The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Decade of Development in Immunoassay Methodology
Abstract
Immunoassays are now very widely used in the clinical laboratory, either because no other type of assay system is feasible or because they are often the most effective and suitable of the possible analytical methods. The last decade has seen the development and refinement of many new immunoassay reagents and systems. The major trend has been away from liquid-phase assays involving radioisotopic labels, towards fast homogeneous or solid-phase assays capable of operation anywhere; and towards precise and reliable nonisotopic, automated or semi-automated laboratory assays, often with detection limits measured in pico- or attomoles. The use of monoclonal antibodies is now widespread, and the methodologies of labels and of solid-phase components are much more sophisticated. New assay formulations, novel homogeneous systems, immunosensors, free-analyte assays, the importance of thorough validation and of interfering substances, and future trends are discussed.
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Cites
Direct determination of free thyroxin in undiluted serum by equilibrium dialysis/radioimmunoassay.
Nelson, J. C., & Tomei, R. T. (1988) · Clinical Chemistry · doi:10.1093/clinchem/34.9.1733 · Cited by 128
Cited by
Rissin, D. M., Kan, C. W., Campbell, T. G., Howes, S. C., Fournier, D. R., Song, L., Piech, T., Patel, P. P., Chang, L., Rivnak, A. J., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1641 · Cited by 2,119
Kelley, S. O., Mirkin, C. A., Walt, D. R., Ismagilov, R. F., Toner, M., & Sargent, E. H. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.261 · Cited by 398
Signal Amplification by Allosteric Catalysis
Zhu, L., & Anslyn, E. V. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200501476 · Cited by 151
Metadata
- Authors
- Gosling, J. P.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-08-01
- Volume
- 36
- Issue
- 8
- Pages
- 1408-1427
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2118699011
- Cited by
- 457
- References
- 1
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- closed
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