Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation
Open accessAbstract
BACKGROUND: Health in early life is crucial for health later in life. Exposure to air pollution during embryonic and early-life development can result in placental epigenetic modification and foetus reprogramming, which can influence disease susceptibility in later life. Objectives: The aim of this paper was to investigate the placental adaptation in the level of global DNA methylation and differential gene expression in the methylation cycle in new-borns exposed to high fine particulate matter in the foetal stage. STUDY DESIGN: This is a nested case-control study. We enrolled pregnant healthy women attending prenatal care clinics in Tehran, Iran, who were residents of selected polluted and unpolluted regions, before the 14th week of pregnancy. We calculated the regional background levels of particle mass- particles with aerodynamics diameter smaller than 2.5 μm (PM2.5) and 10 μm (PM10)-of two regions of interest. At the time of delivery, placental tissue was taken for gene expression and DNA methylation analyses. We also recorded birth outcomes (the new-born's sex, birth date, birth weight and length, head and chest circumference, gestational age, Apgar score, and level of neonatal care required). RESULTS: As regards PM2.5 and PM10 concentrations in different time windows of pregnancy, there were significantly independent positive correlations between PM10 and PM2.5 in the first trimester of all subjects and placental global DNA methylation levels (p-value = 0.01, p-value = 0.03, respectively). The gene expression analysis showed there was significant correlation between S-adenosylmethionine expression and PM2.5 (p = 0.003) and PM10 levels in the first trimester (p = 0.03). CONCLUSION: Our data showed prenatal exposures to air pollutants in the first trimester could influence placental adaptation by DNA methylation.
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Exposure to PM2.5 during the first trimester was significantly associated with decreased (2.2%) global DNA methylation in placenta tissue.
“In a cohort study, exposure to PM2.5 during the first trimester was significantly associated with decreased (2.2%) global DNA methylation in placenta tissue [178] and was also significantly correlated with gene expression of S-adenosylmethionine (SAM), a key substrate involved in methyl group transfers [184].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [184]
The Results (Table 3; page not available) report a significant positive correlation between first-trimester PM2.5 and placental global DNA methylation (rho = 0.26, p = 0.01), contrary to the claimed decrease. The Discussion also describes the correlation as positive, and the cited results do not report a 2.2% decrease. (LLM, conf=0.90)
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Cites
Child Health, Developmental Plasticity, and Epigenetic Programming
Hochberg, Z., Feil, R., Constância, M., Fraga, M. F., Junien, C., Carel, J., Boileau, P., Bouc, Y. L., Deal, C., Lillycrop, K. A., et al. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0039 · Cited by 631 · see citing works
Hermann, A., Goyal, R., & Jeltsch, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403427200 · Cited by 569 · see citing works
Nelissen, E. C. M., van Montfoort, A. P. A., Dumoulin, J. C. M., & Evers, J. L. H. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq052 · Cited by 385 · see citing works
Particulate Air Pollution and Fetal Health
Glinianaia, S. V., Rankin, J. M., Bell, R., Pless‐Mulloli, T., & Howel, D. (2004) · Epidemiology · doi:10.1097/01.ede.0000101023.41844.ac · Cited by 371 · see citing works
A review of the literature on the effects of ambient air pollution on fetal growth
Maisonet, M., Correa, A., Misra, D. P., & Jaakkola, J. J. K. (2004) · Environmental Research · doi:10.1016/j.envres.2004.01.001 · Cited by 329 · see citing works
Update of WHO air quality guidelines
Krzyżanowski, M., & Cohen, A. (2008) · Air Quality Atmosphere & Health · doi:10.1007/s11869-008-0008-9 · Cited by 308 · see citing works
Imprinted Genes, Placental Development and Fetal Growth
Fowden, A. L., Sibley, C. P., Reik, W., & Constância, M. (2006) · Hormone Research in Paediatrics · doi:10.1159/000091506 · Cited by 273 · see citing works
Particulate Urban Air Pollution Affects the Functional Morphology of Mouse Placenta1
Veras, M. M., Damaceno-Rodrigues, N. R., Caldini, E. G., Ribeiro, A. A. C. M., Mayhew, T. M., Saldiva, P. H. N., & Dolhnikoff, M. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.069591 · Cited by 243 · see citing works
