Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554 · see citing works

Mucosal immunity and vaccines

Holmgren, J. R., & Czerkinsky, C. C. (2005) · Nature Medicine · doi:10.1038/nm1213 · Cited by 1,559 · see citing works

Veterinary Immunology: An Introduction (2000)

(2001) · Journal of Equine Veterinary Science · doi:10.1016/s0737-0806(01)70088-3 · Cited by 914 · see citing works

Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.

Jones, B. D., Ghori, N., & Falkow, S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.15 · Cited by 883 · see citing works

Epithelial Cell Specialization within Human Peyer's Patches: An Ultrastructural Study of Intestinal Lymphoid Follicles

Owen, R. L., & Jones, A. L. (1974) · Gastroenterology · doi:10.1016/s0016-5085(74)80102-2 · Cited by 765 · see citing works

NALT- versus PEYER'S-patch-mediated mucosal immunity

Kiyono, H., & Fukuyama, S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1439 · Cited by 745 · see citing works

Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics

Hussain, N. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00152-1 · Cited by 682 · see citing works

Conversion by Peyer's Patch Lymphocytes of Human Enterocytes into M Cells that Transport Bacteria

Kernéis, S. M., Bogdanova, A. A., Kraehenbühl, J.-P., & Pringault, E. (1997) · Science · doi:10.1126/science.277.5328.949 · Cited by 630 · see citing works

Vaccines: past, present and future

Plotkin, S. A. (2005) · Nature Medicine · doi:10.1038/nm1209 · Cited by 597 · see citing works

Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens

Jiang, W., Rk, G., DESHPANDE, M., & Schwendeman, S. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.09.003 · Cited by 480 · see citing works

Epithelial M Cells: Differentiation and Function

Kraehenbühl, J.-P., & Neutra, M. R. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.301 · Cited by 475 · see citing works

Human Neonatal Fc Receptor Mediates Transport of IgG into Luminal Secretions for Delivery of Antigens to Mucosal Dendritic Cells

Yoshida, M., Claypool, S. M., Wagner, J. S., Mizoguchi, E., Mizoguchi, A., Roopenian, D. C., Lencer, W. I., & Blumberg, R. S. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.007 · Cited by 472 · see citing works

Intestinal villous M cells: An antigen entry site in the mucosal epithelium

Jang, M. H., Kweon, M., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert, P. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400969101 · Cited by 471 · see citing works

Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie

Andréoletti, O., Berthon, P., Marc, D., Sarradin, P., Grosclaude, J., van Keulen, L. J. M., Schelcher, F., Elsen, J.-M., & Lantier, F. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-12-3115 · Cited by 418 · see citing works

Number, size, and distribution of Peyer's patches in the human small intestine

Cornes, J. S. (1965) · Gut · doi:10.1136/gut.6.3.225 · Cited by 391 · see citing works

Transgenic mice expressing a human poliovirus receptor: A new model for poliomyelitis

Ren, R., Costantini, F. D., Gorgacz, E. J., Lee, J. J., & Racaniello, V. R. (1990) · Cell · doi:10.1016/0092-8674(90)90168-e · Cited by 379 · see citing works

M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells

Clark, M. A., Hirst, B. H., & Jepson, M. A. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.1237-1243.1998 · Cited by 363 · see citing works

M Cell Transport of Vibrio cholerae from the Intestinal. Lumen into Peyer's Patches: A Mechanism for Antigen Sampling and for Microbial Transepithelial Migration

Owen, R. L., Pierce, N. F., Apple, R. T., & Cray, W. C. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/153.6.1108 · Cited by 350 · see citing works

M Cells in Peyer's Patches of the Intestine

Gebert, A., Rothkötter, H., & Pabst, R. (1996) · International review of cytology · doi:10.1016/s0074-7696(08)61346-7 · Cited by 319 · see citing works

The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches.

Bäumler, A. J., Tsolis, R. M., & Heffron, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.279 · Cited by 288 · see citing works

Expression of specific markers and particle transport in a new human intestinal M-cell model

Gullberg, E., Leonard, M., Karlsson, J., Hopkins, A. M., Brayden, D., Baird, A. W., & Artursson, P. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4038 · Cited by 270 · see citing works

Exploiting M cells for drug and vaccine delivery

Clark, M. A. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00149-1 · Cited by 247 · see citing works

Transepithelial prion transport by M cells

Heppner, F. L., Christ, A. D., Klein, M. A., Prinz, M., Fried, M., Kraehenbühl, J.-P., & Aguzzi, A. (2001) · Nature Medicine · doi:10.1038/nm0901-976 · Cited by 236 · see citing works

Organogenic Role of B Lymphocytes in Mucosal Immunity

Golovkina, T. V., Shlomchik, M. J., Hannum, L. G., & Chervonsky, A. V. (1999) · Science · doi:10.1126/science.286.5446.1965 · Cited by 233 · see citing works

Selective Adherence of IgA to Murine Peyer’s Patch M Cells: Evidence for a Novel IgA Receptor

Mantis, N. J., Cheung, M. C., Chintalacharuvu, K. R., Rey, J., Corthésy, B., & Neutra, M. R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1844 · Cited by 228 · see citing works

Protective Immunity Induced by Oral Immunization with a Rotavirus DNA Vaccine Encapsulated in Microparticles

Chen, S. C., Jones, D. H., Fynan, E. F., Farrar, G. H., Clegg, J. C. S., Greenberg, H. B., & Herrmann, J. E. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5757-5761.1998 · Cited by 226 · see citing works

Differential expression of lectin-binding sites defines mouse intestinal M-cells.

