COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production
Open accessAbstract
Innate antiviral immunity is the first line of the host defense system that rapidly detects invading viruses. Mitochondria function as platforms for innate antiviral signal transduction in mammals through the adaptor protein, MAVS. Excessive activation of MAVS-mediated antiviral signaling leads to dysfunction of mitochondria and cell apoptosis that likely causes the pathogenesis of autoimmunity. However, the mechanism of how MAVS is regulated at mitochondria remains unknown. Here we show that the Cytochrome c Oxidase (CcO) complex subunit COX5B physically interacts with MAVS and negatively regulates the MAVS-mediated antiviral pathway. Mechanistically, we find that while activation of MAVS leads to increased ROS production and COX5B expression, COX5B down-regulated MAVS signaling by repressing ROS production. Importantly, our study reveals that COX5B coordinates with the autophagy pathway to control MAVS aggregation, thereby balancing the antiviral signaling activity. Thus, our study provides novel insights into the link between mitochondrial electron transport system and the autophagy pathway in regulating innate antiviral immunity.
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Mitochondrial fusion promotes RLR signaling, whereas mitochondrial fission inhibits it.
“Multiple studies have demonstrated that mitochondrial fusion promotes, whereas mitochondrial fission inhibits RLR signaling (Castanier et al., 2010; Yasukawa et al., 2009; Zhao et al., 2012).”
From Mitochondria in the Regulation of Innate and Adaptive Immunity (2015) · cites this paper as Zhao et al., 2012
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Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works
Autophagy as a regulated pathway of cellular degradation.
Klionsky, D., & Emr, S. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,794 · see citing works
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329 · see citing works
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680 · see citing works
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562 · see citing works
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401 · see citing works
The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å
Tomitake Tsukihara, A., Aoyama, H., Yamashita, E., Tomizaki, T., Yamaguchi, H., Shinzawa‐Itoh, K., Nakashima, R., Yaono, R., & Yoshikawa, S. (1996) · Science · doi:10.1126/science.272.5265.1136 · Cited by 2,102 · see citing works
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849 · see citing works
IFI16 is an innate immune sensor for intracellular DNA
Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643 · see citing works
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Zhong, B., Yang, Y., Li, S., Wang, Y., Li, Y., Diao, F., Lei, C., He, X., Zhang, L., Tien, P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.003 · Cited by 1,513 · see citing works
Attardi, G. M., & Schatz, G. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.001445 · Cited by 1,392 · see citing works
Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,274 · see citing works
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
Theofilopoulos, A. N., Baccalà, R., Beutler, B., & Kono, D. H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115843 · Cited by 1,185 · see citing works
A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins
Alberti, S., Halfmann, R., King, O. D., Kapila, A., & Lindquist, S. L. (2009) · Cell · doi:10.1016/j.cell.2009.02.044 · Cited by 957 · see citing works
Stojdl, D., Lichty, B., TENOEVER, B., Paterson, J., Power, A., Knowles, S., Marius, R., Reynard, J., Poliquin, L., Atkins, H., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00241-1 · Cited by 894 · see citing works
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells
Lee, H. K., Lund, J. M., Ramanathan, B., Mizushima, N., & Iwasaki, A. (2007) · Science · doi:10.1126/science.1136880 · Cited by 865 · see citing works
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
