The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Direct Comparison of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in a Large Population of Patients with Chronic and Symptomatic Heart Failure: The Valsartan Heart Failure (Val-HeFT) Data
Open accessAbstract
BACKGROUND: The B-type or brain natriuretic peptides (BNP) and the amino-terminal probrain natriuretic peptide (NT-proBNP) are good markers of prognosis and diagnosis in chronic heart failure (HF). It is unclear, however, whether differences in their biological characteristics modify their clinical correlates and prognostic performance in HF. This work aimed to provide a direct comparison of the prognostic value of BNP and NT-proBNP in patients with chronic and stable HF. METHODS: We measured BNP and NT-proBNP at baseline in 3916 patients enrolled in the Valsartan Heart Failure Trial. To identify the variables associated with both peptides, we conducted simple and multivariable linear regression analyses. We used Cox multivariable regression models to evaluate the independent prognostic value for all-cause mortality, mortality and morbidity, and hospitalization for HF. Prognostic performance was assessed by pairwise comparisons of the area under the curve of receiver-operator characteristic curves. RESULTS: NT-proBNP and BNP had similar relationships with age, left ventrical ejection fraction, and internal diameter and creatinine clearance. Either peptide ranked as the first independent predictor of outcome after adjustment for major confounding clinical characteristics. ROC curves were almost superimposable for all-cause mortality (area under the curve (SE): BNP 0.665 (0.011) vs NT-proBNP 0.679 (0.011); P=0.0734), but NT-proBNP was superior to BNP for predicting mortality and morbidity (P=0.032) or hospitalization for HF (P=0.0143). Overall sensitivity and specificity ranged from 0.590 to 0.696. CONCLUSIONS: The natriuretic peptides BNP and NT-proBNP showed subtle differences in their relation to clinical characteristics and prognostic performance in a large population of patients with chronic and stable HF. They were the most powerful independent markers of outcome in HF.
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Hanley, J. A., & McNeil, B. J. (1983) · Radiology · doi:10.1148/radiology.148.3.6878708 · Cited by 7,016
A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure
Cohn, J. N., & Tognoni, G. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010713 · Cited by 3,108
Predictors of mortality and morbidity in patients with chronic heart failure
Pocock, S. J., Wang, D., Pfeffer, M. A., Yusuf, S., McMurray, J. J. V., Swedberg, K. B., Östergren, J., Michelson, E. L., Pieper, K. S., & Granger, C. B. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi555 · Cited by 973
Doust, J. A., Pietrzak, E., Dobson, A., & Glasziou, P. (2005) · BMJ · doi:10.1136/bmj.330.7492.625 · Cited by 710
B-Type Natriuretic Peptide Predicts Sudden Death in Patients With Chronic Heart Failure
Berger, R., Huelsman, M., Strecker, K., Bojic, A., Moser, P., Stanek, B., & Pacher, R. (2002) · Circulation · doi:10.1161/01.cir.0000016642.15031.34 · Cited by 706
Essential Biochemistry and Physiology of (NT-pro)BNP
Hall, C. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2003.12.015 · Cited by 565
Bergler-Klein, J., Klaar, U., Heger, M., Rosenhek, R., Mundigler, G., Gabriel, H., Binder, T., Pacher, R., Maurer, G., & Baumgartner, H. (2004) · Circulation · doi:10.1161/01.cir.0000126825.50903.18 · Cited by 465
C-Reactive Protein in Heart Failure: Prognostic Value and the Effect of Valsartan
Anand, I. S., Latini, R., Florea, V. G., Kuskowski, M. A., Rector, T., Masson, S., Signorini, S., Mocarelli, P., Hester, A., Glazer, R., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.508465 · Cited by 456
Self-citationB-Type Natriuretic Peptides and Ejection Fraction for Prognosis After Myocardial Infarction
Richards, A. M., Nicholls, M. G., Espiner, E. A., Lainchbury, J. G., Troughton, R. W., Elliott, J., Frampton, C., Turner, J., Crozier, I. G., & Yandle, T. G. (2003) · Circulation · doi:10.1161/01.cir.0000070953.76250.b9 · Cited by 436
Lainchbury, J. G., Campbell, E., Frampton, C. M., Yandle, T. G., Nicholls, M. G., & Richards, A. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00787-3 · Cited by 372
Cited by
Braunwald, E. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800239 · Cited by 1,257
Mueller, C., McDonald, K., de Boer, R. A., Maisel, A., Cleland, J. G. F., Kozhuharov, N., Coats, A. J. S., Metra, M., Mebazaa, A., Ruschitzka, F., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1494 · Cited by 804
Ezekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676
Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., et al. (2018) · GeroScience · doi:10.1007/s11357-018-0042-y · Cited by 359
Madamanchi, C., Alhosaini, H., Sumida, A., & Runge, M. S. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.007 · Cited by 357
Metadata
- Authors
- Masson, S.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06-22
- Volume
- 52
- Issue
- 8
- Pages
- 1528-1538
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2172046452
- Cited by
- 359
- References
- 34
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Direct Comparison of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in a Large Population of Patients with Chronic and Symptomatic Heart Failure: The Valsartan Heart Failure (Val-HeFT) Data. https://app.cochat.ai/papers/10.1373/clinchem.2006.069575
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- Masson, S. (2006). Direct Comparison of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in a Large Population of Patients with Chronic and Symptomatic Heart Failure: The Valsartan Heart Failure (Val-HeFT) Data. Clinical Chemistry. https://doi.org/10.1373/clinchem.2006.069575
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