Clark, M. A., Jepson, M. A., Simmons, N. L., Booth, T. A., & Hirst, B. H. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.11.7691933 · Cited by 221 · see citing works

Cryptosporidium: Cellular Localization, Structural Analysis of Absorptive CellParasite Membrane-Membrane Interactions in Guinea Pigs, and Suggestion of Protozoan Transport by M Cells

Marcial, M. A., & Madara, J. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)91112-1 · Cited by 220 · see citing works

Interactions of the Invasive PathogensSalmonella typhimurium,Listeria monocytogenes, andShigella flexneriwith M Cells and Murine Peyer’s Patches

Jensen, V. B., Harty, J. T., & Jones, B. D. (1998) · Infection and Immunity · doi:10.1128/iai.66.8.3758-3766.1998 · Cited by 217 · see citing works

Current Understanding of Gastrointestinal Immunoregulation and Its Relation to Food Allergy

Brandtzæg, P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04131.x · Cited by 208 · see citing works

Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells

Belyakov, I. M., Hammond, S. A., Ahlers, J. D., Glenn, G. M., & Berzofsky, J. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20261 · Cited by 202 · see citing works

Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches— a personal and historical perspective

Owen, R. L. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0171 · Cited by 173 · see citing works

Immunoglobulin diversity, B-cell and antibody repertoire development inlarge farm animals

Butler, J. E. (1998) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.17.1.1096 · Cited by 164 · see citing works

The role of M cells in infection

Jepson, M. A., & Clark, M. A. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01478-2 · Cited by 162 · see citing works

Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers

Ivanov, A. I., Nusrat, A., & Parkos, C. A. (2005) · BioEssays · doi:10.1002/bies.20203 · Cited by 155 · see citing works

Human Intestinal M Cells Display the Sialyl Lewis A Antigen

Giannasca, P. J., Giannasca, K. T., Leichtner, A. M., & Neutra, M. R. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.946-953.1999 · Cited by 155 · see citing works

Regional differences in glycoconjugates of intestinal M cells in mice: potential targets for mucosal vaccines

Giannasca, P. J., Giannasca, K. T., Falk, P., Gordon, J. I., & Neutra, M. R. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.6.g1108 · Cited by 154 · see citing works

Salmonella-induced M-cell formation in germ-free mouse Peyer's patch tissue.

Savidge, T., Mw, S., James, P. S., & Aldred, P. (1991) · PubMed Central · Cited by 151 · see citing works

Proteolytic digestion of reovirus in the intestinal lumens of neonatal mice

Bodkin, D. K., Nibert, M. L., & Fields, B. N. (1989) · Journal of Virology · doi:10.1128/jvi.63.11.4676-4681.1989 · Cited by 149 · see citing works

Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo

Foster, N. M. (1998) · Vaccine · doi:10.1016/s0264-410x(97)00222-3 · Cited by 145 · see citing works

Peyer's Patch Dendritic Cells Process Viral Antigen from Apoptotic Epithelial Cells in the Intestine of Reovirus-infected Mice

Fleeton, M. N., Contractor, N., Leon, F., Wetzel, J. D., Dermody, T. S., & Kelsall, B. L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041132 · Cited by 143 · see citing works

Distribution of prion protein in the ileal Peyer’s patch of scrapie-free lambs and lambs naturally and experimentally exposed to the scrapie agent

Heggebø, R., Press, C. M., Gunnes, G., Lie, K. I., Tranulis, M. A., Ulvund, M. J., Groschup, M. H., & Landsverk, T. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-9-2327 · Cited by 132 · see citing works

Cell renewal and migration in lymphoid follicles of Peyer's patches and cecum—An autoradiographic study in mice

Bhalla, D. K., & Owen, R. L. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90010-5 · Cited by 130 · see citing works

Targeting polymerised liposome vaccine carriers to intestinal M cells

Clark, M. A., Blair, H. J., Liang, L., Brey, R. N., Brayden, D. J., & Hirst, B. H. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00258-4 · Cited by 130 · see citing works

M cell targeting by lectins: a strategy for mucosal vaccination and drug delivery

Jepson, M. A., Clark, M. A., & Hirst, B. H. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.018 · Cited by 130 · see citing works

Studying M cells and their role in infection

Jepson, M. A., & Clark, M. A. (1998) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01337-7 · Cited by 129 · see citing works

The mucosal immune system

MacDonald, T. T. (2003) · Parasite Immunology · doi:10.1046/j.1365-3024.2003.00632.x · Cited by 123 · see citing works

Immunofluorescence Analysis of Poliovirus Receptor Expression in Peyer's Patches of Humans, Primates, and CD155 Transgenic Mice: Implications for Poliovirus Infection

Iwasaki, A., Welker, R., Mueller, S., Linehan, M. M., Nomoto, A., & Wimmer, E. (2002) · The Journal of Infectious Diseases · doi:10.1086/342682 · Cited by 121 · see citing works

Rat intestinal M cells contain acidic endosomal-lysosomal compartments and express class II major histocompatibility complex determinants

Allan, C. H., Mendrick, D. L., & Trier, J. S. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)91004-2 · Cited by 113 · see citing works

Oral immunization of adult volunteers with microencapsulated enterotoxigenic Escherichia coli (ETEC) CS6 antigen

Katz, D. E., Delorimier, A., Wolf, M. K., Hall, E. R., Cassels, F. J., van Hamont, J. E., Newcomer, R., Davachi, M. A., Taylor, D. N., & McQueen, C. E. (2003) · Vaccine · doi:10.1016/s0264-410x(02)00613-8 · Cited by 109 · see citing works

Host restriction phenotypes of Salmonella typhi and Salmonella gallinarum

Pascopella, L., Raupach, B., Ghori, N., Monack, D. M., Falkow, S., & Small, P. L. C. (1995) · Infection and Immunity · doi:10.1128/iai.63.11.4329-4335.1995 · Cited by 106 · see citing works

Selective association and transport of Campylobacter jejuni through M cells of rabbit Peyer's patches

Walker, R. I., Schmauder-Chock, E. A., Parker, J. L., & Burr, D. H. (1988) · Canadian Journal of Microbiology · doi:10.1139/m88-201 · Cited by 104 · see citing works

The Viral σ1 Protein and Glycoconjugates Containing α2-3-Linked Sialic Acid Are Involved in Type 1 Reovirus Adherence to M Cell Apical Surfaces

Helander, A., Silvey, K. J., Mantis, N. J., Hutchings, A. B., Chandran, K., Lucas, W. T., Nibert, M. L., & Neutra, M. R. (2003) · Journal of Virology · doi:10.1128/jvi.77.14.7964-7977.2003 · Cited by 102 · see citing works

