Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944

Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011

Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies

(2004) · The Lancet · doi:10.1016/s0140-6736(03)15268-3 · Cited by 12,717

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143

Adiponectin and Adiponectin Receptors

Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634

Adipose tissue, adipokines, and inflammation

Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 966

Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation

Chassaing, B., Srinivasan, G., Delgado, M. A., Young, A. N., Gewirtz, A. T., & Vijay–Kumar, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044328 · Cited by 584

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554

The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

Chakraborty, S., Kaur, S., Guha, S., & Batra, S. K. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.03.008 · Cited by 503

The Adipokine Lipocalin 2 Is Regulated by Obesity and Promotes Insulin Resistance

Yan, Q.-W., Yang, Q., Mody, N., Graham, T. E., Hsu, C.-H., Xu, Z., Houstis, N. E., Kahn, B. B., & Rosen, E. D. (2007) · Diabetes · doi:10.2337/db07-0007 · Cited by 483

Lipocalin 2: an emerging player in iron homeostasis and inflammation

Xiao, X., Yeoh, B. S., & Vijay-Kumar, M. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064559 · Cited by 426

Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage

Mori, K., & Nakao, K. (2007) · Kidney International · doi:10.1038/sj.ki.5002165 · Cited by 415

Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation

Moschen, A. R., Adolph, T. E., Gerner, R. R., Wieser, V., & Tilg, H. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.01.003 · Cited by 359

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

Thijssen, E., van Caam, A., & van der Kraan, P. M. (2014) · Rheumatology · doi:10.1093/rheumatology/keu464 · Cited by 379

Lipocalin-2: Structure, function, distribution and role in metabolic disorders

Jaberi, S. A., Cohen, A., D’Souza, C. M., Abdulrazzaq, Y. M., Ojha, S. K., Bastaki, S. M. A., & Adeghate, E. A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112002 · Cited by 349

Inflammation and iron deficiency in the hypoferremia of obesity

Yanoff, L. B., Menzie, C. M., Denkinger, B., Sebring, N. G., McHugh, T., Remaley, A. T., & Yanovski, J. A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803625 · Cited by 341

The impact of aging on adipose function and adipokine synthesis

Mancuso, P., & Bouchard, B. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00137 · Cited by 314

Functional and pathological roles of the 12- and 15-lipoxygenases

Dobrian, A. D., Lieb, D. C., Cole, B. K., Taylor, D., Chakrabarti, S. K., & Nadler, J. L. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.10.005 · Cited by 336

Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model

Martín, R., Miquel, S., Chain, F., Natividad, J. M., Jury, J., Lu, J., Sokol, H., Theodorou, V., Bercik, P., Verdu, E. F., et al. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0400-1 · Cited by 309

The Role of Lipocalin 2 in the Regulation of Inflammation in Adipocytes and Macrophages

Zhang, J., Wu, Y., Zhang, Y., LeRoith, D., Bernlohr, D., & Chen, X. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0420 · Cited by 302

The role of osteoblasts in energy homeostasis

Dirckx, N., Moorer, M. C., Clemens, T. L., & Riddle, R. C. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0246-y · Cited by 292

Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention

Zhu, W., Cheng, K. K. Y., Vanhoutte, P. M., Lam, K. S. L., & Xu, A. (2008) · Clinical Science · doi:10.1042/cs20070347 · Cited by 291

The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases

Abella, V., Scotece, M., Conde, J., Gómez, R., Lois, A., Pino, J., Gómez-Reino, J. J., Lago, F., Mobasheri, A., & Gualillo, O. (2015) · Biomarkers · doi:10.3109/1354750x.2015.1123354 · Cited by 288

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

Law, I. K. M., Xu, A., Lam, K. S. L., Berger, T., Mak, T. W., Vanhoutte, P. M., Liu, J. T. C., Sweeney, G., Zhou, M., Yang, B., et al. (2010) · Diabetes · doi:10.2337/db09-1541 · Cited by 297

Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

Rodríguez, A., Ezquerro, S., Méndez-Giménez, L., Becerril, S., & Frühbeck, G. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2015 · Cited by 287

Sex dimorphism and depot differences in adipose tissue function

White, U. A., & Tchoukalova, Y. D. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.006 · Cited by 296

Cytokines and abnormal glucose and lipid metabolism

Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282

Adiposity and Insulin Resistance in Humans: The Role of the Different Tissue and Cellular Lipid Depots

HOCKING, S. L., Samocha‐Bonet, D., Milner, K., Greenfield, J. R., & Chisholm, D. J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1041 · Cited by 295

The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL)

Romejko, K., Markowska, M., & Niemczyk, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310470 · Cited by 264

Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation

Ren, Y., Zhao, H., Yin, C., Lan, X., Wu, L., Du, X., Griffiths, H. R., & Gao, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.873699 · Cited by 276

Inflammation and metabolic dysfunction: links to cardiovascular diseases

Taube, A., Schlich, R., Sell, H., Eckardt, K., & Eckel, J. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00907.2011 · Cited by 246

High Sugar-Induced Insulin Resistance in Drosophila Relies on the Lipocalin Neural Lazarillo

Pasco, M. Y., & Léopold, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036583 · Cited by 234

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

Zimmermann, M. B., Zeder, C., Muthayya, S., Winichagoon, P., Chaouki, N., Aeberli, I., & Hurrell, R. F. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.43 · Cited by 225

Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity-related inflammation rather than by differences in dietary iron intake

Cepeda-Lopez, A. C., Osendarp, S. J. M., Melse‐Boonstra, A., Herter‐Aeberli, I., González‐Salazar, F., Feskens, E. J. M., Villalpando, S., & Zimmermann, M. B. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005439 · Cited by 230

Adipose Inflammation, Insulin Resistance, and Cardiovascular Disease

Shah, A. D., Mehta, N. N., & Reilly, M. P. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108325251 · Cited by 218

A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

Liu, M., Zhou, L., Xu, A., Lam, K. S. L., Wetzel, M. D., Xiang, R., Zhang, J., Xin, X., Dong, L., & Liu, F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806341105 · Cited by 211

Free fatty acids and skeletal muscle insulin resistance

Kraegen, E. W., & Cooney, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000319118.44995.9a · Cited by 210

Diverse functional roles of lipocalin-2 in the central nervous system

Jha, M. K., Lee, S., Park, D. H., Kook, H., Park, K.-G., Lee, I.-K., & Suk, K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.006 · Cited by 195

Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans

Catalán, V., Gómez‐Ambrosi, J., Rodrı́guez, A., Ramírez, B., Silva, C., Rotellar, F., Gil, M. J. C., Cienfuegos, J. A., Salvador, J., & Frühbeck, G. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0486-8 · Cited by 190

New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women

Auguet, T., Quintero, Y., Riesco, D., Morancho, B., Terra, X., Crescenti, A., Broch, M., Aguilar, C., Olona, M., Porras, J. A., et al. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-60 · Cited by 190

Adipocytokines and Insulin Resistance

Esteve, E., Ricart, W., & Fernández‐Real, J. M. (2009) · Diabetes Care · doi:10.2337/dc09-s340 · Cited by 184

The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction

Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 213

Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs

Lee, M.-W., Lee, M., & Oh, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060854 · Cited by 192

Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease†

Milner, K., van der Poorten, D., Xu, A., Bugianesi, E., Kench, J. G., Lam, K. S. L., Chisholm, D. J., & George, J. (2009) · Hepatology · doi:10.1002/hep.22896 · Cited by 176

Adipokines, Metabolic Syndrome and Rheumatic Diseases

Abella, V., Scotece, M., Conde, J., López, V., Lazzaro, V., Pino, J., Gómez-Reino, J. J., & Gualillo, O. (2014) · Journal of Immunology Research · doi:10.1155/2014/343746 · Cited by 160

Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment

Gomez-Chou, S. B., Swidnicka-Siergiejko, A. K., Badi, N., Chavez-Tomar, M., Lesinski, G. B., Bekaii‐Saab, T., Farren, M. R., Mace, T. A., Schmidt, C. R., Liu, Y., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1986 · Cited by 162

The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism

Mayneris‐Perxachs, J., Moreno‐Navarrete, J. M., & Fernández‐Real, J. M. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00721-3 · Cited by 161

The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome

Kim, J. E., Kim, J., Jo, M.-J., Cho, E., Ahn, S.-Y., Kwon, Y.-J., & Ko, G.-J. (2022) · Molecules · doi:10.3390/molecules27020334 · Cited by 164

Control of Metabolic Homeostasis by Stress Signaling Is Mediated by the Lipocalin NLaz

Hull‐Thompson, J., Muffat, J., Sánchez, D., Walker, D. W., Benzer, S., Ganfornina, M. D., & Jasper, H. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000460 · Cited by 152

Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: a narrative review

Xiong, Y., Knoedler, S. A., Alfertshofer, M. G., Kim, B., Jiang, D., Liu, G., Rinkevich, Y., & Mi, B. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07583-3 · Cited by 157

Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease

Choi, K. M., Lee, J. S., Kim, E. J., Baik, S. H., Seo, H. S., Cho, Y., Oh, D. J., & Park, C. G. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0633 · Cited by 139

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer’s disease associated with obesity, metabolic syndrome, and type 2 diabetes

Rodrigues, M. E. D. S., Houser, M. C., Walker, D. I., Jones, D. P., Chang, J., Barnum, C. J., & Tansey, M. G. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0546-4 · Cited by 141

Adipose Tissue Hypertrophy, An Aberrant Biochemical Profile and Distinct Gene Expression in Lipedema

Felmerer, G., Stylianaki, A., Hägerling, R., Wang, A., Ströbel, P., Hollmén, M., Lindenblatt, N., & Gousopoulos, E. (2020) · Journal of Surgical Research · doi:10.1016/j.jss.2020.03.055 · Cited by 141

Getting the message across: mechanisms of physiological cross talk by adipose tissue

Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 140

Lipocalin-2 Induces Cardiomyocyte Apoptosis by Increasing Intracellular Iron Accumulation

Xu, G., Ahn, J. H., Chang, S. Y., Eguchi, M., Ogier, A., Han, S., Park, Y., Shim, C. Y., Jang, Y., Yang, B., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.275719 · Cited by 140

Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

Luciani, A., Schumann, A., Berquez, M., Chen, Z., Nieri, D., Failli, M., Debaix, H., Festa, B. P., Tokonami, N., Raimondi, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14729-8 · Cited by 134

Functional and structural features of adipokine family

Raucci, R., Rusolo, F., Sharma, A., Colonna, G., Castello, G., & Costantini, S. (2012) · Cytokine · doi:10.1016/j.cyto.2012.08.036 · Cited by 139

Chronic Hepatitis C Is Associated With Peripheral Rather Than Hepatic Insulin Resistance

Milner, K., van der Poorten, D., Trenell, M. I., Jenkins, A. B., Xu, A., Smythe, G. A., Dore, G. J., Zekry, A., Weltman, M., Fragomeli, V., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.050 · Cited by 132

Evaluation of the ARCHITECT urine NGAL assay: Assay performance, specimen handling requirements and biological variability

Grenier, F. C., Ali, S., Syed, H., Workman, R., Martens, F., Liao, M., Wang, Y., & Wong, P.-Y. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.12.008 · Cited by 132

Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice

Hui, X., Zhu, W., Wang, Y., Lam, K. S. L., Zhang, J., Wu, D., Kraegen, E. W., Li, Y., & Xu, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.001107 · Cited by 130