Sandovici, I., Hoelle, K., Angiolini, E., & Constância, M. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.03.017 · Cited by 224 · see citing works
Acute Effects of Summer Air Pollution on Respiratory Symptom Reporting in Children
Schwartz, J. E., Dockery, D. W., Neas, L., Wypij, D., Ware, J. H., Spengler, J. D., Koutrakis, P., Speizer, F. E., & Ferris, B. G. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.5.7952546 · Cited by 223 · see citing works
Wilhelm-Benartzi, C. S., Houseman, E. A., Maccani, M. A., Poage, G. M., Koestler, D. C., Langevin, S. M., Gagne, L. A., Banister, C. E., Padbury, J. F., & Marsit, C. J. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1103927 · Cited by 190 · see citing works
DNA methylation in the human placenta and fetal growth (Review)
Koukoura, O., Sifakis, S., & Spandidos, D. A. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.763 · Cited by 185 · see citing works
Ballester, F., Estarlich, M., Íñiguez, C., Llop, S., Ramón, R., Esplugues, A., Lacasaña, M., & Rebagliato, M. (2010) · Environmental Health · doi:10.1186/1476-069x-9-6 · Cited by 179 · see citing works
Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas
Banister, C. E., Koestler, D. C., Maccani, M. A., Padbury, J. F., Houseman, E. A., & Marsit, C. J. (2011) · Epigenetics · doi:10.4161/epi.6.7.16079 · Cited by 144 · see citing works
Imprinted genes and the epigenetic regulation of placental phenotype
Fowden, A. L., Coan, P. M., Angiolini, E., Burton, G. J., & Constancia, M. (2011) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2010.11.005 · Cited by 142 · see citing works
Saenen, N. D., Plusquin, M., Bijnens, E. M., Janssen, B. G., Gyselaers, W., Cox, B., Fierens, F., Molenberghs, G., Penders, J., Vrijens, K., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408549 · Cited by 129 · see citing works
Cai, J., Zhao, Y., Liu, P., Xia, B., Zhu, Q., Wang, X., Song, Q., Kan, H., & Zhang, Y. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.029 · Cited by 119 · see citing works
Saenen, N. D., Vrijens, K., Janssen, B. G., Roels, H. A., Neven, K. Y., Vanden Berghe, W., Gyselaers, W., Vanpoucke, C., Lefebvre, W., De Boever, P., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp38 · Cited by 104 · see citing works
Global DNA methylation as a possible biomarker for diabetic retinopathy
Maghbooli, Z., Hossein‐Nezhad, A., Larijani, B. A., Amini, M., & Keshtkar, A. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2584 · Cited by 97 · see citing works
Self-citationGenome-wide analysis of DNA methylation in bovine placentas
Su, J., Wang, Y., Xing, X., Liu, J., & Zhang, Y. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-12 · Cited by 92 · see citing works
Maternal residential proximity to major roadways, birth weight, and placental DNA methylation
Kingsley, S. L., Eliot, M. N., Whitsel, E. A., Huang, Y.-T., Kelsey, K. T., Marsit, C. J., & Wellenius, G. A. (2016) · Environment International · doi:10.1016/j.envint.2016.03.020 · Cited by 88 · see citing works
Technical Challenges of Multipollutant Air Quality Management
Hidy, G. M., Scheffe, R. D., Pennell, W. T., Molina, L. T., Demerjian, K. L., & Brook, J. R. (2011) · Springer eBooks · doi:10.1007/978-94-007-0304-9 · Cited by 62 · see citing works
Keravnou, A., Ioannides, M., Tsangaras, K., Loizides, C., Hadjidaniel, M. D., Papageorgiou, E. A., Kyriakou, S., Antoniou, P., Mina, P., Achilleos, A., et al. (2016) · Genetics Research · doi:10.1017/s0016672316000136 · Cited by 17 · see citing works
Maghbooli, Z., Hossein‐Nezhad, A., Ramezani, M., & Moattari, S. (2017) · JMIR Research Protocols · doi:10.2196/resprot.7114 · Cited by 12 · see citing works
Self-citationHalek, F. S., & Kavousi, A. (2014) · The international archives of the photogrammetry, remote sensing and spatial information sciences/International archives of the photogrammetry, remote sensing and spatial information sciences · doi:10.5194/isprsarchives-xl-2-w3-141-2014 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Air pollution and DNA methylation: effects of exposure in humans
Rider, C. F., & Carlsten, C. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0713-2 · Cited by 368 · see citing works
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
“2%) global DNA methylation in placenta tissue [178] and was also significantly correlated with gene expression of S-adenosylmethionine (SAM), a key substrate involved in methyl group transfers [184].”
