TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628

Oncology meets immunology: the cancer-immunity cycle.

Chen, D. S., & Mellman, I. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.012 · Cited by 6,929

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062 · cited 1×

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

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Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

Hamid, O., Robert, C., DAUD, A. I., Hodi, F. S., Hwu, W., Kefford, R. F., Wolchok, J. D., Hersey, P., Joseph, R. W., Weber, J. S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1305133 · Cited by 3,427

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

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MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

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High-throughput virtual screening of small-molecule inhibitors targeting immune cell checkpoints to discover new immunotherapeutics for human diseases

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Next-generation bNAbs for HIV-1 cure strategies

Schriek, A. I., Aldon, Y., van Gils, M. J., & de Taeye, S. W. (2023) · Antiviral Research · doi:10.1016/j.antiviral.2023.105788 · Cited by 29

TIGIT blockade enhances NK cell activity against autologous HIV‐1‐infected CD4+ T cells

Holder, K. A., Burt, K., & Grant, M. D. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1348 · Cited by 28

TIGIT and Helios Are Highly Expressed on CD4+ T Cells in Sézary Syndrome Patients

Jariwala, N. N., Benoit, B. M., Kossenkov, A. V., Oetjen, L. K., Whelan, T. M., Cornejo, C. M., Takeshita, J., Kim, B., Showe, L. C., Wysocka, M., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.08.016 · Cited by 26

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

Burwitz, B. J., Wu, H. L., Abdulhaqq, S. A., Shriver-Munsch, C. M., Swanson, T., Legasse, A. W., Hammond, K. B., Junell, S. L., Reed, J. S., Bimber, B. N., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01631-z · Cited by 26

Levels of Human Immunodeficiency Virus DNA Are Determined Before ART Initiation and Linked to CD8 T-Cell Activation and Memory Expansion

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Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming

Lawton, M. L., Inge, M. M., Blum, B. C., Smith-Mahoney, E. L., Bolzan, D., Lin, W., McConney, C., Porter, J., Moore, J., Youssef, A., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002943 · Cited by 25

Expressions of inhibitory checkpoint molecules in acute and chronic HBV and HCV infections: Implications for therapeutic monitoring and personalized therapy

Hakim, M. S., Rahmadika, N., & Jariah, R. O. A. (2019) · Reviews in Medical Virology · doi:10.1002/rmv.2094 · Cited by 26

Shocking HIV-1 with immunomodulatory latency reversing agents

Kula, A., Rodari, A., Darcis, G., & Lint, C. M. V. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101478 · Cited by 28

Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8 + T Cell Exhaustion Marker Expression

Rutishauser, R. L., Hartogensis, W., Deguit, C. D. T., Krone, M., Hoh, R., Hecht, F. M., Pilcher, C. D., Bacchetti, P., Deeks, S. G., Hunt, P. W., et al. (2017) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2016.0324 · Cited by 25

Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation

Gangcuangco, L. M. A., Mitchell, B. I., Siriwardhana, C., Kohorn, L. B., Chew, G. M., Bowler, S. A., Kallianpur, K. J., Chow, D. C., Ndhlovu, L. C., Gerschenson, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231761 · Cited by 24

Expression Profile and Biological Role of Immune Checkpoints in Disease Progression of HIV/SIV Infection

Sun, Y., & Xue, J. (2022) · Viruses · doi:10.3390/v14030581 · Cited by 24

IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT+ HIVGag-specific T cells

Cheng, J., Myers, T. G., Levinger, C., Kumar, P. N., Kumar, J., Goshu, B. A., Bosque, A., & Catálfamo, M. (2021) · iScience · doi:10.1016/j.isci.2021.103588 · Cited by 23

Gene of the month: T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)

Bolm, L., Petruch, N., Sivakumar, S., Annels, N. E., & Frampton, A. E. (2022) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2021-207789 · Cited by 23

TIGIT Blockade: A Multipronged Approach to Target the HIV Reservoir

Holder, K. A., & Grant, M. D. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00175 · Cited by 25

Correlation Between TIGIT Expression on CD8+ T Cells and Higher Cytotoxic Capacity