Adiponectin as a potential biomarker of vascular disease

Mohammadi, S., Arefhosseini, S. R., Ebrahimi‐Mameghani, M., Fallah, P., & Bazi, Z. (2015) · Vascular Health and Risk Management · doi:10.2147/vhrm.s48753 · Cited by 129

Lipocalin 2 is a Regulator Of Macrophage Polarization and NF-κB/STAT3 Pathway Activation

Guo, H., Jin, D., & Chen, X. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1092 · Cited by 134

Induction of lipocalin-2 expression in acute and chronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1β through nuclear factor-κB activation

Borkham‐Kamphorst, E., Drews, F., & Weiskirchen, R. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02495.x · Cited by 127

A Novel Early Pregnancy Risk Prediction Model for Gestational Diabetes Mellitus

Sweeting, A., Wong, J., Appelblom, H., Ross, G. P., Kouru, H., Williams, P. F., Sairanen, M., & Hyett, J. A. (2018) · Fetal Diagnosis and Therapy · doi:10.1159/000486853 · Cited by 128

STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper

Scarl, R. T., Lawrence, C. M., Gordon, H. M., & Nunemaker, C. S. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0594 · Cited by 122

Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks

Francisco, V., Pérez, T., Pino, J., López, V., Franco‐Trepat, E., Alonso‐Pérez, A., González-Gay, M. Á., Mera, A., Lago, F., Gómez, R., et al. (2017) · Journal of Orthopaedic Research® · doi:10.1002/jor.23788 · Cited by 129

Adverse effects of consuming high fat–sugar diets on cognition: implications for understanding obesity

Yeomans, M. R. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117000805 · Cited by 122

A role for novel adipose tissue‐secreted factors in obesity‐related carcinogenesis

Fernández, B. C., Andrade, S., Carreira, M. C., Casanueva, F. F., & Crujeiras, A. B. (2016) · Obesity Reviews · doi:10.1111/obr.12377 · Cited by 108

Lipocalin 2: A New Mechanoresponding Gene Regulating Bone Homeostasis

Rucci, N., Capulli, M., Piperni, S. G., Cappariello, A., Lau, P., Frings‐Meuthen, P., Heer, M. A., & Teti, A. M. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2341 · Cited by 108

Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their complex MMP-9/NGAL in breast cancer disease

Provatopoulou, X., Gounaris, A., Kalogera, E., Zagouri, F., Flessas, I. I., Goussetis, E., Nonni, A., Papassotiriou, I., & Zografos, G. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-390 · Cited by 108

Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo

Gundala, N. K. V., Naidu, V. G. M., & Das, U. N. (2016) · Nutrition · doi:10.1016/j.nut.2016.10.004 · Cited by 107

Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism

Kim, K. E., Jung, Y., Min, S., Nam, M., Heo, R. W., Jeon, B. T., Song, D. H., Yi, C., Jeong, E. A., Kim, H., et al. (2016) · Scientific Reports · doi:10.1038/srep30111 · Cited by 112

Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes

Mosialou, I., Shikhel, S., Luo, N., Πετροπούλου, Π.-Ι., Panitsas, K., Bisikirska, B. C., Rothman, N. J., Τέντα, Ρ., Cariou, B., Wargny, M., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191261 · Cited by 106

Effect of exercise training on A‐FABP, lipocalin‐2 and RBP4 levels in obese women

Choi, K. M., Kim, T. N., Yoo, H. J., Lee, K. W., Cho, G. J., Hwang, T. G., Baik, S. H., Choi, D. S., & Kim, S. M. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03374.x · Cited by 104

Neutrophil Gelatinase–Associated Lipocalin, a Novel Mineralocorticoid Biotarget, Mediates Vascular Profibrotic Effects of Mineralocorticoids

Tarjus, A., Martínez‐Martínez, E., Amador, C. A., Latouche, C., Moghrabi, S. E., Berger, T., Mak, T. W., Fay, R., Farman, N., Rossignol, P., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05431 · Cited by 105

Association of Neutrophil Gelatinase-Associated Lipocalin With the Severity of Coronary Artery Disease