BackgroundSaenen, N. D., Martens, D. S., Neven, K. Y., Alfano, R., Bové, H., Janssen, B. G., Roels, H. A., Plusquin, M., Vrijens, K., & Nawrot, T. S. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0688-z · Cited by 267 · see citing works
Prenatal epigenetics diets play protective roles against environmental pollution
Li, S.-Z., Chen, M., Li, Y.-Y., & Tollefsbol, T. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0659-4 · Cited by 103 · see citing works
Rahman, M. M., Shu, Y., Chow, T., Lurmann, F., Yu, X., Martinez, M. P., Carter, S., Eckel, S. P., Chen, J., Chen, Z., et al. (2022) · Environmental Health Perspectives · doi:10.1289/ehp9509 · Cited by 116 · see citing works
Outdoor Air Pollution and Childhood Respiratory Disease: The Role of Oxidative Stress
Dondi, A., Carbone, C., Manieri, E., Zama, D., Bono, C. D., Betti, L., Biagi, C., & Lanari, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054345 · Cited by 125 · see citing works
Isaevska, E., Moccia, C., Asta, F., Cibella, F., Gagliardi, L., Ronfani, L., Rusconi, F., Stazi, M. A., & Richiardi, L. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110504 · Cited by 99 · see citing works
Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism
Soda, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103106 · Cited by 91 · see citing works
Mukherjee, S., Dasgupta, S., Mishra, P. K., & Chaudhury, K. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16056-x · Cited by 92 · see citing works
Familari, M., Nääv, Å., Erlandsson, L., de Iongh, R. U., Isaxon, C., Strandberg, B., Lundh, T., Hansson, S. R., & Malmqvist, E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218799 · Cited by 89 · see citing works
Yuan, L., Zhang, Y., Wang, W., Chen, R., Liu, Y., Liu, C., Kan, H., Gao, Y., & Tian, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124904 · Cited by 89 · see citing works
Ghazi, T., Naidoo, P., Naidoo, R. N., & Chuturgoon, A. A. (2021) · Cells · doi:10.3390/cells10113025 · Cited by 89 · see citing works
Shi, X., Zheng, Y., Cui, H., Zhang, Y., & Jiang, M. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113893 · Cited by 87 · see citing works
Al-Rifai, R. H., Abdo, N. M., Paulo, M. S., Saha, S., & Ahmed, L. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668447 · Cited by 78 · see citing works
The Impact of Air Pollution on Our Epigenome: How Far Is the Evidence? (A Systematic Review)
Alfano, R., Herceg, Z., Nawrot, T. S., Chadeau‐Hyam, M., Ghantous, A., & Plusquin, M. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0218-8 · Cited by 76 · see citing works
Findley, A. S., Monziani, A., Richards, A. L., Rhodes, K., Ward, M. C., Kalita, C. A., Alazizi, A., Pazokitoroudi, A., Sankararaman, S., Wen, X., et al. (2021) · eLife · doi:10.7554/elife.67077 · Cited by 66 · see citing works
Liang, W., Zhu, H., Xu, J., Zhao, Z., Zhou, L., Zhu, Q. N., Cai, J., & Ji, L. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114802 · Cited by 64 · see citing works
Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health
Covarrubias, D. G., Ramírez‐Díaz, I., Guzmán-Linares, J., Limón, I. D., Manuel-Sánchez, D. M., Molina-Herrera, A., Coral-García, M. Á., Anastasio, E., Anaya‐Hernández, A., López‐Salazar, P., et al. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2023.1306600 · Cited by 62 · see citing works
Environment factors, DNA methylation, and cancer
Liu, J., Huang, B., Ding, F., & Li, Y. (2023) · Environmental Geochemistry and Health · doi:10.1007/s10653-023-01749-8 · Cited by 55 · see citing works
Vlahos, A., Mansell, T., Saffery, R., & Novakovic, B. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008236 · Cited by 52 · see citing works