Blažková, J., Huiting, E. D., Boddapati, A. K., Shi, V., Whitehead, E. J., Justement, J. S., Nordstrom, J. L., Moir, S. L., Lack, J., & Chun, T. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab155 · Cited by 26

OMIP‐037: 16‐color panel to measure inhibitory receptor signatures from multiple human immune cell subsets

Belkina, A. C., & Snyder-Cappione, J. E. (2016) · Cytometry Part A · doi:10.1002/cyto.a.22983 · Cited by 22

The paired receptors TIGIT and DNAM-1 as targets for therapeutic antibodies

Stein, N., Tsukerman, P., & Mandelboim, O. (2016) · Human Antibodies · doi:10.3233/hab-160307 · Cited by 22

Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection

Li, W., Syed, F., Yu, R., Yang, J., Xia, Y., Relich, R. F., Russell, P. M., Zhang, S., Khalili, M., Huang, L., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.833310 · Cited by 23

Co-Expression of TIGIT and Helios Marks Immunosenescent CD8+ T Cells During Aging

Pieren, D. K. J., Smits, N. A. M., Postel, R. J., Kandiah, V., de Wit, J., van Beek, J., van Baarle, D., & Guichelaar, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.833531 · Cited by 22

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig

Manook, M., Olaso, D., Anwar, I. J., DeLaura, I. F., Yoon, J., Bae, Y., Barbas, A. S., Shaw, B. I., Moris, D., Song, M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk6152 · Cited by 22

The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections

Yasuma-Mitobe, K., & Matsuoka, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02755 · Cited by 22

Blockade of the PD-1 axis alone is not sufficient to activate HIV-1 virion production from CD4+ T cells of individuals on suppressive ART

Bui, J. K., Cyktor, J. C., Fyne, E., Campellone, S. C., Mason, S. W., & Mellors, J. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211112 · Cited by 22

Checkpoint inhibitors for the treatment of JC virus-related progressive multifocal leukoencephalopathy

Beck, E., & Cortese, I. C. M. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.02.005 · Cited by 22

Cancer therapies in HIV cure research

Rasmussen, T. A., Anderson, J. L., Wightman, F., & Lewin, S. R. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000328 · Cited by 23

Immune Checkpoint Inhibitors in Melanoma and HIV Infection

Marra, A., Scognamiglio, G., Peluso, I., Botti, G., Fusciello, C., Filippelli, A., Ascierto, P. A., Pepe, S., & Sabbatino, F. (2017) · The Open AIDS Journal · doi:10.2174/1874613601711010091 · Cited by 21

Therapeutic HIV-1 vaccine

Seddiki, N., & Lévy, Y. (2018) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000444 · Cited by 21

Regulatory KIR+RA+ T cells accumulate with age and are highly activated during viral respiratory disease

Pieren, D. K. J., Smits, N. A. M., Hoeboer, J., Kandiah, V., Postel, R. J., Mariman, R., van Beek, J., van Baarle, D., de Wit, J., & Guichelaar, T. (2021) · Aging Cell · doi:10.1111/acel.13372 · Cited by 22

Cellular Activation, Differentiation, and Proliferation Influence the Dynamics of Genetically Intact Proviruses Over Time

Horsburgh, B. A., Hiener, B. M., Fisher, K., Lee, E., Morgan, H. J., Eden, J., von Stockenström, S., Odevall, L., Milush, J. M., Hoh, R., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab291 · Cited by 20

Strategies to target non-T-cell HIV reservoirs

Sacha, J. B., & Ndhlovu, L. C. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000283 · Cited by 20

Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure

Viganó, S., Bobisse, S., Coukos, G., Perreau, M., & Harari, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01350 · Cited by 21

Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection

Deguit, C. D. T., Hough, M., Hoh, R., Krone, M., Pilcher, C. D., Martin, J. N., Deeks, S. G., McCune, J. M., Hunt, P. W., & Rutishauser, R. L. (2019) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002121 · Cited by 20

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

Brunet‐Ratnasingham, E., Morou, A., Dubé, M., Niessl, J., Baxter, A. E., Tastet, O., Brassard, N., Ortega-Delgado, G.-G., Charlebois, R., Freeman, G. J., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104254 · Cited by 20

