Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia
Open accessAbstract
The gut plays a vital role in critical illness, and alterations in the gut structure and function have been reported in endotoxemia and sepsis models. Previously, we have demonstrated a novel link between the diet-induced alteration of the gut microbiome with cellulose and improved outcomes in sepsis. As compared to mice receiving basal fiber (BF) diet, mice that were fed a non-fermentable high fiber (HF) diet demonstrated significant improvement in survival and decreased organ injury in both cecal-ligation and puncture (CLP) and endotoxin sepsis models. To understand if the benefit conferred by HF diet extends to the gut structure and function, we hypothesized that HF diet would be associated with a reduction in sepsis-induced gut epithelial loss and permeability in mice. We demonstrate that the use of dietary cellulose decreased LPS-mediated intestinal hyperpermeability and protected the gut from apoptosis. Furthermore, we noted a significant increase in epithelial cell proliferation, as evidenced by an increase in the percentage of bromodeoxyuridine-positive cells in HF fed mice as compared to BF fed mice. Thus, the use of HF diet is a simple and effective tool that confers benefit in a murine model of sepsis, and understanding the intricate relationship between the epithelial barrier, gut microbiota, and diet will open-up additional therapeutic avenues for the treatment of gut dysfunction in critical illness.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dietary cellulose supplements can ameliorate LPS-mediated intestinal barrier damage and protect against gut epithelial apoptosis.
“Dietary cellulose supplements also can ameliorate LPS-mediated intestinal barrier damage and protect against gut epithelial apoptosis.205”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [205]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Effects of Decontamination of the Oropharynx and Intestinal Tract on Antibiotic Resistance in ICUs
Oostdijk, E. A. N., Kesecioğlu, J., Schultz, M. J., Visser, C. E., de Jonge, E., van Essen, E. H. R., Bernards, A. T., Purmer, I. M., Brimicombe, R. W., Bergmans, D. C. J. J., et al. (2014) · JAMA · doi:10.1001/jama.2014.7247 · Cited by 175 · see citing works
RetractedThe third international consensus definitions for sepsis and septic shock (Sepsis-3).
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250 · see citing works
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Desai, M. S., Seekatz, A. M., Koropatkin, N. M., Kamada, N., Hickey, C. A., Wolter, M., Pudlo, N. A., Kitamoto, S., Terrapon, N., Muller, A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.043 · Cited by 2,805 · see citing works
Intestinal permeability – a new target for disease prevention and therapy
Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755 · see citing works
Taur, Y., Xavier, J. B., Lipuma, L., Ubeda, C., Goldberg, J., Gobourne, A., Lee, Y. J., Dubin, K. A., Socci, N. D., Viale, A., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis580 · Cited by 1,020 · see citing works
Ubeda, C., Taur, Y., Jenq, R. R., Equinda, M. J., Son, T., Samstein, M., Viale, A., Socci, N. D., van den Brink, M. R. M., Kamboj, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43918 · Cited by 943 · see citing works
Multiple-Organ-Failure Syndrome
Carrico, C. J. (1986) · Archives of Surgery · doi:10.1001/archsurg.1986.01400020082010 · Cited by 819 · see citing works
[Multiple organ failure syndrome].
Simbirtsev, S. A., Beliakov, N. A., & Konychev, A. V. (1988) · PubMed · Cited by 796 · see citing works
Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection
Khosravi, A., Yáñez, A., Price, J. G., Chow, A. T., Mérad, M., Goodridge, H. S., & Mazmanian, S. K. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.006 · Cited by 651 · see citing works
JAM-A regulates permeability and inflammation in the intestine in vivo
Laukoetter, M. G., Nava, P., Lee, W. Y., Severson, E. A., Capaldo, C., Babbin, B. A., Williams, I. R., Koval, M. H., Peatman, E., Campbell, J. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071416 · Cited by 512 · see citing works
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460 · see citing works
Clark, J. A., & Coopersmith, C. M. (2007) · Shock · doi:10.1097/shk.0b013e31805569df · Cited by 443 · see citing works
Hill, D. A., Hoffmann, C., Abt, M. C., Du, Y., Kobuley, D. E., Kirn, T. J., Bushman, F. D., & Artis, D. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.132 · Cited by 425 · see citing works
Intestinal Permeability Defects: Is It Time to Treat?