Estimation of stillbirths attributable to ambient fine particles in 137 countries
Xue, T., Tong, M., Li, J., Wang, R., Guan, T., Li, J., Li, P., Liu, H., Lu, H. S., Li, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34250-4 · Cited by 53 · see citing works
Hu, J., & Yu, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.03.096 · Cited by 49 · see citing works
Rosa, M. J., Hair, G. M., Just, A. C., Kloog, I., Svensson, K., Pizano-Zárate, M. L., Pantic, I., Schnaas, L., Tamayo‐Ortiz, M., Baccarelli, A., et al. (2019) · Environmental Research · doi:10.1016/j.envres.2019.109073 · Cited by 48 · see citing works
Yang, S., Lee, S., Lee, S., Kim, H., Kim, H., Kim, J., Lim, H., Park, M. J., Cho, H., Yoon, J., et al. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.09.008 · Cited by 47 · see citing works
Effect of PM2.5 on macrosomia in China: A nationwide prospective cohort study
Chen, S., Wang, S., Li, T., Zhu, H., Liang, S., Xu, K., Zhang, Y., Yuan, X., Yang, Y., Pan, H., et al. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12584 · Cited by 46 · see citing works
Maternal exposure to PM2.5 was linked to elevated risk of stillbirth
Xie, G., Sun, L., Yang, W., Wang, R., Shang, L., Yang, L., Qi, C., Xin, J., Yue, J., & Chung, M. C. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.131169 · Cited by 46 · see citing works
Select Early-Life Environmental Exposures and DNA Methylation in the Placenta
Mortillo, M., & Marsit, C. J. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00385-1 · Cited by 41 · see citing works
Syama, K. P., Blais, E., & Kumarathasan, P. (2025) · Science of The Total Environment · doi:10.1016/j.scitotenv.2025.178999 · Cited by 39 · see citing works
Seo, M., & Anderson, G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191105102545 · Cited by 38 · see citing works
Prenatal exposure to particulate matter and placental gene expression
Enquobahrie, D. A., MacDonald, J. W., Hussey, M. R., Bammler, T. K., Loftus, C. T., Paquette, A. G., Byington, N., Marsit, C. J., Szpiro, A. A., Kaufman, J. D., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107310 · Cited by 36 · see citing works
Ni, Y., Szpiro, A. A., Young, M. T., Loftus, C. T., Bush, N. R., LeWinn, K. Z., Sathyanarayana, S., Enquobahrie, D. A., Davis, R. L., Kratz, M., et al. (2021) · Environmental Health Perspectives · doi:10.1289/ehp7486 · Cited by 36 · see citing works
Deyssenroth, M. A., Rosa, M. J., Eliot, M., Kelsey, K. T., Kloog, I., Schwartz, J. D., Wellenius, G. A., Peng, S., Hao, K., Marsit, C. J., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111342 · Cited by 36 · see citing works
Chen, C., Zhu, Y., Liu, C., Chen, R., Yan, Y., Ren, Y., Li, X., Wang, J., Ge, W., Kan, H., et al. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117629 · Cited by 36 · see citing works
Epigenetics as a Biomarker for Early-Life Environmental Exposure
Schrott, R., Song, A., & Ladd‐Acosta, C. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00373-5 · Cited by 36 · see citing works
Exposure to particulate matter, prenatal depressive symptoms and HPA axis dysregulation
Ahlers, N. E., & Weiss, S. J. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07166 · Cited by 32 · see citing works
Kang, J., Liao, J., Xu, S., Xia, W., Li, Y., Chen, S., & Lü, B. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110673 · Cited by 32 · see citing works
Honkova, K., Rössnerová, A., Chvojkova, I., Milcová, A., Margaryan, H., Pastorková, A., Ambrož, A., Rössner, P., Jiřík, V., Rubeš, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031666 · Cited by 30 · see citing works