HIV Infection, Chromosome Instability, and Micronucleus Formation

Ellwanger, J. H., Kulmann‐Leal, B., Ziliotto, M., & Chies, J. A. B. (2023) · Viruses · doi:10.3390/v15010155 · Cited by 19

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells in vivo

Pan, H., Yang, X., Wang, J., Liang, H., Jiang, Z., Zhao, L., Wang, Y., Liang, Z., Shen, X., Lin, Q., et al. (2023) · Virologica Sinica · doi:10.1016/j.virs.2023.01.003 · Cited by 19

Cancer Immunotherapy and the Nectin Family

Johnston, R. J., Lee, P. S., Strop, P., & Smyth, M. J. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-060920-084910 · Cited by 19

Clinical Interventions in HIV Cure Research

Rasmussen, T. A., & Søgaard, O. S. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0484-2_12 · Cited by 19

Restoration of HCV-Specific Immune Responses with Antiviral Therapy: A Case for DAA Treatment in Acute HCV Infection

Casey, J. L., Feld, J. J., & MacParland, S. A. (2019) · Cells · doi:10.3390/cells8040317 · Cited by 19

A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes

Sebastiani, G., Grieco, G. E., Bruttini, M., Auddino, S., Mori, A., Toniolli, M., Fignani, D., Licata, G., Aiello, E., Nigi, L., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101591 · Cited by 18

Dysfunctional role of elevated TIGIT expression on T cells in oral squamous cell carcinoma patients

Liu, X., Li, Q., Zhou, Y. Y., He, X., Fang, J., Lu, H., Wang, X., Wang, D., Ma, D., Cheng, B., et al. (2020) · Oral Diseases · doi:10.1111/odi.13703 · Cited by 18

Unraveling the Multifaceted Nature of CD8 T Cell Exhaustion Provides the Molecular Basis for Therapeutic T Cell Reconstitution in Chronic Hepatitis B and C

Barili, V., Vecchi, A. L., Rossi, M., Montali, I., Tiezzi, C., Penna, A., Laccabue, D., Missale, G., Fisicaro, P., & Boni, C. (2021) · Cells · doi:10.3390/cells10102563 · Cited by 18

Intact proviruses are enriched in the colon and associated with PD-1(+)TIGIT(-) mucosal CD4(+) T cells of people with HIV-1 on antiretroviral therapy

Vellas, C., Nayrac, M., Collercandy, N., Requena, M., Jeanne, N., Latour, J., Dimeglio, C., Cazabat, M., Barange, K., Alric, L., et al. (2024) · eBioMedicine · doi:10.1016/j.ebiom.2023.104954 · Cited by 17

TCR Transgenic Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanisms

Cho, Y., Lee, I.-G., Joo, Y.-H., Hong, S., & Seo, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249690 · Cited by 17

Persistent T cell unresponsiveness associated with chronic visceral leishmaniasis in HIV-coinfected patients

de Vrij, N., Pollmann, J., Rezende, A. M., Ibarra‐Meneses, A. V., Pham, T., Hailemichael, W., Kassa, M., Bogale, T., Melkamu, R., Yeshanew, A., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06225-2 · Cited by 17

Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts

Sun, Y., Anyalebechi, J. C., Sun, H. Y., Yumoto, T., Xue, M., Liu, D., Liang, Z., Coopersmith, C. M., & Ford, M. L. (2021) · JCI Insight · doi:10.1172/jci.insight.141245 · Cited by 17

Immune Checkpoint Molecules and Glucose Metabolism in HIV-Induced T Cell Exhaustion

Chan, Y. T., Cheong, H. C., Tang, T. F., Rajasuriar, R., Cheng, K., Looi, C. Y., Wong, W. F., & Kamarulzaman, A. (2022) · Biomedicines · doi:10.3390/biomedicines10112809 · Cited by 19

Immune checkpoint molecule TIGIT manipulates T cell dysfunction in septic patients

Sun, Y., Ding, R., Chang, Y. J., Li, J., & Ma, X. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108205 · Cited by 16

Can Soluble Immune Checkpoint Molecules on Exosomes Mediate Inflammation?