Zografos, T. A., Haliassos, A., Korovesis, S., Giazitzoglou, E., Voridis, E. M., & Katritsis, D. G. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.05.023 · Cited by 100

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance

Moreno‐Navarrete, J. M., Manco, M., Ibáñez, J., García‐Fuentes, E., Ortega, F. J., Gorostiaga, E. M., Vendrell, J. J., Izquierdo, M., Martínez, C., Nolfe, G., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.242 · Cited by 100

The Induction of Lipocalin-2 Protein Expression in Vivo and in Vitro

Zhao, P., Elks, C. M., & Stephens, J. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.532234 · Cited by 98

Upregulation of Lipocalin 2 in Adipose Tissues of Severely Obese Women: Positive Relationship With Proinflammatory Cytokines

Auguet, T., Quintero, Y., Terra, X., Martínez, S., Lucas, A., Pellitero, S., Aguilar, C., Hernández, M., Castillo, D. D., & Richart, C. (2011) · Obesity · doi:10.1038/oby.2011.61 · Cited by 99

Lipocalin 2 Expression and Secretion Is Highly Regulated by Metabolic Stress, Cytokines, and Nutrients in Adipocytes

Zhang, Y., Foncea, R. E., Deis, J. A., Guo, H., Bernlohr, D., & Chen, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096997 · Cited by 96

Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

Dekens, D. W., Eisel, U. L. M., Gouweleeuw, L., Schoemaker, R. G., Deyn, P. P. D., & Naudé, P. J. W. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101414 · Cited by 93

Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes

Cabré, A., Lázaro, I., Girona, J., Manzanares, J. M., Marimón, F., Plana, N., Heras, M., & Masana, L. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800102-jlr200 · Cited by 91

Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet

Flowers, M. T., Keller, M. P., Choi, Y., Hong, L., Kendziorski, C. M., Ntambi, J. M., & Attie, A. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00139.2007 · Cited by 95

Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver

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Neutrophil Gelatinase-Associated Lipocalin Is a Novel Mineralocorticoid Target in the Cardiovascular System

Latouche, C., Moghrabi, S. E., Messaoudi, S., Cat, A. N. D., Hernández-Díaz, I., de la Rosa, D. Á., Perret, C., López‐Andrés, N., Rossignol, P., Zannad, F. M., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.187872 · Cited by 96

Regulation of Energy Metabolism by Bone-Derived Hormones

Mera, P., Ferron, M., & Mosialou, I. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031666 · Cited by 90

Changes in Whole Blood Gene Expression in Obese Subjects with Type 2 Diabetes Following Bariatric Surgery: a Pilot Study

Berisha, S. Z., Serre, D., Schauer, P. R., Kashyap, S. R., & Smith, J. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016729 · Cited by 92

Adiponectin improves endothelial function in mesenteric arteries of rats fed a high‐fat diet: role of perivascular adipose tissue

Sena, C. M., Pereira, A. M., Fernandes, R., Letra, L., & Seiça, R. M. F. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13756 · Cited by 91

Experimental and Human Evidence for Lipocalin‐2 (Neutrophil Gelatinase‐Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and Heart Failure

Marques, F. Z., Prestes, P. R., Byars, S., Ritchie, S. C., Würtz, P., Patel, S. K., Booth, S. A., Rana, I., Minoda, Y., Berzins, S. P., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005971 · Cited by 85

Changes of serum and urine neutrophil gelatinase-associated lipocalin in type-2 diabetic patients with nephropathy: one year observational follow-up study

Yang, Y., He, X., Chen, S., Wang, L., Li, E., & Xu, L. (2009) · Endocrine · doi:10.1007/s12020-009-9187-x · Cited by 83

Effect of lifestyle modification on serum chemerin concentration and its association with insulin sensitivity in overweight and obese adults with type 2 diabetes