Ren, Y., Yao, X., Liu, Y., Liu, S., Li, X., Huang, Q., Liu, F., Li, N., Lu, Y., Yuan, Z., et al. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3715-2 · Cited by 30 · see citing works
Zanini, M. J., Domínguez, C., Fernández-Oliva, T., Sánchez, O., Toda, M. T., Foraster, M., Dadvand, P., & Llurba, E. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01088-4 · Cited by 29 · see citing works
Irizar, H., Chun, Y., Hsu, H. L., Li, Y., Zhang, L., Arditi, Z., Grishina, G. T., Grishin, A. V., Vicencio, A. G., Pandey, G. S., et al. (2024) · Allergy · doi:10.1111/all.16174 · Cited by 28 · see citing works
Zhang, H., & Zhao, Y. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11143-x · Cited by 28 · see citing works
Zhou, Y., Zhu, Q., Wang, P., Li, J., Luo, R., Zhao, W., Zhang, L., Shi, H., & Zhang, Y. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119481 · Cited by 27 · see citing works
Zheng, Y., Bian, J., Hart, J. E., Laden, F., Wen, T. S.-T., Zhao, J., Qin, H., & Hu, H. Z. (2022) · Atmospheric Environment · doi:10.1016/j.atmosenv.2022.119409 · Cited by 23 · see citing works
Seasonal Variation of Chronic Villitis of Unknown Etiology
Freedman, A. A., Goldstein, J. A., Miller, G. E., Borders, A. E. B., Keenan‐Devlin, L. S., & Ernst, L. M. (2019) · Pediatric and Developmental Pathology · doi:10.1177/1093526619892353 · Cited by 20 · see citing works
Wang, Y., Hu, C., Fang, T., Jin, Y., & Wu, R. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4983 · Cited by 20 · see citing works
Nutrition paves the way to environmental toxicants and influences fetal development during pregnancy
Meyyazhagan, A., Bhotla, H. K., Tsibizova, V. I., Pappuswamy, M., Chaudhary, A., Arumugam, V. A., Qasem, M. A., & Renzo, G. C. D. (2023) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2023.102351 · Cited by 22 · see citing works
Zordão, O. P., Campolim, C. M., Yariwake, V. Y., Castro, G., Ferreira, C. K. D. O., Santos, A., Norberto, S., Veras, M. M., Saad, M. J. A., Saldiva, P. H. N., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1069243 · Cited by 19 · see citing works
PM10 Alters Trophoblast Cell Function and Modulates miR‐125b‐5p Expression
Chaiwangyen, W., Pintha, K., Tantipaiboonwong, P., Nuntaboon, P., Khantamat, O., & de Sousa, F. L. P. (2022) · BioMed Research International · doi:10.1155/2022/3697944 · Cited by 18 · see citing works
Li, Z., Fu, J., Zhou, L., Tang, Y., Hua, Q., Liu, L., & Zhao, J. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113266 · Cited by 17 · see citing works
Tong, M., Li, P., Wang, M., Sun, Y., Han, Y., Liu, H., Li, J., Li, J., Wu, F., Guan, T., et al. (2022) · International Journal of Epidemiology · doi:10.1093/ije/dyac103 · Cited by 16 · see citing works
Kao, C.-C., Chen, C., Avelino, J. L., Cortez, M.-S. P., Tayo, L. L., Lin, Y., Tsai, M.-H., Lin, C.-W., Hsu, Y.-C., Hsieh, L., et al. (2019) · Aerosol and Air Quality Research · doi:10.4209/aaqr.2019.10.0550 · Cited by 16 · see citing works
Nazzari, S., Cagliero, L., Grumi, S., Pisoni, E., Mallucci, G., Bergamaschi, R. C., Maccarini, J., Giorda, R., & Provenzi, L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02206-9 · Cited by 17 · see citing works
Zeng, Z., Xu, X., Wang, Q., Zhang, Z., Meng, P., & Huo, X. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119665 · Cited by 15 · see citing works
Starling, A. P., Wood, C., Liu, C., Kechris, K. J., Yang, I. V., Friedman, C., Thomas, D. S. K., Peel, J. L., Adgate, J. L., Magzamen, S. L., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113881 · Cited by 15 · see citing works
Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality
