The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
COVID-19 symptoms predictive of healthcare workers’ SARS-CoV-2 PCR results
Open accessAbstract
BACKGROUND: Coronavirus 2019 disease (COVID-19) is caused by the virus SARS-CoV-2, transmissible both person-to-person and from contaminated surfaces. Early COVID-19 detection among healthcare workers (HCWs) is crucial for protecting patients and the healthcare workforce. Because of limited testing capacity, symptom-based screening may prioritize testing and increase diagnostic accuracy. METHODS AND FINDINGS: We performed a retrospective study of HCWs undergoing both COVID-19 telephonic symptom screening and nasopharyngeal SARS-CoV-2 assays during the period, March 9-April 15, 2020. HCWs with negative assays but progressive symptoms were re-tested for SARS-CoV-2. Among 592 HCWs tested, 83 (14%) had an initial positive SARS-CoV-2 assay. Fifty-nine of 61 HCWs (97%) who were asymptomatic or reported only sore throat/nasal congestion had negative SARS-CoV-2 assays (P = 0.006). HCWs reporting three or more symptoms had an increased multivariate-adjusted odds of having positive assays, 1.95 (95% CI: 1.10-3.64), which increased to 2.61 (95% CI: 1.50-4.45) for six or more symptoms. The multivariate-adjusted odds of a positive assay were also increased for HCWs reporting fever and a measured temperature ≥ 37.5°C (3.49 (95% CI: 1.95-6.21)), and those with myalgias (1.83 (95% CI: 1.04-3.23)). Anosmia/ageusia (i.e. loss of smell/loss of taste) was reported less frequently (16%) than other symptoms by HCWs with positive assays, but was associated with more than a seven-fold multivariate-adjusted odds of a positive test: OR = 7.21 (95% CI: 2.95-17.67). Of 509 HCWs with initial negative SARS-CoV-2 assays, nine had symptom progression and positive re-tests, yielding an estimated negative predictive value of 98.2% (95% CI: 96.8-99.0%) for the exclusion of clinically relevant COVID-19. CONCLUSIONS: Symptom and temperature reports are useful screening tools for predicting SARS-CoV-2 assay results in HCWs. Anosmia/ageusia, fever, and myalgia were the strongest independent predictors of positive assays. The absence of symptoms or symptoms limited to nasal congestion/sore throat were associated with negative assays.
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Cites
Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1
van Doremalen, N., Bushmaker, T., Morris, D. H., Holbrook, M. G., Gamble, A., Williamson, B. N., Tamin, A., Harcourt, J. L., Thornburg, N. J., Gerber, S. I., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2004973 · Cited by 9,951
Lauer, S. A., Grantz, K. H., Bi, Q., Jones, F. K., Zheng, Q., Meredith, H. R., Azman, A. S., Reich, N. G., & Lessler, J. (2020) · Annals of Internal Medicine · doi:10.7326/m20-0504 · Cited by 5,970
Viral dynamics in mild and severe cases of COVID-19
Liu, Y., Yan, L.-M., Wan, L., Xiang, T.-X., Le, A., Liu, J.-M., Peiris, M., Poon, L. L. M., & Zhang, W. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30232-2 · Cited by 1,727
Real-time tracking of self-reported symptoms to predict potential COVID-19
Menni, C., Valdes, A. M., Freidin, M. B., Sudre, C. H., Nguyen, L. H., Drew, D. A., Ganesh, S., Varsavsky, T., Cardoso, M. J., El-Sayed Moustafa, J. S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0916-2 · Cited by 1,517
Offeddu, V., Yung, C. F., Low, M. S. F., & Tam, C. C. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix681 · Cited by 297
Cited by
Gómez-Ochoa, S. A., Franco, O. H., Rojas, L. Z., Raguindin, P. F., Roa-Díaz, Z. M., Wyssmann, B. M., Guevara, S. L. R., Echeverría, L. E., Glisic, M., & Muka, T. (2021) · American Journal of Epidemiology · doi:10.1093/aje/kwaa191 · Cited by 785
False-negative results of initial RT-PCR assays for COVID-19: A systematic review
Arevalo-Rodriguez, I., Buitrago-Garcia, D., Simancas-Racines, D., Zambrano-Achig, P., Del Campo, R., Ciapponi, A., Sued, O., Martinez-García, L., Rutjes, A. W., Low, N., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0242958 · Cited by 656
Bein, A., Kim, S., Goyal, G., Cao, W., Fadel, C., Naziripour, A., Sharma, S., Swenor, B., LoGrande, N., Nurani, A., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.718484 · Cited by 83
Metadata
- Authors
- Lan, F.-Y., Filler, R., Mathew, S., Buley, J., Iliaki, E., Bruno-Murtha, L. A., Osgood, R., Christophi, C. A., Fernandez-Montero, A., & Kales, S. N.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-06-26
- Volume
- 15
- Issue
- 6
- Pages
- e0235460
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W3033609484
- Cited by
- 172
- References
- 5
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lan, F.-Y., Filler, R., Mathew, S., Buley, J., Iliaki, E., Bruno-Murtha, L. A., Osgood, R., Christophi, C. A., Fernandez-Montero, A., & Kales, S. N. (2020). COVID-19 symptoms predictive of healthcare workers’ SARS-CoV-2 PCR results. PLOS ONE. https://doi.org/10.1371/journal.pone.0235460
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