Impact of treatment with direct-acting antivirals on anxiety and depression in chronic hepatitis C
Open accessAbstract
BACKGROUND AND AIM: Treatment of hepatitis C with direct-acting antiviral agents (DAA) has few side effects. Although pivotal studies suggested that DAA were safe in patients with psychiatric diseases who could not be treated with previous antiviral therapies, their effects on anxiety and depression have not yet been analysed in clinical practice. The aim of our study was to analyse anxiety and depression in the setting of DAA treatment in a clinical practice series. METHODS: All patients starting DAA treatment between November 1, 2014 and October 31, 2015 were eligible. Patients completed the Hospital Anxiety and Depression scale at different times during treatment. The results were plotted on line graphs and evaluated using a linear regression model with repeated measures. RESULTS: One hundred and forty-five patients were included (11% with major psychiatric disorders; 32% on psychiatric treatment). Sustained virologic response (SVR) was achieved in 97.3% of cases. Anxiety and depression measures did not differ between time points. No differences between patients on psychiatric treatment or with advanced fibrosis or cirrhosis were found at any time point analysed. CONCLUSION: DAA treatment had no impact on anxiety or depression during or after chronic hepatitis C infection treatment, even in high-risk patients with major psychiatric disorders.
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Gallach and colleagues showed the prevalence of self-reported baseline depression was 13.1%.
“Gallach and colleagues showed that the prevalence of self-reported baseline DEP and ANX was 13.1% and 8.3%, respectively.”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [21]
Research suggests that direct-acting antiviral agents do not seem to be associated with treatment-induced depression or anxiety in patients with hepatitis C virus.
“However, when comparing the prevalence rates of DEP and ANX between INF and direct-acting antiviral agents in patients with HCV, research suggests that direct-acting antiviral agents do not seem to be associated with treatment-inducted DEP or ANX.[21]”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [21]
Gallach and colleagues showed the prevalence of self-reported baseline anxiety was 8.3%.
“Gallach and colleagues showed that the prevalence of self-reported baseline DEP and ANX was 13.1% and 8.3%, respectively.”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [21]
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- Authors
- Gallach, M., Vergara, M., da Costa, J. P., Miquel, M., Casas, M., Sanchez-Delgado, J., Dalmau, B., Rudi, N., Parra, I., Monllor, T., Sanchez-Lloansí, M., Dosal, A., Valero, O., & Calvet, X.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Gallach, Marta
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-12-19
- Volume
- 13
- Issue
- 12
- Pages
- e0208112
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6300319
- OpenAlex
- W2904274952
- Cited by
- 32
- References
- 44
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 2 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 3
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-10-26)
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- direct-acting antivirals, chronic hepatitis C, anxiety, depression, psychiatric comorbidity, psychiatric treatment, sustained virological response, treatment safety, advanced fibrosis, liver cirrhosis
- MeSH terms
- Sustained Virologic Response, Patient Health Questionnaire, Aged, Antiviral Agents, Anxiety, Mental Disorders, Depression, Female, Humans, Male, Middle Aged, Prospective Studies, Comorbidity, Hepacivirus, Hepatitis C, Chronic
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