Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement

Schaefer, Martin; Capuron, Lucile; Friebe, Astrid; Diez-Quevedo, Crisanto; Robaeys, Geert; Neri, Sergio; Foster, Graham R.; Kautz, Achim; Forton, Daniel; Pariante, Carmine M.

doi:10.1016/j.jhep.2012.07.037

Cited by 225Hepatitis C virus researchTryptophan and brain disordersCOVID-19 and Mental Health

Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement

Schaefer, Martin, Capuron, Lucile, Friebe, Astrid, Diez-Quevedo, Crisanto, Robaeys, Geert, Neri, Sergio, Foster, Graham R., Kautz, Achim +2 more·2012·Journal of Hepatology

DOI 10.1016/j.jhep.2012.07.037

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Abstract

Mental health problems frequently occur in chronic infection with the hepatitis C virus (HCV) and during antiviral treatment with pegylated interferon-alpha (PegIFNα) and ribavirin. Depression is one of the most important complications during antiviral treatment of chronic hepatitis C infection. However, an increased prevalence of depression, fatigue, and cognitive disturbances has also been reported in untreated HCV-positive patients. Patients with psychiatric disorders or drug addiction also have an increased risk of HCV infection. Furthermore, because of possible drug-drug interactions, new antivirals administered together with PegIFNα and ribavirin may complicate psychiatric side effect management, even if no specific psychiatric adverse events are known so far for these new drugs. The European liver patient's organization (ELPA) organised a European expert conference to review the literature and develop expert recommendations for the management of mental health problems in HCV infected patients. This paper results from the output of the 2011 EASL meeting and subsequent dialogue with patient groups and relevant experts in Europe. It summarises the current knowledge of HCV infection and the brain; prevalence, course, and neurobiology of IFN-α associated psychiatric side effects; possible risk factors for IFN-α associated depression and suicide attempts; psychiatric management of HCV infected patients before and during antiviral treatment; prevention of IFN- α associated psychiatric side effects; and psychiatric aspects of the new antivirals. The summarised current knowledge about mental health changes before and during antiviral treatment should improve interdisciplinary management of HCV infected patients.

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Historical data have shown that interferon-based antiviral therapy for patients with hepatitis C virus is frequently associated with treatment-induced depression and anxiety.
“Historical data have shown that interferon (INF)based antiviral therapy for patients with HCV is frequently associated with treatment-induced DEP and ANX.[22]”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [22]
Schaefer and colleagues reported the prevalence of depression during interferon treatment to be 30%-70% based on 10 studies, though prevalence rates varied by type of screening instrument.
“Schaefer and colleagues reported the prevalence of DEP during INF treatment to be 30%-70% based on 10 studies, though prevalence rates varied by type of screening instrument.”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [22]
Major depressive disorder developed in 15%-45% of patients treated with interferon, as assessed by diagnostic interview.
“For example, it was estimated that MDD developed in 15%-45% of patients treated with INF, [22] as assessed by diagnostic interview.”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [22]