Saitoh, T., Fujita, N., Hayashi, T., Takahara, K., Satoh, T., Lee, H., Matsunaga, K., Kageyama, S., Omori, H., Noda, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911267106 · Cited by 854 · see citing works
Protein Turnover Via Autophagy: Implications for Metabolism
Mizushima, N., & Klionsky, D. J. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093749 · Cited by 793 · see citing works
The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses
Sun, Q., Sun, L., Liu, H.-H., Chen, X., Seth, R. B., Forman, J., & Chen, Z. J. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.004 · Cited by 604 · see citing works
RNA recognition and signal transduction by RIG‐I‐like receptors
Yoneyama, M., & Fujita, T. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00727.x · Cited by 594 · see citing works
NLRX1 is a regulator of mitochondrial antiviral immunity
Moore, C. B., Bergstralh, D. T., Duncan, J. A., Lei, Y. L., Morrison, T. E., Zimmermann, A. G., Accavitti-Loper, M. A., Madden, V. J., Sun, L., Ye, Z., et al. (2008) · Nature · doi:10.1038/nature06501 · Cited by 586 · see citing works
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
Tal, M. C., Sasai, M., Lee, H. K., Yordy, B., Shadel, G. S., & Iwasaki, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807694106 · Cited by 573 · see citing works
The Atg5–Atg12 conjugate associates with innate antiviral immune responses
Jounai, N., Takeshita, F., Kobiyama, K., Sakaue-Sawano, A., Miyawaki, A., Xin, K.-Q., Ishii, K. J., Kawai, T., Akira, S., Suzuki, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704014104 · Cited by 562 · see citing works
Zhong, B., Zhang, L., Lei, C., Li, Y., Mao, A., Yang, Y. F., Wang, Y., Zhang, X., & Shu, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.008 · Cited by 478 · see citing works
Drosophila RNAi screen identifies host genes important for influenza virus replication
Hao, L., Sakurai, A., Watanabe, T., Sorensen, E. M., Nidom, C. A., Newton, M. A., Ahlquist, P., & Kawaoka, Y. (2008) · Nature · doi:10.1038/nature07151 · Cited by 426 · see citing works
Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism
Onoguchi, K., Yoneyama, M., Takemura, A., Akira, S., Taniguchi, T., Namiki, H., & Fujita, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608618200 · Cited by 354 · see citing works
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
You, F., Sun, H., Zhou, X., Sun, W., Liang, S., Zhai, Z., & Jiang, Z. (2009) · Nature Immunology · doi:10.1038/ni.1815 · Cited by 340 · see citing works
Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase
Kadenbach, B., Hüttemann, M., Arnold, S., Lee, I., & Bender, E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00305-1 · Cited by 268 · see citing works
Iwamura, T., Yoneyama, M., Yamaguchi, K., Suhara, W., Mori, W., Shiota, K., Okabe, Y., Namiki, H., & Fujita, T. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00426.x · Cited by 265 · see citing works
Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling
Koshiba, T., Yasukawa, K., Yanagi, Y., & Kawabata, S.-I. (2011) · Science Signaling · doi:10.1126/scisignal.2001147 · Cited by 257 · see citing works
Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling
Yasukawa, K., Oshiumi, H., Takeda, M., Ishihara, N., Yanagi, Y., Seya, T., Kawabata, S.-I., & Koshiba, T. (2009) · Science Signaling · doi:10.1126/scisignal.2000287 · Cited by 255 · see citing works
Xu, M., Skaug, B. A., Zeng, W., & Chen, Z. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.002 · Cited by 246 · see citing works
MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins
Lei, Y. L., Moore, C. B., Liesman, R. M., O’Connor, B. P., Bergstralh, D. T., Chen, Z. J., Pickles, R. J., & Ting, J. P. ‐. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005466 · Cited by 204 · see citing works
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix
Arnoult, D., Soares, F., Tattoli, I., Castanier, C., Philpott, D. J., & Girardin, S. E. (2009) · Journal of Cell Science · doi:10.1242/jcs.051193 · Cited by 203 · see citing works
Interferons as pathogenic effectors in autoimmunity
Baccalà, R., Kono, D. H., & Theofilopoulos, A. N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00252.x · Cited by 199 · see citing works
Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3
Zeng, W., Xu, M., Liu, S., Sun, L., & Chen, Z. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.037 · Cited by 187 · see citing works
Onoguchi, K., Onomoto, K., Takamatsu, S., Jogi, M., Takemura, A., Morimoto, S., Julkunen, I., Namiki, H., Yoneyama, M., & Fujita, T. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001012 · Cited by 180 · see citing works
Soucy-Faulkner, A., Mukawera, E., Fink, K., Martel, A., Jouan, L., Nzengue, Y., Lamarre, D., Velde, C. V., & Grandvaux, N. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000930 · Cited by 142 · see citing works
Antioxidant properties of MitoTEMPOL and its hydroxylamine
Trnka, J., Blaikie, F. H., Logan, A., Smith, R. A. J., & Murphy, M. P. (2008) · Free Radical Research · doi:10.1080/10715760802582183 · Cited by 141 · see citing works
Gonzalez‐Dosal, R., Horan, K., Rahbek, S. H., Ichijo, H., Chen, Z. J., Mieyal, J. J., Hartmann, R., & Paludan, S. R. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002250 · Cited by 134 · see citing works
Díaz, F., Enrı́quez, J. A., & Moraes, C. T. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06051-11 · Cited by 131 · see citing works
An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis
Park, W. H., Han, Y. W., Kim, S. H., & Kim, S. Z. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21280 · Cited by 110 · see citing works
Polo-like Kinase 1 (PLK1) Regulates Interferon (IFN) Induction by MAVS
Vitour, D., Dabo, S., Pour, M. A., Vilasco, M., Vidalain, P., Jacob, Y., Mesel‐Lemoine, M., Paz, S., Arguello, M., Lin, R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018275 · Cited by 101 · see citing works
Galati, D. F., Srinivasan, S., Raza, H., Prabu, S. K., Hardy, M., Chandran, K., López, M., Kalyanaraman, B., & Avadhani, N. G. (2009) · Biochemical Journal · doi:10.1042/bj20090214 · Cited by 92 · see citing works
Jiang, J., Stoyanovsky, D. A., Belikova, N. A., Tyurina, Y. Y., Zhao, Q., Tungekar, M. A., Kapralova, V. I., Huang, Z., Mintz, A. H., Greenberger, J. S., et al. (2009) · Radiation Research · doi:10.1667/rr1729.1 · Cited by 76 · see citing works
Human liver protein map: Update 1993
Hughes, G. J., Frutiger, S., Paquet, N., Pasquali, C., Sanchez, J., Tissot, J., Bairoch, A., Appel, R. D., & Hochstrasser, D. F. (1993) · Electrophoresis · doi:10.1002/elps.11501401181 · Cited by 73 · see citing works
The non-canonical role of Atg family members as suppressors of innate antiviral immune signaling
Takeshita, F., Kobiyama, K., Miyawaki, A., Jounai, N., & Okuda, K. (2008) · Autophagy · doi:10.4161/auto.5055 · Cited by 61 · see citing works
Cytochrome c Oxidase Activity and Oxygen Tolerance
Campian, J. L., Gao, X., Qian, M., & Eaton, J. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m604547200 · Cited by 60 · see citing works
Beauchemin, A., Gottlieb, B., Beitel, L. K., Elhaji, Y., Pinsky, L., & Trifiro, M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00583-4 · Cited by 58 · see citing works
Beauvoit, B. P., & Rigoulet, M. (2001) · IUBMB Life · doi:10.1080/152165401317316545 · Cited by 35 · see citing works
Lomax, M. I., Hsieh, C., Darras, B. T., & Francke, U. (1991) · Genomics · doi:10.1016/0888-7543(91)90476-u · Cited by 32 · see citing works
Autophagic control of RLR signaling
Tal, M. C., & Iwasaki, A. (2009) · Autophagy · doi:10.4161/auto.5.5.8789 · Cited by 29 · see citing works
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Innate Immune Pattern Recognition: A Cell Biological Perspective
Brubaker, S. W., Bonham, K. S., Zanoni, I., & Kagan, J. C. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112240 · Cited by 1,475 · see citing works
Mitochondria in the Regulation of Innate and Adaptive Immunity
Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960 · see citing works
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis
Cadwell, K. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.100 · Cited by 478 · see citing works
Matsuzawa, Y., Hwang, S., & Cadwell, K. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053253 · Cited by 378 · see citing works
