The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Testosterone Measured by 10 Immunoassays and by Isotope-Dilution Gas Chromatography–Mass Spectrometry in Sera from 116 Men, Women, and Children
Abstract
Background: Commercially available testosterone immunoassays give divergent results, especially at the low concentrations seen in women. We compared immunoassays and a nonimmunochemical method that could quantify low testosterone concentrations. Methods: We measured serum testosterone in 50 men, 55 women, and 11 children with use of eight nonisotopic immunoassays, two isotopic immunoassays, and isotope-dilution gas chromatography–mass spectrometry (ID/GC-MS). Results: Compared with ID/GC-MS, 7 of the 10 immunoassays tested overestimated testosterone concentrations in samples from women; mean immunoassay results were 46% above those obtained by ID/GC-MS. The immunoassays underestimated testosterone concentrations in samples from men, giving mean results 12% below those obtained by ID/GC-MS. In women, at concentrations of 0.6–7.2 nmol/L, 3 of the 10 immunoassays gave positive mean differences >2.0 nmol/L (range, −0.7 to 3.3 nmol/L) compared with ID/GC-MS; in men at concentrations of 8.2–58 nmol/L, 3 of the 10 immunoassays tested gave mean differences >4.0 nmol/L (range, −4.8 to 2.6 nmol/L). Conclusion: None of the immunoassays tested was sufficiently reliable for the investigation of sera from children and women, in whom very low (0.17 nmol/L) and low (<1.7 nmol/L) testosterone concentrations are expected.
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Metadata
- Authors
- Taieb, J., Mathian, B., Millot, F., Patricot, M.-C., Mathieu, E., Queyrel, N., Lacroix, I., Somma-Delpero, C., & Boudou, P.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-08-01
- Volume
- 49
- Issue
- 8
- Pages
- 1381-1395
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2119682509
- Cited by
- 640
- References
- 48
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taieb, J., Mathian, B., Millot, F., Patricot, M.-C., Mathieu, E., Queyrel, N., Lacroix, I., Somma-Delpero, C., & Boudou, P. (2003). Testosterone Measured by 10 Immunoassays and by Isotope-Dilution Gas Chromatography–Mass Spectrometry in Sera from 116 Men, Women, and Children. Clinical Chemistry. https://doi.org/10.1373/49.8.1381
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