Atypical speech versus non-speech detection and discrimination in 4- to 6- yr old children with autism spectrum disorder: An ERP study
Open accessAbstract
Previous event-related potential (ERP) research utilizing oddball stimulus paradigms suggests diminished processing of speech versus non-speech sounds in children with an Autism Spectrum Disorder (ASD). However, brain mechanisms underlying these speech processing abnormalities, and to what extent they are related to poor language abilities in this population remain unknown. In the current study, we utilized a novel paired repetition paradigm in order to investigate ERP responses associated with the detection and discrimination of speech and non-speech sounds in 4- to 6-year old children with ASD, compared with gender and verbal age matched controls. ERPs were recorded while children passively listened to pairs of stimuli that were either both speech sounds, both non-speech sounds, speech followed by non-speech, or non-speech followed by speech. Control participants exhibited N330 match/mismatch responses measured from temporal electrodes, reflecting speech versus non-speech detection, bilaterally, whereas children with ASD exhibited this effect only over temporal electrodes in the left hemisphere. Furthermore, while the control groups exhibited match/mismatch effects at approximately 600 ms (central N600, temporal P600) when a non-speech sound was followed by a speech sound, these effects were absent in the ASD group. These findings suggest that children with ASD fail to activate right hemisphere mechanisms, likely associated with social or emotional aspects of speech detection, when distinguishing non-speech from speech stimuli. Together, these results demonstrate the presence of atypical speech versus non-speech processing in children with ASD when compared with typically developing children matched on verbal age.
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When a non-speech sound is followed by a speech sound, TD children present match/mismatch effects at approximately 600 ms, as opposed to ASD.
“When a non-speech sound is followed by a speech sound, TD children present match/mismatch effects at approximately 600 ms, as opposite to ASD (Galilee et al. 2017).”
From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Galilee et al. 2017
In children with ASD, speech-related events were only detected over temporal electrodes in the left hemisphere, compared to bilaterally N330 match/mismatch responses in neurotypical children.
“When comparing ERP responses for speech and non-speech sounds, speech-related events where only detected over temporal electrodes in the left hemisphere (Galilee et al. 2017), compared to bilaterally N330 match/mismatch responses in neurotypical children (Galilee et al. 2017).”
From Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing (2023) · cites this paper as Galilee et al. 2017
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- Authors
- Galilee, A., Stefanidou, C., & McCleery, J. P.
- Affiliations
- Dalhousie University (CA)
- University of Birmingham (GB)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Galilee, Alena
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-07-24
- Volume
- 12
- Issue
- 7
- Pages
- e0181354
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5524336
- OpenAlex
- W2737304330
- Cited by
- 16
- References
- 46
- Citations by year
- 2026: 2 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2017: 1
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/publicdomain/zero/1.0/ (vor)
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, public-domain)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, public-domain)
- Funders
- Autistica (N/A)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, speech detection, event-related potentials, P600, hemispheric lateralization, right hemisphere, language processing
- MeSH terms
- Autism Spectrum Disorder, Auditory Perception, Brain, Child, Child, Preschool, Electroencephalography, Evoked Potentials, Evoked Potentials, Auditory, Female, Humans, Male, Phonetics, Speech, Speech Perception
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