655 · Cited by 177
Ng, B. J., Le Couteur, D. G., & Hilmer, S. N. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0544-4 · Cited by 118
Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
Kripke, D. F. (2016) · F1000Research · doi:10.12688/f1000research.8729.1 · Cited by 106
Insomnia and Other Sleep Disorders in Older Adults
Cohen, Z. L., Eigenberger, P., Sharkey, K. M., Conroy, M. L., & Wilkins, K. M. (2022) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2022.07.002 · Cited by 92
Richardson, K., Loke, Y. K., Fox, C., Maidment, I., Howard, R., Steel, N., Arthur, A., Boyd, P. J., Aldus, C., Ballard, C., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01821-5 · Cited by 73
Polypharmacy and injurious falls in older adults: a nationwide nested case-control study
Morin, L., Calderón‐Larrañaga, A., Welmer, A., Rizzuto, D., Wastesson, J. W., & Johnell, K. (2019) · Clinical Epidemiology · doi:10.2147/clep.s201614 · Cited by 69
Ngcobo, N. N. (2025) · Clinical Pharmacokinetics · doi:10.1007/s40262-024-01466-0 · Cited by 116
Machado‐Duque, M. E., Castaño, J. P., Medina-Morales, D. A., Castro‐Rodríguez, A., González-Montoya, A., & Machado‐Alba, J. E. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217002745 · Cited by 68
Evrard, P., Pétein, C., Beuscart, J.-B., & Spinewine, A. (2022) · Implementation Science · doi:10.1186/s13012-022-01206-7 · Cited by 62
Association Between Atrial Fibrillation and Dementia: A Meta-Analysis
Islam, M. M., Poly, T. N., Walther, B. A., Yang, H., Wu, C., Lin, M., Chien, S.-C., & Li, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00305 · Cited by 64
Incidence of and Characteristics Associated With Long-term Benzodiazepine Use in Finland
Taipale, H. T., Särkilä, H., Tanskanen, A. J., Kurko, T., Taiminen, T. J., Tiihonen, J., Sund, R., Tuulio‐Henriksson, A., Saastamoinen, L., & Hietala, J. A. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.19029 · Cited by 63
Pharmacotherapy for chronic non-specific low back pain: current and future options
Koes, B. W., Backes, D., & Bindels, P. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1454430 · Cited by 62
Kastora, S. L., Kounidas, G., Perrott, S. L., Carter, B., Hewitt, J., & Myint, P. K. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.100896 · Cited by 60
Self-citationBronskill, S. E., Campitelli, M. A., Iaboni, A., Herrmann, N., Guan, J., Maclagan, L. C., Watt, J., Rochon, P. A., Morris, A. M., Jeffs, L., et al. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15519 · Cited by 54
Poly, T. N., Islam, M. M., Yang, H.-C., & Li, Y.-C. (. (2020) · Joint Bone Spine · doi:10.1016/j.jbspin.2019.11.003 · Cited by 53
Tseng, L.-Y., Huang, S., Peng, L., Chen, L., & Hsiao, F. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00801-9 · Cited by 54
Takano, A., Ono, S., Yamana, H., Matsui, H., Matsumoto, T., Yasunaga, H., & Kawakami, N. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-029641 · Cited by 49
Sedative Hypnotics and the Risk of Falls and Fractures in the Elderly
Andrade, C. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.18f12340 · Cited by 43
Sleep Disruption and Bone Health
Swanson, C. M. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00733-y · Cited by 40
Benzodiazepine Use and Deprescribing in Belgian Nursing Homes: Results from the COME‐ON Study
Evrard, P., Henrard, S., Foulon, V., & Spinewine, A. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16751 · Cited by 38
Gray, S. L., Marcum, Z. A., Dublin, S., Walker, R. L., Golchin, N., Rosenberg, D. E., Bowles, E. J. A., Crane, P. K., & Larson, E. B. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz270 · Cited by 39
