Cited by 7Maternal Mental Health During Pregnancy and PostpartumAnesthesia and Pain ManagementMaternal and Perinatal Health Interventions

Association between the use of epidural analgesia during labour and incidence of postpartum depression

Open access
Ahmad, Hanin Mohammed Yaqoob, Althagafi, Lama Adnan, Albluwe, Ghazal Zuhair, Kadi, Shahd Mohammed, Alhassani, Relam Ibrahim, Bahkali, Nedaa Mohammed·2023·PLOS ONE

Abstract

Introduction: Postpartum depression is a significant episode of depression beginning after giving birth. The prevalence of postpartum depression is approximately 20% in Jeddah, Saudi Arabia. Epidural analgesia is the gold standard for labour pain management. Conflicting results exist regarding the association between postpartum depression and epidural analgesia use during labour. Accordingly, this study assessed the association between epidural analgesia use and postpartum depression incidence. Methods: A prospective observational study of 170 mothers was conducted, with surveys administered after labour and at six weeks postpartum. Surveys included the following: mothers’ demographics, obstetric history, postpartum depression (Edinburgh Postnatal Depression Scale), and pain severity (Visual Analogue Scale). Results: In the final analysis, 91 patients were enrolled. Epidural analgesia was administered to 48.4% of mothers during labour. Nearly two-thirds of mothers learned about EA via sources including family members and social media. However, more than half reported worries regarding epidural analgesia. Edinburgh Postnatal Depression Scale scores showed that 38 mothers (41.8%) likely had depressive symptoms within two days following delivery. Further, 35 (38.5%) met criteria for postpartum depression at six weeks postpartum. For both groups regardless use of analgesia, the mean Visual Analogue Scale score at two days postpartum was 4.16 ± 2.13. Data revealed no correlation between epidural analgesia use and Edinburgh Postnatal Depression Scale within two days and at six weeks postpartum. Multiple regression analysis showed Edinburgh Postnatal Depression Scale scores correlated with Visual Analogue Scale scores but not epidural analgesia use at 1–2 days postpartum. Conclusion: This study showed that depressive symptoms resolved in three percent of participants. This suggests that institutions should increase postpartum depression awareness during the antenatal period and implement effective post-delivery screening systems for postpartum depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0289595

