The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
MDA-5 Recognition of a Murine Norovirus
Open accessAbstract
Noroviruses are important human pathogens responsible for most cases of viral epidemic gastroenteritis worldwide. Murine norovirus-1 (MNV-1) is one of several murine noroviruses isolated from research mouse facilities and has been used as a model of human norovirus infection. MNV-1 infection has been shown to require components of innate and adaptive immunity for clearance; however, the initial host protein that recognizes MNV-1 infection is unknown. Because noroviruses are RNA viruses, we investigated whether MDA5 and TLR3, cellular sensors that recognize dsRNA, are important for the host response to MNV-1. We demonstrate that MDA5-/- dendritic cells(DC) have a defect in cytokine response to MNV-1. In addition, MNV-1 replicates to higher levels in MDA5-/- DCs as well as in MDA5-/- mice in vivo. Interestingly, TLR3-/- DCs do not have a defect in vitro, but TLR3-/- mice have a slight increase in viral titers. This is the first demonstration of an innate immune sensor for norovirus and shows that MDA5 is required for the control of MNV-1 infection. Knowledge of the host response to MNV-1 may provide keys for prevention and treatment of the human disease.
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Cites
A Toll-like receptor recognizes bacterial DNA
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Cited by
Immune Signaling by RIG-I-like Receptors
Loo, Y.-M., & Gale, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.003 · Cited by 1,875
Jensen, S., & Thomsen, A. R. (2012) · Journal of Virology · doi:10.1128/jvi.05738-11 · Cited by 604
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Metadata
- Authors
- McCartney, S. A., Thackray, L. B., Gitlin, L., Gilfillan, S., Virgin IV, H. W., & Colonna, M.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-07-18
- Volume
- 4
- Issue
- 7
- Pages
- e1000108
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2127096990
- Cited by
- 228
- References
- 8
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- McCartney, S. A., Thackray, L. B., Gitlin, L., Gilfillan, S., Virgin IV, H. W., & Colonna, M. (2008). MDA-5 Recognition of a Murine Norovirus. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1000108
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