Scieszka, D. P., Bolt, A. M., McCormick, M. A., Brigman, J. L., & Campen, M. J. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1267667 · Cited by 13 · see citing works
Srividhya, D., Korlimarla, A., Ravikumar, G., Snijesh, V. P., Kaku, S. M., & Visweswariah, A. M. (2022) · Birth Defects Research · doi:10.1002/bdr2.2119 · Cited by 13 · see citing works
Tsamou, M., Nawrot, T. S., Carollo, R. M., Trippas, A.-J., Lefebvre, W., Vanpoucke, C., & Vrijens, K. (2020) · Environment International · doi:10.1016/j.envint.2020.105860 · Cited by 13 · see citing works
Kim, S., Yang, S., Lim, H., Lee, S., Park, M. J., Song, K., Choi, E. J., Oh, H. Y., Kim, H., Shin, Y., et al. (2021) · Clinical and Translational Allergy · doi:10.1002/clt2.12070 · Cited by 13 · see citing works
Li, G., Hu, W., Lu, H., Liu, J., Li, X., He, J., Zhu, J., Zhao, H., Hao, J., & Huang, F. (2023) · Pediatric Obesity · doi:10.1111/ijpo.13004 · Cited by 11 · see citing works
Lupus, DNA Methylation, and Air Pollution: A Malicious Triad
Rasking, L., Roelens, C., Sprangers, B., Thienpont, B., Nawrot, T. S., & Vusser, K. D. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192215050 · Cited by 11 · see citing works
Bellizzi, D., Guarasci, F., Iannone, F., Passarino, G., & Rose, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_7 · Cited by 10 · see citing works
Impact assessment of particulate pollution on maternal mortality in Nigeria
Emetere, M. E., & Oladimeji, T. E. (2022) · Scientific Reports · doi:10.1038/s41598-022-19518-5 · Cited by 9 · see citing works
Fine particulate matter‑induced cardiac developmental toxicity (Review)
Meng, X., Du, W., & Sun, Z. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12756 · Cited by 10 · see citing works
Kim, H., Lee, S. H., Yang, D. Y., Lee, S., Kim, J., Kim, H., Choi, K., Lee, S., Yang, S., Suh, D. I., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125471 · Cited by 9 · see citing works
Consequences of the exposome to gestational diabetes mellitus
Rudge, M. V. C., Alves, F. C. B., Hallur, R. L. S., de Oliveira, R. G., Vega, S., Reyes, D. R. A., Floriano, J. F., Prudêncio, C. B., Garcia, G. A., Reis, F. V. D. S., et al. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130282 · Cited by 9 · see citing works
Early-life exposure to residential black carbon and childhood cardiometabolic health
Friedman, C., Dabelea, D., Glueck, D. H., Allshouse, W. B., Adgate, J. L., Keller, K. P., Martenies, S. E., Magzamen, S. L., & Starling, A. P. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117285 · Cited by 9 · see citing works
Kumar, S. H., Acharyya, S., Chouksey, A., Soni, N., Nazeer, N., & Mishra, P. K. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108675 · Cited by 9 · see citing works
GPR61 methylation in cord blood: a potential target of prenatal exposure to air pollutants
Feng, F., Huang, L., Zhou, G., Wang, J., Zhang, R. Q., Li, Z., Zhang, Y., & Ba, Y. (2020) · International Journal of Environmental Health Research · doi:10.1080/09603123.2020.1773414 · Cited by 8 · see citing works
Health impact assessment of air pollution in Lisbon, Portugal
Abe, K. C., Rodrigues, M. A., & Miraglia, S. G. E. K. (2022) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2022.2118192 · Cited by 8 · see citing works
Epigenetic reprogramming by air pollution: linking prenatal exposures to birth outcomes
Parikh, G., & Patel, B. M. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05345-5 · Cited by 7 · see citing works
Wan, Z., Zhang, S., Zhuang, G., Liu, W., Qiu, C., Lai, H., & Liu, W. (2024) · European Journal of Public Health · doi:10.1093/eurpub/ckae094 · Cited by 7 · see citing works
