Effects of periodontitis on the development of asthma: The role of photodynamic therapy
Open accessAbstract
To evaluate whether periodontitis modulates lung inflammation in an experimental model of asthma as well as the photodynamic therapy (PDT) is associated with a reduction of lung inflammation. Seventy-two BALB/c male mice (~2 months) were randomly divided into 8 groups (n = 9): Basal, Periodontitis (P), P+PT, P+PT+PDT, Asthma (A), A+P, A+P+PT, and A+P+PT+PDT. Periodontitis was induced by using the ligature technique and asthma was induced by ovalbumin (OVA). PT was performed with curettes and PDT with methylene blue (0.005%), λ = 660nm, with a radiant exposure of 318J/cm2. After 43 days, euthanasia was carried out prior to lung and mandible morphological analyzes. All of the manipulations of the animals were performed by only one operator. The total and differential cell counts and cytokines IL-4, IL-5, IL-10, IFN-γ, TNF-α, IL-1β, and IL-6 were evaluated in the bronchoalveolar lavage (BAL) and in the serum. Mucus and alkaline phosphatase were also quantified. Statistical analyzes were performed by a blinded statistician. One-way analysis of variance (ANOVA) was employed, followed by the Student-Newman-Keuls test. Periodontitis group (P) increased alkaline phosphatase and bone resorption (p<0.05), validating the experimental model of periodontitis. The A group and the P group increased the total amount of cells (p <0.05) in the BAL. However, in the A+P group, there was a decrease in these cells, except for in the A+P+PT+PDT group (p<0.05). The asthma group increased the Th2 cytokines and P group increased the Th1 cytokine profile, and A+P+PT+PDT group increased IL-10 cytokine. Mucus was increased for the A and P groups. In conclusion, periodontitis in the asthmatic mice reduced the inflammatory migrated cells in the BAL (eosinophils, lymphocytes, macrophages). In addition, it reduced the levels of the IL-4 and TNF-α cytokines, which was also accompanied by a decreased mucus production. After PDT treatment the total cell count increased however, this increase was not accompanied by a pro-inflammatory cytokines release. Only in PDT group the anti-inflammatory IL-10 was increased. Further studies are needed to understand this mechanism of action.
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Asthmatic patients tend to breathe through the mouth, causing continuous dehydration of the alveolar mucosa, especially during an acute asthmatic attack.
“Another factor that contributes to the presence of these alterations is the tendency of these patients to breathe through the mouth, thus causing continuous dehydration of the alveolar mucosa, especially during an acute asthmatic attack [100,101,102].”
From Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health (2023) · cites this paper as [100]
The Introduction describes asthma symptoms and airway obstruction, while the Results report mucus production in an animal model; neither addresses mouth breathing or dehydration of the alveolar mucosa. Searches for mouth breathing, mucosal dehydration, and acute asthmatic attacks found no passage supporting the attributed claim. The paper’s page numbers were not available in our copy. (LLM, conf=0.76)
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- Authors
- Candeo, L. C., Rigonato-Oliveira, N. C., Brito, A. A., Marcos, R. L., França, C. M., Fernandes, K. P. S., Mesquita-Ferrari, R. A., Bussadori, S. K., Vieira, R. P., Lino-dos-Santos-Franco, A., Ligeiro-Oliveira, A. P., & Horliana, A. C. R. T.
- Affiliations
- Universidade Nove de Julho (BR)
- Oregon Health & Science University (US)
- Corresponding author
- Horliana, Anna Carolina Ratto Tempestini
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-11-16
- Volume
- 12
- Issue
- 11
- Pages
- e0187945
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5689838
- OpenAlex
- W2769952990
- Cited by
- 19
- References
- 72
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 1
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Fundação de Amparo a Pesquisa do Estado de São Paulo—FAPESP (2015/20535-1, 2012/16498-5, 2015/23152-6, 2015/00830-9)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- periodontitis, asthma, photodynamic therapy, methylene blue, ovalbumin-induced asthma, lung inflammation, Th2 cytokines, Th1 cytokines, IL-10, mucus production, eosinophils, bone resorption, bronchoalveolar lavage, ligature-induced periodontitis, mouse model
- MeSH terms
- Animals, Asthma, Male, Mice, Inbred BALB C, Periodontitis, Photochemotherapy, Cytokines, Mice
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