Transepithelial transport of HIV-1 by M cells is receptor-mediated

Fotopoulos, G., Harari, A., Michetti, P., Trono, D., Pantaleo, G., & Kraehenbühl, J.-P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142586899 · Cited by 101 · see citing works

Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches

Debard, N., Sierro, F., Browning, J. L., & Kraehenbühl, J.-P. (2001) · Gastroenterology · doi:10.1053/gast.2001.22476 · Cited by 99 · see citing works

Mucosal immune responses following oral immunization with rotavirus antigens encapsulated in alginate microspheres

Kim, B. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00280-8 · Cited by 93 · see citing works

THE ROLE OF GUT‐ASSOCIATED LYMPHOID TISSUES IN THE GENERATION OF IMMUNOGLOBULIN‐BEARING LYMPHOCYTES IN SHEEP

Gerber, H., Morris, B., & Trevella, W. (1986) · Immunology and Cell Biology · doi:10.1038/icb.1986.22 · Cited by 89 · see citing works

Poliovirus transcytosis through M-like cells

Ouzilou, L., Caliot, É., Pelletier, I., Prévost, M., Pringault, E., & Colbère-Garapin, F. (2002) · Journal of General Virology · doi:10.1099/0022-1317-83-9-2177 · Cited by 88 · see citing works

Antigen Transport into Peyer's Patches

Gebert, A., Steinmetz, I., Fassbender, S., & Wendlandt, K.-H. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63097-0 · Cited by 87 · see citing works

Improving M cell mediated transport across mucosal barriers: do certain bacteria hold the keys?

Man, A., Prieto‐Garcia, M. E., & Nicoletti, C. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01964.x · Cited by 86 · see citing works

Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer's patch by expression profiling of Caco-2/Raji co-cultures

Lo, D. D. (2003) · International Immunology · doi:10.1093/intimm/dxh011 · Cited by 83 · see citing works

Effectiveness of Liposomes Possessing Surface-Linked Recombinant B Subunit of Cholera Toxin as an Oral Antigen Delivery System

Harokopakis, E., Hajishengallis, G., & Michalek, S. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.9.4299-4304.1998 · Cited by 80 · see citing works

Quantitative determination of macromolecular transport rate across intestinal Peyer's patches

Keljo, D. J., & Hamilton, J. R. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.244.6.g637 · Cited by 80 · see citing works

Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells: a technical update

Kernéis, S., Caliot, E., Stubbe, H., Bogdanova, A., Kraehenbuhl, J.-P., & Pringault, E. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)01266-1 · Cited by 79 · see citing works

Role of Immunoglobulin A in Protection against Reovirus Entry into Murine Peyer's Patches

Silvey, K. J., Hutchings, A. B., Vajdy, M., Petzke, M. M., & Neutra, M. R. (2001) · Journal of Virology · doi:10.1128/jvi.75.22.10870-10879.2001 · Cited by 78 · see citing works

Secretory Immunoglobulin A Antibodies against the σ1 Outer Capsid Protein of Reovirus Type 1 Lang Prevent Infection of Mouse Peyer's Patches

Hutchings, A. B., Helander, A., Silvey, K. J., Chandran, K., Lucas, W. T., Nibert, M. L., & Neutra, M. R. (2003) · Journal of Virology · doi:10.1128/jvi.78.2.947-957.2004 · Cited by 78 · see citing works

Toll-like receptor 2 is expressed on the intestinal M cells in swine

Tohno, M., Shimosato, T., Kitazawa, H., Katoh, S., Iliev, I. D., Kimura, T., Kawai, Y., Watanabe, K., Aso, H., Yamaguchi, T., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.017 · Cited by 77 · see citing works

Peptidoglycan recognition protein expression in mouse Peyer’s Patch follicle associated epithelium suggests functional specialization

Lo, D. D., Tynan, W., Dickerson, J., Mendy, J., Chang, H.-W., Scharf, M., Byrne, D., Brayden, D. J., Higgins, L. M., Evans, C. F., et al. (2003) · Cellular Immunology · doi:10.1016/s0008-8749(03)00155-2 · Cited by 76 · see citing works

Up‐regulation of microsphere transport across the follicle‐associated epithelium of Peyer's patch by exposure to Streptococcus pneumoniae R36a

Meynell, H. M., Thomas, N. W., James, P. S., Holland, J., Taussig, M., & Nicoletti, C. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.6.611 · Cited by 76 · see citing works

Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer's patches

Shimosato, T., Tohno, M., Kitazawa, H., Katoh, S., Watanabe, K., Kawai, Y., Aso, H., Yamaguchi, T., & Saito, T. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.10.026 · Cited by 73 · see citing works

Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy

Frossard, C. P., Tropia, L., Hauser, C., & Eigenmann, P. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.017 · Cited by 73 · see citing works

New technology platforms in the development of vaccines for the future

Glück, R., & Metcalfe, I. C. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00513-3 · Cited by 72 · see citing works

The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue

(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70 · see citing works

Lymphotoxin and TNF Produced by B Cells Are Dispensable for Maintenance of the Follicle-Associated Epithelium but Are Required for Development of Lymphoid Follicles in the Peyer’s Patches

Tumanov, A. V., Kuprash, D. V., Mach, J. A., Nedospasov, S. A., & Chervonsky, A. V. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.86 · Cited by 69 · see citing works

Transport of Chitosan Microparticles for Mucosal Vaccine Delivery in a Human Intestinal M-cell Model

van der Lubben, I. M., van Opdorp, F. A. C., Hengeveld, M. R., Onderwater, J. J. M., Koerten, H. K., Verhoef, J. C., Borchard, G., & Junginger, H. E. (2002) · Journal of drug targeting · doi:10.1080/1061186021000038319 · Cited by 67 · see citing works

Accessibility of glycolipid and oligosaccharide epitopes on rabbit villus and follicle-associated epithelium

Mantis, N. J., Frey, A., & Neutra, M. R. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.6.g915 · Cited by 63 · see citing works

Exploiting receptor biology for oral vaccination with biodegradable particulates

Foster, N. M., & Hirst, B. H. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.09.009 · Cited by 60 · see citing works

Use of fluorescence imaging to investigate the structure and function of intestinal M cells