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy
Wang, R., Zhu, Y., Ren, C., Yang, S., Tian, S., Chen, H., Jin, M., & Zhou, H. (2020) · Autophagy · doi:10.1080/15548627.2020.1725375 · Cited by 203 · see citing works
Mechanisms of MAVS Regulation at the Mitochondrial Membrane
Jacobs, J. L., & Coyne, C. B. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.10.007 · Cited by 197 · see citing works
Buskiewicz, I. A., Montgomery, T. L., Yasewicz, E. C., Huber, S. A., Murphy, M. P., Hartley, R. C., Kelly, R., Crow, M. K., Perl, A., Budd, R. C., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aaf1933 · Cited by 177 · see citing works
Mitochondrial Oxidative Stress and “Mito-Inflammation”: Actors in the Diseases
Patergnani, S., Bouhamida, E., Leo, S., Pinton, P., & Rimessi, A. (2021) · Biomedicines · doi:10.3390/biomedicines9020216 · Cited by 172 · see citing works
RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation
He, X., Zhu, Y., Zhang, Y., Geng, Y., Gong, J., Geng, J., Zhang, P., Zhang, X., Liu, N., Peng, Y., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100978 · Cited by 155 · see citing works
Mitochondria: An Organelle of Bacterial Origin Controlling Inflammation
Meyer, A., LAVERNY, G., Bernardi, L., Charles, A. L., Alsaleh, G., Pottecher, J., Sibilia, J., & Gény, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00536 · Cited by 153 · see citing works
Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury
Kim, S., Kim, Y., Kim, D.-J., Park, S. H., Jeong, K.-H., Lee, Y. H., Lim, S. J., Lee, S.-H., & Moon, J.-Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02563 · Cited by 149 · see citing works
Silwal, P., Kim, J. K., Kim, Y. J., & Jo, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01649 · Cited by 131 · see citing works
Hou, J., Han, L., Zhao, Z., Liu, H., Zhang, L., Ma, C., Yi, F., Liu, B., Zheng, Y., & Gao, C. (2021) · Nature Communications · doi:10.1038/s41467-021-23219-4 · Cited by 130 · see citing works
Li, Z., Liu, G., Sun, L., Teng, Y., Guo, X., Jia, J., Sha, J., Yang, X. Y., Chen, D., & Sun, Q. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004783 · Cited by 130 · see citing works
Wang, R., Zhu, Y., Lin, X., Ren, C., Zhao, J., Wang, F., Gao, X., Xiao, R., Zhao, L., Chen, H., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1580089 · Cited by 127 · see citing works
Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery
Wang, L.-F., Lin, Y.-S., Huang, N., Yu, C.-Y., Tsai, W.-L., Chen, J., Kubota, T., Matsuoka, M., Chen, S.-R., Yang, C.-S., et al. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0038 · Cited by 127 · see citing works
Mitochondrial Dysfunction in Lung Pathogenesis
Piantadosi, C. A., & Suliman, H. B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034322 · Cited by 122 · see citing works
Regulation of RIG-I-like receptor signaling by host and viral proteins
Chiang, J. J., Davis-Gardner, M. E., & Gack, M. U. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.06.005 · Cited by 122 · see citing works
Li, J., Lin, Q., Shao, X., Li, S., Zhu, X., Wu, J., Mou, S., Gu, L., Wang, Q., Zhang, M., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05587-5 · Cited by 120 · see citing works
Cadwell, K., & Debnath, J. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201706157 · Cited by 106 · see citing works
Pan, Y., Li, R., Meng, J., Mao, H.-T., Zhang, Y., & Zhang, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302632 · Cited by 107 · see citing works
Chu, Q., Xu, T., Zheng, W., Chang, R., & Zhang, L. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008670 · Cited by 106 · see citing works
Mitochondrial Interactome: A Focus on Antiviral Signaling Pathways
Refolo, G., Vescovo, T., Piacentini, M., Fimia, G. M., & Ciccosanti, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00008 · Cited by 102 · see citing works
Mitochondrial Control of Innate Immunity and Inflammation
Jin, H. S., Suh, H., Kim, S., & Jo, E. (2017) · Immune Network · doi:10.4110/in.2017.17.2.77 · Cited by 101 · see citing works
Xu, T., Chu, Q., Cui, J., & Bi, D. (2017) · Journal of Virology · doi:10.1128/jvi.01594-17 · Cited by 92 · see citing works