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Kraus, M. R., Schäfer, A., Schöttker, K., Keicher, C., Weißbrich, B., Hofbauer, I., & Scheurlen, M. (2007) · Gut · doi:10.1136/gut.2007.131607 · Cited by 118 · see citing works
Interferon gama induced Tryptophan Degradation Neuropsychiatric and Immunological Consequences
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Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy
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Cerebral immune activation in chronic hepatitis C infection: A magnetic resonance spectroscopy study
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Treatment of chronic hepatitis C in patients with drug dependence: time to change the rules?
Schaefer, M., Heinz, A., & Backmund, M. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00821.x · Cited by 107 · see citing works
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Activation of brain macrophages/microglia cells in hepatitis C infection
Wilkinson, J., Radkowski, M., Eschbacher, J. M., & Laskus, T. (2010) · Gut · doi:10.1136/gut.2009.199356 · Cited by 107 · see citing works
Suicidal ideation during interferon-α2b and ribavirin treatment of patients with chronic hepatitis C
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Addressing Tri‐Morbidity (Hepatitis C, Psychiatric Disorders, and Substance Use): The Importance of Routine Mental Health Screening as a Component of a Comanagement Model of Care
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Effect of single intracerebroventricular injection of α-interferon on monoamine concentrations in the rat brain
Kamata, M. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)00067-x · Cited by 105 · see citing works
Morbidity of Chronic Hepatitis C as Seen in a Tertiary Care Medical Center
Lee, D. H., Jamal, H., Regenstein, F., & Perrillo, R. P. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018818012378 · Cited by 104 · see citing works
Serotonin-1A Receptor Gene HTR1A Variation Predicts Interferon-Induced Depression in Chronic Hepatitis C
Kraus, M. R., Al‐Taie, O., Schäfer, A., Pfersdorff, M., Lesch, K., & Scheurlen, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.053 · Cited by 104 · see citing works
Health-Related Quality of Life and Depression in Patients with Chronic Hepatitis C
Gallegos-Orozco, J. F., Fuentes, A. P., Argueta, J. G., Pérez-Pruna, C., Hinojosa, C. A., Sixtos-Alonso, M. S., Cruz-Castellanos, S., Gutiérrez‐Reyes, G., Olivera-Martinez, M. A., Gutiérrez‐Ruíz, M. C., et al. (2003) · Archives of Medical Research · doi:10.1016/s0188-4409(03)00003-1 · Cited by 102 · see citing works
Co‐morbid medical and psychiatric illness and substance abuse in HCV‐infected and uninfected veterans
Butt, A. A., Khan, U. A., McGinnis, K. A., Skanderson, M., & Kwoh, C. K. (2007) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2007.00885.x · Cited by 102 · see citing works
Impact of treatment on extra hepatic manifestations in patients with chronic hepatitis C
Cacoub, P., Ratziu, V., Myers, R. P., Ghillani‐Dalbin, P., Piette, J. C., Moussalli, J., & Poynard, T. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00067-3 · Cited by 101 · see citing works
Effect of ondansetron, a 5-HT 3 receptor antagonist, on fatigue in chronic hepatitis C: a randomised, double blind, placebo controlled study
Piche, T., Vanbiervliet, G., Cherikh, F., Antoun, Z., Huet, P., Gelsi, E., Demarquay, J.-F., Caroli‐Bosc, F., Benzaken, S., Rigault, M.-C., et al. (2005) · Gut · doi:10.1136/gut.2004.055251 · Cited by 101 · see citing works
Evaluation of depression as a risk factor for treatment failure in chronic hepatitis C†
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Prophylactic SSRI during interferon alpha re‐therapy in patients with chronic hepatitis C and a history of interferon‐induced depression
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A randomized trial of paroxetine to prevent interferon-α-induced depression in patients with hepatitis C
Morasco, B. J., Rifai, M. A., Loftis, J. M., Indest, D. W., Moles, J. K., & Hauser, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.007 · Cited by 96 · see citing works
Association of chronic hepatitis C with major depressive disorders: irrespective of interferon-alpha therapy
Carta, M. G., Hardoy, M., Garofalo, A., Pisano, E., Nonnoi, V., Intilla, G., Serra, G., Balestrieri, C., Chessa, L., Cauli, C., et al. (2007) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-3-22 · Cited by 91 · see citing works
Molecular and Bioinformatic Evidence of Hepatitis C Virus Evolution in Brain
Fishman, S. L., Murray, J., Eng, F. J., Walewski, J. L., Morgello, S., & Branch, A. D. (2008) · The Journal of Infectious Diseases · doi:10.1086/526519 · Cited by 89 · see citing works
Development and reliability of the HAM-D/MADRS Interview: An integrated depression symptom rating scale
Iannuzzo, R. W., Jaeger, J., Goldberg, J. F., Kafantaris, V., & Sublette, M. E. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.10.009 · Cited by 88 · see citing works