BUDA, A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.07.014 · Cited by 59 · see citing works

Establishment of Mycobacterium avium subsp. paratuberculosis infection in the intestine of ruminants

Sigurðardóttir, O. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.032 · Cited by 58 · see citing works

M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy

Roth-Walter, F., Schöll, I., Untersmayr, E., Fuchs, R., Boltz-Nitulescu, G., Weissenböck, A., Scheiner, O., Gabor, F., & Jensen-Jarolim, E. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.08.010 · Cited by 58 · see citing works

Development of Peyer's patches, follicle-associated epithelium and M cell: Lessons from immunodeficient and knockout mice

Debard, N., Sierro, F., & Kraehenbühl, J.-P. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0174 · Cited by 56 · see citing works

Mucosal targeting of allergen-loaded microspheres by Aleuria aurantia lectin

Roth-Walter, F., Schöll, I., Untersmayr, E., Ellinger, A., Boltz-Nitulescu, G., Scheiner, O., Gabor, F., & Jensen-Jarolim, E. (2005) · Vaccine · doi:10.1016/j.vaccine.2004.11.052 · Cited by 55 · see citing works

Distribution of rotavirus antigen in intestinal lymphoid tissues: potential role in development of the mucosal immune response to rotavirus.

Dharakul, T., Riepenhoff-Talty, M., Albini, B., & Ogra, P. L. O. (1988) · PubMed Central · Cited by 54 · see citing works

Epithelial M cells in the rabbit caecal lymphoid patch display distinctive surface characteristics

Jepson, M. A., Clark, M. A., Simmons, N. L., & Hirst, B. H. (1993) · Histochemistry and Cell Biology · doi:10.1007/bf00267824 · Cited by 52 · see citing works

Validation and quantitation of an in vitro M-cell model

Tyrer, P., Ruth Foxwell, A., Kyd, J., Harvey, M., Sizer, P., & Cripps, A. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02631-1 · Cited by 51 · see citing works

Expression and distribution of β1 integrins in in vitro-induced M cells: implications for Yersinia adhesion to Peyer's patch epithelium

Hamzaoui, N., Kernéis, S. M., Caliot, É., & Pringault, E. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00391.x · Cited by 50 · see citing works

Involvement of gut-associated lymphoid tissue of ruminants in the spread of transmissible spongiform encephalopathies

Press, C. M. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.09.008 · Cited by 43 · see citing works

Rotavirus Vaccines' Second Chance

Roberts, L. (2004) · Science · doi:10.1126/science.305.5692.1890 · Cited by 42 · see citing works

Gut-level decisions in peace and war

Rescigno, M., & Chieppa, M. (2005) · Nature Medicine · doi:10.1038/nm0305-254 · Cited by 42 · see citing works

Toward Targeted Oral Vaccine Delivery Systems: Selection of Lectin Mimetics from Combinatorial Libraries

Lambkin, I., Pinilla, C., Hamashin, C., Spindler, L., Russell, S., Schink, A., Moya-Castro, R., Allicotti, G., Higgins, L., Smith, M., et al. (2003) · Pharmaceutical Research · doi:10.1023/a:1025061317400 · Cited by 39 · see citing works

Interaction ofListeria monocytogeneswith the intestinal epithelium

Daniels, J. J. D., Autenrieth, I. B., & Goebel, W. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09306.x · Cited by 38 · see citing works

Human Peyer's Patches: Lympho-Epithelial Relationships and Characteristics of Immunoglobulin-Producing Cells

Brandtzaeg, P., & Bjerke, K. (1989) · Immunological Investigations · doi:10.3109/08820138909112225 · Cited by 37 · see citing works

An experimental divalent vaccine based on biodegradable microspheres induces protective immunity against tetanus and diphtheria

Peyre, M., Sesardic, D., Merkle, H. P., Gander, B., & Johansen, P. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10361 · Cited by 36 · see citing works

Lymphoepithelial Interactions Trigger Specific Regulation of Gene Expression in the M Cell-Containing Follicle-Associated Epithelium of Peyer’s Patches

Bahi, S. E., Caliot, É., Bens, M., Bogdanova, A. A., Kernéis, S. M., Kahn, A., Vandewalle, A., & Pringault, E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.8.3713 · Cited by 33 · see citing works

Expression of junction-associated proteins differentiates mouse intestinal M cells from enterocytes

Clark, A. M., & Hirst, B. H. (2002) · Histochemistry and Cell Biology · doi:10.1007/s00418-002-0433-z · Cited by 32 · see citing works

Peyer's patch adherence of enteropathogenic Escherichia coli strains in rabbits

MOLL, L. K. V., & Cantey, J. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3788-3793.1997 · Cited by 31 · see citing works

Automated histochemical analysis of cell populations in the intact follicle-associated epithelium of the mouse Peyer's patch

Mw, S., James, P. S., Tivey, D. R., & Brown, D. (1988) · The Histochemical Journal · doi:10.1007/bf01002430 · Cited by 30 · see citing works

Glycocalyx on Rabbit Intestinal M Cells Displays Carbohydrate Epitopes from Muc2

Lelouard, H., Reggio, H., Roy, C., Sahuquet, A., Mangeat, P. H., & Montcourrier, P. (2001) · Infection and Immunity · doi:10.1128/iai.69.2.1061-1071.2001 · Cited by 29 · see citing works

Expression of ICAM-I on M cells covering isolated lymphoid follicles of the human colon.