Odenwald, M. A., & Turner, J. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.001 · Cited by 366 · see citing works
Redefining the gut as the motor of critical illness
Mittal, R., & Coopersmith, C. M. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.08.004 · Cited by 342 · see citing works
Coopersmith, C. M. (2002) · JAMA · doi:10.1001/jama.287.13.1716 · Cited by 295 · see citing works
Mechanisms of Intestinal Barrier Dysfunction in Sepsis
Yoseph, B. P., Klingensmith, N. J., Liang, Z., Breed, E. R., Burd, E. M., Mittal, R., Dominguez, J. A., Petrie, B., Ford, M. L., & Coopersmith, C. M. (2016) · Shock · doi:10.1097/shk.0000000000000565 · Cited by 256 · see citing works
Disruption of the gut microbiome as a risk factor for microbial infections
Khosravi, A., & Mazmanian, S. K. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.03.009 · Cited by 235 · see citing works
Saidel‐Odes, L., Polachek, H., Peled, N., Riesenberg, K., Schlaeffer, F., Trabelsi, Y., Eskira, S., Yousef, B., Smolykov, R., Codish, S., et al. (2011) · Infection Control and Hospital Epidemiology · doi:10.1086/663206 · Cited by 182 · see citing works
Regulation of intestinal epithelial proliferation: a few answers, many questions
Podolsky, D. K. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.264.2.g179 · Cited by 178 · see citing works
The Interplay Between Fiber and the Intestinal Microbiome in the Inflammatory Response
Kuo, S. (2013) · Advances in Nutrition · doi:10.3945/an.112.003046 · Cited by 175 · see citing works
Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacterium
Vernazza, C. L., Gibson, G. R., & Rastall, R. A. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.02832.x · Cited by 143 · see citing works
Khounlotham, M., Kim, W., Peatman, E., Nava, P., Contreras, O. M., Addis, C. R., Koch, S., Fournier, B., Nusrat, A., Denning, T. L., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.017 · Cited by 129 · see citing works
Coopersmith, C. M., Stromberg, P. E., Davis, C. G., Dunne, W. M., Amiot, D. M., Karl, I. E., Hotchkiss, R. S., & Buchman, T. G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000055385.29232.11 · Cited by 110 · see citing works
Disruption of tight junctions during polymicrobial sepsis in vivo
Li, Q., Zhang, Q., Wang, C., Liu, X., Li, N., & Li, J. (2009) · The Journal of Pathology · doi:10.1002/path.2525 · Cited by 106 · see citing works
Rupani, B., Caputo, F. J., Watkins, A. C., Vega, D., Magnotti, L. J., Lu, Q., Xu, D. Z., & Deitch, E. A. (2007) · Surgery · doi:10.1016/j.surg.2006.10.008 · Cited by 102 · see citing works
Dysbiosis in the intensive care unit: Microbiome science coming to the bedside
Kitsios, G. D., Morowitz, M. J., Dickson, R. P., Huffnagle, G. B., McVerry, B. J., & Morris, A. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.09.029 · Cited by 91 · see citing works
Self-citationCp, S., Hk, V. S., Dr, M., & Zandstra, D. F. (1983) · PubMed · Cited by 72 · see citing works
Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease
Cabrera-Pérez, J., Badovinac, V. P., & Griffith, T. S. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216669610 · Cited by 70 · see citing works
Morowitz, M. J., Caro, V. D., Pang, D., Cummings, J. L., Firek, B., Rogers, M. B., Ranganathan, S., Clark, R. S. B., & Aneja, R. K. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002291 · Cited by 61 · see citing works
Self-citationPeroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro
Potoka, D. A., Upperman, J. S., Zhang, X.-R., Kaplan, J. R., Corey, S. J., Grishin, A., Zamora, R., & Ford, H. R. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2002 · Cited by 55 · see citing works
Selective decontamination of the digestive tract: an update of the evidence.
Silvestri, L., & SAENE, H. K. F. V. (2012) · Europe PMC (PubMed Central) · Cited by 52 · see citing works
Kalhs, P., Brugger, S. A., Schwarzinger, I., GREINIX, H. T., Keil, F., Kyrle, P. A., Knöbl, P., SCHNEIDER, B., Höcker, P., Linkesch, W., et al. (1995) · Transplantation · doi:10.1097/00007890-199511000-00012 · Cited by 43 · see citing works
Pathophysiology of the Gut and the Microbiome in the Host Response
Lyons, J. D., & Coopersmith, C. M. (2017) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001046 · Cited by 34 · see citing works
Dietary Cellulose Supplementation Modulates the Immune Response in a Murine Endotoxemia Model
Caro, V. D., Cummings, J. L., Alcamo, A. M., Piganelli, J. D., Clark, R. S. B., Morowitz, M. J., & Aneja, R. K. (2018) · Shock · doi:10.1097/shk.0000000000001180 · Cited by 23 · see citing works
Self-citationKalhs, P., Brugger, S. A., Schwarzinger, I., GREINIX, H. T., Keil, F., Kyrle, P. A., Knöbl, P., SCHNEIDER, B., Höcker, P., Linkesch, W., et al. (1995) · Transplantation · doi:10.1097/00007890-199511150-00012 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works
Lofts, A., Abu-Hijleh, F. A., Rigg, N., Mishra, R. K., & Hoare, T. R. (2022) · CNS Drugs · doi:10.1007/s40263-022-00930-4 · Cited by 108 · see citing works
Elucidating the role of the gut microbiota in the physiological effects of dietary fiber
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Pérez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y., Cole, J. L., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01248-5 · Cited by 108 · see citing works
Zhan, L., Pu, J., Zheng, J., Hang, S., Pang, L., Dai, M., & Ji, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112741 · Cited by 35 · see citing works
The diet-microbiota axis: a key regulator of intestinal permeability in human health and disease
Tamang, R. L., Juritsch, A. F., Ahmad, R., Salomon, J., Dhawan, P., Ramer‐Tait, A. E., & Singh, A. B. (2022) · Tissue Barriers · doi:10.1080/21688370.2022.2077069 · Cited by 30 · see citing works
Papa, A., Santini, P., Lucia, S. S. D., Maresca, R., Porfidia, A., Pignatelli, P., Gasbarrini, A., Violi, F., & Pola, R. (2023) · Thrombosis Research · doi:10.1016/j.thromres.2023.11.005 · Cited by 29 · see citing works
Fiber in the ICU: Should it Be a Regular Part of Feeding?