Kim, S. H., Lee, S., Ahn, K. Y., Lee, D. H., Suh, Y. J., Cho, S. G., Choi, Y. J., Lee, D. H., Lee, S. Y., Hong, S. B., et al. (2013) · Clinical Endocrinology · doi:10.1111/cen.12249 · Cited by 81

Evidence for Masculinization of Adipokine Gene Expression in Visceral and Subcutaneous Adipose Tissue of Obese Women With Polycystic Ovary Syndrome (PCOS)

Martínez-García, M. Á., Montes‐Nieto, R., Fernández‐Durán, E., Insenser, M. R., Luque‐Ramírez, M., & Escobar-Morreale, H. F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3414 · Cited by 81

Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease

Wong, Y., & Tse, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.713191 · Cited by 82

Direct effects of adipokines on the heart: focus on adiponectin

Park, M. S., & Sweeney, G. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9337-8 · Cited by 79

Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people

Huang, Y., Yang, Z. H., Ye, Z., Li, Q., Wen, J., Tao, X., Chen, L., He, M., Wang, X., Lü, B., et al. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-11 · Cited by 78

Deamidated Lipocalin‐2 Induces Endothelial Dysfunction and Hypertension in Dietary Obese Mice

Song, E., Fan, P., Huang, B., Deng, H., Cheung, B. M. Y., Félétou, M., Vilaine, J., Villeneuve, N., Xu, A., Vanhoutte, P. M., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000837 · Cited by 77

Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats.

Rouse, R., Zhang, J., Stewart, S., Rosenzweig, B., Espandiari, P., & Sadrieh, N. (2011) · Kidney International · doi:10.1038/ki.2010.463 · Cited by 79

Lipocalin 2 regulation and its complex role in inflammation and cancer

Li, C., & Chan, Y. R. (2011) · Cytokine · doi:10.1016/j.cyto.2011.07.021 · Cited by 79

Lipocalin 2 Plays an Important Role in Regulating Inflammation in Retinal Degeneration

Parmar, T., Parmar, V. M., Perusek, L., Georges, A., Takahashi, M., Crabb, J. W., & Maeda, A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701573 · Cited by 76

Small lipid‐binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin‐2

Wang, Y. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01528.x · Cited by 75

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

van Dijk, G., van Heijningen, S., Reijne, A. C., Nyakas, C., van der Zee, E. A., & Eisel, U. L. M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00173 · Cited by 75

Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics

Farahbakhsh-Farsi, P., Djalali, M., Koohdani, F., Saboor-Yaraghi, A. A., Eshraghian, M. R., Javanbakht, M. H., Chamari, M., & Djazayery, A. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-13-1 · Cited by 74

STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes

Zhao, P., & Stephens, J. M. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.04.003 · Cited by 73

Neurophil gelatinase-associated lipocalin as a new biomarker in laboratory medicine

Makris, K., Rizos, D., Kafkas, N. V., & Haliassos, A. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0227 · Cited by 74

Emerging clinical and experimental evidence for the role of lipocalin‐2 in metabolic syndrome

Jang, Y., Lee, J. H., Wang, Y., & Sweeney, G. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05557.x · Cited by 64

Circulating lipocalin 2 is associated with body fat distribution at baseline but is not an independent predictor of insulin resistance: the prospective Cyprus Metabolism Study

Liu, X., Hamnvik, O. R., Petrou, M., Gong, H., Chamberland, J. P., Christophi, C. A., Kales, S. N., Christiani, D. C., & Mantzoros, C. S. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0660 · Cited by 38

Recent advances in the study of lipocalin-2

Yuqian, B. (2009)

Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans

Catalán, V., Gómez‐Ambrosi, J., Rodrı́guez, A., Ramírez, B., Silva, C., Rotellar, F., Gil, M. J. C., Cienfuegos, J. A., Salvador, J., & Frühbeck, G. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0486-8 · Cited by 190

Relationship between serum lipocalin-2 and obesity and type 2 diabetes mellitus

Chen, Y.-T., & Cheng, X. (2011)