Hepatitis C, alpha interferon, anxiety and depression disorders: A prospective study of 71 patients
Gohier, B., Goëb, J.-L., Rannou-Dubas, K., Fouchard, I., Calès, P., & Garré, J.-B. (2003) · The World Journal of Biological Psychiatry · doi:10.1080/15622970310029904 · Cited by 87 · see citing works
Psychiatric and Substance Use Disorders in Individuals with Hepatitis C: Epidemiology and Management
Loftis, J. M., Matthews, A. M., & Hauser, P. (2006) · Drugs · doi:10.2165/00003495-200666020-00003 · Cited by 86 · see citing works
Psychopharmacological Treatment of Depression, Anxiety, Irritability and Insomnia in Patients Receiving Interferon-α: a Prospective Case Series and a Discussion of Biological Mechanisms
Maddock, C., Baita, A., Orrù, M. G., Sitzia, R., Costa, A., Muntoni, E., Farci, M. G., Carpiniello, B., & Pariante, C. M. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104040230 · Cited by 85 · see citing works
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Psychiatric symptoms related to interferon therapy for chronic hepatitis C: Clinical features and prognosis
Hosoda, S., Takimura, H., Shibayama, M., Kanamura, H., Ikeda, K., & Kumada, H. (2000) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2000.00754.x · Cited by 85 · see citing works
Baseline Immune Activation as a Risk Factor for the Onset of Depression During Interferon-Alpha Treatment
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Prevalence of Hepatitis C Among Psychiatric Patients in the Public Sector
Dinwiddie, S. H., Shicker, L., & Newman, T. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.172 · Cited by 83 · see citing works
Depression, anxiety, post-traumatic stress, and alcohol-related problems among veterans with chronic hepatitis C
Lehman, C. L., & Cheung, R. C. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.06042.x · Cited by 81 · see citing works
Hepatitis C and depression
Yates, W. R., & Gleason, O. C. (1998) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1998)7:4 · Cited by 81 · see citing works
Suicide risk in hepatitis C and during interferon-alpha therapy: a review and clinical update
Sockalingam, S., Links, P. S., & Abbey, S. E. (2010) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2010.01393.x · Cited by 79 · see citing works
De novo depression and anxiety disorders and influence on adherence during peginterferon‐alpha‐2a and ribavirin treatment in patients with hepatitis C
Martín‐Santos, R., Díez, C., Castellví, P., Navinés, R., Miquel, M., Masnou, H., Soler, A., Ardévol, M., GARCÍA, F., Galeras, J. A., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03568.x · Cited by 79 · see citing works
Spectrum of Disease in U.S. Veteran Patients With Hepatitis C
Nguyen, H. A., Miller, A. I., Dieperink, E. W., Willenbring, M. L., Tetrick, L. L., Durfee, J. M., Ewing, S. L., & Ho, S. B. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05800.x · Cited by 72 · see citing works
Escitalopram for the Prevention of Peginterferon-α2a–Associated Depression in Hepatitis C Virus–Infected Patients Without Previous Psychiatric Disease
Schaefer, M., Sarkar, R., Knop, V., Effenberger, S., Friebe, A., Heinze, L., Spengler, U., Schlaepfer, T. E., Reimer, J., Buggisch, P., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-2-201207170-00006 · Cited by 68 · see citing works
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Comparing the safety, tolerability and quality of life in patients with chronic hepatitis B vs chronic hepatitis C treated with peginterferon alpha‐2a
Marcellin, P., Lau, G. K. K., Zeuzem, S., Heathcote, E. J., Pockros, P. J., Reddy, K. R., Piratvisuth, T., Farci, P., Chow, W. C., Jia, J., et al. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01696.x · Cited by 67 · see citing works
Psychiatric side effects of pegylated interferon alfa-2b as compared to conventional interferon alfa-2b in patients with chronic hepatitis C
Kraus, M. R. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i12.1769 · Cited by 65 · see citing works
Prospective Analysis of Depression During Peginterferon and Ribavirin Therapy of Chronic Hepatitis C
Evon, D. M., Ramcharran, D., Belle, S. H., Terrault, N. A., Fontana, R. J., & Fried, M. W. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.528 · Cited by 63 · see citing works
Interferon Alfa–Induced Adverse Effects in Patients with a Psychiatric Diagnosis
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Self-citation
High prevalence and coinfection rate of hepatitis G and C infections in intravenous drug addicts
Diamantis, I. D., Bassetti, S., Erb, P., Ladewig, D., Gyr, K. E., & Battegay, M. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80244-9 · Cited by 58 · see citing works
Prophylactic Antidepressant Treatment in Patients With Hepatitis C on Antiviral Therapy: A Double-Blind, Placebo-Controlled Trial
Morasco, B. J., Loftis, J. M., Indest, D. W., Ruimy, S., Davison, J. W., Felker, B. L., & Hauser, P. (2010) · Psychosomatics · doi:10.1176/appi.psy.51.5.401 · Cited by 53 · see citing works
