Quercetin metabolism by fecal microbiota from healthy elderly human subjects
Open accessAbstract
Quercetin is a polyphenol found in food that has numerous health benefits. This study investigated the relationship between quercetin metabolism, gut microbiota composition, and dietary intake in elderly Japanese subjects. A food frequency questionnaire was used to assess dietary intake during the week prior to stool sample collection. Fecal suspensions from 56 subjects were anaerobically incubated with quercetin and fecal microbiota composition was analyzed by next-generation sequencing. Inter-individual variations in quercetin concentration and fecal microbiota composition at family level suggested differences in microbial quercetin metabolism. The abundance of Sutterellaceae (r = -0.292) and Oscillospiraceae (r = -0.334) was negatively correlated whereas that of Fusobacteriaceae (r = 0.361) and Enterobacteriaceae (r = 0.321) was positively correlated with quercetin concentration. Niacin (r = -0.313), vitamin B6 (r = -0.297), vitamin B12 (r = -0.266), vitamin D (r = -0.301), and ratio of animal protein to total protein (r = -0.27) were also negatively correlated with quercetin concentration. Bacterial abundance was positively or negatively related to intake of food components. This is the first report describing the relationship between fecal quercetin metabolism, human microbiota, and dietary intake in the elderly.
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Some flavonoids, such as quercetin, resveratrol, and catechin, can regulate the gut microbiota in animal models.
“The ability of some flavonoids, such as quercetin, resveratrol, and catechin, to regulate the gut microbiota has been documented in animal models (25–27).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [26]
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- Authors
- Tamura, M., Hoshi, C., Kobori, M., Takahashi, S., Tomita, J., Nishimura, M., & Nishihira, J.
- Affiliations
- National Agriculture and Food Research Organization (JP)
- Technosuruga Laboratory Co., Ltd. (Japan) (JP)
- Hokkaido Information University (JP)
- Corresponding author
- Tamura, Motoi
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-11-27
- Volume
- 12
- Issue
- 11
- Pages
- e0188271
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5703521
- OpenAlex
- W2768546014
- Cited by
- 60
- References
- 34
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 10 · 2023: 8 · 2022: 2 · 2021: 10 · 2020: 5 · 2019: 8 · 2018: 2
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Ministry of Agriculture, Forestry and Fisheries
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- quercetin, gut microbiota, polyphenol metabolism, older adults, dietary intake, Oscillospiraceae, Fusobacteriaceae, Enterobacteriaceae, nicotinic acid, vitamin B6, vitamin B12, vitamin D, interindividual variability, family-level variation
- MeSH terms
- Aged, Aged, 80 and over, Feces, Feeding Behavior, Health, Humans, Male, Quercetin, Surveys and Questionnaires, Body Mass Index, Asian People, Microbiota
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