Joseph, J., Rahmani, B., Cole, Y., Puttagunta, N., Lin, E., Khan, Z. K., & Jain, P. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10018-3 · Cited by 16

A Randomized Placebo-Controlled Efficacy Study of a Prime Boost Therapeutic Vaccination Strategy in HIV-1-Infected Individuals: VRI02 ANRS 149 LIGHT Phase II Trial

Lévy, Y., Lacabaratz, C., Lhomme, É., Wiedemann, A., Bauduin, C., Fenwick, C. W., Foucat, E., Surénaud, M., Guillaumat, L., Boilet, V., et al. (2021) · Journal of Virology · doi:10.1128/jvi.02165-20 · Cited by 16

Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection

Lee, M. Y.-H., Upadhyay, A. A., Walum, H., Chan, C. N., Dawoud, R. A., Grech, C., Harper, J. L., Karunakaran, K. A., Nelson, S. A., Mahar, E. A., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009674 · Cited by 16

Treating cancer with immunotherapy in HIV-positive patients: A challenging reality

Guaitoli, G., Baldessari, C., Maur, M., Mussini, C., Meschiari, M., Barbieri, F., Cascinu, S., & Bertolini, F. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.102836 · Cited by 16

CD155-TIGIT Axis as a Therapeutic Target for Cancer Immunotherapy

Mu, Y., & Guan, X. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230324152532 · Cited by 15

Safety and efficacy of fecal microbiota transplantation for viral diseases: A systematic review of clinical trials

Ebrahimi, R., Masouri, M. M., Khozani, A. A. S. A., Hussein, D. R., & Nejadghaderi, S. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0311731 · Cited by 15

New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV

Carrillo, M. A., Zhen, A., Zack, J. A., & Kitchen, S. G. (2017) · Translational research · doi:10.1016/j.trsl.2017.07.002 · Cited by 16

Antigen processing and presentation in HIV infection

Boucau, J., & Gall, S. L. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.03.027 · Cited by 15

TIGIT marks exhausted T cells and serves as a target for immune restoration in patients with chronic HBV infection.

Wei, Y., Fan, J., Shan, M., Yin, D., Wang, L., Ye, W., & Zhao, W. (2022) · PubMed Central · Cited by 15

Methods for Characterization of Senescent Circulating and Tumor-Infiltrating T-Cells: An Overview from Multicolor Flow Cytometry to Single-Cell RNA Sequencing

Franzin, R., Stasi, A., Castellano, G., & Gesualdo, L. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1507-2_6 · Cited by 14

Metformin facilitates viral reservoir reactivation and their recognition by anti-HIV-1 envelope antibodies

Fert, A., Richard, J., Marchand, L. R., Planas, D., Routy, J., Chomont, N., Finzi, A., & Ancuța, P. (2024) · iScience · doi:10.1016/j.isci.2024.110670 · Cited by 15

CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection

Qin, K., Boppana, S., Du, V. Y., Carlson, J. M., Yue, L., Dilernia, D. A., Hunter, E., Mailliard, R. B., Mallal, S. A., Bansal, A., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007970 · Cited by 14

Immune involvement of the contralateral hemisphere in a glioblastoma mouse model

Crommentuijn, M. H. W., Schetters, S. T. T., Dusoswa, S. A., Kruijssen, L. J. W., García-Vallejo, J. J., & van Kooyk, Y. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000323 · Cited by 15

Immune checkpoint molecules in prevention and development of asthma

Kanannejad, Z., Soleimanian, S., Ghahramani, Z., Sepahi, N., Mohkam, M., Alyasin, S. S., & Kheshtchin, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1070779 · Cited by 14

Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults

Zhang, Z., Chew, G. M., Shikuma, C. M., Gangcuangco, L. M. A., Souza, S. A., Shiramizu, B. T., Nakamoto, B. K., Gong, T., Mannem, S. R., Mitchell, B. I., et al. (2018) · HIV Clinical Trials · doi:10.1080/15284336.2018.1514821 · Cited by 14

