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Novel Positive Regulatory Role for the SPL6 Transcription Factor in the N TIR-NB-LRR Receptor-Mediated Plant Innate Immunity
Open accessAbstract
Following the recognition of pathogen-encoded effectors, plant TIR-NB-LRR immune receptors induce defense signaling by a largely unknown mechanism. We identify a novel and conserved role for the SQUAMOSA PROMOTER BINDING PROTEIN (SBP)-domain transcription factor SPL6 in enabling the activation of the defense transcriptome following its association with a nuclear-localized immune receptor. During an active immune response, the Nicotiana TIR-NB-LRR N immune receptor associates with NbSPL6 within distinct nuclear compartments. NbSPL6 is essential for the N-mediated resistance to Tobacco mosaic virus. Similarly, the presumed Arabidopsis ortholog AtSPL6 is required for the resistance mediated by the TIR-NB-LRR RPS4 against Pseudomonas syringae carrying the avrRps4 effector. Transcriptome analysis indicates that AtSPL6 positively regulates a subset of defense genes. A pathogen-activated nuclear-localized TIR-NB-LRR like N can therefore regulate defense genes through SPL6 in a mechanism analogous to the induction of MHC genes by mammalian immune receptors like CIITA and NLRC5.
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Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Specific effects of microRNAs on the plant transcriptome
Schwab, R., Palatnik, J. F., Riester, M., Schommer, C., Schmid, M., & Weigel, D. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.01.018 · Cited by 1,467
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NLR family member NLRC5 is a transcriptional regulator of MHC class I genes
Meissner, T. B., Li, A., Biswas, A., Lee, K.-H., Liu, Y.-J., Bayir, E., Iliopoulos, D., van den Elsen, P. J., & Kobayashi, K. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008684107 · Cited by 447
Cited by
Effector-Triggered Immunity: From Pathogen Perception to Robust Defense
Cui, H., Tsuda, K., & Parker, J. E. (2015) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050213-040012 · Cited by 1,428
Xu, M., Hu, T., Zhao, J., Park, M.-Y., Earley, K. W., Wu, G., Yang, L., & Poethig, R. S. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006263 · Cited by 586
Transcriptional networks in plant immunity
Tsuda, K., & Somssich, I. E. (2015) · New Phytologist · doi:10.1111/nph.13286 · Cited by 552
Le Roux, C., Huet, G., Jauneau, A., Camborde, L., Trémousaygue, D., Kraut, A., Zhou, B., Levaillant, M., Adachi, H., Yoshioka, H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.025 · Cited by 489
Wang, H., & Wang, H. (2015) · Molecular Plant · doi:10.1016/j.molp.2015.01.008 · Cited by 356
Metadata
- Authors
- Padmanabhan, M. S., Ma, S., Burch-Smith, T. M., Czymmek, K., Huijser, P., & Dinesh-Kumar, S. P.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-03-14
- Volume
- 9
- Issue
- 3
- Pages
- e1003235
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W1965074763
- Cited by
- 195
- References
- 4
- FWCI
- 22.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Padmanabhan, M. S., Ma, S., Burch-Smith, T. M., Czymmek, K., Huijser, P., & Dinesh-Kumar, S. P. (2013). Novel Positive Regulatory Role for the SPL6 Transcription Factor in the N TIR-NB-LRR Receptor-Mediated Plant Innate Immunity. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1003235
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