Tian, F., Li, H., Chen, Z., & Xu, T. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14348 · Cited by 38
Shaw, J. C., Murphy, A. L., Turner, J. P., Gardner, D. M., Silvius, J. L., Bouck, Z., Gordon, D., & Tannenbaum, C. (2019) · Healthcare policy · doi:10.12927/hcpol.2019.25857 · Cited by 34
Psychotropic Drug-Associated Pneumonia in Older Adults
Rajamaki, B., Hartikainen, S. A., & Tolppanen, A. (2020) · Drugs & Aging · doi:10.1007/s40266-020-00754-1 · Cited by 34
Højlund, M., Gudmundsson, L. S., Andersen, J. H., Saastamoinen, L., Zoëga, H., Skurtveit, S. O., Wastesson, J. W., Hallas, J., & Pottegård, A. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13811 · Cited by 33
Okuda, S., Qureshi, Z. P., Yanagida, Y., Ito, C., Homma, Y., & Tokita, S. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04683-2 · Cited by 36
Gronich, N. (2024) · Drugs & Aging · doi:10.1007/s40266-024-01117-w · Cited by 41
Benzodiazepine and opioid co-usage in the US population, 1999–2014: an exploratory analysis
Vozoris, N. T. (2019) · SLEEP · doi:10.1093/sleep/zsy264 · Cited by 32
Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods
Zhang, Y.-X., Zhang, Y., Bian, Y., Liu, Y., Ai, R., Zhou, Y., Shi, D., & Feng, X. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.03.007 · Cited by 30
Insomnia, Benzodiazepine Use, and Falls among Residents in Long-term Care Facilities
Jiang, Y., Xia, Q., Wang, J., Zhou, P., Jiang, S., Diwan, V. K., & Xu, B. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16234623 · Cited by 30
Mathieu, C., Joly, P., Jacqmin‐Gadda, H., Wanneveich, M., Bégaud, B., & Pariente, A. (2020) · Drug Safety · doi:10.1007/s40264-020-00992-7 · Cited by 29
Orthostatic hypertension and major adverse events: a systematic review and meta-analysis
Pasdar, Z., Paola, L. D., Carter, B., Pana, T. A., Potter, J. F., & Myint, P. K. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad158 · Cited by 29
Self-citationAssociation of Receiving Multiple, Concurrent Fracture-Associated Drugs With Hip Fracture Risk
Emeny, R. T., Chang, C., Skinner, J., O’Malley, A. J., Smith, J., Chakraborti, G., Rosen, C. J., & Morden, N. E. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.15348 · Cited by 30
Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
Kripke, D. F. (2018) · F1000Research · doi:10.12688/f1000research.8729.3 · Cited by 28
Barriers to Deprescribing Benzodiazepines in Older Adults in a Survey of European Physicians
Shapoval, V., Hubert, M. D. S., Evrard, P., Sibille, F., Aubert, C. E., Bolt, L., Tsoutsi, V., Κollia, P., Salvà, A., Miralles, R., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.59883 · Cited by 26
Pétein, C., Spinewine, A., & Henrard, S. (2021) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253211011874 · Cited by 25
Parhizkar, S., Bao, X., Chen, W., Rensing, N. R., Chen, Y., Kipnis, M., Song, S., Gent, G., Tycksen, E., Manis, M., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01966-7 · Cited by 27
Gentle rocking movements during sleep in the elderly
van Sluijs, R., Wilhelm, E., Rondei, Q. J., Omlin, X., Crivelli, F., Straumann, D., Jaeger, L., Riener, R., & Achermann, P. (2020) · Journal of Sleep Research · doi:10.1111/jsr.12989 · Cited by 24
Role of nurses in supporting proactive deprescribing
Wright, D. J., Scott, S., Buck, J., & Bhattacharya, D. (2019) · Nursing Standard · doi:10.7748/ns.2019.e11249 · Cited by 24
Sleep disruptions and bone health: what do we know so far?
