Cited by 323HIV Research and TreatmentT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

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Chew, Glen M., Fujita, Tsuyoshi, Webb, Gabriela M., Burwitz, Benjamin J., Wu, Helen L., Reed, Jason S., Hammond, Katherine B., Clayton, Kiera L., Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I., Hecht, Frederick M., Ostrowski, Mario, Shikuma, Cecilia M., Hansen, Scott G., Maurer, Mark, Korman, Alan J., Deeks, Steven G., Sacha, Jonah B., Ndhlovu, Lishomwa C.·2016·PLoS Pathogens

DOI 10.1371/journal.ppat.1005349PMC PMC4704737

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Abstract

HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection in blood and SIV infection in lymphoid tissue exhibit higher levels of the negative checkpoint receptor TIGIT. Increased frequencies of TIGIT+ and TIGIT+ PD-1+ CD8+ T cells correlated with parameters of HIV and SIV disease progression. TIGIT remained elevated despite viral suppression in those with either pharmacological antiretroviral control or immunologically in elite controllers. HIV and SIV-specific CD8+ T cells were dysfunctional and expressed high levels of TIGIT and PD-1. Ex-vivo single or combinational antibody blockade of TIGIT and/or PD-L1 restored viral-specific CD8+ T cell effector responses. The frequency of TIGIT+ CD4+ T cells correlated with the CD4+ T cell total HIV DNA. These findings identify TIGIT as a novel marker of dysfunctional HIV-specific T cells and suggest TIGIT along with other checkpoint receptors may be novel curative HIV targets to reverse T cell exhaustion.

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Authors: Chew, G. M., Fujita, T., Webb, G. M., Burwitz, B. J., Wu, H. L., Reed, J. S., Hammond, K. B., Clayton, K. L., Ishii, N., Abdel-Mohsen, M., Liegler, T., Mitchell, B. I., Hecht, F. M., Ostrowski, M., Shikuma, C. M., Hansen, S. G., Maurer, M., Korman, A. J., Deeks, S. G., Sacha, J. B., & Ndhlovu, L. C.
Affiliations: University of Hawaiʻi at Mānoa (US)
Oregon National Primate Research Center (US)
University of Toronto (CA)
Tohoku University (JP)
San Francisco General Hospital (US)
Bristol-Myers Squibb (United States) (US)
Corresponding author: Ndhlovu, Lishomwa C.
ORCID: Chew, Glen M.
Fujita, Tsuyoshi
Webb, Gabriela M.
Burwitz, Benjamin J.
Wu, Helen L.
Reed, Jason S.
Hammond, Katherine B.
Clayton, Kiera L.
Ishii, Naoto
Hecht, Frederick M.
Ostrowski, Mario
Shikuma, Cecilia M.
Hansen, Scott G.
Maurer, Mark
Korman, Alan J.
Deeks, Steven G.
Sacha, Jonah B.
Ndhlovu, Lishomwa C.
Venue: PLoS Pathogens
Publisher: Public Library of Science (PLoS)
Published: 2016-01-07
Volume: 12
Issue: 1
Pages: e1005349
ISSN: 1553-7366 (ISSN-L)
1553-7374
DOI: 10.1371/journal.ppat.1005349
PMC: PMC4704737
OpenAlex: W2225639217
Cited by: 323
References: 63
Citations by year: 2026: 10 · 2025: 25 · 2024: 30 · 2023: 33 · 2022: 33 · 2021: 47 · 2020: 44 · 2019: 36 · 2018: 32 · 2017: 18 · 2016: 12
FWCI: 22.59
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS Pathogens (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
eScholarship (California Digital Library) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: Bristol-Myers Squibb
Oregon Health and Science University (OD011092)
International AIDS Society
National Institutes of Health (n01ai085341-004, OD-011092, RR024131, AI027763, NOI-AI-85341, P51OD011092)
University of California, San Francisco (P30AI027763, UL1RR024131)
Japan Society for the Promotion of Science (15H04742)
National Institute of General Medical Sciences (P30GM103341)
National Institute of Allergy and Infectious Diseases (N01 AI085341, K24AI069994, OD011092, RO1 AI087145, AI027763, RR024131, AI067039, AI069994, AI087145, NOI-AI-85341, HIV-1, R01AI087145, N0I-AI-85341, R24AI067039, P30AI027763)
National Center for Research Resources (UL1RR024131, RR 024131)
Office of AIDS Research
National Institute on Minority Health and Health Disparities (U54MD007584)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: TIGIT, T cell exhaustion, HIV infection, SIV infection, CD8+ T cells, PD-1, PD-L1, immune checkpoint receptors, disease progression, elite controllers, viral suppression, T cell dysfunction, immune restoration, antibody blocking
MeSH terms: Animals, Cell Separation, DNA, Viral, Flow Cytometry, Humans, Lymphocyte Activation, Macaca mulatta, Receptors, Immunologic, RNA, Viral, CD4-Positive T-Lymphocytes, HIV Infections, Simian Acquired Immunodeficiency Syndrome, CD8-Positive T-Lymphocytes, Disease Progression, B7-H1 Antigen

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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

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