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 28

  1. [1]Bell CC. DSM-IV: diagnostic and statistical manual of mental disorders. Jama. 1994; 272(10): 828– 9.
  2. [2]Cohen LS, Wang B, Nonacs R, Viguera AC, Lemon EL, Freeman MP. Treatment of mood disorders during pregnancy and postpartum. Psychiatric Clinics. 2010; 33(2): 273– 93. doi: 10.1016/j.psc.2010.02.001 20385337 · DOI · Paper page
  3. [3]Grace SL, Evindar A, Stewart D. The effect of postpartum depression on child cognitive development and behavior: a review and critical analysis of the literature. Archives of women’s mental health. 2003; 6(4): 263– 74. doi: 10.1007/s00737-003-0024-6 14628179 · DOI · Paper page
  4. [4]Lane WE, Cobert J, Horres CR, Strouch Z, Mehdiratta J. Undetected uterine rupture during induction of labor for intrauterine fetal demise using epidural anesthesia. Journal of clinical anesthesia. 2019; 58: 20– 1. doi: 10.1016/j.jclinane.2019.04.023 31054522 · DOI
  5. [5]JM CC. Postpartum depression: Risks and early detection. Archivos Argentinos de Pediatria. 2020; 118(3): 154– 5. 32470247
  6. [6]Howard LM, Molyneaux E, Dennis C-L, Rochat T, Stein A, Milgrom J. Non-psychotic mental disorders in the perinatal period. The Lancet. 2014; 384(9956): 1775– 88. doi: 10.1016/S0140-6736(14)61276-9 25455248 · DOI · Paper page
  7. [7]Wang Z, Liu J, Shuai H, Cai Z, Fu X, Liu Y, et al. Mapping global prevalence of depression among postpartum women. Translational psychiatry. 2021; 11(1): 1– 13. 34671011 PMC8528847
  8. [9]Alsayed NA, Altayyeb JF, Althuniyyan LS, Alzubaidi SK, Farahat F. Prevalence of postpartum depression and associated risk factors among women in Jeddah, western Saudi Arabia. Cureus. 2021; 13(4). doi: 10.7759/cureus.14603 34040904 PMC8139603 · DOI
  9. [10]Jones L, Othman M, Dowswell T, Alfirevic Z, Gates S, Newburn M, et al. Pain management for women in labour: an overview of systematic reviews. Cochrane database of systematic reviews. 2012(3). doi: 10.1002/14651858.CD009234.pub2 22419342 PMC7132546 · DOI
  10. [11]Sitras V, Šaltytė Benth J, Eberhard-Gran M. Obstetric and psychological characteristics of women choosing epidural analgesia during labour: A cohort study. PloS one. 2017; 12(10): e0186564. doi: 10.1371/journal.pone.0186564 29045499 PMC5646833 · DOI
  11. [12]Ashagrie HE, Fentie DY, Kassahun HG. A review article on epidural analgesia for labor pain management: A systematic review. International Journal of Surgery Open. 2020; 24: 100– 4.
  12. [13]Ezeonu PO, Anozie OB, Onu FA, Esike CU, Mamah JE, Lawani LO, et al. Perceptions and practice of epidural analgesia among women attending antenatal clinic in FETHA. International journal of women’s health. 2017; 9: 905. doi: 10.2147/IJWH.S144953 29276414 PMC5731435 · DOI
  13. [14]Anim‐Somuah M, Smyth RM, Cyna AM, Cuthbert A. Epidural versus non‐epidural or no analgesia for pain management in labour. Cochrane database of systematic reviews. 2018(5). doi: 10.1002/14651858.CD000331.pub4 29781504 PMC6494646 · DOI · Paper page
  14. [15]Luo D, Yuan Y, Guo L, Chen Z. A comparative study of epidural labor analgesia and natural delivery without analgesia. American Journal of Translational Research. 2021; 13(6): 7015. 34306457 PMC8290643
  15. [16]Silva M, Halpern SH. Epidural analgesia for labor: Current techniques. Local and regional anesthesia. 2010; 3: 143. doi: 10.2147/LRA.S10237 23144567 PMC3417963 · DOI
  16. [17]Lim G, Farrell LM, Facco FL, Gold MS, Wasan AD. Labor analgesia as a predictor for reduced postpartum depression scores: a retrospective observational study. Anesthesia and analgesia. 2018; 126(5): 1598. doi: 10.1213/ANE.0000000000002720 29239949 PMC5908733 · DOI · Paper page
  17. [18]Sun J, Xiao Y, Zou L, Liu D, Huang T, Zheng Z, et al. Epidural labor analgesia is associated with a decreased risk of the edinburgh postnatal depression scale in trial of labor after cesarean: a multicenter, prospective cohort study. BioMed Research International. 2020; 2020. doi: 10.1155/2020/2408063 32025517 PMC6991168 · DOI · Paper page
