The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)
Open accessAbstract
Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each other both clinically and epidemiologically. Recent findings suggest a causative link between periodontal infection and rheumatoid arthritis via bacteria-dependent induction of a pathogenic autoimmune response to citrullinated epitopes. Here we showed that infection with viable periodontal pathogen Porphyromonas gingivalis strain W83 exacerbated collagen-induced arthritis (CIA) in a mouse model, as manifested by earlier onset, accelerated progression and enhanced severity of the disease, including significantly increased bone and cartilage destruction. The ability of P. gingivalis to augment CIA was dependent on the expression of a unique P. gingivalis peptidylarginine deiminase (PPAD), which converts arginine residues in proteins to citrulline. Infection with wild type P. gingivalis was responsible for significantly increased levels of autoantibodies to collagen type II and citrullinated epitopes as a PPAD-null mutant did not elicit similar host response. High level of citrullinated proteins was also detected at the site of infection with wild-type P. gingivalis. Together, these results suggest bacterial PAD as the mechanistic link between P. gingivalis periodontal infection and rheumatoid arthritis.
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Cites
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Klareskog, L., Catrina, A. I., & Paget, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60008-8 · Cited by 787
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
Harre, U., Georgess, D., Bang, H., Bozec, A., Axmann, R., Ossipova, E., Jakobsson, P.-J., Baum, W., Nimmerjahn, F., Szarka, E., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60975 · Cited by 736
Wegner, N., Wait, R., Sroka, A., Eick, S., Nguyen, K., Lundberg, K., Kinloch, A., Culshaw, S., Potempa, J., & Venables, P. J. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27552 · Cited by 683
Self-citationCitrullination: A posttranslational modification in health and disease
György, B., Tóth, E., Tarcsa, E., Falus, A., & Buzás, E. I. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.03.008 · Cited by 500
Periodontal Disease as a Specific, albeit Chronic, Infection: Diagnosis and Treatment
Loesche, W. J., & Grossman, N. S. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.727-752.2001 · Cited by 495
Periodontitis in systemic rheumatic diseases
de Pablo, P., Chapple, I. L. C., Buckley, C. D., & Dietrich, T. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.28 · Cited by 478
Wegner, N., Lundberg, K., Kinloch, A., Fisher, B., Malmström, V., Feldmann, M., & Venables, P. J. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00850.x · Cited by 471
Self-citationPeriodontal disease and the oral microbiota in new‐onset rheumatoid arthritis
Scher, J. U., Ubeda, C., Equinda, M., Khanin, R., Buischi, Y., Viale, A., Lipuma, L., Attur, M., Pillinger, M. H., Weissmann, G., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34539 · Cited by 468
Immunity to Citrullinated Proteins in Rheumatoid Arthritis
Klareskog, L., Rönnelid, J., Lundberg, K., Padyukov, L., & Alfredsson, L. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090244 · Cited by 463
Cited by
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
Hajishengallis, G., & Chavakis, T. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00488-6 · Cited by 1,871
Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line
How, K. Y., Song, K. P., & Chan, K. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00053 · Cited by 858
Molecular mimicry and autoimmunity
Rojas, M., Restrepo-Jiménez, P., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., & Anaya, J.-M. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.012 · Cited by 627
The case for periodontitis in the pathogenesis of rheumatoid arthritis
Potempa, J., Mydel, P., & Koziel, J. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.132 · Cited by 437
Self-citation
Metadata
- Authors
- Maresz, K. J., Hellvard, A., Sroka, A., Adamowicz, K., Bielecka, E., Koziel, J., Gawron, K., Mizgalska, D., Marcinska, K. A., Benedyk, M., Pyrc, K., Quirke, A.-M., Jonsson, R., Alzabin, S., Venables, P. J., Nguyen, K.-A., Mydel, P., & Potempa, J.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-09-12
- Volume
- 9
- Issue
- 9
- Pages
- e1003627
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2061067592
- Cited by
- 290
- References
- 46
- FWCI
- 17.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD). https://app.cochat.ai/papers/10.1371/journal.ppat.1003627
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- Maresz, K. J., Hellvard, A., Sroka, A., Adamowicz, K., Bielecka, E., Koziel, J., Gawron, K., Mizgalska, D., Marcinska, K. A., Benedyk, M., Pyrc, K., Quirke, A.-M., Jonsson, R., Alzabin, S., Venables, P. J., Nguyen, K.-A., Mydel, P., & Potempa, J. (2013). Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD). PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1003627
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
