Placental Syncytiotrophoblast Constitutes a Major Barrier to Vertical Transmission of Listeria monocytogenes
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Listeria monocytogenes is an important cause of maternal-fetal infections and serves as a model organism to study these important but poorly understood events. L. monocytogenes can infect non-phagocytic cells by two means: direct invasion and cell-to-cell spread. The relative contribution of each method to placental infection is controversial, as is the anatomical site of invasion. Here, we report for the first time the use of first trimester placental organ cultures to quantitatively analyze L. monocytogenes infection of the human placenta. Contrary to previous reports, we found that the syncytiotrophoblast, which constitutes most of the placental surface and is bathed in maternal blood, was highly resistant to L. monocytogenes infection by either internalin-mediated invasion or cell-to-cell spread. Instead, extravillous cytotrophoblasts-which anchor the placenta in the decidua (uterine lining) and abundantly express E-cadherin-served as the primary portal of entry for L. monocytogenes from both extracellular and intracellular compartments. Subsequent bacterial dissemination to the villous stroma, where fetal capillaries are found, was hampered by further cellular and histological barriers. Our study suggests the placenta has evolved multiple mechanisms to resist pathogen infection, especially from maternal blood. These findings provide a novel explanation why almost all placental pathogens have intracellular life cycles: they may need maternal cells to reach the decidua and infect the placenta.
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Incubation of placental villi with listeria in vitro revealed that the bacteria are only able to penetrate at sites where the syncytiotrophoblast is damaged or absent.
“They are also potential portals for infectious agents; indeed, incubation of placental villi with listeria in vitro revealed that the bacteria are only able to penetrate at sites where the syncytiotrophoblast is damaged or absent (465).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [465]
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- Authors
- Robbins, J. R., Skrzypczynska, K. M., Zeldovich, V. B., Kapidzic, M., & Bakardjiev, A. I.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Bakardjiev, Anna I.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-01-22
- Volume
- 6
- Issue
- 1
- Pages
- e1000732
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC2809766
- OpenAlex
- W2047338466
- Cited by
- 212
- References
- 78
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 7 · 2023: 15 · 2022: 12 · 2021: 23 · 2020: 17 · 2019: 11 · 2018: 7 · 2017: 15 · 2016: 12 · 2015: 8 · 2014: 10 · 2013: 18 · 2012: 12
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Exhibit - A Showcase of Scholarship, Creativity and Preservation Provided by Xavier University Library (Xavier University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (K08AI064951, T32AI060537)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Listeria monocytogenes in Food Safety
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- Listeria monocytogenes, syncytiotrophoblast, placenta, vertical transmission, maternal-fetal infection, extravillous cytotrophoblast, E-cadherin, cell-to-cell transmission, decidua, placental barrier
- MeSH terms
- Female, Fluorescent Antibody Technique, Humans, Image Processing, Computer-Assisted, Listeriosis, Listeria monocytogenes, Organ Culture Techniques, Placenta Diseases, Pregnancy, Pregnancy Complications, Infectious, Trophoblasts, Infectious Disease Transmission, Vertical, Microscopy, Confocal
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