Swanson, C. M. (2021) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000639 · Cited by 23
Moriarty, F., Thompson, W., & Boland, F. (2021) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2021.05.007 · Cited by 21
Tikhonova, T. A., Rassokhina, I. V., Kondrakhin, E. A., Fedosov, M. A., Bukanova, J. V., Rossokhin, A. V., Sharonova, I. N., Kovalev, G. I., Zavarzin, I. V., & Volkova, Y. A. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103334 · Cited by 21
Jansana, A., Poblador‐Plou, B., Miguel, A. G., Lanzuela, M., Prados‐Torres, A., Domingo, L., Comas, M., Sanz‐Cuesta, T., del Cura-González, I., Ibáñez, B., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33736 · Cited by 21
Oliva, V., Fanelli, G., Zamparini, M., Zarbo, C., Rocchetti, M., Casiraghi, L., Starace, F., Martinelli, A., Serretti, A., & de Girolamo, G. (2022) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000433 · Cited by 20
Richardson, K., Savva, G. M., Boyd, P. J., Aldus, C. F., Maidment, I., Pakpahan, E., Loke, Y. K., Arthur, A. J., Steel, N., Ballard, C. G., et al. (2021) · Health Technology Assessment · doi:10.3310/hta25010 · Cited by 21
Zeraatkar, D., Nagraj, S. K., Ling, M., Jassal, T., Kirsh, S., Lima, J. P., Pitre, T., Couban, R., Hussain, M., Seterelv, S. S., et al. (2025) · BMJ · doi:10.1136/bmj-2024-081336 · Cited by 22
Keenan, R. J., Daykin, H. J., Metha, J. A., Cornthwaite‐Duncan, L., Wright, D. K., Clarke, K. M., Oberrauch, S., Brian, M. L., Stephenson, S. E. M., Nowell, C. J., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16212 · Cited by 17
Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)
Fisher, L., Fisher, A., & Smith, P. N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103253 · Cited by 18
1,4-Benzodiazepines and New Derivatives: Description, Analysis, and Organic Synthesis
Batlle, E., Lizano, E., Viñas, M., & Pujol, M. D. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.79879 · Cited by 19
Assimon, M. M., & Flythe, J. E. (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.10070620 · Cited by 18
Hip, vertebral, and wrist fracture risks and schizophrenia: a nationwide longitudinal study
Chu, Y.-W., Chen, W., Yang, A. C., Tsai, S., Hu, L., Lee, S.-C., Lee, Y., & Shen, C. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-03723-7 · Cited by 17
Soumerai, S. B., Shahzad, M., & Salzman, C. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240030 · Cited by 16
Vicens, C., Leiva, A., Bejarano, F., Sempere-Verdú, E., Rodríguez-Rincón, R. M., Fiol, F., Mengual, M., Ajenjo-Navarro, A., Do Pazo, F., Mateu, C., et al. (2022) · PLOS Medicine · doi:10.1371/journal.pmed.1003983 · Cited by 15
“…advocate short-term use of BZDs [2,3] because long-term use leads to tolerance and dependence and is associated with many adverse effects, including somnolence, daytime drowsiness, memory disruption [4–6], increased risk of falls resulting in hip fracture [7–9], and motor vehicle accidents [10,11].”
Rozing, M. P., Wium‐Andersen, M. K., Wium‐Andersen, I. K., Jørgensen, T. S. H., Jørgensen, M. B., & Osler, M. (2023) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13610 · Cited by 15
Joza, S., Camicioli, R. M., & Ba, F. (2019) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2019.287 · Cited by 15
Hill, S. L., & Thomas, S. H. L. (2016) · Medicine · doi:10.1016/j.mpmed.2015.12.030 · Cited by 16
Benzodiazepine Treatment and Fracture Risk in Young Persons With Anxiety Disorders
Bushnell, G., Gerhard, T., Crystal, S., & Olfson, M. (2020) · PEDIATRICS · doi:10.1542/peds.2019-3478 · Cited by 16
Insomnia in primary care: Considerations for screening, assessment, and management
Yamamoto, M., Lim, C. T., Huang, H., Spottswood, M., & Huang, H. Y. (2023) · The Journal of Medicine Access · doi:10.1177/27550834231156727 · Cited by 16
Isomura, K., Wang, X., Chang, Z., Hellner, C., Hasselström, J., Ekheden, I. G., Jayaram‐Lindström, N., Lichtenstein, P., D'Onofrio, B. M., Mataix‐Cols, D., et al. (2023) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-023-03515-2 · Cited by 15
