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Cited by 27Cervical Cancer and HPV ResearchReproductive tract infections researchViral-associated cancers and disorders

Human papilloma and other DNA virus infections of the cervix: A population based comparative study among tribal and general population in India

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Ghosh, Supriti, Shetty, Ranjitha S., Pattanshetty, Sanjay M., Mallya, Sneha D., Pandey, Deeksha, Kabekkodu, Shama Prasada, Kamath, Veena G., Prabhu, Navya +2 more·2019·PLOS ONE
DOI 10.1371/journal.pone.0219173PMC PMC6597196
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Abstract

BACKGROUND: Despite being preventable, cervical cancer remains a major health concern among women. Persistent Human Papillomavirus (HPV) and other viral co-infections may influence cervical dysplasia. We determined and compared the prevalence and risk factors of cervical viral infections among the tribal and general population of southern coastal Karnataka, India. METHODS: A population-based cross-sectional survey was conducted among 1140 and 1100 women from tribal and general population, respectively. Cervical infections with HPV, Epstein-Barr Virus (EBV), Cytomegalovirus (CMV) and Herpes-Simplex Virus (HSV) were examined using polymerase chain reactions (PCR) and DNA sequencing. RESULTS: HPV prevalence was higher among tribal women (40.6%) than general population (14.3%) while the prevalence of EBV (55.1%) and CMV (49.4%) were lower among tribal women than general population (74.3% and 77.5%, respectively). HSV infection was observed in tribal women only (1.8%). Among HR-HPV strains, HPV-18 was predominant among tribal population (28.3%) while, HPV-16 was predominant among the general population (9.1%). Infections were associated with age, educational status, unemployment and personal hygiene of tribal women. Phylogenetic analysis revealed that HPV-16 variants of tribal participants were closely related to non-European sublineages indicating greater risk of HPV persistence and carcinogenesis. CONCLUSION: The study provides a comparative estimate for DNA virus infections of the cervix among women from general as well as tribal population in this region and also reveals a different type-specific pattern of viral infection. Further research is required to delineate the role of specific interactions between multiple virus infections and their role in carcinogenesis.

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Cited by

Sorted by citations

Authors
Ghosh, S., Shetty, R. S., Pattanshetty, S. M., Mallya, S. D., Pandey, D., Kabekkodu, S. P., Kamath, V. G., Prabhu, N., D’souza, J., & Satyamoorthy, K.
Affiliations
Manipal Academy of Higher Education (IN)
Corresponding author
Shetty, Ranjitha S.
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2019-06-27
Volume
14
Issue
6
Pages
e0219173
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0219173
PMC
PMC6597196
OpenAlex
W2956145026
Cited by
27
References
0
Citations by year
2026: 5 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3
FWCI
2.09
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • Indian Council of Medical Research (TRIBAL/70/2013-ECD-II)
  • Manipal Academy of Higher Education (FNE0131)
  • Innovation in Science Pursuit for Inspired Research (IF150647)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
human papillomavirus, Epstein-Barr virus, cytomegalovirus, herpes simplex virus, tribal women, HPV prevalence, HPV16, HPV 18, viral coinfection, cervical cancer risk factors, southern Karnataka
MeSH terms
Adult, Uterine Cervical Diseases, Cross-Sectional Studies, Cytomegalovirus Infections, DNA Virus Infections, Ethnicity, Female, Herpes Simplex, Humans, India, Middle Aged, Phylogeny, Risk Factors, Prevalence, Epstein-Barr Virus Infections, Papillomavirus Infections, Human papillomavirus 16, Coinfection

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