Ueki, T., Mizuno, M., Uesu, T., Kiso, T., & Tsuji, T. (1995) · PubMed · doi:10.18926/amo/30412 · Cited by 27 · see citing works

Occluding junctions in the epithelia of the gut-associated lymphoid tissue (GALT) of the rabbit ileum and caecum

Gebert, A., & Bartels, H. (1991) · Cell and Tissue Research · doi:10.1007/bf00318186 · Cited by 25 · see citing works

Vimentin-positive Cells in the Epithelium of Rabbit Ileal Villi Represent Cup Cells but not M-cells

Ramı́rez-Santana, C., & Gebert, A. (2003) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540305101113 · Cited by 21 · see citing works

A distinctive electrophysiological signature from the Peyer's patches of rabbit intestine

Brayden, D. J., & Baird, A. W. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17031.x · Cited by 19 · see citing works

Expression of ICAM-1 on M cells covering isolated lymphoid follicles of the human colon

亨, 植. (1995) · Institutional Repositories DataBase (IRDB) · doi:10.11501/3104897 · Cited by 11 · see citing works

Cellular Kinetics of Villous Epithelial Cells and M Cells in Rabbit Small Intestine

Takeuchi, T., & Gonda, T. (2004) · Journal of Veterinary Medical Science · doi:10.1292/jvms.66.689 · Cited by 11 · see citing works

Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach

des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305 · see citing works

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Homayun, B., Lin, X., & Choi, H. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030129 · Cited by 919 · see citing works

Advances in Oral Drug Delivery

Alqahtani, M. S., Kazi, M., Alsenaidy, M. A., & Ahmad, M. Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.618411 · Cited by 886 · see citing works

Formulation, stabilisation and encapsulation of bacteriophage for phage therapy

Malik, D. J., Sokolov, I. J., Vinner, G. K., Mancuso, F., Cinquerrui, S., Vladisavljevic, G. T., Clokie, M. R. J., Garton, N. J., Stapley, A. G. F., & Kirpichnikova, A. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.05.014 · Cited by 594 · see citing works

Is the oral route possible for peptide and protein drug delivery?

Morishita, M., & Peppas, N. A. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.08.005 · Cited by 515 · see citing works

Current challenges in non-invasive insulin delivery systems: A comparative review

Khafagy, E., Morishita, M., Onuki, Y., & Takayama, K. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.019 · Cited by 436 · see citing works

Current state and challenges in developing oral vaccines

Ramirez, J. E. V., Sharpe, L. A., & Peppas, N. A. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.008 · Cited by 410 · see citing works

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Zhu, Q., Chen, Z., Paul, P. K., Lü, Y., Wu, W., & Qi, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.04.001 · Cited by 366 · see citing works

A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives

Muheem, A., Shakeel, F., Jahangir, M. A., Anwar, M., Mallick, N., Jain, G. K., Warsi, M. H., & Ahmad, F. J. (2014) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2014.06.004 · Cited by 343 · see citing works

PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination

Garinot, M., Fiévez, V., Pourcelle, V., Stoffelbach, F., des Rieux, A., Plapied, L., Theate, I., Freichels, H., Jérôme, C., Marchand-Brynaert, J., et al. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.04.021 · Cited by 331 · see citing works

M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis

Corr, S. C., Gahan, C. C. G. M., & Hill, C. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00359.x · Cited by 320 · see citing works

Biopharmaceutical Parameters to Consider in Order to Alter The Fate of Nanocarriers After Oral Delivery

Roger, E., Lagarce, F., Garcion, E., & Benoît, J. (2010) · Nanomedicine · doi:10.2217/nnm.09.110 · Cited by 324 · see citing works

Fate of polymeric nanocarriers for oral drug delivery

Plapied, L., Duhem, N., Rieux, A. D., & Véronique Préat, A. (2011) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2010.12.005 · Cited by 320 · see citing works

Intestinal permeability and its relevance for absorption and elimination

Lennernäs, H. (2007) · Xenobiotica · doi:10.1080/00498250701704819 · Cited by 304 · see citing works

An update on oral drug delivery via intestinal lymphatic transport

Zhang, Z., Lü, Y., Qi, J., & Wu, W. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.12.022 · Cited by 242 · see citing works

Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic

Maher, S., Leonard, T. W., Jacobsen, J. B., & Brayden, D. J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.09.006 · Cited by 227 · see citing works

Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems

Xu, Y., Shrestha, N., Véronique Préat, A., & Beloqui, A. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.006 · Cited by 215 · see citing works

Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1

Batbayar, S., Lee, D.-H., & Kim, H.-W. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.5.433 · Cited by 198 · see citing works

Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination

Slütter, B., Plapied, L., Fievez, V., Alonso, M. J., Rieux, A. D., Schneider, Y., van Riet, E., Jiskoot, W., & Véronique Préat, A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.05.011 · Cited by 192 · see citing works

Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells

Azizi, A., Kumar, A., Diaz-Mitoma, F., & Mestecky, J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001147 · Cited by 180 · see citing works

Biodegradable polymers in drug delivery and oral vaccination

Jana, P., Shyam, M., Singh, S., Jayaprakash, V., & Dev, A. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.110155 · Cited by 180 · see citing works

A novel M cell–specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses

Nochi, T., Yuki, Y., Matsumura, A., Mejima, M., Terahara, K., Kim, D. Y., Fukuyama, S., Iwatsuki‐Horimoto, K., Kawaoka, Y., Kohda, T., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070607 · Cited by 177 · see citing works

Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

Lee, Y., Kamada, N., & Moon, J. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114021 · Cited by 168 · see citing works

Cyclodextrin nanosystems in oral drug delivery: A mini review

Adeoye, O., & Cabral-Marques, H. M. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.04.050 · Cited by 158 · see citing works

Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug delivery systems - A systematic review

Balusamy, B., Çelebioğlu, A., Anitha, S., & Uyar, T. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.038 · Cited by 158 · see citing works

Oral delivery of nanoparticle-based vaccines

Marasini, N., Skwarczyński, M., & Tóth, I. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2014.936852 · Cited by 157 · see citing works

Animal data: The contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo☆

Lennernäs, H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.016 · Cited by 155 · see citing works

Matrix-loaded biodegradable gelatin nanoparticles as new approach to improve drug loading and delivery

Ofokansi, K. C., Winter, G., Fricker, G., & Coester, C. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.04.008 · Cited by 149 · see citing works

Targeted nanoparticles with novel non-peptidic ligands for oral delivery

Rieux, A. D., Pourcelle, V., Cani, P. D., Marchand‐Brynaert, J., & Véronique Préat, A. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.01.002 · Cited by 148 · see citing works

Advances in oral absorption of polysaccharides: Mechanism, affecting factors, and improvement strategies

Zheng, Z., Pan, X., Luo, L., Zhang, Q., Huang, X., Liu, Y., Wang, K., & Zhang, Y. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119110 · Cited by 146 · see citing works