Fungal effectors, the double edge sword of phytopathogens
Pradhan, A., Ghosh, S., Sahoo, D., & Jha, G. (2020) · Current Genetics · doi:10.1007/s00294-020-01118-3 · Cited by 91 · see citing works
Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay
Zhang, G., Xu, Y., Wang, X., Zhu, Y., Wang, L., Zhang, W., Wang, Y., Gao, Y., Wu, X., Cheng, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28547-7 · Cited by 88 · see citing works
Huang, X., Yue, Y.-F., Li, D., Zhao, Y., Qiu, L., Chen, J., Pan, Y., Xi, J., Wang, X., Sun, Q., et al. (2016) · Scientific Reports · doi:10.1038/srep22303 · Cited by 87 · see citing works
Qi, N., Shi, Y., Zhang, R., Zhu, W., Yuan, B., Li, X., Wang, C., Zhang, X., & Hou, F. (2017) · Nature Communications · doi:10.1038/ncomms15676 · Cited by 83 · see citing works
Autophagy and microbial pathogenesis
Keller, M. D., Torres, V. J., & Cadwell, K. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-019-0481-8 · Cited by 83 · see citing works
MAVS maintains mitochondrial homeostasis via autophagy
Sun, X., Sun, L., Zhao, Y., Li, Y., Lin, W., Chen, D., & Sun, Q. (2016) · Cell Discovery · doi:10.1038/celldisc.2016.24 · Cited by 77 · see citing works
Martin, P. K., Marchiando, A. M., Xu, R., Rudensky, E., Yeung, F., Schuster, S. L., Kernbauer, E., & Cadwell, K. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0229-0 · Cited by 76 · see citing works
Mitochondrial control of innate immune responses
Chen, S., Liao, Z., & Xu, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1166214 · Cited by 77 · see citing works
NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells
Singh, K., Poteryakhina, A. V., Zheltukhin, A. O., Bhatelia, K., Prajapati, P., Sripada, L., Tomar, D., Singh, R. K., Singh, A. K., Chumakov, P. M., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.01.016 · Cited by 66 · see citing works
The MAVS Immune Recognition Pathway in Viral Infection and Sepsis
Sharma, A., Kontodimas, K., & Bosmann, M. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0167 · Cited by 64 · see citing works
LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan
Ji, S., Luo, Y., Cai, Q., Cao, Z., Zhao, Y., Mei, J., Li, C., Xia, P., Xie, Z., Xia, Z., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.004 · Cited by 57 · see citing works
Tur, J., Vico, T., Lloberas, J., Antonio Zorzano, A., & Celada, A. (2017) · Advances in immunology · doi:10.1016/bs.ai.2016.12.001 · Cited by 57 · see citing works
MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis
Chen, Y., Shi, Y., Wu, J., & Qi, N. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.744348 · Cited by 51 · see citing works
Mitochondrial dynamics and the innate antiviral immune response
Pourcelot, M., & Arnoult, D. (2014) · FEBS Journal · doi:10.1111/febs.12940 · Cited by 50 · see citing works
Autophagy during Early Virus–Host Cell Interactions
Viret, C., Rozières, A., & Faure, M. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.04.018 · Cited by 50 · see citing works
Galão, R. P., Wilson, H., Schierhorn, K. L., Debeljak, F., Bodmer, B. S., Goldhill, D. H., Hoenen, T., Wilson, S. J., Swanson, C. M., & Neil, S. J. D. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010530 · Cited by 46 · see citing works
Liu, C., Huang, S., Wang, X., Wen, M., Zheng, J., Wang, W., Fu, Y., Tian, S.-L., Li, L., Li, Z., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800656 · Cited by 49 · see citing works
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response
Shi, Y., Yuan, B., Qi, N., Zhu, W., Su, J., Li, X., Qi, P., Zhang, D., & Hou, F. (2015) · Nature Communications · doi:10.1038/ncomms8811 · Cited by 49 · see citing works
Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection
Zhang, S., Carrière, J., Lin, X., Xie, N., & Feng, P. (2018) · Viruses · doi:10.3390/v10100521 · Cited by 50 · see citing works
Cellular stress responses in hepatitis C virus infection: Mastering a two-edged sword
Vasallo, C., & Gastaminza, P. (2015) · Virus Research · doi:10.1016/j.virusres.2015.03.013 · Cited by 47 · see citing works
Jacobs, J. L., Zhu, J., Sarkar, S. N., & Coyne, C. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.520254 · Cited by 46 · see citing works