Methodological approaches in the assessment of interferon‐alfa‐induced depression in patients with chronic hepatitis C – a critical review
Schäfer, A., Wïttchen, H., Seufert, J., & Kraus, M. R. (2007) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.229 · Cited by 53 · see citing works
Investigating health-related quality of life, mood and neuropsychological test performance in a homogeneous cohort of Irish female hepatitis C patients
Lowry, D., Coughlan, B., McCarthy, O., & Crowe, S. F. (2009) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2009.01188.x · Cited by 51 · see citing works
Hepatitis C Treatment in Patients with Drug Addiction: Clinical Management of Interferon-Alpha-Associated Psychiatric Side Effects
Schaefer, M., & Mauss, S. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801020177 · Cited by 46 · see citing works
Self-citation
Prophylactic Treatment With Escitalopram of Pegylated Interferon Alfa-2a–Induced Depression in Hepatitis C
Díez, C., Masnou, H., Planas, R., Castellví, P., Giménez, M. D., Morillas, R. M., Martín‐Santos, R., Navinés, R., Sola, R. L., Giner, P., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05282blu · Cited by 45 · see citing works
The Impact of Chronic Hepatitis C and Comorbid Psychiatric Illnesses on Health-related Quality of Life
Lim, J. K., Cronkite, R. C., Goldstein, M. K., & Cheung, R. C. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200607000-00012 · Cited by 44 · see citing works
Depression Comorbidity and Antidepressant Use in Veterans With Chronic Hepatitis C
Nelligan, J. A., Loftis, J. M., Matthews, A. M., Zucker, B. L., Linke, A., & Hauser, P. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0514 · Cited by 43 · see citing works
Comorbid medical and psychiatric conditions and substance abuse in HCV infected persons on dialysis
Butt, A. A., Evans, R., Skanderson, M., & Shakil, A. O. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.01.024 · Cited by 42 · see citing works
Randomised clinical trial: escitalopram for the prevention of psychiatric adverse events during treatment with peginterferon‐alfa‐2a and ribavirin for chronic hepatitis C
de Knegt, R. J., Bezemer, G., Gool, A. R. V., Drenth, J. P. H., Hansen, B. E., Fortuyn, H. A. D., Weegink, C. J., Hengeveld, M. W., & Janssen, H. L. A. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04867.x · Cited by 42 · see citing works
A Review of Sleep Disturbance in Hepatitis C
Sockalingam, S., Abbey, S. E., Alosaimi, F. D., & Novák, M. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181b314ea · Cited by 41 · see citing works
The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function<sup>1</sup>
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Self-citation
High frequency of unrecognized mental disorders in HCV-infected patients
Batista-Neves, S. C., Quarantini, L. C., Almeida, A. G.-D., Bressan, R. A., Lacerda, A. L. T., de-Oliveira, I. R., Paraná, R., & Miranda‐Scippa, Â. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.08.014 · Cited by 39 · see citing works
Cognitive function does not worsen during pegylated interferon and ribavirin retreatment of chronic hepatitis C
Fontana, R. J., Bieliauskas, L. A., Lindsay, K. L., Back‐Madruga, C., Wright, E. C., Snow, K. K., Lok, A. S. F., Kronfol, Z., & Padmanabhan, L. (2007) · Hepatology · doi:10.1002/hep.21633 · Cited by 38 · see citing works
Immune system activation and fatigue during treadmill running: role of interferon
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A Multidisciplinary Therapeutic Approach for Reducing the Risk of Psychiatric Side Effects in Patients With Chronic Hepatitis C Treated With Pegylated Interferon α and Ribavirin
Neri, S., Bertino, G., Petralia, A., Giancarlo, C., Rizzotto, A., Calvagno, G. S., Mauceri, B., Abate, G., Boemi, P., Di Pino, A., et al. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181d88af5 · Cited by 37 · see citing works
Self-citation
Association Between Apolipoprotein E ɛ4 and Neuropsychiatric Symptoms During Interferon α Treatment for Chronic Hepatitis C
Gochee, P., Powell, E. E., Purdie, D. M., Pandeya, N., Kelemen, L., Shorthouse, C., Jonsson, J. R., & Kelly, B. J. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.1.49 · Cited by 36 · see citing works
IL28B Polymorphism Is Associated with Both Side Effects and Clearance of Hepatitis C During Interferon-Alpha Therapy
Lotrich, F. E., Loftis, J. M., Ferrell, R. E., Rabinovitz, M., & Hauser, P. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0074 · Cited by 35 · see citing works
Depression during Therapy with Interferon α - How Long Should an Antidepressant Treatment Last?
Nickel, T., Sonntag, A., Backmund, M., & Pollmächer, T. (2005) · Pharmacopsychiatry · doi:10.1055/s-2005-837813 · Cited by 34 · see citing works
Preventing Relapse of Major Depression During Interferon-α Therapy for Hepatitis C—A Pilot Study
Gleason, O. C., Fucci, J. C., Yates, W. R., & Philipsen, M. A. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9729-5 · Cited by 34 · see citing works