The M Cell-Targeting Ligand Promotes Antigen Delivery and Induces Antigen-Specific Immune Responses in Mucosal Vaccination

Kim, S., Seo, K.-W., Kim, J., Lee, K., & Jang, Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903184 · Cited by 132 · see citing works

Transepithelial transport of nanoparticles in oral drug delivery: From the perspective of surface and holistic property modulation

Zheng, Y., Luo, S., Xu, M., He, Q., Xie, J., Wu, J., & Huang, Y. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.06.015 · Cited by 132 · see citing works

Transplacental transport of nanomaterials

Saunders, M. (2009) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.53 · Cited by 116 · see citing works

Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells

Primard, C., Rochereau, N., Luciani, E., Genin, C., Delair, T., Paul, S., & Verrier, B. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.021 · Cited by 112 · see citing works

Enhanced anticancer activity and oral bioavailability of ellagic acid through encapsulation in biodegradable polymeric nanoparticles

Mady, F. M., & Shaker, M. A. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s147740 · Cited by 111 · see citing works

Alternative Methods of Vaccine Delivery: An Overview of Edible and Intradermal Vaccines

Criscuolo, E., Caputo, V., Diotti, R. A., Sautto, G. A., Kirchenbaum, G. A., & Clementi, N. (2019) · Journal of Immunology Research · doi:10.1155/2019/8303648 · Cited by 110 · see citing works

Mucosal vaccines: novel advances in technology and delivery

Yuki, Y., & Kiyono, H. (2009) · Expert Review of Vaccines · doi:10.1586/erv.09.61 · Cited by 109 · see citing works

Transport of chitosan–DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes

Kadiyala, I., Loo, Y., Roy, K., Rice, J., & Leong, K. W. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.11.002 · Cited by 109 · see citing works

Bilosomes in the context of oral immunization: development, challenges and opportunities

Shukla, A., Mishra, V. K., & Kesharwani, P. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.03.013 · Cited by 108 · see citing works

Towards tailored vaccine delivery: Needs, challenges and perspectives

Amorij, J., Kersten, G. F. A., Saluja, V., Tonnis, W. F., Hinrichs, W. L. J., Slütter, B., Bal, S. M., Bouwstra, J. A., Huckriede, A. L. W., & Jiskoot, W. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.039 · Cited by 102 · see citing works

A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation

Beloqui, A., Brayden, D. J., Artursson, P., Véronique Préat, A., & Rieux, A. D. (2017) · Nature Protocols · doi:10.1038/nprot.2017.041 · Cited by 100 · see citing works

Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases

Jazayeri, S. D., Lim, H. X., Shameli, K., Yeap, S. K., & Poh, C. L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.682286 · Cited by 100 · see citing works

Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites

Lin, S., Wang, Z., Lam, K., Zeng, S., Tan, B. K., & Hu, J. (2019) · Food & Nutrition Research · doi:10.29219/fnr.v63.1518 · Cited by 96 · see citing works

Could the Induction of Trained Immunity by β-Glucan Serve as a Defense Against COVID-19?

Geller, A. E., & Yan, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01782 · Cited by 93 · see citing works

Crossing the barrier: Targeting epithelial receptors for enhanced oral vaccine delivery

Devriendt, B., Geest, B. G. D., Goddeeris, B. M., & Cox, E. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.02.006 · Cited by 93 · see citing works

Impact of low and high molecular weight oat beta-glucan on oxidative stress and antioxidant defense in spleen of rats with LPS induced enteritis

Błaszczyk, K., Wilczak, J., Harasym, J., Gudej, S., Suchecka, D., Królikowski, T., Lange, E., & Gromadzka-Ostrowska, J. (2015) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2015.05.025 · Cited by 93 · see citing works

Nimodipine nanocrystals for oral bioavailability improvement: Role of mesenteric lymph transport in the oral absorption

Fu, Q., Sun, J., Ai, X., Zhang, P., Li, M., Wang, Y., Liu, X., Sun, Y. H., Sui, X., Sun, L., et al. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.01.065 · Cited by 91 · see citing works

Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations

Bal, S. M., Slütter, B., van Riet, E., Kruithof, A. C., Ding, Z., Kersten, G. F. A., Jiskoot, W., & Bouwstra, J. A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.11.018 · Cited by 89 · see citing works

Oral Vaccine Delivery for Intestinal Immunity—Biological Basis, Barriers, Delivery System, and M Cell Targeting

Kang, S. H., Hong, S. J., Lee, Y.-K., & Cho, S. (2018) · Polymers · doi:10.3390/polym10090948 · Cited by 86 · see citing works

Engineering Nano‐ and Microparticles as Oral Delivery Vehicles to Promote Intestinal Lymphatic Drug Transport

Miao, Y., Lin, Y., Chen, K., Luo, P.-K., Chuang, S., Yu, Y., Tai, H., Chen, C., Lin, K., & Sung, H. (2021) · Advanced Materials · doi:10.1002/adma.202104139 · Cited by 87 · see citing works

Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination

Slütter, B., & Jiskoot, W. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.06.009 · Cited by 86 · see citing works

Role of Microbiota in Sexually Dimorphic Immunity

Elderman, M. E., de Vos, P., & Faas, M. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01018 · Cited by 87 · see citing works

Innovative bioinformatic approaches for developing peptide‐based vaccines against hypervariable viruses

Sirskyj, D., Díaz‐Mitoma, F., Golshani, A., Kumar, A., & Azizi, A. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.65 · Cited by 80 · see citing works

Influence of Particle Geometry on Gastrointestinal Transit and Absorption following Oral Administration

Li, D., Zhuang, J., He, H., Jiang, S., Banerjee, A., Lü, Y., Wu, W., Mitragotri, S., Gan, L., & Qi, J. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b11821 · Cited by 79 · see citing works

β‐glucan as a new tool in vaccine development

Větvička, V., Vannucci, L. E., & Šíma, P. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12833 · Cited by 78 · see citing works

Investigation of lectinized liposomes as M-cell targeted carrier-adjuvant for mucosal immunization