Green, C. H., Busch, R. A., & Patel, J. J. (2021) · Current Gastroenterology Reports · doi:10.1007/s11894-021-00814-5 · Cited by 17 · see citing works
Ma, H., Shen, L., Zhao, L., & Ji, H. (2025) · Food & Function · doi:10.1039/d5fo02694f · Cited by 7 · see citing works
Effects of pine pollen wall on gut microbiota and biomarkers in mice with dyslipidemia
Song, X., Wang, Y., Guan, R., Ma, N., Yin, L., Zhong, M., Wang, T., Shi, L., & Geng, Y. (2020) · Phytotherapy Research · doi:10.1002/ptr.6952 · Cited by 6 · see citing works
Wang, X., Miao, S., Yang, Y., Yang, Q., Meng, D., & Hong, L. (2024) · Nutrition Journal · doi:10.1186/s12937-023-00894-1 · Cited by 3 · see citing works
Lawless, C., Kovacs, K., Dehcheshmeh, M. M., Ebrahimie, E., Messele, Y. E., Snowball, M., Trott, D. J., & McLelland, D. J. (2025) · Animals · doi:10.3390/ani15131831 · Cited by 1 · see citing works
Kynkäänniemi, E., Lindén, J., Ngambundit, S., Saarimäki, L. A., Greco, D., Slabá, H., Lahtinen, M. H., Mikkonen, K. S., & Pajari, A. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07757 · Cited by 1 · see citing works
Íleon terminal en la COVID-19. Aspectos a tener en cuenta
Jiménez, F. N. P., de Paz, V. C., González, T. M., & Torres, J. F. R. (2023) · Belize Journal of Medicine · doi:10.61997/bjm.v12i1.287
Wang, X., Miao, S., Yang, Y., Yang, Q., Meng, D., & Hong, L. (2024) · Figshare · doi:10.6084/m9.figshare.24934321
Armet, A. M., Li, F., Deehan, E. C., Nikolaeva, D. D., Delannoy-Bruno, O., Siegwald, L., Berger, B. W., Minehira, K., Rodionov, D. A., Arzamasov, A. A., et al. (2025) · medRxiv · doi:10.1101/2025.11.20.25340625 · Cited by 1 · see citing works
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766580
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766598
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766586
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766601
Wang, X., Miao, S., Yang, Y., Yang, Q., Meng, D., & Liang, H. (2024) · Figshare · doi:10.6084/m9.figshare.24934735
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766592
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766607
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766604
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766574
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766595
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766610
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766589
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766577
Deehan, E. C., Zhang, Z., Riva, A., Armet, A. M., Perez-Muñoz, M. E., Nguyen, N. K., Krysa, J. A., Seethaler, B., Zhao, Y.-Y., Cole, J. L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19766583
Plant-Derived Polymers and Their Contribution to the Management of Inflammatory Bowel Disease.
Gupta, S., Agrawal, N., Siddiqui, M. A., Jaiswal, M., & Lanjhiyana, S. K. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898817268126010007
Factors associated with constipation in critically ill children: A retrospective study
Marino, L. V., Rothman, B., O’Connor, G., Sheppard, J., Kinoshita, M., Kidd, C., Latten, L., & Shine, A. M. (2026) · Nutrition in Clinical Practice · doi:10.1002/ncp.70155
Zhang, L., Yang, S., Wu, H., & Zhou, H. (2026) · Molecular Medicine Reports · doi:10.3892/mmr.2026.13978
Chen, S., Li, H., Juhasz, A. L., Bai, R., Li, K., & Li, J. (2026) · Environmental Research · doi:10.1016/j.envres.2026.125775
- Authors
- Di Caro, V., Alcamo, A. M., Cummings, J. L., Clark, R. S. B., Novak, E. A., Mollen, K. P., Morowitz, M. J., & Aneja, R. K.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Aneja, Rajesh K.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-12-02
- Volume
- 14
- Issue
- 12
- Pages
- e0224838
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6886840
- OpenAlex
- W2992376566
- Cited by
- 32
- References
- 38
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 17 · 2021: 2 · 2020: 1
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01GM098474)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- dietary cellulose, high-fiber diet, intestinal barrier, intestinal permeability, apoptosis, endotoxemia, sepsis, gut microbiota, epithelial cell proliferation, lipopolysaccharide, cecal ligation and puncture, critical illness, dietary fiber
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cellulose, Disease Models, Animal, Gene Expression Regulation, Intestinal Mucosa, Male, Mice, Inbred C57BL, Permeability, Apoptosis, Endotoxemia, Dietary Supplements, Cell Proliferation, Mice, Tight Junction Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
