Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias
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Abstract
Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals’ social capital and various indicators of Alzheimer’s disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action.
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Several studies have shown an association of SDoH factors such as education level, isolation, and loneliness with the onset of Alzheimer's disease and related dementias (ADRD) in older adults.
“Several studies have shown the association of SDoH factors such as education level, isolation, and loneliness with the onset of Alzheimer’s disease and related dementias (ADRD) in older adults84–86.”
From Social determinants of health extraction from clinical notes across institutions using large language models (2025) · cites this paper as [84]
AD risk factors include obesity, diabetes, high blood pressure, and high cholesterol.
“AD risk factors include obesity, diabetes, high blood pressure, and high cholesterol [51,52,53].”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [53]
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- Authors
- Shafighi, K., Villeneuve, S., Rosa Neto, P., Badhwar, A., Poirier, J., Sharma, V., Medina, Y. I., Silveira, P. P., Dube, L., Glahn, D., & Bzdok, D.
- Affiliations
- McGill University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Douglas Mental Health University Institute (CA)
- Boston Children's Hospital (US)
- Corresponding author
- Shafighi, Kimia
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2023-02-01
- Volume
- 18
- Issue
- 2
- Pages
- e0280471
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC9891507
- OpenAlex
- W4318753563
- Cited by
- 51
- References
- 73
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 14 · 2023: 7 · 2022: 2
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- social isolation, loneliness, Alzheimer's disease, dementia risk factors, social support, social capital, social deprivation, neurodegeneration, lifestyle factors, mental health, physical health, dementia prevention
- MeSH terms
- Alzheimer Disease, Canada, Humans, Longitudinal Studies, Risk Factors, Social Isolation
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