Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

Etxeberria, U.; Arias, N.; Boqué, N.; Macarulla, M.T.; Portillo, M.P.; Martínez, J.A.; Milagro, F.I.

doi:10.1016/j.jnutbio.2015.01.002

Cited by 446Gut microbiota and healthSirtuins and Resveratrol in MedicineGastrointestinal motility and disorders

Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

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Etxeberria, U., Arias, N., Boqué, N., Macarulla, M.T., Portillo, M.P., Martínez, J.A., Milagro, F.I.·2015·The Journal of Nutritional Biochemistry

DOI 10.1016/j.jnutbio.2015.01.002

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Abstract

Diet-induced obesity is associated to an imbalance in the normal gut microbiota composition. Resveratrol and quercetin, widely known for their health beneficial properties, have low bioavailability, and when they reach the colon, they are targets of the gut microbial ecosystem. Hence, the use of these molecules in obesity might be considered as a potential strategy to modulate intestinal bacterial composition. The purpose of this study was to determine whether trans-resveratrol and quercetin administration could counteract gut microbiota dysbiosis produced by high-fat sucrose diet (HFS) and, in turn, improve gut health. Wistar rats were randomised into four groups fed an HFS diet supplemented or not with trans-resveratrol [15 mg/kg body weight (BW)/day], quercetin (30 mg/kg BW/day) or a combination of both polyphenols at those doses. Administration of both polyphenols together prevented body weight gain and reduced serum insulin levels. Moreover, individual supplementation of trans-resveratrol and quercetin effectively reduced serum insulin levels and insulin resistance. Quercetin supplementation generated a great impact on gut microbiota composition at different taxonomic levels, attenuating Firmicutes/Bacteroidetes ratio and inhibiting the growth of bacterial species previously associated to diet-induced obesity (Erysipelotrichaceae, Bacillus, Eubacterium cylindroides). Overall, the administration of quercetin was found to be effective in lessening HFS-diet-induced gut microbiota dysbiosis. In contrast, trans-resveratrol supplementation alone or in combination with quercetin scarcely modified the profile of gut bacteria but acted at the intestinal level, altering the mRNA expression of tight-junction proteins and inflammation-associated genes.

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Resveratrol consumption can significantly modulate the growth of certain gut microbiota in vivo, including increasing the Bacteroidetes-to-Firmicutes ratio and the growth of Bacteroides, Lactobacillus, and Bifidobacterium.
“Moreover, it has been found that RSV consumption can significantly modulate the growth of certain gut microbiota in vivo, including increasing the Bacteroidetes-to-Firmicutes ratios, and the growth of Bacteroides, Lactobacillus, and Bifidobacterium (18–22).”
From Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota (2016) · cites this paper as [22]

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Role of the gut microbiota in nutrition and health
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Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota
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Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice
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Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice
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Potential interactions among phenolic compounds and probiotics for mutual boosting of their health-promoting properties and food functionalities – A review
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Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota
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Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice
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Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases
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Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?
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Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts
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Dietary polyphenols: Regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases
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Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation
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Authors: Etxeberria, U., Arias, N., Boqué, N., Macarulla, M. T., Portillo, M. P., Martínez, J. A., & Milagro, F. I.
Affiliations: University of the Basque Country (ES)
Technological Center of Nutrition and Health (ES)
Instituto de Salud Carlos III (ES)
Corresponding author: Martínez, J.A.
ORCID: Boqué, N.
Macarulla, M.T.
Portillo, M.P.
Martínez, J.A.
Milagro, F.I.
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2015-06
Volume: 26
Issue: 6
Pages: 651-660
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/j.jnutbio.2015.01.002
OpenAlex: W2143728413
Cited by: 446
References: 92
Citations by year: 2026: 17 · 2025: 30 · 2024: 31 · 2023: 43 · 2022: 49 · 2021: 64 · 2020: 54 · 2019: 53 · 2018: 37 · 2017: 34 · 2016: 26 · 2015: 7
FWCI: 15.06
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
Funders: Ministerio de Economía y Competitividad (AGL2011-27406-ALI)
Instituto de Salud Carlos III (CIBERobn)
Government of the Basque Country (IT-572-13)
University of the Basque Country (UPV/EHU) (ELDUNANOTEK UFI11/32)
Línea Especial about Nutrition, Obesity and Health (University of Navarra LE/97, Spain)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, trans-resveratrol, quercetin, high-fat sucrose diet, diet-induced obesity, dysbiosis, Firmicutes/Bacteroidetes ratio, insulin resistance, serum insulin, polyphenols, tight junction proteins, intestinal inflammation, Erysipelotrichaceae, Bacillus, weight gain
MeSH terms: Bacillota, Firmicutes, Gastrointestinal Microbiome, Resveratrol, Animals, Bacillus, DNA, Bacterial, Fatty Acids, Volatile, Feces, Insulin Resistance, Gas Chromatography-Mass Spectrometry, Obesity, Quercetin, Stilbenes, Sucrose, Weight Gain, Rats, Wistar, Dietary Supplements, Bacteroidetes, Gastrointestinal Tract, Rats, Diet, High-Fat

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Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

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