Intratumoral and Combination Therapy in Melanoma and Other Skin Cancers

Oglesby, A., Algazi, A. P., & DAUD, A. I. (2019) · American Journal of Clinical Dermatology · doi:10.1007/s40257-019-00452-8 · Cited by 14

Immune checkpoints and the HIV-1 reservoir: proceed with caution

Olesen, R., Leth, S., Nymann, R., Østergaard, L. J., Søgaard, O. S., Denton, P. W., & Tolstrup, M. (2016) · Journal of Virus Eradication · doi:10.1016/s2055-6640(20)30463-5 · Cited by 14

Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affected

Parker, E., Judge, M. A., Pastor, L., de la Fuente, L., Jairoce, C., Carter, K. W., Anderson, D. R., Mandomando, I., Clifford, H. D., Naniche, D., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1074847 · Cited by 13

Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy

de Armas, L. R., Pallikkuth, S., Rinaldi, S., Pahwa, R., & Pahwa, S. G. (2019) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2019.0135 · Cited by 13

Effects of Brief Adjunctive Metformin Therapy in Virologically Suppressed HIV-Infected Adults on Polyfunctional HIV-Specific CD8 T Cell Responses to PD-L1 Blockade

Chew, G. M., Padua, A. J., Chow, D. C., Souza, S. A., Clements, D. M., Corley, M. J., Pang, A. P. S., Alejandria, M. M., Gerschenson, M., Shikuma, C. M., et al. (2020) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2020.0172 · Cited by 13

Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice

Rout, S. S., Di, Y., Dittmer, U., Sutter, K., & Lavender, K. J. (2021) · AIDS · doi:10.1097/qad.0000000000003111 · Cited by 13

Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis

Moriarty, R. V., Rodgers, M., Ellis-Connell, A. L., Balgeman, A. J., Larson, E. C., Hopkins, F. F., Chase, M. R., Maiello, P. A., Fortune, S. M., Scanga, C. A., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01724-21 · Cited by 13

Insights into the HIV-1 Latent Reservoir and Strategies to Cure HIV-1 Infection

Bai, R., Lv, S., Wu, H., & Dai, L. (2022) · Disease Markers · doi:10.1155/2022/6952286 · Cited by 13

Active PD-L1 incorporation within HIV virions functionally impairs T follicular helper cells

Muñoz, O., Banga, R., Schelling, R., Procopio, F. A., Mastrángelo, A., Nortier, P., Ohmiti, K., Daraspe, J., Cavassini, M. L., Fenwick, C. W., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010673 · Cited by 13

Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA

Tannig, P., Peter, A. S., Lapuente, D., Klessing, S., Damm, D., Tenbusch, M., Überla, K., & Temchura, V. (2020) · Vaccines · doi:10.3390/vaccines8010027 · Cited by 14

Upregulation of Multiple CD8+ T Cell Exhaustion Pathways Is Associated with Recurrent Ocular Herpes Simplex Virus Type 1 Infection

Coulon, P.-G. A., Roy, S., Prakash, S., Srivastava, R., Dhanushkodi, N. R., Salazar, S. N., Amezquita, C., Nguyễn, L., Vahed, H., Nguyen, A., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000131 · Cited by 14

Phenotypic and Functional Analyses Guiding Combination Immune Checkpoint Immunotherapeutic Strategies in HTLV-1 Infection

Clements, D. M., Crumley, B. L., Chew, G. M., Davis, E., Bruhn, R. L., Murphy, E. L., Ndhlovu, L. C., & Jain, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.608890 · Cited by 13

Expression of Inhibitory Receptors TIGIT, TIM-3, and LAG-3 on CD4+ T Cells from Patients with Different Clinical Forms of Chronic Chagas Disease

Ferragut, F., Alcaráz, P. B., Beati, P., Girard, M. C., Ossowski, M. S., Chadi, R., Fernandez, M. L., Hernández-Vásquez, Y., Acevedo, G. R., & Gómez, K. A. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200436 · Cited by 12

KIR3DL1-Negative CD8 T Cells and KIR3DL1-Negative Natural Killer Cells Contribute to the Advantageous Control of Early Human Immunodeficiency Virus Type 1 Infection in HLA-B Bw4 Homozygous Individuals