Gupta, P. N., & Vyas, S. P. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.08.027 · Cited by 78 · see citing works

Ligand-mediated active targeting for enhanced oral absorption

Zhang, X., & Wu, W. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.03.001 · Cited by 78 · see citing works

Implication of nanoparticles/microparticles in mucosal vaccine delivery

Vyas, S. P., & Gupta, P. N. (2007) · Expert Review of Vaccines · doi:10.1586/14760584.6.3.401 · Cited by 76 · see citing works

Epithelia transmembrane transport of orally administered ultrafine drug particles evidenced by environment sensitive fluorophores in cellular and animal studies

Xie, Y., Shi, B., Xia, F., Qi, J., Dong, X., Zhao, W., Li, T., Wu, W., & Lü, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.046 · Cited by 75 · see citing works

Salmonella translocates across an in vitro M cell model independently of SPI-1 and SPI-2

Martínez‐Argudo, I., & Jepson, M. A. (2008) · Microbiology · doi:10.1099/mic.0.2008/021162-0 · Cited by 67 · see citing works

Structural Constraints for the Binding of Short Peptides to Claudin-4 Revealed by Surface Plasmon Resonance

Ling, J., Liao, H., Clark, R. T., Wong, M. S. M., & Lo, D. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803548200 · Cited by 66 · see citing works

Evaluation of nanoparticle-encapsulated outer membrane proteins for the control of Campylobacter jejuni colonization in chickens

Annamalai, T., Pina-Mimbela, R., Kumar, A., Binjawadagi, B., Liu, Z., Renukaradhya, G. J., & Rajashekara, G. (2013) · Poultry Science · doi:10.3382/ps.2012-03004 · Cited by 65 · see citing works

Oral delivery of insulin with intelligent glucose-responsive switch for blood glucose regulation

Zhou, X., Wu, H., Long, R., Wang, S., Huang, H., Xia, Y., Wang, P., Lei, Y., Cai, Y., Cai, D., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00652-z · Cited by 64 · see citing works

Expression of dengue-3 premembrane and envelope polyprotein in lettuce chloroplasts

Kanagaraj, A., Verma, D., & Daniell, H. (2011) · Plant Molecular Biology · doi:10.1007/s11103-011-9766-0 · Cited by 64 · see citing works

Analysis of Interactions of Salmonella Type Three Secretion Mutants with 3-D Intestinal Epithelial Cells

Radtke, A. L., Wilson, J. W., Sarker, S. F., & Nickerson, C. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015750 · Cited by 64 · see citing works

Nanocompounds of iron and zinc: their potential in nutrition

Zimmermann, M. B., & Hilty, F. M. (2011) · Nanoscale · doi:10.1039/c0nr00858c · Cited by 61 · see citing works

Tracking translocation of glucan microparticles targeting M cells: implications for oral drug delivery

Xie, Y., Hu, X., He, H., Xia, F., Ma, Y., Qi, J., Dong, X., Zhao, W., Lü, Y., & Wu, W. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02706c · Cited by 59 · see citing works

Nanoparticle oral absorption and its clinical translational potential

Kim, K. S., Na, K., & Bae, Y. H. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.06.024 · Cited by 57 · see citing works

Lipid coated mesoporous silica nanoparticles as an oral delivery system for targeting and treatment of intravacuolar Salmonella infections

Mudakavi, R. J., Raichur, A. M., & Chakravortty, D. (2014) · RSC Advances · doi:10.1039/c4ra12973c · Cited by 54 · see citing works

M cell-targeted delivery of vaccines and therapeutics

KuoLee, R., & Chen, W. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.6.693 · Cited by 54 · see citing works

In vitro identification of targeting ligands of human M cells by phage display

Fiévez, V., Plapied, L., Plaideau, C., Legendre, D., Rieux, A. D., Pourcelle, V., Freichels, H., Jérôme, C., Marchand, J., Véronique Préat, A., et al. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.04.023 · Cited by 53 · see citing works

Translocation of enteropathogenic Escherichia coli across an in vitro M cell model is regulated by its type III secretion system

Martínez‐Argudo, I., Sands, C. J., & Jepson, M. A. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00891.x · Cited by 52 · see citing works

Bioadhesive nanoparticles of fungal chitosan for oral DNA delivery

Plapied, L., Vandermeulen, G., Vroman, B., Véronique Préat, A., & Rieux, A. D. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.07.041 · Cited by 51 · see citing works

Dietary (1→3), (1→4)-β-d-glucans from oat activate nuclear factor-κB in intestinal leukocytes and enterocytes from mice

Volman, J. J., Mensink, R. P., Ramakers, J. D., de Winther, M. P. J., Carlsen, H., Blomhoff, R., Buurman, W. A., & Plat, J. (2010) · Nutrition Research · doi:10.1016/j.nutres.2009.10.023 · Cited by 51 · see citing works

Recent advances in mucosal delivery of vaccines: role of mucoadhesive/biodegradable polymeric carriers

Mishra, N., Goyal, A. K., Tiwari, S., Paliwal, R., Paliwal, S. R., Vaidya, B., Mangal, S., Gupta, M., Dube, D., Mehta, A., et al. (2010) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543771003730425 · Cited by 52 · see citing works

An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells

Corr, S. C., Hill, C., & Gahan, C. G. M. (2006) · Microbial Pathogenesis · doi:10.1016/j.micpath.2006.08.003 · Cited by 50 · see citing works

Bilosomes: Superior Vesicular Carriers

Palekar-Shanbhag, P., Lande, S., Chandra, R., & Rane, D. (2019) · Current Drug Therapy · doi:10.2174/1574885514666190917145510 · Cited by 49 · see citing works

Challenges and opportunities in delivering oral peptides and proteins

Peng, H., Wang, J., Chen, J., Peng, Y., Wang, X., Chen, Y., Kaplan, D. L., & Wang, Q. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2237408 · Cited by 46 · see citing works

Oral immunization with aLactobacillus casei-based anti-porcine epidemic diarrhoea virus (PEDV) vaccine expressing microfold cell-targeting peptide Co1 fused with the COE antigen of PEDV