Gao, S., Sun, H., Jiang, H., Li, L., Hu, X., Xu, X., & Jin, W. (2015) · Oncotarget · doi:10.18632/oncotarget.6222 · Cited by 45 · see citing works
Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination
Gao, Y., Zhu, Y., Wang, H., Cheng, Y., Zhao, D., Sun, Q., & Chen, D. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.02.035 · Cited by 46 · see citing works
RIG-I-like receptors: Molecular mechanism of activation and signaling
Zheng, J., Shi, W., Yang, Z., Chen, J., Qi, A., Yang, Y., Deng, Y., Yang, D., Song, N., Song, B., et al. (2023) · Advances in immunology · doi:10.1016/bs.ai.2023.03.001 · Cited by 45 · see citing works
Raising the ‘Good’ Oxidants for Immune Protection
Dumas, A., & Knaus, U. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.698042 · Cited by 43 · see citing works
A renewed focus on the interplay between viruses and mitochondrial metabolism
Claus, C., & Liebert, U. G. (2013) · Archives of Virology · doi:10.1007/s00705-013-1841-1 · Cited by 44 · see citing works
Zhu, Q. J., Li, M., Lu, W., Wang, Y., Li, X., & Cheng, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065877 · Cited by 40 · see citing works
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
Lin, W., Zhang, J., Lin, H., Li, Z., Sun, X., Xin, D., Yang, M., Sun, L., Li, L., Wang, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11848 · Cited by 39 · see citing works
Li, X., Li, Y., Zhao, J., Li, L., Wang, Y., Zhang, Y., Li, Y., Chen, Y., Liu, W., & Gao, L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00021 · Cited by 40 · see citing works
Zhao, X., Huo, R., Yan, X., & Xu, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00867 · Cited by 35 · see citing works
Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood
Karan, K. R., Trumpff, C., McGill, M. A., Thomas, J. E., Sturm, G., Lauriola, V., Sloan, R. P., Rohleder, N., Kaufman, B. A., Marsland, A. L., et al. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100080 · Cited by 34 · see citing works
Yao, X., Sha, S., Wang, Y., Sun, X., Cao, J., Kang, J., Jiang, L., Chen, M., & Ma, Y. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw118 · Cited by 34 · see citing works
Chen, Y., Cao, B., Zheng, W., Sun, Y., & Xu, T. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101730 · Cited by 33 · see citing works
Hwang, K. Y., & Choi, Y. B. (2015) · Journal of Virology · doi:10.1128/jvi.01903-15 · Cited by 32 · see citing works
Kim, J., Park, M.-E., Nikapitiya, C., Kim, T., Uddin, M. B., Lee, H., Kim, E., Yeul, J., Jung, J. U., Kim, C., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006398 · Cited by 32 · see citing works
Picking up a Fight: Fine Tuning Mitochondrial Innate Immune Defenses Against RNA Viruses
Dutta, S., Das, N., & Mukherjee, P. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01990 · Cited by 33 · see citing works
Gu, H., Yang, J., Zhang, J., Song, Y., Zhang, Y., Xu, P., Zhu, Y., Wang, L., Zhang, P., Li, L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29266-9 · Cited by 32 · see citing works
Song, J.-H., Ahn, J.-H., Kim, S.-R., Cho, S., Hong, E., Kwon, B.-E., Kim, D., Choi, M., Choi, H., Cha, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45868-8 · Cited by 31 · see citing works
Induction and Evasion of Type-I Interferon Responses during Influenza A Virus InfectionPreprint
Muñoz-Moreno, R., Martínez‐Romero, C., & García‐Sastre, A. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a038414 · Cited by 33 · see citing works
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling
Lin, Y., Yang, J., Yang, Q., Zeng, S., Zhang, J., Zhu, Y., Tong, Y., Li, L., Tan, W., Chen, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43419-4 · Cited by 28 · see citing works
Roles of Mitochondrial Respiratory Complexes during Infection
Escoll, P., Platon, L., & Buchrieser, C. (2019) · Immunometabolism · doi:10.20900/immunometab20190011 · Cited by 25 · see citing works
Wang, Y., Liu, Y., Liu, X., Jiang, L., Yang, G., Sun, X., Geng, C., Li, Q., Yao, X., & Chen, M. (2015) · Toxins · doi:10.3390/toxins7083030 · Cited by 27 · see citing works
The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease
Reynolds, N. D., Aceves-Ewing, N. M., Liu, J. L., Compton, J. R., Leary, D. H., Freitas, B. T., Pegan, S. D., Doctor, K. Z., Wu, F. Y., Hu, X., et al. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00866 · Cited by 26 · see citing works
Autophagy dysfunction in autoinflammatory diseases
Hua, Y., Shen, M., McDonald, C., & Yao, Q. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.10.012 · Cited by 24 · see citing works
Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction
Lu, L.-F., Zhang, C., Zhou, X.-Y., Li, Z.-C., Chen, D., Zhou, Y., Zhou, F. J., Zhang, Y., & Li, S. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901387 · Cited by 24 · see citing works
Interplay of autophagy and apoptosis during PRRSV infection of Marc145 cell
Li, S., Zhou, A., Wang, J., & Zhang, S. (2016) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2016.01.011 · Cited by 24 · see citing works
Parkin negatively regulates the antiviral signaling pathway by targeting TRAF3 for degradation
Xin, D., Gu, H., Liu, E., & Sun, Q. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001201 · Cited by 23 · see citing works
Münz, C. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.03.005 · Cited by 23 · see citing works
Chang, R., Zheng, W., Sun, Y., Geng, S., & Xu, T. (2021) · Journal of Virology · doi:10.1128/jvi.01484-21 · Cited by 22 · see citing works
Cytosolic Low Molecular Weight FGF2 Orchestrates RIG-I–Mediated Innate Immune Response
Liu, X., Luo, D., & Yang, N. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501503 · Cited by 21 · see citing works
Citreoviridin induces ROS-dependent autophagic cell death in human liver HepG2 cells
Liu, Y., Wang, Y., Liu, X., Jiang, L., Yang, G., Sun, X., Geng, C., Li, Q., Chen, M., & Yao, X. (2014) · Toxicon · doi:10.1016/j.toxicon.2014.12.014 · Cited by 21 · see citing works
Label-free proteomic analysis of silkworm midgut infected by Bombyx mori nuclear polyhedrosis virus
Zhang, Y., Xia, D., Zhao, Q., Zhang, G., Zhang, Y., Qiu, Z., Shen, D., & Lu, C. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.03.011 · Cited by 20 · see citing works
MITA modulated autophagy flux promotes cell death in breast cancer cells
Bhatelia, K., Singh, K., Prajapati, P., Sripada, L., Roy, M., & Singh, R. K. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.03.024 · Cited by 19 · see citing works
Xing, W., Tangjuan, Y., Xu, J. D., Li, G., Liang, P., & Lü, H. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.08.013 · Cited by 19 · see citing works
Sun, N., Cai, Q., Zhang, Y., Zhang, R.-R., Jiang, J., Yang, H., Qin, C., & Cheng, G. (2024) · Science Signaling · doi:10.1126/scisignal.adf8016 · Cited by 18 · see citing works
Zhou, P., Li, Y., Liu, A., Zhang, Q., Wu, W., Jin, H., Jongkaewwattana, A., He, Q., & Luo, R. (2022) · Journal of Virology · doi:10.1128/jvi.00816-22 · Cited by 17 · see citing works
Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight
Cuervo, N. Z., Osseman, Q., & Grandvaux, N. (2018) · Viruses · doi:10.3390/v10020056 · Cited by 17 · see citing works
Comparison of Sericins from Different Sources as Natural Therapeutics against Ulcerative Colitis
Ma, Y., Zhou, L., Yang, C., Wang, L., Yi, S., Tong, X., Xiao, B., & Chen, J. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00256 · Cited by 17 · see citing works
Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization
Nobre, L., Wise, D., Ron, D., & Volmer, R. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136883 · Cited by 12 · see citing works
Du, C., Liu, H., Lin, Y., Wang, X., Ma, J., Li, Y., Wang, X., & Zhou, J. (2015) · PROTEOMICS · doi:10.1002/pmic.201400279 · Cited by 16 · see citing works
Haridevamuthu, B., Guru, A., Velayutham, M., Priya, P. S., Arshad, A., & Arockiaraj, J. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12709 · Cited by 16 · see citing works
dos Reis, L. M., Berçot, M. R., Castelucci, B. G., Martins, A. J. E., Castro, G., & Moraes‐Vieira, P. M. (2023) · Viruses · doi:10.3390/v15020525 · Cited by 15 · see citing works
Reactive oxygen species-initiated autophagy opposes aldosterone-induced podocyte injury