Uragami, M., Matsushita, K., Shibata, Y., Takata, S., Karasugi, T., Sueyoshi, T., Masuda, T., Nakamura, T., Tokunaga, T., Hisanaga, S., et al. (2023) · Bone · doi:10.1016/j.bone.2023.116865 · Cited by 13
Keck, M. E., Nicolussi, S., Spura, K., Blohm, C., Zahner, C., & Drewe, J. (2020) · Phytotherapy Research · doi:10.1002/ptr.6618 · Cited by 12
van de Ven, L. I., Klop, C., Overbeek, J. A., de Vries, F., Burden, A. M., & Janssen, P. K. C. (2018) · Osteoporosis International · doi:10.1007/s00198-018-4632-4 · Cited by 13
Holmerová, I., Auer, S., Beránková, A., Höfler, M., Ratajczak, P., & Šteffl, M. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s188601 · Cited by 13
Takeuchi, Y., Sano, H., Asai, Y., Miyazaki, M., Iwakura, M., & Maeda, Y. (2019) · Current Medical Research and Opinion · doi:10.1080/03007995.2019.1700361 · Cited by 13
Xu, C., Leung, J. C. N., Shi, J., Lum, D. H., & Lai, F. T. T. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101866 · Cited by 15
BPSD Patterns in Patients With Severe Neuropsychiatric Disturbances: Insight From the RECAGE Study
Cognat, E., Sabia, S., Fayel, A., Lilamand, M., Handels, R. L. H., Fascendini, S., Bergh, S., Frisoni, G. B., Fabbo, A., Tsolaki, M., et al. (2023) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.03.014 · Cited by 13
Kim, C. H., Lee, Y.-J., Kang, S., & Lee, S. H. (2025) · Journal of Medical Internet Research · doi:10.2196/67751 · Cited by 13
Yoshioka, R., Yamamoto, S., & Nakatani, E. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284726 · Cited by 11
Tevik, K., Selbæk, G., Engedal, K., Seim, A., Krokstad, S., & Helvik, A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214813 · Cited by 11
Chukwulebe, S. B., Kim, H. S., McCarthy, D. M., Courtney, D. M., Lank, P. M., Gravenor, S. J., & Dresden, S. M. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15722 · Cited by 11
Case–control study examining the association between hip fracture and zaleplon use in older adults
Lai, S., Chang-Ou, K.-C., Lin, C., & Liao, K. (2019) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2019-136467 · Cited by 10
Evrard, P., Damiaens, A., Patey, A. M., Grimshaw, J., & Spinewine, A. (2023) · Exploratory Research in Clinical and Social Pharmacy · doi:10.1016/j.rcsop.2023.100258 · Cited by 10
Bell, J. S., Caze, A. L., Steeper, M., Haines, T. P., Hilmer, S. N., Troeung, L., Quirke, L., Wesson, J., Pond, C. D., Buys, L. R., et al. (2024) · Implementation Science · doi:10.1186/s13012-024-01353-z · Cited by 10
Depression and the Risk of Fractures in Later Life: the Health In Men Cohort Study
Almeida, O. P., Hankey, G. J., Golledge, J., Yeap, B. B., & Flicker, L. A. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.12.004 · Cited by 10
Relevance of Sleep Disturbances to Orthopaedic Surgery
Beetz, G., Babiloni, A. H., Jodoin, M., Charlebois‐Plante, C., Lavigne, G. J., Beaumont, L. D., & Rouleau, D. M. (2021) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.21.00176 · Cited by 20
Le, T. M., Campbell, S., Andraos, A., Ahlmark, P., Hoang, H., Isserman, S. L., Goldzweig, C. L., Mays, A. M., Bradley, K., & Keller, M. S. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-080109 · Cited by 9
Impact of Chinese criteria on potentially inappropriate medication use in China
Tian, F., Chen, Z., Zhang, Y., Feng, Q., & Chen, X. (2025) · Journal of Global Health · doi:10.7189/jogh.15.04063 · Cited by 10
Hypnotic Discontinuation Using a Blinded (Masked) Tapering Approach: A Case Series
Fung, C. H., Martin, J. L., Alessi, C., Dzierzewski, J. M., Cook, I. A., Moore, A. A., Grinberg, A. M., Zeidler, M. R., & Kierlin, L. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00717 · Cited by 10
Adomi, M., Maeda, M., Murata, F., & Fukuda, H. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18068 · Cited by 9
Benzodiazepine Use and Falls in Older Adults: Is It Worth the Risk?