Zhang, X., Lu, X., Moog, C., Yuan, L., Liu, Z., Li, Z., Xia, W., Zhou, Y., Wu, H., Zhang, T., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01855 · Cited by 12

Mycophenolate mofetil enhances the effects of tacrolimus on the inhibitory function of regulatory T cells in patients after liver transplantation via PD-1 and TIGIT receptors

Zeng, Q., Yuan, X., Cao, J., Zhao, X., Wang, Y., Liu, B., Liu, W., Zhu, Z., & Dou, J. (2021) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2021.1891247 · Cited by 12

Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection

Webb, G. M., Pessoa, C. T., McCullen, A. J., Hwang, J. M., Humkey, M. C., Thormin-Odum, R., Kukula, K. A., Smedley, J. V., Fischer, M. B., Sciurba, J., et al. (2024) · Journal of Virology · doi:10.1128/jvi.00273-24 · Cited by 11

Expression of TIGIT and FCRL3 is Altered in T Cells from Patients with Distinct Patterns of Chronic Autoimmune Thyroiditis

Štefanić, M., Tokić, S., Suver-Stević, M., & Glavaš‐Obrovac, L. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0597-8948 · Cited by 11

Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques

O’Connor, M. A., Munson, P. V., Tunggal, H. C., Hajari, N., Lewis, T. B., Bratt, D., Moats, C. R., Smedley, J. V., Bagley, K., Mullins, J. I., et al. (2018) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2018.0184 · Cited by 11

DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease

Jacobs, M. E., Pouw, J. N., Nordkamp, M. A. M. O., Radstake, T. R. D. J., Leijten, E. F. A., & Boes, M. L. (2020) · Immunotherapy Advances · doi:10.1093/immadv/ltaa004 · Cited by 10

Dampening antiviral immunity can protect the host

Panetti, C., Kao, K., & Joller, N. (2021) · FEBS Journal · doi:10.1111/febs.15756 · Cited by 10

HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy

Mallarino-Haeger, C., Pino, M., Viox, E. G., Pagliuzza, A., King, C. T., Nguyen, K., Harper, J. L., Aldrete, S. D. M., Cervasi, B., Delman, K. A., et al. (2023) · Journal of Virology · doi:10.1128/jvi.01670-22 · Cited by 10

Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter

Rezaei, S., Timani, K. A., & He, J. J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0705 · Cited by 10

Clinical trials aimed at HIV cure or remission: new pathways and lessons learned

Schou, M. D., Søgaard, O. S., & Rasmussen, T. A. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2273919 · Cited by 10

OMIP‐046: Characterization of invariant T cell subset activation in humans

Lal, K. G., Leeansyah, E., Sandberg, J. K., & Eller, M. A. (2018) · Cytometry Part A · doi:10.1002/cyto.a.23357 · Cited by 10

Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection

Mitchell, B. I., Eiser, I. E. Y., Kallianpur, K. J., Gangcuangco, L. M. A., Chow, D. C., Ndhlovu, L. C., Paul, R., & Shikuma, C. M. (2024) · Journal of NeuroVirology · doi:10.1007/s13365-024-01223-w · Cited by 11

Identification of CD98 as a Novel Biomarker for HIV-1 Permissiveness and Latent Infection

Zhang, W., Zhou, M., Chen, C., Wu, S., Wang, L., Xia, B., Liu, J., Ma, X., Pan, T. S., Zhang, H., et al. (2022) · mBio · doi:10.1128/mbio.02496-22 · Cited by 10

mTOR signaling mediates effects of common gamma-chain cytokines on T cell proliferation and exhaustion

Taylor, H. E., Calantone, N., & D’Aquila, R. T. (2018) · AIDS · doi:10.1097/qad.0000000000001997 · Cited by 10

Managing Viral Hepatitis in Cancer Patients Under Immune Checkpoint Inhibitors: Should we Take the Risk?