Dong, M., Liu, X., Xiao, J., Sun, X., Ye, Y., Feng, B., Zeng, W., Hu, J., Li, X., Guo, L., et al. (2020) · Atmospheric Environment · doi:10.1016/j.atmosenv.2020.117523 · Cited by 7 · see citing works
RUNX1 gene expression changes in the placentas of women smokers
Bermúdez, L. G., Madariaga, I., Zuñiga, M., Olaya, M., Cañas, A., Rodríguez, L., Moreno, O. M., & Rojas, A. P. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10334 · Cited by 7 · see citing works
Ambient PM2.5 exposure and salivary cortisol output during pregnancy in a multi-ethnic urban sample
Cowell, W., Kloog, I., Just, A. C., Coull, B. A., Carroll, K. N., & Wright, R. J. (2022) · Inhalation Toxicology · doi:10.1080/08958378.2022.2051647 · Cited by 7 · see citing works
Ziemendorff, A., Böhm-González, S. T., Meireson, E., Weyers, S., Nawrot, T. S., Bijnens, E. M., & Gielen, M. (2025) · Environmental Research · doi:10.1016/j.envres.2025.120952 · Cited by 6 · see citing works
Zhang, T., Jiang, W., Huang, Y., Wang, C., Cao, J., Qiu, W., Huang, R., Zhang, J., Ye, W., & Zhang, Q. (2025) · BMC Public Health · doi:10.1186/s12889-025-22913-y · Cited by 6 · see citing works
Orenshtein, S., Sheiner, E., Kloog, I., & Wainstock, T. (2023) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2023.101050 · Cited by 6 · see citing works
Jie, X., Wu, H., Yang, M., He, M. L., Zhao, G., Ling, S., Huang, Y., Yue, B., Yang, N., & Zhang, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.995700 · Cited by 6 · see citing works
Xu, R., Zhang, Y., Gao, Y., Jia, S., Choi, S., Xu, Y., & Gong, J. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135018 · Cited by 5 · see citing works
Inhaled ultrafine particles, epigenetics and systemic autoimmune rheumatic diseases
Farhat, S. C. L., Yariwake, V. Y., Veras, M. M., Braga, A. L. F., Sallum, A. M. E., & Silva, C. A. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102640 · Cited by 5 · see citing works
Chen, K., Liu, H., Wang, T., Luo, M., Ruan, X., Sun, M., Li, Z., Wei, J., & Qin, J. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126471 · Cited by 4 · see citing works
Tong, M., Lin, W., Liu, H., Gong, J., Zhang, J. J., & Xue, T. (2023) · Environmental Health · doi:10.1186/s12940-023-01016-4 · Cited by 4 · see citing works
Hou, Y., Yan, W., Li, G., & Sang, N. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165004 · Cited by 3 · see citing works
Zheng, Y., He, D., Cai, X. T., Zhang, X., Zheng, C., & Yao, Y. (2025) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-025-03603-5 · Cited by 3 · see citing works
Morris, R. H., Chabrier, G., Counsell, S. J., McGonnell, I. M., & Thornton, C. (2022) · Developmental Neuroscience · doi:10.1159/000524829 · Cited by 3 · see citing works
Luo, Y., Zhang, Y., Pan, H., & Chen, S. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.735699 · Cited by 3 · see citing works
Tang, W., Xu, W., Pan, Y.-R., Cai, Q., Wen, L., Xu, J., Wang, Y., Li, J.-Z., Liu, T., & Wang, L. (2025) · Journal of Diabetes Research · doi:10.1155/jdr/6633118 · Cited by 2 · see citing works
Impacts of PM 2.5 on stillbirth and the potential mechanism: a narrative review
Li, Z., Liu, R., & Zhang, E. (2025) · Reviews on Environmental Health · doi:10.1515/reveh-2025-0090 · Cited by 2 · see citing works
Itziou, A., Michou, V., Lakioti, E., & Karayannis, V. (2026) · Applied Sciences · doi:10.3390/app16041898 · Cited by 2 · see citing works
Ambient air pollution and human epigenetic modifications
Xu, R., Li, S., Abramson, M. J., & Guo, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820951-6.00010-7 · Cited by 2 · see citing works
Can Breathing Poor-quality Air Lead to Poor-quality Sleep in Children?