Wang, X., Wang, L., Zheng, D., Chen, S., Shi, W., Qiao, X., Jiang, Y., Tang, L., Xu, Y., & Li, Y. J. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13652 · Cited by 46 · see citing works

Receptor mediated targeting of M-cells

Tyrer, P. C., Foxwell, A. R., Kyd, J. M., Otczyk, D. C., & Cripps, A. W. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.01.028 · Cited by 44 · see citing works

Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials

Ude, V. C., Brown, D. M., Stone, V., & Johnston, H. J. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0503-1 · Cited by 44 · see citing works

Exploiting or overcoming the dome trap for enhanced oral immunization and drug delivery

Qi, J., Zhuang, J., Lv, Y., Lü, Y., & Wu, W. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.021 · Cited by 43 · see citing works

Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS via oral route

Xia, F., Chen, Z., Zhu, Q., Qi, J., Dong, X., Zhao, W., Wu, W., & Lü, Y. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.006 · Cited by 43 · see citing works

Oral Gavage Delivery of PR8 Antigen with β-Glucan-Conjugated GRGDS Carrier to Enhance M-Cell Targeting Ability and Induce Immunity

Lee, D.-Y., Nurunnabi, M., Kang, S. H., Nafiujjaman, M., Huh, K. M., Lee, Y.-K., & Kim, Y. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.6b01855 · Cited by 42 · see citing works

The stomach, small intestine, and colon-specific gastrointestinal tract delivery systems for bioactive nutrients

Liang, S., Zhao, D., Liu, X., Liu, B., & Li, Y. (2025) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2025.103503 · Cited by 41 · see citing works

Enhancement of atorvastatin oral bioavailability via encapsulation in polymeric nanoparticles

Shaker, M. A., Elbadawy, H. M., Thagfan, S. S. A., & Shaker, M. A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.120077 · Cited by 41 · see citing works

The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration

Yang, X., Chen, X., Lei, T., Qin, L., Zhou, Y., Hu, C., Liu, Q., & Gao, H. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.02.011 · Cited by 40 · see citing works

Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy

Miao, Y., Xu, T., Gong, Y., Chen, A., Zou, L., Jiang, T., & Shi, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01991-3 · Cited by 43 · see citing works

Preliminary studies on the development of IgA-loaded chitosan–dextran sulphate nanoparticles as a potential nasal delivery system for protein antigens

Sharma, S., Benson, H. A., Mukkur, T. K. S., Rigby, P. J., & Chen, Y. (2012) · Journal of Microencapsulation · doi:10.3109/02652048.2012.726279 · Cited by 39 · see citing works

Oral delivery of protein-based therapeutics: Gastroprotective strategies, physiological barriers and in vitro permeability prediction

Wright, L., Barnes, T. J., & Prestidge, C. A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119488 · Cited by 39 · see citing works

Improving Oral Delivery

Gabor, F., Fillafer, C., Neutsch, L., Ratzinger, G., & Wirth, M. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00477-3_12 · Cited by 38 · see citing works

Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells

Liang, Y., Hastürk, H., Elliot, J., Noronha, A. M., Liu, X., Wetzler, L. M., Massari, P., Kantarcı, A., Winter, H. S., & Farraye, F. A. (2010) · Clinical Immunology · doi:10.1016/j.clim.2010.09.003 · Cited by 38 · see citing works

Artemisia argyi extract alleviates inflammation in a DSS-induced colitis mouse model and enhances immunomodulatory effects in lymphoid tissues

Shin, J. M., Son, Y., Ha, I. J., Erdenebileg, S., Jung, D. S., Song, D., Kim, Y. S., Kim, S. M., & Nho, C. W. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03536-x · Cited by 36 · see citing works

BILOSOME: A BILE SALT BASED NOVEL CARRIER SYSTEM GAINING INTEREST IN PHARMACEUTICAL RESEARCH

Rajput, T., & Chauhan, M. K. (2017) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v7i5.1479 · Cited by 34 · see citing works

Metabolic regulation mechanism of fucoidan via intestinal microecology in diseases

Sun, T., Xue, M., Yang, J., Pei, Z., Zhang, N., Qin, K., & Liang, H. W. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11202 · Cited by 34 · see citing works

Recent advances in nano/microparticle-based oral vaccines

Li, M., Kaminskas, L. M., & Marasini, N. (2021) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-021-00537-9 · Cited by 34 · see citing works

Formulation Design Considerations for Oral Vaccines

Wilkhu, J. S., McNeil, S. E., Kirby, D. J., & Perrie, Y. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.82 · Cited by 33 · see citing works

The third dimension: new developments in cell culture models for colorectal research

Pereira, J. C., Awatade, N. T., Loureiro, C. A., Matos, P., Amaral, M. D., & Jordan, P. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2258-2 · Cited by 32 · see citing works

β-Glucan successfully stimulated the immune system in different jawed vertebrate species

de Oliveira, C. A. F., Větvička, V., & Zanuzzo, F. S. (2018) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2018.11.006 · Cited by 30 · see citing works

Adhesion of Enteropathogenic, Enterotoxigenic, and Commensal Escherichia coli to the Major Zymogen Granule Membrane Glycoprotein 2

Bartlitz, C., Kolenda, R., Chilimoniuk, J., Grzymajło, K., Rödiger, S., Bauerfeind, R., Ali, A., Tchesnokova, V. L., Roggenbuck, D., & Schierack, P. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.02279-21 · Cited by 29 · see citing works

M cell: intestinal immunity’s gateway

Tran‐Van, H., Le-Dao, H.-A., & Dinh, T. M. (2021) · Science and Technology Development Journal - Natural Sciences · doi:10.32508/stdjns.v5i4.1111

M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis

Corr, S. C., Gahan, C. C. G. M., & Hill, C. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00359.x · Cited by 320 · see citing works

Apical membrane receptors on intestinal M cells: potential targets for vaccine delivery

Brayden, D. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.036 · Cited by 43 · see citing works

Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells

Azizi, A., Kumar, A., Diaz-Mitoma, F., & Mestecky, J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001147 · Cited by 180 · see citing works

Functional differences between M cells and enterocytes in sampling luminal antigens

Kyd, J. M., & Cripps, A. W. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.09.061 · Cited by 75 · see citing works