Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study
Abstract
An investigation has been undertaken to determine the effects of fenfluramine on glucose tolerance, insulin, fasting lipid and lipoprotein levels, in a series of twenty-five patients suffering from peripheral arterial disease. The results indicate that fenfluramine significantly improved glucose tolerance and that this was not the result of increased insulin production. Small but significant reduction in fasting cholesterol and β lipoprotein levels also occurred in most of the patients. Fenfluramine had no consistent effect on fasting nonesterified fatty acid, glycerides or pre-β lipoproteins.
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- Authors
- Hooshmand, B., Solomon, A., Kåreholt, I., Leiviskä, J., Rusanen, M., Ahtiluoto, S., Winblad, B., Laatikainen, T., Soininen, H., & Kivipelto, M.
- Affiliations
- University of Eastern Finland (FI)
- Venue
- Neurology
- Published
- 2010-10-19
- Volume
- 75
- Issue
- 16
- Pages
- 1408-1414
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1979444541
- Cited by
- 122
- References
- 43
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 13
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- homocysteine, holotranscobalamin, Alzheimer's disease, fenfluramine, glucose tolerance, insulin, peripheral arterial disease, fasting lipids, cholesterol, low-density lipoprotein, free fatty acids
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