Outcome of Chronic Hepatitis C Patients who Required Early Termination of Pegylated Interferon-α plus Ribavirin Combination Therapy
Yu, M., Dai, C., Lee, L., Hsieh, M., Hou, N., Huang, J., Lin, Z., Chen, S., Hsieh, M., Wang, L., et al. (2006) · Antiviral Therapy · doi:10.1177/135965350601100814 · Cited by 32 · see citing works
Plasma Levels of Citalopram in Depressed Patients With Hepatitis C
Gleason, O. C., Yates, W. R., Philipsen, M. A., Isbell, M. D., & Pollock, B. G. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.1.29 · Cited by 29 · see citing works
Physician???patient relationship and disclosure behaviour in chronic hepatitis C in a group of German outpatients
fer, A. S., Scheurlen, M., Felten, M., & Kraus, M. R. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200512000-00019 · Cited by 28 · see citing works
Pretreatment Levels of sTNF-R1 and sIL-6R are Associated With a Higher Vulnerability for IFN-α–induced Depressive Symptoms in Patients With Malignant Melanoma
Friebe, A., Schwarz, M., Schmid-Wendtner, M.-H., Volkenandt, M., Schmidt, F., Horn, M., Janssen, G., & Schaefer, M. (2007) · Journal of Immunotherapy · doi:10.1097/01.cji.0000211346.19330.c9 · Cited by 26 · see citing works
Self-citation
Psychosocial Issues and Mental Health Treatment Recommendations for Patients With Hepatitis C
Silberbogen, A. K., Ulloa, E. W., Janke, E. A., & Mori, D. L. (2009) · Psychosomatics · doi:10.1176/appi.psy.50.2.114 · Cited by 25 · see citing works
Factors influencing long‐term changes in mental health after interferon‐alpha treatment of chronic hepatitis C
Schmidt, F., Janssen, G., Martin, G., Lorenz, R., Loeschke, K., Soyka, M., Folwaczny, C., & Schaefer, M. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04123.x · Cited by 24 · see citing works
Self-citation
Chronic intraperitoneal injection of interferon‐α reduces serotonin levels in various regions of rat brain, but does not change levels of serotonin transporter mRNA, nitrite or nitrate
Sato, T., Suzuki, E., Yokoyama, M., Semba, J., Watanabe, S., & Miyaoka, H. (2006) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2006.01538.x · Cited by 24 · see citing works
Major Depressive Disorder in Hepatitis C
Gleason, O. C., Yates, W. R., & Philipsen, M. A. (2005) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v07n0503 · Cited by 20 · see citing works
Bupropion for Treatment of Interferon-Induced Depression
Malek-Ahmadi, P., & Ghandour, E. C. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1d516 · Cited by 20 · see citing works
Modafinil’s Use in Combating Interferon-Induced Fatigue
Martin, K. A., Krahn, L. E., Balan, V., & Rosati, M. J. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9519-0 · Cited by 19 · see citing works
Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks
Robaeys, G. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i43.5736 · Cited by 19 · see citing works
Self-citation
Need-adapted HCV-treatment setting for injection drug users
Reimer, J., & Haasen, C. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60347-0 · Cited by 18 · see citing works
An extremely rare case of delusional parasitosis in a chronic hepatitis C patient during pegylated interferon alpha-2b and ribavirin treatment
Robaeys, G. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i16.2379 · Cited by 18 · see citing works
Self-citation
Hepatitis C, interferon alpha and psychiatric co-morbidity in intravenous drug users (IVDU) : guidelines for clinical practice.
Bie, J. D., Robaeys, G., & Buntinx, F. (2005) · PubMed · Cited by 17 · see citing works
Self-citation
Three Cases of Successful Tryptophan Add-On or Monotherapy of Hepatitis C and IFNα-Associated Mood Disorders
Schaefer, M., Winterer, J., Sarkar, R., Uebelhack, R., Franke, L., Heinz, A., & Friebe, A. (2008) · Psychosomatics · doi:10.1176/appi.psy.49.5.442 · Cited by 13 · see citing works
Self-citation
[Hepavir, the first observational study of one cohort of patients treated with alpha-2a interferon, monotherapy. Evaluation of asthenia and its social consequences].
Roudot‐Thoraval, F., Abergel, A., Allaert, F., Bourlière, M., Desmorat, H., Fagnani, F., Fontanges, T., Hanana, A., Pol, S., Zarski, J., et al. (2001) · PubMed · Cited by 10 · see citing works
New psychiatric and psychological aspects of diagnosis and treatment of hepatitis C and relevance for opiate dependence
Reimer, J., Backmund, M., & Haasen, C. (2005) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000186812.01202.a5 · Cited by 7 · see citing works
Guidelines for the management of chronic hepatitis C in patients infected after substance use.
Robaeys, G., Buntinx, F., Bottieau, E., Bourgeois, S., Brenard, R., Colle, I. O., Bie, J. D., Matheï, C., Mulkay, J., Damme, P. V., et al. (2005) · PubMed · Cited by 5 · see citing works
Self-citation
An extremely rare case of delusional parasitosis in a chronic hepatitis C patient during pegylated interferon alpha-2b and ribavirin treatment
Geert, Robaeys, Jozef, Bie, Marc, M., van, Ranst, Frank, & Buntinx (2007) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 1 · see citing works