  18. [19]Suhitharan T, Pham TPT, Chen H, Assam PN, Sultana R, Han N-LR, et al. Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case–control study. Neuropsychiatric Disease and Treatment. 2016; 12: 1333. doi: 10.2147/NDT.S105918 27354803 PMC4908936 · DOI · Paper page
  19. [20]Edipoglu IS, Aslan DD. Association of postpartum depression and epidural analgesia in women during labor: an observational study. Brazilian Journal of Anesthesiology. 2021; 71: 208– 13. doi: 10.1016/j.bjane.2021.02.021 33941362 PMC9373269 · DOI
  20. [21]Tan CW, Sultana R, Kee MZ, Meaney MJ, Sng BL. Investigating the association between labour epidural analgesia and postpartum depression: A prospective cohort study. European Journal of Anaesthesiology| EJA. 2020; 37(9): 796– 802. 32453169
  21. [22]Tobin CD, Wilson SH, Hebbar L, Roberts LL, Wolf BJ, Guille C. Labor epidural analgesia and postpartum depression. Archives of depression and anxiety. 2017; 2(2): 044. doi: 10.17352/2455-5460.000014 32500106 PMC7272057 · DOI · Paper page
  22. [23]Eckerdal P, Kollia N, Karlsson L, Skoog-Svanberg A, Wikström A-K, Högberg U, et al. Epidural analgesia during childbirth and postpartum depressive symptoms: a population-based longitudinal cohort study. Anesthesia & Analgesia. 2020; 130(3): 615– 24. doi: 10.1213/ANE.0000000000004292 31274600 · DOI · Paper page
  23. [24]Bhusal BR, Bhandari N, Chapagai M, Gavidia T. Validating the Edinburgh Postnatal Depression Scale as a screening tool for postpartum depression in Kathmandu, Nepal. International journal of mental health systems. 2016; 10(1): 1– 7. PMC5073833 27785152
  24. [25]Ding T, Wang D-X, Qu Y, Chen Q, Zhu S-N. Epidural labor analgesia is associated with a decreased risk of postpartum depression: a prospective cohort study. Anesthesia & Analgesia. 2014; 119(2): 383– 92. doi: 10.1213/ANE.0000000000000107 24797120 · DOI · Paper page
  25. [26]Nahirney M, Metcalfe A, Chaput KH. Administration of epidural labor analgesia is not associated with a decreased risk of postpartum depression in an urban Canadian population of mothers: a secondary analysis of prospective cohort data. Local and regional anesthesia. 2017; 10: 99. doi: 10.2147/LRA.S141569 29184440 PMC5673041 · DOI · Paper page
  26. [27]Kaur A, Mitra S, Singh J, Sarna R, Pandher DK, Saroa R, et al. Pain, stress, analgesia and postpartum depression: Revisiting the controversy with a randomized controlled trial. Saudi Journal of Anaesthesia. 2020; 14(4): 473. doi: 10.4103/sja.SJA_814_19 33447189 PMC7796742 · DOI
  27. [28]Orbach-Zinger S, Landau R, Harousch AB, Ovad O, Caspi L, Kornilov E, et al. The Relationship Between Women’s Intention to Request a Labor Epidural Analgesia, Actually Delivering With Labor Epidural Analgesia, and Postpartum Depression at 6 Weeks: A Prospective Observational Study. Anesth Analg. 2018; 126(5): 1590– 7. doi: 10.1213/ANE.0000000000002501 28930940 · DOI
  28. [29]Hildingsson I, Rubertsson C, Karlstrom A, Haines H. Exploring the Fear of Birth Scale in a mixed population of women of childbearing age-A Swedish pilot study. Women Birth. 2018; 31(5): 407– 13. doi: 10.1016/j.wombi.2017.12.005 29249331 · DOI

Cited by

Sorted by citations

Authors
Ahmad, H. M. Y., Althagafi, L. A., Albluwe, G. Z., Kadi, S. M., Alhassani, R. I., & Bahkali, N. M.
Affiliations
King Abdulaziz University (SA)
Corresponding author
Ahmad, Hanin Mohammed Yaqoob
Venue
PLOS ONE
Published
2023-10-31
Volume
18
Issue
10
Pages
e0289595
ISSN
1932-6203 (ISSN-L)
OpenAlex
W4388041496
Cited by
7
References
1
Citations by year
2026: 3 · 2025: 3 · 2024: 1
FWCI
1.78
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Keywords
epidural analgesia, postpartum depression, labor analgesia, postpartum pain, Edinburgh Postnatal Depression Scale, postpartum depression screening, maternal mental health, Saudi Arabia
MeSH terms
Female, Humans, Labor, Obstetric, Pain, Pregnancy, Analgesia, Epidural, Incidence, Analgesia, Obstetrical, Depression, Postpartum, Pain Management

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review