McDonald, E. M., & Caslangen, J. (2019) · Research in Gerontological Nursing · doi:10.3928/19404921-20190813-01 · Cited by 9
Guo, M., Tao, S., Xiong, Y., Dong, M., Yan, Z., Ye, Z., & Wu, D. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115974 · Cited by 9
Ogawa, Y., Hirai, T., & Mihara, K. (2021) · Journal of Pharmaceutical Health Care and Sciences · doi:10.1186/s40780-021-00213-y · Cited by 8
Tsuboi, T., Takaesu, Y., Hasegawa, N., Ochi, S., Fukumoto, K., Ohi, K., Muraoka, H., Okada, T., Kodaka, F., Igarashi, S., et al. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13489 · Cited by 8
Sessa, M., Mascolo, A., Dalhoff, K., & Andersen, M. T. (2020) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2020.1711882 · Cited by 8
Care coordination needs for deprescribing benzodiazepines and benzodiazepine receptor agonists
McCarthy, M. S., Mak, S., Kaufmann, C. N., Lum, H. D., & Fung, C. H. (2021) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2021.06.025 · Cited by 8
Pétein, C., Spinewine, A., Laroche, M., Niquille, A., & Henrard, S. (2023) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2023.05.010 · Cited by 7
Fi, B., Sumin, A. N., Garganeeva, N. P., Ларева, Н. В., Петрова, М. М., Петрунько, О. В., Попонина, Т. М., Repin, A. N., & Собенников, В. С. (2024) · Complex Issues of Cardiovascular Diseases · doi:10.17802/2306-1278-2024-13-3s-222-253 · Cited by 8
Ohara, E., Bando, Y., Yoshida, T., Ohara, M., Kirino, Y., & Iihara, N. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00737 · Cited by 7
Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years
Liu, P.-S., Huang, H., & Ding, D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246653 · Cited by 7
Hwang, S., Son, H., Kim, M., Lee, S. K., & Jung, K. (2022) · Journal of Clinical Neurology · doi:10.3988/jcn.2022.18.1.65 · Cited by 7
Chen, C., Hennessy, S., Brensinger, C. M., Acton, E. K., Bilker, W. B., Chung, S. P., Dawwas, G. K., Horn, J. R., Miano, T. A., Nguyen, T. P. P., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-19551-4 · Cited by 8
Efficacy and Safety of Naproxen for Acute Pain
Weisman, S. R. (2020) · The Journal of Family Practice · doi:10.12788/jfp.0064 · Cited by 8
Loosen, S. H., Killer, A., Bock, H. H., Luedde, T., Roderburg, C., & Kostev, K. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13206152 · Cited by 6
Mansi, E. T., Rentsch, C. T., Bourne, R. S., Guthrie, B., & Lone, N. (2024) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.70056 · Cited by 6
Unger, C., & Kohlmeier, K. A. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.108743 · Cited by 7
Mansi, E. T., Rentsch, C. T., Bourne, R. S., Jeffery, A., Guthrie, B., & Lone, N. (2025) · Intensive Care Medicine · doi:10.1007/s00134-024-07762-4 · Cited by 6
Managing the Burden of Dementia-Related Delusions and Hallucinations
Small (2020) · The Journal of Family Practice · doi:10.12788/jfp.0065 · Cited by 6
Kang, Y.-J., Lee, M., Kim, M.-S., You, S., Lee, J.-E., Eom, J.-H., & Jung, S. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00872-4 · Cited by 7
Metadata
- Authors
- Donnelly, K., Bracchi, R., Hewitt, J., Routledge, P. A., & Carter, B.
- Affiliations
- University Hospital Llandough (GB)
- Cardiff University (GB)
- University of Nottingham (GB)
- Corresponding author
- Carter, Ben
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-04-27
- Volume
- 12
- Issue
- 4
- Pages
- e0174730
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5407557
- OpenAlex
- W2600488841
- Cited by
- 225
- References
- 58
- Citations by year
- 2026: 19 · 2025: 35 · 2024: 24 · 2023: 23 · 2022: 27 · 2021: 24 · 2020: 35 · 2019: 21 · 2018: 11 · 2017: 4
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Funders
- South London and Maudsley NHS Foundation Trust
- National Institute for Health and Care Research
- King's College London
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Surgery › Hip and Femur Fractures
- Keywords
- benzodiazepines, Z-drugs, hip fracture, older adults, hypnotics, fall risk, drug safety, duration of drug use, adverse drug reactions
- MeSH terms
- Zolpidem, Benzodiazepines, Hip Fractures, Humans, Pyridines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