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EASL Clinical Practice Guidelines: Management of hepatitis C virus infection European Association for the Study of the Liver ⇑
Peck, M., Craxı̀, A., Fried, M., & Zeuzem, S. (2013) · Cited by 1,080 · see citing works
EASL Clinical Practice Guidelines: Management of hepatitis C virus infection
(2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.11.003 · Cited by 858 · see citing works
Extrahepatic Morbidity and Mortality of Chronic Hepatitis C
Negro, F., Forton, D. M., Craxı̀, A., Sulkowski, M., Feld, J. J., & Manns, M. P. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.035 · Cited by 356 · see citing works
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Prevalence of hepatitis C virus infection in patients with chronic mental disorders: The relevance of dual disorders
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Authors: Schaefer, M., Capuron, L., Friebe, A., Diez-Quevedo, C., Robaeys, G., Neri, S., Foster, G. R., Kautz, A., Forton, D., & Pariante, C. M.
Affiliations: Kliniken Essen-Mitte (DE)
Université de Bordeaux (FR)
Ruhr University Bochum (DE)
Ziekenhuis Oost-Limburg (BE)
University of Catania (IT)
Queen Mary University of London (GB)
University of London (GB)
King's College London (GB)
Corresponding author: Schaefer, Martin
ORCID: Schaefer, Martin
Capuron, Lucile
Friebe, Astrid
Robaeys, Geert
Neri, Sergio
Foster, Graham R.
Forton, Daniel
Pariante, Carmine M.
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2012-12
Volume: 57
Issue: 6
Pages: 1379-1390
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2012.07.037
OpenAlex: W2153538902
Cited by: 225
References: 151
Citations by year: 2026: 4 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 20 · 2017: 22 · 2016: 26 · 2015: 20 · 2014: 26 · 2013: 24 · 2012: 2
FWCI: 14.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: European Association for the Study of the Liver
Topics: Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
Keywords: hepatitis C, chronic hepatitis C, depression, psychiatric adverse effects, pegylated interferon-alpha, ribavirin, antiviral therapy, mental health, fatigue, cognitive disorders, drug addiction, suicide risk, drug-drug interactions, psychiatric management
MeSH terms: Antiviral Agents, Depression, Drug Interactions, Hepatitis C, Humans, Mental Health, Risk Factors, Suicide, Attempted, Interferon-alpha

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Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement

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