Association between the use of epidural analgesia during labour and incidence of postpartum depression
Open accessAbstract
Introduction: Postpartum depression is a significant episode of depression beginning after giving birth. The prevalence of postpartum depression is approximately 20% in Jeddah, Saudi Arabia. Epidural analgesia is the gold standard for labour pain management. Conflicting results exist regarding the association between postpartum depression and epidural analgesia use during labour. Accordingly, this study assessed the association between epidural analgesia use and postpartum depression incidence. Methods: A prospective observational study of 170 mothers was conducted, with surveys administered after labour and at six weeks postpartum. Surveys included the following: mothers’ demographics, obstetric history, postpartum depression (Edinburgh Postnatal Depression Scale), and pain severity (Visual Analogue Scale). Results: In the final analysis, 91 patients were enrolled. Epidural analgesia was administered to 48.4% of mothers during labour. Nearly two-thirds of mothers learned about EA via sources including family members and social media. However, more than half reported worries regarding epidural analgesia. Edinburgh Postnatal Depression Scale scores showed that 38 mothers (41.8%) likely had depressive symptoms within two days following delivery. Further, 35 (38.5%) met criteria for postpartum depression at six weeks postpartum. For both groups regardless use of analgesia, the mean Visual Analogue Scale score at two days postpartum was 4.16 ± 2.13. Data revealed no correlation between epidural analgesia use and Edinburgh Postnatal Depression Scale within two days and at six weeks postpartum. Multiple regression analysis showed Edinburgh Postnatal Depression Scale scores correlated with Visual Analogue Scale scores but not epidural analgesia use at 1–2 days postpartum. Conclusion: This study showed that depressive symptoms resolved in three percent of participants. This suggests that institutions should increase postpartum depression awareness during the antenatal period and implement effective post-delivery screening systems for postpartum depression.
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In the same study, 38.5% of mothers met the criteria for postpartum depression at six weeks.
“EPDS is a universal screening method that showed that nearly 40% of these mothers had depressive symptoms two days following delivery, and 38.5% of these mothers met the criteria for PPD at six weeks.82”
In a study of 91 patients, nearly 40% of mothers had depressive symptoms two days following delivery.
“EPDS is a universal screening method that showed that nearly 40% of these mothers had depressive symptoms two days following delivery, and 38.5% of these mothers met the criteria for PPD at six weeks.82”
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Fagan, J., Dufour, S., Duet, S., Downs, E., Siddaiah, H., Viswanath, O., Shekoohi, S., & Kaye, A. (2026) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s579920
- Authors
- Ahmad, H. M. Y., Althagafi, L. A., Albluwe, G. Z., Kadi, S. M., Alhassani, R. I., & Bahkali, N. M.
- Affiliations
- King Abdulaziz University (SA)
- Corresponding author
- Ahmad, Hanin Mohammed Yaqoob
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2023-10-31
- Volume
- 18
- Issue
- 10
- Pages
- e0289595
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC10617733
- OpenAlex
- W4388041496
- Cited by
- 7
- References
- 1
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- epidural analgesia, postpartum depression, labor analgesia, postpartum pain, Edinburgh Postnatal Depression Scale, postpartum depression screening, maternal mental health, Saudi Arabia
- MeSH terms
- Female, Humans, Labor, Obstetric, Pain, Pregnancy, Analgesia, Epidural, Incidence, Analgesia, Obstetrical, Depression, Postpartum, Pain Management
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