Keukeleire, S. D., Vermassen, T., Nezhad, Z. M., Kerre, T. C. C., Krüse, V., Vlierberghe, H. V., Vermaelen, K. Y., & Rottey, S. (2021) · Immunotherapy · doi:10.2217/imt-2020-0273 · Cited by 10

Targeting Epigenetics to Cure HIV-1: Lessons From (and for) Cancer Treatment

Svensson, J. P. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.668637 · Cited by 9

Renal Cell Carcinoma Associated With HIV/AIDS: A Review of the Epidemiology, Risk Factors, Diagnosis, and Treatment

Zhu, Z., Zhang, Y., Wang, H., Jiang, T., Zhang, M., Zhang, Y., Su, B., & Tian, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.872438 · Cited by 9

So Pathogenic or So What?—A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research

Kleinman, A. J., Pandrea, I., & Apetrei, C. (2022) · Viruses · doi:10.3390/v14010135 · Cited by 11

Combination rhIL-15 and Anti-PD-L1 (Avelumab) Enhances HIVGag-Specific CD8 T-Cell Function

Goshu, B. A., Chen, H., Moussa, M., Cheng, J., & Catálfamo, M. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa269 · Cited by 9

Changing roles of CD3+CD8low T cells in combating HIV-1 infection

Zhang, X., Wang, X., Qin, L., Lu, X., Liu, Z., Li, Z., Yuan, L., Wang, R., Jin, J., Ma, Z., et al. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002458 · Cited by 8

The dual role of TIGIT in regulatory and effector T cells in chronic liver disease

Bozward, A. G., Davies, S. P., Fiancette, R., Wootton, G. E., Faustini, S. E., Kwok, H. F., Richardson, N., Morris, S. M., Kayani, K., Middleton, G., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101405 · Cited by 8

Mapping clinical CAR-T cells: insights from scRNA-seq

Meehl, M. M., Ward, M. B., & Krenciute, G. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.12.006 · Cited by 8

Use of programmed cell death protein 1 (PD-1) inhibitor therapy in HIV-infected patients with advanced cancer: a single-center study from China

Wu, L., Su, J., Yang, J., Gu, L., Zhang, R., Liu, L., Lu, H., & Chen, J. (2023) · Infectious Agents and Cancer · doi:10.1186/s13027-023-00512-z · Cited by 8

5-Aza-2′-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD4 T cells

Fehn, A., Witzleben, A. V., Grages, A., Kors, T. A., Ezić, J., Betzler, A. C., Brunner, C., Schuler, P. J., Theodoraki, M., Hoffmann, T. K., et al. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101086 · Cited by 8

PD-1+ and TIGIT+ CD4 T Cells Are Associated With Coronary Artery Calcium Progression in HIV-Infected Treated Adults

Bowler, S. A., Chew, G. M., Budoff, M. J., Chow, D. C., Mitchell, B. I., D’Antoni, M. L., Siriwardhana, C., Ndhlovu, L. C., & Shikuma, C. M. (2019) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002001 · Cited by 8

Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection

Webb, G. M., Pessoa, C. T., McCullen, A. J., Hwang, J. M., Humkey, M. C., Thormin-Odum, R., Kukula, K. A., Smedley, J. V., Fischer, M. B., Sciurba, J., et al. (2024) · Journal of Virology · doi:10.1128/jvi.00273-24 · Cited by 11

Role of the TIGIT Immune Checkpoint Pathway in the Eradication of HIV Infection.

Chew, G. M. (2017) · ScholarSpace (University of Hawaii at Manoa)

Correlation Between TIGIT Expression on CD8+ T Cells and Higher Cytotoxic Capacity

Blažková, J., Huiting, E. D., Boddapati, A. K., Shi, V., Whitehead, E. J., Justement, J. S., Nordstrom, J. L., Moir, S. L., Lack, J., & Chun, T. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab155 · Cited by 26

Expression Profile and Biological Role of Immune Checkpoints in Disease Progression of HIV/SIV Infection

Sun, Y., & Xue, J. (2022) · Viruses · doi:10.3390/v14030581 · Cited by 24

TIGIT engagement impairs antiviral effector functions of CD8⁺ T cells from people living with HIV

Ghasemi, N. (2024) · Memorial University Research Repository (Memorial University) · doi:10.48336/60pd-tg67