The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans
Abstract
Background: Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies. Methods: We used real-time PCR and in-house immunoassays to quantify the mRNA and serum concentrations of lipocalin-2 in C57BL/KsJ db/db obese mice and their age- and sex-matched lean littermates. We analyzed the association between serum lipocalin-2 concentrations and various metabolic and inflammatory variables in 229 persons (121 men and 108 women) recruited from a previous cross-sectional study, and we evaluated the effect of the insulin-sensitizing drug rosiglitazone on serum lipocalin-2 concentrations in 32 diabetic patients (21 men and 11 women). Results: Compared with the lean littermates, lipocalin-2 mRNA expression in adipose tissue and liver and its circulating concentrations were significantly increased in db/db diabetic/obese mice (P <0.001). These changes were normalized after rosiglitazone treatment. In humans, circulating lipocalin-2 concentrations were positively correlated (P <0.005) with adiposity, hypertriglyceridemia, hyperglycemia, and the insulin resistance index, but negatively correlated (P = 0.002) with HDL cholesterol. There was also a strong positive association between lipocalin-2 concentrations and high sensitivity C-reactive protein (hs-CRP), independent of age, sex, and adiposity (P = 0.007). Furthermore, rosiglitazone-mediated decreases in lipocalin-2 concentrations correlated significantly with increases in insulin sensitivity (r = 0.527; P = 0.002) and decreases in hs-CRP concentrations (r = 0.509; P = 0.003). Conclusions: Lipocalin-2 is an inflammatory marker closely related to obesity and its metabolic complications. Measurement of serum lipocalin-2 might be useful for evaluating the outcomes of various clinical interventions for obesity-related metabolic and cardiovascular diseases.
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“Most importantly, lipocalin 2 (siderocalin/NGAL) is strongly associated with the development of diabetes [612,613].”
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1 retracted
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Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
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Metadata
- Authors
- Wang, Y., Lam, K. S. L., Kraegen, E. W., Sweeney, G., Zhang, J., Tso, A. W., Chow, W.-S., Wat, N. M., Xu, J. Y., Hoo, R. L., & Xu, A.
- Affiliations
- Genome Research Center and Department of Biochemistry,
- University of Hong Kong (HK)
- Garvan Institute of Medical Research (AU)
- York University (CA)
- Research Center of Heart, Brain, Hormone and Healthy Aging, and
- Corresponding author
- Xu, Aimin
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-01-01
- Volume
- 53
- Issue
- 1
- Pages
- 34-41
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2123416046
- Cited by
- 578
- References
- 42
- Citations by year
- 2026: 18 · 2025: 29 · 2024: 31 · 2023: 28 · 2022: 45 · 2021: 36 · 2020: 28 · 2019: 39 · 2018: 31 · 2017: 33 · 2016: 20 · 2015: 31 · 2014: 43 · 2013: 35 · 2012: 34
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- neutrophil gelatinase-associated lipocalin, obesity, insulin resistance, hyperglycemia, inflammation, C-reactive protein, adipose tissue, liver, rosiglitazone, type 2 diabetes, hypertriglyceridemia, HDL cholesterol, db/db mice, biomarkers
- MeSH terms
- Lipocalin-2, Rosiglitazone, Acute-Phase Proteins, Adult, Age Factors, Aged, Animals, C-Reactive Protein, Diabetes Mellitus, Type 2, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hyperglycemia, Inflammation, Insulin Resistance, Male, Mice, Inbred C57BL, Mice, Obese, Middle Aged, Obesity, Proto-Oncogene Proteins, Sex Factors, Biomarkers, Oncogene Proteins, Body Mass Index, Polymerase Chain Reaction, Thiazolidinediones, PPAR gamma, Mice, Lipocalins
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