Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System
Open accessAbstract
A non-invasive functional-brain-imaging system based on optically-pumped-magnetometers (OPM) is presented. The OPM-based magnetoencephalography (MEG) system features 20 OPM channels conforming to the subject's scalp. We have conducted two MEG experiments on three subjects: assessment of somatosensory evoked magnetic field (SEF) and auditory evoked magnetic field (AEF) using our OPM-based MEG system and a commercial MEG system based on superconducting quantum interference devices (SQUIDs). We cross validated the robustness of our system by calculating the distance between the location of the equivalent current dipole (ECD) yielded by our OPM-based MEG system and the ECD location calculated by the commercial SQUID-based MEG system. We achieved sub-centimeter accuracy for both SEF and AEF responses in all three subjects. Due to the proximity (12 mm) of the OPM channels to the scalp, it is anticipated that future OPM-based MEG systems will offer enhanced spatial resolution as they will capture finer spatial features compared to traditional MEG systems employing SQUIDs.
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OPM-MEG experiments involving participant motion require an OPM-optimised MSR with a very low remnant magnetic field and active magnetic shielding.
“These constraints mean that OPM-MEG experiments involving participant motion require an OPM-optimised MSR with a very low remnant magnetic field along with ‘active’ magnetic shielding”
From Naturalistic Hyperscanning with Wearable Magnetoencephalography (2023) · cites this paper as [36]
The Materials and methods section describes a custom magnetic shield with coils that null the remnant DC field; Results > Array characterization reports a background field below 0.3 nT. But Methods > Experimental setup assumes stationary sensors during measurement. The paper does not establish that experiments involving participant motion require an OPM-optimised room or active shielding during motion. (LLM, conf=0.86)
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“…mean OPM-MEG experiments involving participant motion not only require an MSR, but also ‘active’ magnetic shielding in the form of electromagnetic coils which cancel any residual magnetic field experienced by the array (Borna et al., 2020; Holmes et al., 2019, 2018; Iivanainen et al., 2019).”
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Self-citation
- Authors
- Borna, A., Carter, T. R., Colombo, A. P., Jau, Y.-Y., McKay, J., Weisend, M., Taulu, S., Stephen, J. M., & Schwindt, P. D. D.
- Affiliations
- Sandia National Laboratories (US)
- University of Washington (US)
- Mind Research Network (US)
- Corresponding author
- Borna, Amir
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-01-24
- Volume
- 15
- Issue
- 1
- Pages
- e0227684
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6980641
- OpenAlex
- W3002374698
- Cited by
- 158
- References
- 6
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 37 · 2023: 29 · 2022: 29 · 2021: 25 · 2020: 6
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R56EB013302, R01EB013302)
- Topics
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Atomic and Subatomic Physics Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Magnetic Field Sensors Techniques
- Keywords
- optically pumped magnetometers, magnetoencephalography, functional neuroimaging, somatosensory evoked fields, auditory evoked magnetic fields, equivalent current dipole, SQUID comparison, spatial resolution, non-invasive brain imaging
- MeSH terms
- Superconductivity, Adult, Brain, Brain Mapping, Equipment Design, Evoked Potentials, Auditory, Evoked Potentials, Somatosensory, Humans, Male, Signal Processing, Computer-Assisted, Magnetoencephalography, Optical Devices, Functional Neuroimaging
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