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The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.

Heart Failure Association of the European Society of Cardiology Practical Guidance on the Use of Natriuretic Peptide Concentrations

Open access
Mueller, Christian, McDonald, Kenneth, de Boer, Rudolf A., Maisel, Alan, Cleland, John G.F., Kozhuharov, Nikola, Coats, Andrew J.S., Metra, Marco, Mebazaa, Alexandre, Ruschitzka, Frank, Lainscak, Mitja, Filippatos, Gerasimos, Seferovic, Petar M., Meijers, Wouter C., Bayes-Genis, Antoni, Mueller, Thomas, Richards, Mark, Januzzi, James L.·2019·European Journal of Heart Failure

Abstract

Natriuretic peptide [NP; B-type NP (BNP), N-terminal proBNP (NT-proBNP), and midregional proANP (MR-proANP)] concentrations are quantitative plasma biomarkers for the presence and severity of haemodynamic cardiac stress and heart failure (HF). End-diastolic wall stress, intracardiac filling pressures, and intracardiac volumes seem to be the dominant triggers. This paper details the most important indications for NPs and highlights 11 key principles underlying their clinical use shown below. (i)NPs should always be used in conjunction with all other clinical information.(ii)NPs are reasonable surrogates for intracardiac volumes and filling pressures.(iii)NPs should be measured in all patients presenting with symptoms suggestive of HF such as dyspnoea and/or fatigue, as their use facilitates the early diagnosis and risk stratification of HF.(iv)NPs have very high diagnostic accuracy in discriminating HF from other causes of dyspnoea: the higher the NP, the higher the likelihood that dyspnoea is caused by HF.(v)Optimal NP cut-off concentrations for the diagnosis of acute HF (very high filling pressures) in patients presenting to the emergency department with acute dyspnoea are higher compared with those used in the diagnosis of chronic HF in patients with dyspnoea on exertion (mild increase in filling pressures at rest).(vi)Obese patients have lower NP concentrations, mandating the use of lower cut-off concentrations (about 50% lower).(vii)In stable HF patients, but also in patients with other cardiac disorders such as myocardial infarction, valvular heart disease, atrial fibrillation or pulmonary embolism, NP concentrations have high prognostic accuracy for death and HF hospitalization.(viii)Screening with NPs for the early detection of relevant cardiac disease including left ventricular systolic dysfunction in patients with cardiovascular risk factors may help to identify patients at increased risk, therefore allowing targeted preventive measures to prevent HF.(ix)BNP, NT-proBNP and MR-proANP have comparable diagnostic and prognostic accuracy.(x)In patients with shock, NPs cannot be used to identify cause (e.g. cardiogenic vs. septic shock), but remain prognostic.(xi)NPs cannot identify the underlying cause of HF and, therefore, if elevated, must always be used in conjunction with cardiac imaging.

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Metadata

Authors
Mueller, C., McDonald, K., de Boer, R. A., Maisel, A., Cleland, J. G. F., Kozhuharov, N., Coats, A. J. S., Metra, M., Mebazaa, A., Ruschitzka, F., Lainscak, M., Filippatos, G., Seferovic, P. M., Meijers, W. C., Bayes-Genis, A., Mueller, T., Richards, M., & Januzzi, J. L.
Venue
European Journal of Heart Failure
Published
2019-06-01
Volume
21
Issue
6
Pages
715-731
ISSN
  • 1388-9842 (ISSN-L)
  • 1879-0844
OpenAlex
W2944687799
Cited by
804
References
152
FWCI
53.47
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Heart Failure Association of the European Society of Cardiology Practical Guidance on the Use of Natriuretic Peptide Concentrations. https://app.cochat.ai/papers/10.1002/ejhf.1494
The paper
Mueller, C., McDonald, K., de Boer, R. A., Maisel, A., Cleland, J. G. F., Kozhuharov, N., Coats, A. J. S., Metra, M., Mebazaa, A., Ruschitzka, F., Lainscak, M., Filippatos, G., Seferovic, P. M., Meijers, W. C., Bayes-Genis, A., Mueller, T., Richards, M., & Januzzi, J. L. (2019). Heart Failure Association of the European Society of Cardiology Practical Guidance on the Use of Natriuretic Peptide Concentrations. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1494

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.