Osteopontin activates mesenchymal stem cells to repair skin wound
Open accessAbstract
Mesenchymal stem cells (MSCs) are promising candidates for skin wound repair due to their capabilities of accumulating at wounds and differentiating into multiple types of skin cells. However, the underlying mechanisms responsible for these processes remain unclear. In this study, we found that osteopontin (OPN) stimulated the migration of MSCs in vitro, and observed the recruitment of endogenous MSCs to a skin wound and their differentiation into keratinocytes and endothelial cells. In OPN knock-out mice, the recruitment of MSCs to the skin wound was significantly inhibited, and wound closure was hampered after an intradermal injection of exogenous MSCs compared to wild-type mice. Consistent with these observations, the expressions of adhesion molecule CD44 and its receptor E-selectin were significantly decreased in the lesions of OPN knock-out mice compared with wild-type mice suggesting that OPN may regulate the migration of MSCs through its interactions with CD44 during skin wound recovery. In summary, our data demonstrated that OPN played a critical role in activating the migration of MSCs to injured sites and their differentiation into specific skin cell types during skin wound healing.
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Osteopontin encoded by SPP1 shows decreased expression in cEDS patients' cells.
“Osteopontin encoded by SPP1, which shows a decreased expression in patients’ cells, is involved in several physiological processes related to inflammation, biomineralization, cell viability, and wound healing [56,57].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [56]
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Toxicant-induced injury and tissue repair
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Bovine milk osteopontin induces cytokine release in buccal carcinoma cells
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- Authors
- Wang, W., Li, P., Li, W., Jiang, J., Cui, Y., Li, S., & Wang, Z.
- Affiliations
- Army Medical University (CN)
- Chinese People's Liberation Army (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Chongqing Medical University (CN)
- Corresponding author
- Li, Shirong
- Wang, Zhenxiang
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-09-28
- Volume
- 12
- Issue
- 9
- Pages
- e0185346
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5619734
- OpenAlex
- W2759760274
- Cited by
- 58
- References
- 42
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 4
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81071563, 81272102)
- Chongqing Application Development Grant (CSTC2014yykfA110015)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- osteopontin, mesenchymal stem cells, skin wound healing, cell migration, CD44, E-selectin, keratinocyte differentiation, endothelial differentiation, stem cell recruitment
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cell Separation, Fluorescent Antibody Technique, Male, Mice, Inbred C57BL, Recombinant Proteins, Skin, von Willebrand Factor, Wound Healing, Down-Regulation, Keratinocytes, Hyaluronan Receptors, E-Selectin, Platelet Endothelial Cell Adhesion Molecule-1, Endothelial Cells, Green Fluorescent Proteins, Osteopontin, Keratin-14, Mesenchymal Stem Cells
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