Proneness to psychological distress and risk of Alzheimer disease in a biracial community
Abstract
Persons without dementia residing in a biracial community completed a brief scale of proneness to psychological distress, and 1,064 were subsequently examined for incident Alzheimer disease (AD) 3 to 6 years later. In analyses controlling for selected demographic and clinical variables, persons prone to distress were 2.4 times more likely to develop AD than persons not distress prone. This effect was substantially stronger in white persons compared to African Americans.
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- Authors
- Wilson, R. S., Barnes, L. L., Bennett, D. A., Li, Y., Bienias, J. L., de Leon, C. F. M., & Evans, D. A.
- Affiliations
- Rush University Medical Center (US)
- From Rush Alzheimer’s Disease Center (Drs. Wilson, Barnes, and Bennett) and Rush Institute for Healthy Aging (Drs. Li, Bienias, Mendes de Leon, and Evans) and Departments of Neurological Sciences (Drs. Wilson, Barnes, Bennett, and Evans), Internal Medicine (Drs. Li, Bienias, Mendes de Leon, and Evans), and Psychology (Drs. Wilson and Barnes), Rush University Medical Center, Chicago, IL.
- Venue
- Neurology
- Published
- 2005-01-25
- Volume
- 64
- Issue
- 2
- Pages
- 380-382
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2017465880
- Cited by
- 201
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 9 · 2014: 15 · 2013: 8 · 2012: 15
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG017917, P30-AG 10161, R01‐AG17917, R01AG11101, R01AG011101, P30AG010161)
- National Institute of Environmental Health Sciences (R01ES010902, R01ES10902)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- psychological distress, Alzheimer's disease, risk factors, African Americans, racial differences
- MeSH terms
- Aged, Alzheimer Disease, Black or African American, Chicago, Disease Susceptibility, Female, Humans, Male, Risk, Sampling Studies, Stress, Psychological, Cohort Studies, Incidence, White People
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