Associations between spouses’ oxytocin receptor gene polymorphism, attachment security, and marital satisfaction
Open accessAbstract
OXTR rs53576, a polymorphism on the oxytocin receptor gene, has previously been linked to individual differences in social behaviors. That is, individuals with the GG genotype show greater empathy, sociability, and emotional stability. In the context of close relationships, such psychological resources are associated with better relationship outcomes. However, no studies to our knowledge have examined associations between spouses' OXTR polymorphisms, attachment security, and marital satisfaction. In the current study, 178 married couples (N = 356; ages 37-90) completed self-report measures of attachment security and marital satisfaction and provided saliva samples for genotyping. Results from Actor Partner Interdependence Models showed that individuals who had the GG genotype (actor effect) or had a spouse with the GG genotype (partner effect) reported greater marital satisfaction than individuals with AA or AG genotypes. Furthermore, greater attachment security mediated associations between GG genotype and marital satisfaction.
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Genetic polymorphisms in the human OXTR and AVP1RA genes have been linked to bonding and relationship outcomes.
“Genetic polymorphisms in the human OXTR and AVP1RA genes have been linked to bonding and relationship outcomes.”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [149]
The Introduction (§ OXTR gene and romantic relationships) reports links between OXTR variants and partner bonding or relationship quality, and the Results report an association between OXTR rs53576 and marital satisfaction. Our copy does not report a link between AVP1RA polymorphisms and bonding or relationship outcomes; the reference mentioning vasopressin receptor 1a concerns empathy instead. (LLM, conf=0.88)
Experimental — accuracy not yet measuredWomen with the GG genotype of the rs53576 OXTR polymorphism display enhanced empathy, sociability, and emotional stability while also reporting greater marital satisfaction than those with the AA or AG genotype.
“Women with the GG genotype of the rs53576 OXTR polymorphism display enhanced empathy, sociability, and emotional stability while also reporting greater marital satisfaction than those with the AA or AG genotype, suggesting genetic variations in OXTR expression may influence human social behavior [149].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [149]
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The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives
Blumenthal, S. A., & Young, L. J. (2023) · Biology · doi:10.3390/biology12060844 · Cited by 59 · see citing works
- Authors
- Monin, J. K., Goktas, S. O., Kershaw, T., & DeWan, A.
- Affiliations
- Yale University (US)
- Corresponding author
- Monin, Joan K.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-02-28
- Volume
- 14
- Issue
- 2
- Pages
- e0213083
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6395040
- OpenAlex
- W2916577850
- Cited by
- 26
- References
- 39
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 1
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (K01 AG042450-01, P30 AG021342)
- Topics
- Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Keywords
- oxytocin receptor gene, attachment security, marital satisfaction, married couples, gene-environment association, mediation, actor-partner effects, close relationships
- MeSH terms
- Adult, Aged, Aged, 80 and over, Emotions, Female, Genetic Markers, Genotype, Humans, Male, Marriage, Middle Aged, Models, Genetic, Models, Psychological, Object Attachment, Personal Satisfaction, Receptors, Oxytocin, Spouses, Polymorphism, Single Nucleotide
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