Bai, M., Che, R., Zhang, Y., Yuan, Y., Zhu, C., Ding, G., Jia, Z., Huang, S., & Zhang, A. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00409.2015 · Cited by 15 · see citing works
The role of mitochondria in cytokine and chemokine signalling during ageing
Kalykaki, M., Rubio‐Tomás, T., & Tavernarakis, N. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111993 · Cited by 14 · see citing works
ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization
Liu, E., Sun, J., Yang, J., Li, L., Yang, Q., Zeng, J., Zhang, J., Chen, D., & Sun, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.710967 · Cited by 13 · see citing works
Sae‐khow, K., Phuengmaung, P., Issara-Amphorn, J., Makjaroen, J., Visitchanakun, P., Boonmee, A., Benjaskulluecha, S., Palaga, T., & Leelahavanichkul, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210175 · Cited by 13 · see citing works
Yang, J., Li, W., Zhang, Z., Gong, X., Chen, Y., Peng, X., Hu, G.-S., Dai, X., He, Y., Huang, Y., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2408117121 · Cited by 11 · see citing works
Zhu, X., Lu, M., Li, W., Li, L., Liu, Y., Zhou, J., Shang, J., Shi, X., Lu, J., Xing, J., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143288 · Cited by 11 · see citing works
The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development
Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113873 · Cited by 10 · see citing works
Chen, J., Liu, Z., Fang, H., Su, Q., Fan, Y., Song, L., & He, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05151-5 · Cited by 10 · see citing works
The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance
Du, Y., Pan, D., Jia, R. L., Chen, Y., Jia, C., Wang, J., & Hu, B. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2167129 · Cited by 9 · see citing works
Innate sensing and cellular metabolism: role in fine tuning antiviral immune responses
Ahmed, D., Daraawi, M. A., & Cassol, E. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiac011 · Cited by 8 · see citing works
Li, D., Yang, W., Ru, Y., Ren, J., Liu, X., & Zheng, H. (2020) · Journal of Virology · doi:10.1128/jvi.01756-19 · Cited by 8 · see citing works
Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
Harris, R., Yang, J., Pagan, K., Cho, S. J., & Stout-Delgado, H. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212097 · Cited by 9 · see citing works
Zhang, G., Miao, Y., Song, Y., Wang, L., Li, Y., Zhu, Y., Zhang, W., Sun, Q., & Chen, D. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2410261121 · Cited by 7 · see citing works
- Authors
- Zhao, Y., Sun, X., Nie, X., Sun, L., Tang, T.-S., Chen, D., & Sun, Q.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Sun, Qinmiao
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-12-20
- Volume
- 8
- Issue
- 12
- Pages
- e1003086
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC3534373
- OpenAlex
- W1974115318
- Cited by
- 129
- References
- 53
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 11 · 2023: 10 · 2022: 7 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 14 · 2015: 14 · 2014: 9 · 2013: 3
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Texas Southwestern Medical Center
- National Natural Science Foundation of China (2010CB945300)
- Chinese Academy of Sciences
- Tsinghua University
- Wuhan University
- National Key Research and Development Program of China (2010CB945300)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- COX5B, MAVS, cytochrome c oxidase, antiviral signaling, reactive oxygen species, autophagy, ATG5, mitochondria, antiviral innate immunity, autoimmunity
- MeSH terms
- Autophagy-Related Protein 5, Animals, Autophagy, Cells, Cultured, Electron Transport Complex IV, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunity, Innate, Microtubule-Associated Proteins, Mitochondria, Protein Binding, RNA, Messenger, Vesicular stomatitis Indiana virus, Virion, Blotting, Western, Signal Transduction, NF-kappa B, Apoptosis, Reactive Oxygen Species, Reverse Transcriptase Polymerase Chain Reaction, Immunoprecipitation, Adaptor Proteins, Signal Transducing, Cell Proliferation, Vesicular Stomatitis, Real-Time Polymerase Chain Reaction
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