Balmes, J. R. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202210-1968ed · Cited by 2 · see citing works
The role of climate change in maternal nutrition and fetal development: a narrative review
Musa, A., Imam, M. U., Ibrahim, K. G., & Kasimu, S. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.02.001 · Cited by 1 · see citing works
Yuan, X., Li, X., Chen, K., Lim, E. L., Wei, Y., Jin, R., Weng, L., Karasaki, T., Luo, H., Qing, L., et al. (2026) · The Innovation · doi:10.1016/j.xinn.2026.101347 · Cited by 1 · see citing works
Early-life air pollution exposure: epigenetics and child allergy
Li, G., Xiao, Y., Wu, Z., Zeng, X., & Liu, J. (2026) · Epigenomics · doi:10.1080/17501911.2026.2671164 · Cited by 1 · see citing works
Airborne contaminant exposure and bone development: a systematic review and meta-analysis
Vera-Colón, M. K. M., Meletz, R. M., Phillipson, C. N., & Sparks, N. R. L. (2026) · Toxicological Sciences · doi:10.1093/toxsci/kfag067 · Cited by 1 · see citing works
Yang, D. Y., Yang, S., Park, Y. J., Lee, S.-H., Kim, H., Lim, S., Herkenrath, M., Song, A.-Y., Kim, J., Kim, H.-B., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76298-6 · Cited by 1 · see citing works
How much innovation is enough? The case of Australian small firms
Gronum, S., & Verreynne, M. (2011) · Swinburne figshare (Swinburne University of Technology) · doi:10.25916/sut.26273014 · Cited by 1 · see citing works
Epigenetics, exposome and development of the intestinal microbiota in the neonate
Benitez, P. S., & y Terrón, R. P. (2020) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2020.13.2.0367 · Cited by 1 · see citing works
Asthma Epigenetics: Elucidating an Expanding Paradigm
Miller, R. L., & Chen, J. (2022) · Springer eBooks · doi:10.1007/978-3-030-94475-9_16 · Cited by 1 · see citing works
- Authors
- Maghbooli, Z., Hossein-nezhad, A., Adabi, E., Asadollah-pour, E., Sadeghi, M., Mohammad-nabi, S., Zakeri Rad, L., Malek Hosseini, A.-A., Radmehr, M., Faghihi, F., Aghaei, A., Omidifar, A., Aghababei, Y., & Behzadi, H.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Milad Hospital (IR)
- Islamic Azad University, Tehran (IR)
- Shahid Beheshti University (IR)
- Corresponding author
- Maghbooli, Zhila
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-07-06
- Volume
- 13
- Issue
- 7
- Pages
- e0199772
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6034814
- OpenAlex
- W2822549645
- Cited by
- 113
- References
- 25
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 9 · 2023: 14 · 2022: 23 · 2021: 17 · 2020: 11 · 2019: 15 · 2018: 3
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/publicdomain/zero/1.0/ (vor)
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- The National Institute for Medical Research Development of Iran (940173)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- air pollution, prenatal exposure, PM2.5, PM10, placental DNA methylation, global DNA methylation, placental adaptation, S-adenosylmethionine, first trimester, epigenetic reprogramming, birth outcomes, neonatal outcomes
- MeSH terms
- Acclimatization, Adult, Air Pollution, Birth Weight, Female, Humans, Infant, Newborn, Iran, Placenta, Pregnancy, Cohort Studies, Biomarkers, Case-Control Studies, Maternal Exposure, DNA Methylation, Epigenesis, Genetic, Particulate Matter
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