CoChat
Sign Up
Cited by 119Gut microbiota and healthSpinal Cord Injury ResearchGastrointestinal motility and disorders

The DOI matches its Crossref record; 72 of the 73 references it cites were found in a registry or an index.

Fecal transplant prevents gut dysbiosis and anxiety-like behaviour after spinal cord injury in rats

Open access
Schmidt, Emma K. A., Torres-Espin, Abel, Raposo, Pamela J. F., Madsen, Karen L., Kigerl, Kristina A., Popovich, Phillip G., Fenrich, Keith K., Fouad, Karim·2020·PLoS ONE
DOI 10.1371/journal.pone.0226128PMC PMC6961833
Open this paper in CoChat — free accountOpen PDF

Abstract

Secondary manifestations of spinal cord injury beyond motor and sensory dysfunction can negatively affect a person's quality of life. Spinal cord injury is associated with an increased incidence of depression and anxiety; however, the mechanisms of this relationship are currently not well understood. Human and animal studies suggest that changes in the composition of the intestinal microbiota (dysbiosis) are associated with mood disorders. The objective of the current study is to establish a model of anxiety following a cervical contusion spinal cord injury in rats and to determine whether the microbiota play a role in the observed behavioural changes. We found that spinal cord injury caused dysbiosis and increased symptoms of anxiety-like behaviour. Treatment with a fecal transplant prevented both spinal cord injury-induced dysbiosis as well as the development of anxiety-like behaviour. These results indicate that an incomplete unilateral cervical spinal cord injury can cause affective disorders and intestinal dysbiosis, and that both can be prevented by treatment with fecal transplant therapy.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0226128

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 73 references

1 of the 73 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. R Studio Team, 2015, RStudio: integrated development for R

Cited by

Sorted by citations

Items 101–119 of 119

Related

See all

Metadata

Authors
Schmidt, E. K. A., Torres-Espin, A., Raposo, P. J. F., Madsen, K. L., Kigerl, K. A., Popovich, P. G., Fenrich, K. K., & Fouad, K.
Affiliations
  • University of Alberta (CA)
  • The Ohio State University Wexner Medical Center (US)
Corresponding author
Fouad, Karim
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2020-01-15
Volume
15
Issue
1
Pages
e0226128
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0226128
PMC
PMC6961833
OpenAlex
W2998874562
Cited by
119
References
73
Citations by year
2026: 8 · 2025: 12 · 2024: 12 · 2023: 24 · 2022: 17 · 2021: 31 · 2020: 15
FWCI
7.13
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • Craig H. Neilsen Foundation (542589)
  • Canadian Institutes of Health Research (119281)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
fecal microbiota transplantation, spinal cord injury, gut dysbiosis, anxiety-like behavior, gut microbiota, mood disorders, depression
MeSH terms
Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Anxiety, Behavior, Animal, Spinal Cord Injuries, Maze Learning, Recovery of Function, Rats, Dysbiosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review